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Production and characterization of testosterone undecanoate-loaded NLC for oral bioavailability enhancement

Abstract : Nanostructured lipid carriers were loaded with testosterone undecanoate (TU), which has a low oral bioavailability. Methods: Different NLC dispersions were produced using the hot high pressure homogenization method. Particles were characterized using dynamic and static light scattering techniques, differential scanning calorimetry and X-ray diffraction. And the bioavailability was compared to a marketed product. Results: Nanostructured lipid carriers with up to 30% TU load and sizes of about 600 and 200 nm could be achieved, allowing a direct comparison of the size effect in in vivo bioavailability studies. The zeta potentials varied between − 20 and − 40 mV. The bioavailability of Andriol Testocaps® in the fed state was matched. Conclusions: This opens the perspective of administering a single dose of dose of TU in one oral dosage unit and simultaneously having a bioavailability less dependent on the fed state.
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https://hal.univ-lorraine.fr/hal-01634550
Contributor : Cithefor Ul <>
Submitted on : Tuesday, November 14, 2017 - 11:37:25 AM
Last modification on : Wednesday, February 27, 2019 - 11:08:02 AM

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M. Muchow, P. Maincent, R.H. Müller, C.M. Keck. Production and characterization of testosterone undecanoate-loaded NLC for oral bioavailability enhancement. Drug Development and Industrial Pharmacy, Taylor & Francis, 2010, 37 (1), pp.8 - 14. ⟨10.3109/03639045.2010.489559⟩. ⟨hal-01634550⟩

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