Studying the Evolution of Histone Variants Using Phylogeny - Institut Curie Accéder directement au contenu
Chapitre D'ouvrage Année : 2018

Studying the Evolution of Histone Variants Using Phylogeny

Résumé

Histones wrap DNA to form nucleosomes that package eukaryotic genomes. Histone variants have evolved for diverse functions including gene expression, DNA repair, epigenetic silencing, and chromosome segregation. With the rapid increase of newly sequenced genomes the repertoire of histone variants expands, demonstrating a great diversification of these proteins across eukaryotes. In this chapter, we are providing guidelines for the computational characterization and annotation of histone variants. We describe methods to predict the characteristic histone fold domain and list features specific to known histone variants that can be used to categorize newly identified histone fold proteins. We continue describing procedures to retrieve additional related histone variants for comparative sequence analyses and phylogenetic reconstructions to refine the annotation and to determine the evolutionary trajectories of the variant in question.
Fichier principal
Vignette du fichier
Spinger_Methods.pdf (812.9 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04092660 , version 1 (12-05-2023)

Identifiants

Citer

Antoine Molaro, Ines Drinnenberg. Studying the Evolution of Histone Variants Using Phylogeny. Guillermo A. Orsi; Geneviève Almouzni. Histone Variants. Methods and Protocols, 1832, Springer New York, pp.273-291, 2018, Methods in Molecular Biology, ⟨10.1007/978-1-4939-8663-7_15⟩. ⟨hal-04092660⟩
29 Consultations
17 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More