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Sources of 7-ketocholesterol, metabolism and inactivation strategies: food and biomedical applications

Imen Ghzaiel , Khouloud Sassi , Amira Zarrouk , Shubhrima Ghosh , Irundika Dias , et al.
Redox Experimental Medicine, 2022, 2022 (1), pp.R40-R56. ⟨10.1530/REM-22-0005⟩
Article dans une revue hal-04506089v1

Biological activities of Schottenol and Spinasterol, two natural phytosterols present in argan oil and in cactus pear seed oil, on murine miroglial BV2 cells

M'Hammed Saïd El Kebbaj , David Masson , Gérard Lizard , Boubker Nasser , Mustapha Cherkaoui-Malki , et al.
Biochemical and Biophysical Research Communications, 2014, 446 (3, SI), pp.798-804. ⟨10.1016/j.bbrc.2014.02.074⟩
Article dans une revue hal-01518331v1

Attenuation of 7-ketocholesterol- and 7β-hydroxycholesterol-induced oxiapoptophagy by nutrients, synthetic molecules and oils: Potential for the prevention of age-related diseases

T. Nury , A. Yammine , I. Ghzaiel , K. Sassi , A. Zarrouk , et al.
Ageing Research Reviews - ARR, 2021, 68, pp.101324. ⟨10.1016/j.arr.2021.101324⟩
Article dans une revue hal-04506059v1

Comparison of the effects of major fatty acids present in the Mediterranean diet (oleic acid, docosahexaenoic acid) and in hydrogenated oils (elaidic acid) on 7-ketocholesterol-induced oxiapoptophagy in microglial BV-2 cells

Meryam Debbabi , Amira Zarrouk , Maryem Bezine , Wiem Meddeb , Thomas Nury , et al.
Chemistry and Physics of Lipids, 2017, 207 (Pt B), pp.151-170. ⟨10.1016/j.chemphyslip.2017.04.002⟩
Article dans une revue hal-01912331v1
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Dimethyl fumarate and monomethyl fumarate attenuate oxidative stress and mitochondrial alterations leading to oxiapoptophagy in 158N murine oligodendrocytes treated with 7β-hydroxycholesterol

Randa Sghaier , Thomas Nury , Valerio Leoni , Claudio Caccia , Jean-Paul Pais de Barros , et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 194, pp.105432. ⟨10.1016/j.jsbmb.2019.105432⟩
Article dans une revue hal-03487954v1

Protective effects of milk thistle (Sylibum marianum) seed oil and α-tocopherol against 7β-hydroxycholesterol-induced peroxisomal alterations in murine C2C12 myoblasts: Nutritional insights associated with the concept of pexotherapy

Imen Ghzaiel , Amira Zarrouk , Soukaina Essadek , Lucy Martine , Souha Hammouda , et al.
Steroids, 2022, 183, pp.109032. ⟨10.1016/j.steroids.2022.109032⟩
Article dans une revue hal-03715700v1

Personalized nutrition in aging society: redox control of major-age related diseases through the NutRedOx Network (COST Action CA16112)

Josep Tur , Claus Jacob , Patrick Chaimbault , Mohammad Tadayyon , Elke Richling , et al.
Free Radical Research, 2019, 53 (suppl 1), pp.1163-1170. ⟨10.1080/10715762.2019.1572890⟩
Article dans une revue hal-02044918v1

Chemical and Biochemical Features of Spinasterol and Schottenol

Farid Khallouki , Mohamed Ksila , Imen Ghzaiel , Soukaina Essadek , Mounia Tahri Joutey , et al.
Implication of Oxysterols and Phytosterols in Aging and Human Diseases, 1440, Springer International Publishing, pp.45-55, 2023, Advances in Experimental Medicine and Biology, 978-3-031-43883-7. ⟨10.1007/978-3-031-43883-7_3⟩
Chapitre d'ouvrage hal-04509752v1
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Induction of a non-apoptotic mode of cell death associated with autophagic characteristics with steroidal maleic anhydrides and 7β-hydroxycholesterol on glioma cells

K. Sassi , T. Nury , A. Zarrouk , R. Sghaier , A. Khalafi-Nezhad , et al.
Journal of Steroid Biochemistry and Molecular Biology, 2019, 191, pp.105371. ⟨10.1016/j.jsbmb.2019.04.020⟩
Article dans une revue hal-03485843v1

Modulation of Kv3.1b potassium channel level and intracellular potassium concentration in 158N murine oligodendrocytes and BV-2 murine microglial cells treated with 7-ketocholesterol, 24S-hydroxycholesterol or tetracosanoic acid (C24:0)

Maryem Bezine , Sonia Maatoug , Rym Ben Khalifa , Meryam Debbabi , Amira Zarrouk , et al.
Biochimie, 2018, 153, pp.56-69. ⟨10.1016/j.biochi.2018.02.008⟩
Article dans une revue hal-01876263v1
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Antioxidant properties and cytoprotective effect of pistacia lentiscus l. Seed oil against 7β-hydroxycholesterol-induced toxicity in c2c12 myoblasts: Reduction in oxidative stress, mitochondrial and peroxisomal dysfunctions and attenuation of cell death

Imen Ghzaiel , Amira Zarrouk , Thomas Nury , Michela Libergoli , Francesca Florio , et al.
Antioxidants , 2021, 10 (11), pp.1772. ⟨10.3390/antiox10111772⟩
Article dans une revue hal-03443580v1

An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system

Asmaa Badreddine , Karym El Mostafa , Amira Zarrouk , Thomas Nury , Youssef El Kharrassi , et al.
Steroids, 2015, 99 (B, SI), pp.119-124. ⟨10.1016/j.steroids.2015.01.005⟩
Article dans une revue hal-01518108v1

Evidence of K+ homeostasis disruption in cellular dysfunction triggered by 7-ketocholesterol, 24S-hydroxycholesterol, and tetracosanoic acid (C24:0) in 158N murine oligodendrocytes

Maryem Bezine , Meryam Debbabi , Thomas Nury , Rym Ben-Khalifa , Mohammad Samadi , et al.
Chemistry and Physics of Lipids, 2017, 207 (Pt B), pp.135-150. ⟨10.1016/j.chemphyslip.2017.03.006⟩
Article dans une revue pasteur-01964971v1
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Two Argan Oil Phytosterols, Schottenol and Spinasterol, Attenuate Oxidative Stress and Restore LPS-Dysregulated Peroxisomal Functions in Acox1−/− and Wild-Type BV-2 Microglial Cells

Soukaina Essadek , Catherine Gondcaille , Stéphane Savary , Mohammad Samadi , Joseph Vamecq , et al.
Antioxidants , 2023, 12 (1), pp.168. ⟨10.3390/antiox12010168⟩
Article dans une revue hal-03994321v1

Induction of oxiapoptophagy on 158N murine oligodendrocytes treated by 7-ketocholesterol-, 7 beta-hydroxycholesterol-, or 24(S)-hydroxycholesterol: Protective effects of alpha-tocopherol and docosahexaenoic acid (DHA; C22:6 n-3)

Thomas Nury , Amira Zarrouk , John J. Mackrill , Mohammad Samadi , Philippe Durand , et al.
Steroids, 2015, 99 (B, SI), pp.194-203. ⟨10.1016/j.steroids.2015.02.003⟩
Article dans une revue hal-01518110v1

Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4 alpha- and 4 beta-hydroxycholesterol) and C7 (7-ketocholesterol, 7 alpha- and 7 beta-hydroxycholesterol) on cells of the central nervous system

Thomas Nury , Mohammad Samadi , Amira Zarrouk , Jean Marc Riedinger , Gérard Lizard
European Journal of Medicinal Chemistry, 2013, 70, pp.558-567. ⟨10.1016/j.ejmech.2013.09.028⟩
Article dans une revue istex hal-01518904v1