Effect of PPI stimulation on osteoarthritic articular human chondrocytes - Ingénierie Moléculaire, Cellulaire, Thérapeutique & Glycosyltransférases (MolCelTEG) Accéder directement au contenu
Article Dans Une Revue Osteoarthritis and Cartilage Année : 2016

Effect of PPI stimulation on osteoarthritic articular human chondrocytes

Résumé

Osteoarthritis (OA) is the most common form of chronic joint disease, characterized by cartilage degeneration that results from complex changes in the chondrocyte phenotype. The presence of phosphate-containing microcrystals in the injured cartilage areas suggests the contribution of the phosphocalcic metabolism in the phenotype switch of some chondrocytes during the disease. The balance between the concentrations of inorganic pyrophosphate (PPi) and inorganic phosphate (Pi) present in the joint environment has emerged as an important regulator of the chondrocyte phenotype. If numerous studies have shown that elevated concentrations of extracellular Pi (ePi) or ePPi have, respectively, activating or repressive mineralizing effects on articular cartilage, we recently demonstrated that ePPi also prevents the in vitro
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Dates et versions

hal-03602710 , version 1 (09-03-2022)

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Mathilde Guibert, Jean-Baptiste Vincourt, Hervé Kempf, Arnaud Bianchi. Effect of PPI stimulation on osteoarthritic articular human chondrocytes. Osteoarthritis and Cartilage, 2016, 24 (1), pp.S401. ⟨10.1016/j.joca.2016.01.725⟩. ⟨hal-03602710⟩
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