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Novel benzofuran-chromone and -coumarin derivatives: synthesis and biological activity in K562 human leukemia cells

Abstract : Not widely distributed in nature, aurones, (Z)-2-benzylidene-benzofuran-3(2H)-ones, are one of the less common and lesser-known representatives of a flavonoid subclass. Nevertheless, they exhibit a strong and broad variety of biological activities. We have combined the benzofuranone part of a classical aurone with either a chromone or a coumarin scaffold which proved to feature interesting biological activities including antimicrobial, antiviral, anticancer, anti-inflammatory and antioxidant properties. Herein we present a series of 26 novel benzofuran derivatives with the first biological results in K562 human leukemia cells showing that compounds 21b, 29b and 29c are able to induce around 24% apoptosis.
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https://hal.univ-lorraine.fr/hal-01494094
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Submitted on : Wednesday, March 22, 2017 - 4:40:39 PM
Last modification on : Saturday, August 21, 2021 - 8:56:03 PM

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Clemens Zwergel, Sergio Valente, Angela Salvato, Zhanjie Xu, Oualid Talhi, et al.. Novel benzofuran-chromone and -coumarin derivatives: synthesis and biological activity in K562 human leukemia cells. MedChemComm, Royal Society of Chemistry, 2013, 4 (12), pp.1571-1579. ⟨10.1039/c3md00241a⟩. ⟨hal-01494094⟩

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