7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19 - LCP-A2MC - Laboratoire de Chimie et Physique - Approche Multi-échelle des Milieux Complexes
Article Dans Une Revue Journal of Steroid Biochemistry and Molecular Biology Année : 2021

7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19

Résumé

7-Ketocholesterol, which is one of the earliest cholesterol oxidization products identified, is essentially formed by the auto-oxidation of cholesterol. In the body, 7-ketocholesterol is both provided by food and produced endogenously. This pro-oxidant and pro-inflammatory molecule, which can activate apoptosis and autophagy at high concentrations, is an abundant component of oxidized Low Density Lipoproteins. 7-Ketocholesterol appears to significantly contribute to the development of age-related diseases (cardiovascular diseases, age-related macular degeneration, and Alzheimer’s disease), chronic inflammatory bowel diseases and to certain cancers. Recent studies have also shown that 7-ketocholesterol has anti-viral activities, including on SARS-CoV-2, which are, however, lower than those of oxysterols resulting from the oxidation of cholesterol on the side chain. Furthermore, 7 ketocholesterol is increased in the serum of moderately and severely affected COVID-19 patients. In the case of COVID-19, it can be assumed that the antiviral activity of 7 ketocholesterol could be counter-balanced by its toxic effects, including pro-oxidant, pro-inflammatory and pro-coagulant activities that might promote the induction of cell death in alveolar cells. It is therefore suggested that this oxysterol might be involved in the pathophysiology of COVID-19 by contributing to the acute respiratory distress syndrome and promoting a deleterious, even fatal outcome. Thus, 7-ketocholesterol could possibly constitute a lipid biomarker of COVID-19 outcome and counteracting its toxic effects with adjuvant therapies might have beneficial effects in COVID-19 patients.

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Chimie
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hal-04842319 , version 1 (19-12-2024)

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Imen Ghzaiel, Khouloud Sassi, Amira Zarrouk, Thomas Nury, Mohamed Ksila, et al.. 7-Ketocholesterol: Effects on viral infections and hypothetical contribution in COVID-19. Journal of Steroid Biochemistry and Molecular Biology, 2021, 212, pp.105939. ⟨10.1016/j.jsbmb.2021.105939⟩. ⟨hal-04842319⟩
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