Skip to Main content Skip to Navigation
Journal articles

pH- and glutathione-responsive release of curcumin from mesoporous silica nanoparticles coated using tannic acid-Fe(III) complex

Abstract : A novel pH-and glutathione-responsive drug delivery system has been developed by deposition of tannic acid (TA)-Fe(III) complex on the surface of mesoporous silica nanoparticles (MSN). The coating was easily accomplished within 30 seconds by successive addition of iron chloride (FeCl3) and tannic acid in aqueous dispersion of MSN (e.g. MCM-41). A hydrophobic model drug, curcumin, showed sustainable drug release under physiological condition (pH 7.4), while a rapid curcumin release was triggered by lowering the pH to 6.0 or 4.5. Moreover, curcumin release could be controlled by adjusting the glutathione level, which accelerate the decomposition of TA-Fe(III) complex by competitive liganding. Therefore, these results would allow developing novel and simple pH-and glutathione-responsive drug delivery systems with potential applications such as in biomedicine.
Document type :
Journal articles
Complete list of metadata

https://hal.univ-lorraine.fr/hal-01495963
Contributor : Srsmc Ul Connect in order to contact the contributor
Submitted on : Monday, March 27, 2017 - 10:23:30 AM
Last modification on : Wednesday, December 1, 2021 - 2:35:48 PM

Identifiers

Collections

Citation

Sanghoon Kim, Stephanie Philippot, Stéphane Fontanay, Raphaël E. Duval, Emmanuel Lamouroux, et al.. pH- and glutathione-responsive release of curcumin from mesoporous silica nanoparticles coated using tannic acid-Fe(III) complex. RSC Advances, Royal Society of Chemistry, 2015, 5 (110), pp.90550-90558. ⟨10.1039/c5ra16004a⟩. ⟨hal-01495963⟩

Share

Metrics

Record views

196