FR alpha: a target for prophylactic photodynamic therapy of ovarian peritoneal metastasis?

Abstract : Partly due to delays in its diagnosis, ovarian cancer's prognosis remains dire after primary therapy. Treatment consists in complete cytoreductive surgery and platinum-based chemotherapy. Recurrence rates are disappointingly high, as 60 % of women with advanced epithelial ovarian cancer considered in remission will develop recurrent disease within five years. Special attention to undetected peritoneal metastasis and residual tumorous cells during surgery is necessary as they are the main predictors of recurrences. Targeted therapies aim to bring chemotherapy, radiotherapy and selective tumor photosensitizer (PS) agents to the targeted cell and its tumoral microenvironment. Folate receptor alpha (FR alpha) shows promising prospects in targeting ovarian cancerous cells. Indeed, with good specificity and frequent overexpression in ovarian cancer, FR alpha is a recurrent topic in recent publications. The aim of this review is to present FR alpha and the reasons that make it an ideal targeting ligand for ovarian carcinoma therapy. Prophylactic photodynamic therapy (PPDT) using new generation FR alpha-coupled agents combined with complete cytoreductive surgery could allow for a significant decrease in recurrence rates. Preclinical trials are being run in order to allow for human clinical applications.
Type de document :
Article dans une revue
Bulletin du Cancer, John Libbey Eurotext, 2014, 101 (12), pp.1109-1113. 〈10.1684/bdc.2014.1977〉
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https://hal.univ-lorraine.fr/hal-01274054
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Soumis le : lundi 15 février 2016 - 12:13:39
Dernière modification le : mercredi 20 juin 2018 - 14:12:01

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Henri Azais, Albert Moussaron, Soraya Khodja Bach, Alfred Bassil, Nacim Betrouni, et al.. FR alpha: a target for prophylactic photodynamic therapy of ovarian peritoneal metastasis?. Bulletin du Cancer, John Libbey Eurotext, 2014, 101 (12), pp.1109-1113. 〈10.1684/bdc.2014.1977〉. 〈hal-01274054〉

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