Oncogenic Properties of the EBV ZEBRA Protein - Groupe VIH et Virus Humains Persistants / HIV and Human Persistent Virus Group (IBS-HIV&HPV) Access content directly
Journal Articles Cancers Year : 2020

Oncogenic Properties of the EBV ZEBRA Protein

Diego Germini
Fatimata Bintou Sall
  • Function : Author
Anna Shmakova
  • Function : Author
Joëlle Wiels
Svetlana Dokudovskaya
Emmanuel Drouet
  • Function : Author
Yegor Vassetzky

Abstract

Epstein Barr Virus (EBV) is one of the most common human herpesviruses. After primary infection, it can persist in the host throughout their lifetime in a latent form, from which it can reactivate following specific stimuli. EBV reactivation is triggered by transcriptional transactivator proteins ZEBRA (also known as Z, EB-1, Zta or BZLF1) and RTA (also known as BRLF1). Here we discuss the structural and functional features of ZEBRA, its role in oncogenesis and its possible implication as a prognostic or diagnostic marker. Modulation of host gene expression by ZEBRA can deregulate the immune surveillance, allow the immune escape, and favor tumor progression. It also interacts with host proteins, thereby modifying their functions. ZEBRA is released into the bloodstream by infected cells and can potentially penetrate any cell through its cell-penetrating domain; therefore, it can also change the fate of non-infected cells. The features of ZEBRA described in this review outline its importance in EBV-related malignancies.
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Dates and versions

hal-02988636 , version 1 (06-11-2020)

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Diego Germini, Fatimata Bintou Sall, Anna Shmakova, Joëlle Wiels, Svetlana Dokudovskaya, et al.. Oncogenic Properties of the EBV ZEBRA Protein. Cancers, 2020, 12 (6), pp.1479. ⟨10.3390/cancers12061479⟩. ⟨hal-02988636⟩
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