M. Gellert, V(D)J Recombination: RAG Proteins, Repair Factors, and Regulation, Annual Review of Biochemistry, vol.71, issue.1
DOI : 10.1146/annurev.biochem.71.090501.150203

N. Guéguinou, Could spaceflight-associated immune system weakening preclude the expansion of human presence beyond Earth's orbit?, Journal of Leukocyte Biology, vol.86, issue.5, pp.1027-1038, 2009.
DOI : 10.1189/jlb.0309167

C. Huin-schohn, Gravity changes during animal development affect IgM heavy-chain transcription and probably lymphopoiesis, The FASEB Journal, vol.27, issue.1, pp.333-341, 2013.
DOI : 10.1096/fj.12-217547

URL : https://hal.archives-ouvertes.fr/hal-01480291

C. Lescale, Hind limb unloading, a model of spaceflight conditions, leads to decreased B lymphopoiesis similar to aging, The FASEB Journal, vol.29, issue.2, pp.455-463, 2015.
DOI : 10.1096/fj.14-259770

URL : https://hal.archives-ouvertes.fr/hal-01481935

R. Boxio, C. Dournon, and J. Frippiat, Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl, Journal of Applied Physiology, vol.98, issue.3
DOI : 10.1152/japplphysiol.00957.2004

C. C. Woods, K. E. Banks, R. Gruener, and D. Deluca, Loss of T cell precursors after spaceflight and exposure to vector-averaged gravity, The FASEB Journal, vol.17, pp.1526-1528, 2003.
DOI : 10.1096/fj.02-0749fje

C. Trigueros, Pre-TCR signaling regulates IL-7 receptor ?? expression promoting thymocyte survival at the transition from the double-negative to double-positive stage, European Journal of Immunology, vol.33, issue.7, pp.1968-1977, 2003.
DOI : 10.1002/eji.200323831

C. C. Woods, Use of a microgravity organ culture dish system to demonstrate the signal dampening effects of modeled microgravity during T cell development, Developmental & Comparative Immunology, vol.29, issue.6, pp.565-582, 2005.
DOI : 10.1016/j.dci.2004.09.006

R. Mazzucchelli and S. K. Durum, Interleukin-7 receptor expression: intelligent design, Nature Reviews Immunology, vol.18, issue.2, pp.144-154, 2007.
DOI : 10.1038/nri2023

P. Mombaerts, RAG-1-deficient mice have no mature B and T lymphocytes, Cell, vol.68, issue.5, pp.869-877, 1992.
DOI : 10.1016/0092-8674(92)90030-G

B. Al-lazikani, A. M. Lesk, and C. Chothia, Canonical structures for the hypervariable regions of T cell ???? receptors, Journal of Molecular Biology, vol.295, issue.4, pp.979-995, 2000.
DOI : 10.1006/jmbi.1999.3358

E. M. Sajdel-sulkowska, Effects of hypergravity exposure on the developing central nervous system: possible involvement of thyroid hormone, Exp. Biol. Med. Maywood NJ, vol.226, pp.790-798, 2001.

C. Bozzo, Hypergravity from conception to adult stage: effects on contractile properties and skeletal muscle phenotype, Journal of Experimental Biology, vol.207, issue.16, pp.2793-2802, 2004.
DOI : 10.1242/jeb.01076

URL : https://hal.archives-ouvertes.fr/hal-00095288

L. Macho, R. Kvetnansky, M. Fickova, I. A. Popova, and A. Grigoriev, Effects of exposure to space flight on endocrine regulations in experimental animals, Endocr. Regul, vol.35, pp.101-114, 2001.

F. P. Baqai, Effects of spaceflight on innate immune function and antioxidant gene expression, Journal of Applied Physiology, vol.106, issue.6, pp.1935-1942, 1985.
DOI : 10.1152/japplphysiol.91361.2008

D. S. Gridley, Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets, J. Appl. Physiol. Bethesda Md, vol.94, pp.2095-2103, 1985.

M. J. Pecaut, S. J. Simske, and M. Fleshner, Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models, Am. J. Physiol. Regul. Integr. Comp. Physiol, vol.279, pp.2072-2078, 2000.

S. K. Chapes, S. J. Simske, G. Sonnenfeld, E. S. Miller, and R. J. Zimmerman, Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses, J. Appl. Physiol. Bethesda Md, vol.86, pp.2065-2076, 1985.

C. C. Congdon, Lymphatic tissue changes in rats flown on Spacelab Life Sciences-2, J. Appl. Physiol. Bethesda Md, vol.81, pp.172-177, 1985.

C. L. Gould, M. Lyte, J. Williams, A. D. Mandel, and G. Sonnenfeld, Inhibited interferon-gamma but normal interleukin-3 production from rats flown on the space shuttle, Aviat. Space Environ. Med, vol.58, pp.983-986, 1987.

G. Sonnenfeld, Spaceflight alters immune cell function and distribution, J. Appl. Physiol. Bethesda Md, vol.73, pp.191-195, 1985.

H. Aviles, T. Belay, M. Vance, and G. Sonnenfeld, Effects of Space Flight Conditions on the Function of the Immune System and Catecholamine Production Simulated in a Rodent Model of Hindlimb Unloading, Neuroimmunomodulation, vol.12, issue.3, pp.173-181, 2005.
DOI : 10.1159/000084850

E. Kainuma, Association of glucocorticoid with stress-induced modulation of body temperature, blood glucose and innate immunity, Psychoneuroendocrinology, vol.34, issue.10, pp.1459-1468, 2009.
DOI : 10.1016/j.psyneuen.2009.04.021

J. E. Staples, Estrogen receptor alpha is necessary in thymic development and estradiol-induced thymic alterations, J. Immunol. Baltim. Md, vol.163, pp.4168-4174, 1950.

M. C. Erlandsson, C. Ohlsson, J. A. Gustafsson, and H. Carlsten, Role of oestrogen receptors alpha and beta in immune organ development and in oestrogen-mediated effects on thymus, Immunology, vol.161, issue.1, pp.17-25, 2001.
DOI : 10.1210/en.138.3.863

P. Erdeljan, J. F. Macdonald, and S. G. Matthews, Glucocorticoids and serotonin alter glucocorticoid receptor (GR) but not mineralocorticoid receptor (MR) mRNA levels in fetal mouse hippocampal neurons, in vitro, Brain Research, vol.896, issue.1-2, pp.130-136, 2001.
DOI : 10.1016/S0006-8993(01)02075-3

T. W. Lebsack, Microarray analysis of spaceflown murine thymus tissue reveals changes in gene expression regulating stress and glucocorticoid receptors, Journal of Cellular Biochemistry, vol.21, pp.372-381, 2010.
DOI : 10.1002/jcb.22547

M. Lefranc, IMGT(R), the international ImMunoGeneTics information system(R), Nucleic Acids Research, vol.37, issue.Database, pp.1006-1012, 2009.
DOI : 10.1093/nar/gkn838

URL : https://hal.archives-ouvertes.fr/hal-00357158

M. P. Happ and E. Palmer, Thymocyte development: an analysis of T cell receptor gene expression in 519 newborn thymocyte hybridomas, European Journal of Immunology, vol.335, issue.7, pp.1317-1325, 1989.
DOI : 10.1002/eji.1830190725

A. J. Feeney, Junctional sequences of fetal T cell receptor beta chains have few N regions, Journal of Experimental Medicine, vol.174, issue.1, pp.115-124, 1991.
DOI : 10.1084/jem.174.1.115

M. Cherrier, A. Cardona, I. Rosinski-chupin, F. Rougeon, and N. Doyen, Substantial N diversity is generated in T cell receptor ? genes at birth despite low levels of terminal deoxynucleotidyl transferase expression in mouse thymus, European Journal of Immunology, vol.14, issue.12, pp.3651-3656, 2002.
DOI : 10.1002/1521-4141(200212)32:12<3651::AID-IMMU3651>3.0.CO;2-D

W. Ndifon, Chromatin conformation governs T-cell receptor J?? gene segment usage, Proceedings of the National Academy of Sciences, vol.109, issue.39, pp.15865-15870, 2012.
DOI : 10.1073/pnas.1203916109

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465372

R. Subrahmanyam, Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions, Nature Immunology, vol.174, issue.12, pp.1205-1212, 2012.
DOI : 10.1016/S1097-2765(00)80406-2

URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3685187

K. P. Singh, R. Kumari, and J. W. Dumond, Simulated microgravity-induced epigenetic changes in human lymphocytes, Journal of Cellular Biochemistry, vol.6, issue.1, pp.123-129, 2010.
DOI : 10.1002/jcb.22674

L. L. Jones, L. A. Colf, J. D. Stone, K. C. Garcia, and D. M. Kranz, Distinct CDR3 Conformations in TCRs Determine the Level of Cross-Reactivity for Diverse Antigens, but Not the Docking Orientation, The Journal of Immunology, vol.181, issue.9, pp.181-6255, 1950.
DOI : 10.4049/jimmunol.181.9.6255

K. Rubtsova, Many different V?? CDR3s can reveal the inherent MHC reactivity of germline-encoded TCR V regions, Proceedings of the National Academy of Sciences, vol.106, issue.19, pp.7951-7956, 2009.
DOI : 10.1073/pnas.0902728106

E. C. Goyarts, Point mutations in the ?? chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I\peptide complex over a broad interface area, Molecular Immunology, vol.35, issue.10, pp.593-607, 1998.
DOI : 10.1016/S0161-5890(98)00056-X

T. Komori, L. Pricop, A. Hatakeyama, C. A. Bona, and F. W. Alt, Repertoires of Antigen Receptors in Tdt Congenitally Deficient Mice, International Reviews of Immunology, vol.143, issue.4, pp.317-325, 1996.
DOI : 10.1128/MCB.9.7.3049

M. Yassai, A Molecular Marker for Thymocyte-Positive Selection: Selection of CD4 Single-Positive Thymocytes with Shorter TCRB CDR3 During T Cell Development, The Journal of Immunology, vol.168, issue.8, pp.3801-3807, 1950.
DOI : 10.4049/jimmunol.168.8.3801

M. A. Gavin and M. J. Bevan, Increased peptide promiscuity provides a rationale for the lack of N regions in the neonatal T cell repertoire, Immunity, vol.3, issue.6, pp.793-800, 1995.
DOI : 10.1016/1074-7613(95)90068-3

N. Guéguinou, Stress response and humoral immune system alterations related to chronic hypergravity in mice, Psychoneuroendocrinology, vol.37, issue.1, pp.137-147, 2012.
DOI : 10.1016/j.psyneuen.2011.05.015

J. Moore and J. Duke, Effect of chronic centrifugation on mouse breeding pairs and their offspring, The Physiologist, vol.31, pp.120-121, 1988.

E. Alamyar, P. Duroux, M. Lefranc, and V. Giudicelli, IMGT?? Tools for the Nucleotide Analysis of Immunoglobulin (IG) and T Cell Receptor (TR) V-(D)-J Repertoires, Polymorphisms, and IG Mutations: IMGT/V-QUEST and IMGT/HighV-QUEST for NGS, Methods Mol. Biol. Clifton NJ, vol.882, pp.569-604, 2012.
DOI : 10.1007/978-1-61779-842-9_32

URL : https://hal.archives-ouvertes.fr/hal-00722893