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Probing interactions in fungal PKS

Abstract : Biosynthesis of polyketides can depend on interactions between the acyl carrier proteins (ACPs) which hold the growing chains and their enzymatic partners. In this issue of Chemistry & Biology, Bruegger and colleagues demonstrate that mechanism-based probes tethered to the ACPs of fungal nonreducing polyketide synthases can provide insights into these contacts.
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Kira J Weissman. Probing interactions in fungal PKS. Chemistry & biology, 2013, 20 (9), pp.1089-91. ⟨10.1016/j.chembio1.2013.09.001⟩. ⟨hal-01467279⟩



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