D. Versari, E. Daghini, A. Virdis, L. Ghiadoni, and S. Taddei, Endothelium-575 dependent contractions and endothelial dysfunction in human hyper-576 tension, Pharmacol, vol.157, pp.527-563, 2009.

J. Davignon and P. Ganz, Role of endothelial dysfunction in atherosclerosis, p.579

, Circul ati on, vol.109, pp.27-32, 2004.

S. Moncada, R. M. Palmer, and E. A. Higgs, Nitric oxide, p.582

, Pharmacol Rev, vol.43, pp.109-151, 1991.

H. Cai and D. G. Harrison, Endothelial dysfunction in cardiovascular diseases, p.585

, The role of oxidant stress, Circ Res, vol.87, pp.840-844, 2000.

C. Napoli, F. De-nigris, S. Williams-ignarro, O. Pignalosa, and V. Sica,

, Nitric oxide and atherosclerosis: An update, Nitric Oxide, vol.589

S. Ji-yeon, Nitric oxide and pulmonary hypertension, Anesthesiol, vol.591, pp.4-14, 2010.

J. Loscalzo, Nitric oxide insufficiency, platelet activation, and arterial 593 thrombosis, Circ Res, vol.88, pp.756-62, 2001.
DOI : 10.1161/hh0801.089861

J. P. Bolaños and A. Almeida, Roles of nitric oxide in brain hypoxia-ischemia, vol.596

, Biochim Biophys Acta, vol.1411, pp.415-451, 1999.

J. Tamargo, R. Caballero, R. Gómez, and E. Delpón, Cardiac electrophysio-599 logical effects of nitric oxide, Cardiovasc Res, vol.87, pp.593-600, 2010.


N. Hogg, R. J. Singh, and B. Kalyanaraman, The role of glutathione in the 602 transport and catabolism of nitric oxide, FEBS Lett, vol.382, p.603, 1996.


D. A. Riccio, K. P. Dobmeier, E. M. Hetrick, B. J. Privett, and H. S. Paul, , p.605

. Mh, Nitric oxide-releasing S-nitrosothiol-modified xerogels

E. J. Langford, A. S. Brown, R. J. Wainwright, A. J. De-belder, and M. R. Thomas, , p.609

R. E. Smith, Inhibition of platelet activity by S-nitrosoglutathione 610 during coronary angioplasty, Lancet, vol.344, pp.1458-60, 1994.

R. J. Macallister, A. L. Calver, J. Riezebos, J. Collier, and P. Vallance, Relative 613 potency and arteriovenous selectivity of nitrovasodilators on human 614 blood vessels: An insight into the targeting of nitric oxide delivery, p.615

, Pharmacol Exp Ther, vol.273, pp.154-60, 1995.

T. Rassaf, P. Kleinbongard, M. Preik, A. Dejam, P. Gharini et al., , p.617

, Plasma nitrosothiols contribute to the systemic vasodilator effects of 618 intravenously applied NO: Experimental and clinical study on the fate of 619 NO in human blood, Circ Res, vol.91, pp.470-477, 2002.

A. J. Friedman, K. Blecher, D. Schairer, C. Tuckman-vernon, and P. Nacharaju, , p.622

D. Sanchez, Improved antimicrobial efficacy with nitric oxide 623 releasing nanoparticle generated S-nitrosoglutathione, Nitric Oxide, vol.624, pp.381-387, 2011.

D. E. Jensen, G. K. Belka, D. Bois, and G. C. , S-Nitrosoglutathione is a substrate 631 for rat alcohol dehydrogenase class III isoenzyme, Biochem J, vol.632, issue.2, pp.659-68, 1998.

R. L. Bateman, D. Rauh, B. Tavshanjian, and K. M. Shokat, Human carbonyl 634 reductase 1 is an S-nitrosoglutathione reductase, J Biol Chem, vol.635, pp.35756-62, 2008.

Q. Chen, R. E. Sievers, M. Varga, S. Kharait, D. J. Haddad et al.,

A. B. Seabra, G. F. De-souza, L. L. Da-rocha, M. N. Eberlin, M. De-oliveira et al., Solid films of 645 blended poly(vinyl alcohol)/poly(vinyl pyrrolidone) for topical S-646 nitrosoglutathione and nitric oxide release, Pharmacological inhibition of S-nitrosoglutathione reductase improves 638 endothelial vasodilatory function in rats in vivo, vol.639, pp.994-647, 2004.

A. De-mel, N. Naghavi, and B. G. Cousins,

A. Darbyshire, Nitric oxide-eluting nanocomposite for cardiovas-650 cular implants, J Mater Sci Mater Med, vol.25, pp.917-946, 2014.


P. D. Marcato, L. F. Adami, R. De-melo-barbosa, P. S. Melo, and I. R. Ferreira,

L. Paula, Development of a sustained-release system for nitric oxide 654 delivery using alginate/chitosan nanoparticles, Curr Nanosci, vol.655, pp.1-7, 2013.

, Glutathione and S-nitrosoglutathione in alginate/chitosan nanoparticles, p.658

. Cytotoxicity, JPCS, vol.304, p.12045, 2011.

S. U. Shah, N. Martinho, M. Socha, P. Reis, C. Gibaud et al., Synthesis and 661 characterization of S-nitrosoglutathione-oligosaccharide-chitosan as a 662 nitric oxide donor, Expert Opin Drug Deliv, vol.12, pp.1-15, 2015.

W. Wu, C. Gaucher, R. Diab, I. Fries, Y. L. Xiao et al., Time lasting 665 S-nitrosoglutathione polymeric nanoparticles delay cellular protein S-666 nitrosation, Pharm Biopharm, vol.89, pp.1-8, 2015.

W. Wu, C. Gaucher, I. Fries, X. M. Hu, P. Maincent et al.,

S. N. Bhattacharya, M. R. Kamal, and R. K. Gupta, Polymer nanocomposite particles of S-nitrosoglutathione: A suitable 670 formulation for protection and sustained oral delivery, Pharm, vol.671, pp.354-61, 2015.

, Gomez-Orellana I. Strategies to improve oral drug bioavailability. Ex-676 pert Opin, Drug Deliv, vol.29, pp.419-452, 2005.

H. Zhang, J. Zhang, and J. B. Streisand, Oral mucosal drug delivery: Clinical 679 pharmacokinetics and therapeutic applications, Clin Pharmacokinet, vol.680, pp.661-80, 2002.

V. Dodane, A. Khan, M. Merwin, and J. R. , Effect of chitosan on epthelial 683 permeability and structure, Pharm, vol.182, pp.21-32, 1999.

M. Thanou, J. C. Verhoef, and H. E. Junginger, Oral drug absorption 685 enhancement by chitosan and its derivatives, Adv Drug Deliv Rev, vol.686, pp.231-240, 2001.

M. Parent, F. Dahboul, R. Schneider, I. Clarot, P. Maincent et al., 688 A complete physicochemical identity card of S-nitrosoglutathione, Curr 689 Pharm Anal, vol.9, pp.31-42, 2013.

J. Sun, X. Zhang, M. Broderick, and H. Fein, Measurement of nitric oxide 691 production in biological systems by using griess reaction assay, Sensors, vol.692, pp.276-84, 2003.

C. Y. Liu, M. Zhao, C. Y. Ren, Y. Gp, P. F. Li et al.,

, Anal Chem, vol.37, pp.1463-1470, 2009.

J. H. Lim, S. K. You, J. S. Baek, C. J. Hwang, Y. G. Na et al., , p.698

, Preparation and evaluation of polymeric microparticulates for improving 699 cellular uptake of gemcitabine, Nanomedicine, vol.7, pp.2307-2321, 2012.


M. Parent, A. Boudier, I. Fries, A. Gosty?ska, M. Rychter et al., Nitric 702 oxide-eluting scaffolds and their interaction with smooth muscle cells in 703

, J Biomed Mater Res A, vol.103, pp.3303-3314, 2015.

P. J. Hutchinson, R. M. Palmer, and S. Moncada, Comparative pharmacology, p.706

, EDRF and nitric oxide on vascular strips, Pharmacol, vol.141, p.707, 1987.

, , vol.87, pp.90563-90565

T. R. Everett, I. B. Wilkinson, A. A. Mahendru, C. M. Mceniery, and S. F. Garner, , p.709

A. H. Goodall, S-Nitrosoglutathione improves haemodynamics in 710 early-onset pre-eclampsia, Clin Pharmacol, vol.78, pp.660-669, 2014.


A. S. Hasan, M. Socha, A. Lamprecht, F. E. Ghazouani, and A. Sapin,

M. , Effect of the microencapsulation of nanoparticles on the 714 reduction of burst release, Pharm, vol.344, pp.53-61, 2007.

A. B. Seabra, D. Oliveira, and M. G. , Poly(vinyl alcohol) and poly(vinyl 717

, pyrrolidone) blended films for local nitric oxide release, Biomaterials, vol.718, pp.3773-82, 2004.

A. B. Seabra, A. Fitzpatrick, J. Paul, D. Oliveira, M. G. Weller et al., Topically 720 applied S-nitrosothiol-containing hydrogels as experimental, p.721

, macological nitric oxide donors in human skin, Dermatol, vol.722, pp.977-83, 2004.

M. George and T. E. Abraham, Polyionic hydrocolloids for the intestinal 724 delivery of protein drugs: Alginate and chitosan -a review, J Control 725 Release, vol.114, pp.1-14, 2006.

G. Garrait, E. Beyssac, and M. Subirade, Development of a novel drug delivery 727 system: Chitosan nanoparticles entrapped in alginate microparticles, J 728 Microencapsul, vol.31, pp.363-72, 2014.

B. H. Bajka, N. M. Rigby, K. L. Cross, A. Macierzanka, and A. R. Mackie, The 731

, Colloids Surf B: Biointerfaces, vol.135, pp.73-80, 2015.

C. Gaucher, A. Boudier, F. Dahboul, M. Parent, and P. Leroy,

, denitrosation in cardiovascular pathologies: Facts and concepts for the 736 rational design of S-nitrosothiols, Curr Pharm Des, vol.19, 2013.

J. L. Alencar, I. Lobysheva, M. Geffard, M. Sarr, and C. Schott,

. Vb, Role of S-nitrosation of cysteine residues in long-lasting 739

S. I. Khan, E. A. Abourashed, I. A. Khan, and L. A. Walker, Transport of harman 742 alkaloids across Caco-2 cell monolayers, Chem Pharm Bull, vol.743, pp.394-401, 2004.

I. L. Megson, I. R. Greig, G. A. Gray, D. J. Webb, and A. R. Butler, Prolonged effect of a 745 novel S-nitrosated glyco-amino acid in endothelium-denuded rat femoral 746 arteries: Potential as a slow release nitric oxide donor drug, Pharmacol, vol.747, pp.1617-1641, 1997.

I. L. Megson, S. Morton, I. R. Greig, F. A. Mazzei, R. A. Field et al.,

. Substituted-analogues-of-s-nitroso-n-acetyl-d,-l-penicillamine, Chem-750 femoral arteries, Pharmacol, vol.126, pp.639-687, 1999.


E. Nozik-grayck, E. J. Whalen, J. S. Stamler, T. J. Mcmahon, and P. Chitano, , p.754

C. A. Piantadosi, S-nitrosoglutathione inhibits alpha1-adrenergic receptor-755 mediated vasoconstriction and ligand binding in pulmonary artery