J. Ahlert, E. Shepard, N. Lomovskaya, E. Zazopoulos, A. Staffa et al., The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS, Science, vol.297, issue.5584, pp.1173-1176, 2002.
DOI : 10.1126/science.1072105

B. Aigle, D. Schneider, C. Morilhat, D. Vandewiele, A. Dary et al., An amplifiable and deletable locus of Streptomyces ambofaciens RP181110 contains a very large gene homologous to polyketide synthase genes, Microbiology, vol.142, issue.10, pp.2815-2824, 1996.
DOI : 10.1099/13500872-142-10-2815

URL : https://hal.archives-ouvertes.fr/hal-01659577

S. F. Altschul, T. L. Madden, A. A. Schäffer, J. Zhang, Z. Zhang et al., Gapped BLAST and PSI-BLAST: a new generation of protein database search programs, Nucleic Acids Research, vol.25, issue.17, pp.3389-3402, 1997.
DOI : 10.1093/nar/25.17.3389

W. S. Ayer, A. G. Mcinnes, P. Thibault, J. A. Walter, J. L. Doull et al., Jadomycin, a novel 8H-benz[b]oxazolo[3,2-f]phenanthridine antibiotic from from streptomyces venezuelae ISP5230., Tetrahedron Letters, vol.32, issue.44, pp.6301-6304, 1991.
DOI : 10.1016/0040-4039(91)80152-V

N. Bate, A. R. Butler, A. R. Gandecha, and E. Cundliffe, Multiple regulatory genes in the tylosin biosynthetic cluster of Streptomyces fradiae, Chemistry & Biology, vol.6, issue.9, pp.617-624, 1999.
DOI : 10.1016/S1074-5521(99)80113-6

S. D. Bentley, K. F. Chater, A. M. Cerdeno-tarraga, G. L. Challis, N. R. Thomson et al., Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2), Complete genome sequence of the model actinomycete Streptomyces coelicolor A3, pp.141-147, 2002.
DOI : 10.1073/pnas.85.8.2444

M. Bierman, R. Logan, K. O-'brien, E. T. Seno, R. N. Rao et al., Plasmid cloning vectors for the conjugal transfer of DNA from Escherichia coli to Streptomyces spp., Gene, vol.116, issue.1, pp.43-49, 1992.
DOI : 10.1016/0378-1119(92)90627-2

K. L. Buttner, K. F. Chater, and M. J. Bibb, Cloning, disruption and transcriptional analysis of three RNA polymerase genes of Streptomyces coelicolor, J. Bacteriol, vol.3, issue.172, pp.3367-3378, 1990.

W. Champness, Actinomycete development, antibiotic production, and phylogeny: questions and challenges, Prokaryotic development, pp.11-31, 2000.

E. Culebras, E. Martinez, A. Carnero, and F. Malpartida, Cloning and characterization of a regulatory gene of the SARP family and its flanking region from Streptomyces ambofaciens, Molecular and General Genetics MGG, vol.262, issue.4-5, pp.730-737, 1999.
DOI : 10.1007/s004380051135

K. A. Datsenko and B. L. Wanner, One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products, Proc. Natl. Acad, 2000.
DOI : 10.1093/nar/27.2.389

H. Decker and S. Haag, Cloning and characterization of a polyketide synthase gene from Streptomyces fradiae T??2717, which carries the genes for biosynthesis of the angucycline antibiotic urdamycin A and a gene probably involved in its oxygenation., Journal of Bacteriology, vol.177, issue.21, pp.6126-6136, 1995.
DOI : 10.1128/jb.177.21.6126-6136.1995

H. Drautz, H. Zahner, J. Rohr, and A. Zeeck, Metabolic products of microorganisms. 234 Urdamycins, new angucycline antibiotics from Streptomyces fradiae. I Isolation, characterization and biological properties., The Journal of Antibiotics, vol.39, issue.12, pp.1657-1669, 1986.
DOI : 10.7164/antibiotics.39.1657

P. Engel, L. L. Scharfenstein, J. M. Dyer, and J. W. Cary, Disruption of a gene encoding a putative ??-butyrolactone-binding protein in Streptomyces tendae affects nikkomycin production, Applied Microbiology and Biotechnology, vol.56, issue.3-4, pp.414-419, 2001.
DOI : 10.1007/s002530100621

G. A. Evans, K. Lewis, and B. E. Rothenberg, High efficiency vectors for cosmid microcloning and genomic analysis, Gene, vol.79, issue.1, pp.9-20, 1989.
DOI : 10.1016/0378-1119(89)90088-7

B. Faust, D. Hoffmeister, G. Weitnauer, L. Westrich, S. Haag et al., Two new tailoring enzymes, a glycosyltransferase and an oxygenase, involved in biosynthesis of the angucycline antibiotic urdamycin A in Streptomyces fradiae T??2717, Microbiology, vol.146, issue.1, pp.147-154, 2000.
DOI : 10.1099/00221287-146-1-147

C. Fischer, F. Lipata, and J. Rohr, The Complete Gene Cluster of the Antitumor Agent Gilvocarcin V and Its Implication for the Biosynthesis of the Gilvocarcins, Journal of the American Chemical Society, vol.125, issue.26, pp.7818-7819, 2003.
DOI : 10.1021/ja034781q

S. A. Flint, G. Stratigopoulos, A. R. Butler, and E. Cundliffe, Expression of tyIM genes during tylosin production: Phantom promoters and enigmatic translational coupling motifs, Journal of Industrial Microbiology and Biotechnology, vol.28, issue.3, pp.160-167, 2002.
DOI : 10.1038/sj.jim.7000223

B. Gust, G. L. Challis, K. Fowler, T. Kieser, and K. F. Chater, PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin, Proc. Natl, 2003.
DOI : 10.1126/science.277.5333.1820

L. Han, K. Yang, E. Ramalingam, R. H. Mosher, and L. C. Vining, Cloning and characterization of polyketide synthase genes for jadomycin B biosynthesis in Streptomyces venezuelae ISP5230, Microbiology, vol.140, issue.12, pp.3379-3389, 1994.
DOI : 10.1099/13500872-140-12-3379

D. Hanahan, Studies on transformation of Escherichia coli with plasmids, Journal of Molecular Biology, vol.166, issue.4, pp.557-580, 1983.
DOI : 10.1016/S0022-2836(83)80284-8

D. A. Hopwood, Genetic Contributions to Understanding Polyketide Synthases, Chemical Reviews, vol.97, issue.7, pp.2465-2497, 1997.
DOI : 10.1021/cr960034i

D. A. Hopwood, K. F. Chater, and M. J. Bibb, Genetics of Antibiotic Production in Streptomyces coelicolor A3(2), a Model Streptomycete, Bio/ Technology, vol.28, pp.65-102, 1995.
DOI : 10.1016/B978-0-7506-9095-9.50009-5

H. Ikeda, J. Ishikawa, A. Hanamoto, M. Shinose, H. Kikuchi et al., Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis, Nature Biotechnology, vol.21, issue.5, pp.526-531, 2003.
DOI : 10.1038/nbt820

K. Kulowski, E. Wendt-pienkowski, L. Han, K. Yang, L. C. Vining et al., Gene As a Cyclase Forming Angucyclinones, Journal of the American Chemical Society, vol.121, issue.9, pp.1786-1794, 1999.
DOI : 10.1021/ja982707f

R. H. Lambalot, A. M. Gehring, R. S. Flugel, P. Zuber, M. Lacelle et al., A new enzyme superfamily ??? the phosphopantetheinyl transferases, Chemistry & Biology, vol.3, issue.11, pp.923-936, 1996.
DOI : 10.1016/S1074-5521(96)90181-7

P. Leblond and B. Decaris, Unstable " linear chromosomes: the case of Streptomyces Organization of the prokaryotic genome, pp.235-261, 1999.

P. Leblond, G. Fischer, F. X. Francou, F. Berger, M. Guérineau et al., The unstable region of Streptomyces ambofaciens includes 210 kb terminal inverted repeats flanking the extremities of the linear chromosomal DNA, Molecular Microbiology, vol.19, issue.2, pp.261-271, 1996.
DOI : 10.1046/j.1365-2958.1996.366894.x

URL : https://hal.archives-ouvertes.fr/hal-01658762

A. Li and J. Piel, A Gene Cluster from a Marine Streptomyces Encoding the Biosynthesis of the Aromatic Spiroketal Polyketide Griseorhodin A, Chemistry & Biology, vol.9, issue.9, pp.1017-1026, 2002.
DOI : 10.1016/S1074-5521(02)00223-5

F. Lombo, G. Blanco, E. Fernandez, C. Mendez, and J. A. Salas, Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin, Gene, vol.172, issue.1, pp.87-91, 1996.
DOI : 10.1016/0378-1119(96)00029-7

D. J. Macneil, K. M. Gewain, C. L. Ruby, G. Dezeny, P. H. Gibbons et al., Analysis of Streptomyces avermitilis genes required for avermectin biosynthesis utilizing a novel integration vector, Gene, vol.111, issue.1, pp.61-68, 1992.
DOI : 10.1016/0378-1119(92)90603-M

M. A. Marahiel, Protein templates for the biosynthesis of peptide antibiotics, Chemistry & Biology, vol.4, issue.8, pp.561-567, 1997.
DOI : 10.1016/S1074-5521(97)90242-8

M. Metsä-ketelä, L. Halo, E. Munukka, J. Hakala, P. Mäntsälä et al., Molecular Evolution of Aromatic Polyketides and Comparative Sequence Analysis of Polyketide Ketosynthase and 16S Ribosomal DNA Genes from Various Streptomyces Species, Applied and Environmental Microbiology, vol.68, issue.9, pp.4472-4479, 2002.
DOI : 10.1128/AEM.68.9.4472-4479.2002

S. Mochizuki, K. Hiratsu, M. Suwa, T. Ishii, F. Sugino et al., The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism, Molecular Microbiology, vol.263, issue.6, pp.1501-1510, 2003.
DOI : 10.1093/oxfordjournals.jbchem.a022670

. Noel, Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone, J. Nat. Prod, vol.65, pp.1956-1962, 2002.

R. Novakova, J. Bistakova, D. Homerova, B. Rezuchova, and J. Kormanec, Cloning and characterization of a polyketide synthase gene cluster involved in biosynthesis of a proposed angucycline-like polyketide auricin in Streptomyces aureofaciens CCM 3239, Gene, vol.297, issue.1-2, pp.197-208, 2002.
DOI : 10.1016/S0378-1119(02)00889-2

S. Omura, H. Ikeda, J. Ishikawa, A. Hanamoto, C. Takahashi et al., Genome sequence of an industrial microorganism Streptomyces avermitilis: Deducing the ability of producing secondary metabolites, Proc. Natl. Acad. Sci. USA 98, pp.12215-12220, 2001.
DOI : 10.1016/S1074-5521(00)00011-9

M. S. Paget, L. Chamberlin, A. Atrih, S. J. Foster, and M. J. Buttner, Evidence that the extracytoplasmic function sigma factor E is required for normal cell wall structure in Streptomyces coelicolor A3(2), J. Bacteriol, vol.181, pp.204-211, 1999.

S. Pandza, G. Biukovic, A. Paravic, A. Dadbin, J. Cullum et al., Recombination between the linear plasmid pPZG101 and the linear chromosome of Streptomyces rimosus can lead to exchange of ends, Molecular Microbiology, vol.76, issue.6, pp.1165-1176, 1998.
DOI : 10.1016/0378-1119(85)90120-9

S. Pinnert-sindico, L. Ninet, J. Preud-'homme, and C. Cosar, A new antibiotic spiramycin. Antibiot. Ann, pp.724-727, 1954.

M. A. Richardson, S. Kuhstoss, M. L. Huber, L. Ford, O. Godfrey et al., Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis., Journal of Bacteriology, vol.172, issue.7, pp.3790-3798, 1990.
DOI : 10.1128/jb.172.7.3790-3798.1990

J. Rohr and R. Thiericke, Angucycline group antibiotics, Natural Product Reports, vol.9, issue.2, pp.103-137, 1992.
DOI : 10.1039/np9920900103

K. Rutherford, J. Parkhill, J. Crook, T. Horsnell, P. Rice et al., Artemis: sequence visualization and annotation, Bioinformatics, vol.16, issue.10, pp.944-945, 2000.
DOI : 10.1093/bioinformatics/16.10.944

URL : https://academic.oup.com/bioinformatics/article-pdf/16/10/944/598346/160944.pdf

J. Sambrook, E. F. Fritsch, and T. Maniatis, Molecular cloning: a laboratory manual, 1989.

C. Schauner, A. Dary, A. Lebrihi, P. Leblond, B. Decaris et al., Modulation of lipid metabolism and spiramycin biosynthesis in Streptomyces ambofaciens unstable mutants, Appl. Environ. Microbiol, vol.65, pp.2730-2737, 1999.
URL : https://hal.archives-ouvertes.fr/hal-01658995

G. Stratigopoulos and E. Cundliffe, Expression Analysis of the Tylosin-Biosynthetic Gene Cluster, Chemistry & Biology, vol.9, issue.1, pp.71-78, 2002.
DOI : 10.1016/S1074-5521(01)00095-3

A. Trefzer, S. Pelzer, J. Schimana, S. Stockert, C. Bihlmaier et al., Biosynthetic Gene Cluster of Simocyclinone, a Natural Multihybrid Antibiotic, Antimicrobial Agents and Chemotherapy, vol.46, issue.5, pp.1174-1182, 2002.
DOI : 10.1128/AAC.46.5.1174-1182.2002

L. Wang, J. Mcvey, and L. C. Vining, Cloning and functional analysis of a phosphopantetheinyl transferase superfamily gene associated with jadomycin biosynthesis in Streptomyces venezuelae ISP5230, Microbiology, vol.147, issue.6, pp.1535-1545, 2001.
DOI : 10.1099/00221287-147-6-1535

L. Westrich, S. Domann, B. Faust, D. Bedford, D. A. Hopwood et al., Cloning and characterization of a gene cluster from Streptomyces cyanogenus S136 probably involved in landomycin biosynthesis, FEMS Microbiology Letters, vol.170, issue.2, pp.381-387, 1999.
DOI : 10.1111/j.1574-6968.1999.tb13398.x

A. Wietzorrek and M. Bibb, A novel family of proteins that regulates antibiotic production in streptomycetes appears to contain an OmpR-like DNA-binding fold, Molecular Microbiology, vol.25, issue.6, pp.1181-1184, 1997.
DOI : 10.1046/j.1365-2958.1997.5421903.x

F. Wright and M. J. Bibb, Codon usage in the G+C-rich Streptomyces genome, Gene, vol.113, issue.1, pp.55-65, 1992.
DOI : 10.1016/0378-1119(92)90669-G

K. Yang, L. Han, S. W. Ayer, and L. C. Vining, Accumulation of the angucycline antibiotic rabelomycin after disruption of an oxygenase gene in the jadomycin B biosynthetic gene cluster of Streptomyces venezuelae, Microbiology, vol.142, issue.1, pp.123-132, 1996.
DOI : 10.1099/13500872-142-1-123