Novel benzofuran-chromone and -coumarin derivatives: synthesis and biological activity in K562 human leukemia cells

Abstract : Not widely distributed in nature, aurones, (Z)-2-benzylidene-benzofuran-3(2H)-ones, are one of the less common and lesser-known representatives of a flavonoid subclass. Nevertheless, they exhibit a strong and broad variety of biological activities. We have combined the benzofuranone part of a classical aurone with either a chromone or a coumarin scaffold which proved to feature interesting biological activities including antimicrobial, antiviral, anticancer, anti-inflammatory and antioxidant properties. Herein we present a series of 26 novel benzofuran derivatives with the first biological results in K562 human leukemia cells showing that compounds 21b, 29b and 29c are able to induce around 24% apoptosis.
Type de document :
Article dans une revue
MedChemComm, Royal Society of Chemistry, 2013, 4 (12), pp.1571-1579. 〈10.1039/c3md00241a〉
Domaine :
Liste complète des métadonnées

https://hal.univ-lorraine.fr/hal-01494094
Contributeur : Srsmc Ul <>
Soumis le : mercredi 22 mars 2017 - 16:40:39
Dernière modification le : jeudi 20 septembre 2018 - 01:08:00

Identifiants

Collections

Citation

Clemens Zwergel, Sergio Valente, Angela Salvato, Zhanjie Xu, Oualid Talhi, et al.. Novel benzofuran-chromone and -coumarin derivatives: synthesis and biological activity in K562 human leukemia cells. MedChemComm, Royal Society of Chemistry, 2013, 4 (12), pp.1571-1579. 〈10.1039/c3md00241a〉. 〈hal-01494094〉

Partager

Métriques

Consultations de la notice

62