P. Bertin, P. Lejeune, C. Laurent-wintcr, and A. Danchin, Mutations in bglY, the structural gene for the DNA-binding protein H1, affect expression of several Escherichia coli genes, Biochimie, vol.72, issue.12, pp.889-891, 1990.
DOI : 10.1016/0300-9084(90)90008-5

A. Birch, A. Hatisler, and R. Hiltter, Genome rearrangement and genetic instability in Streptomyces spp., Journal of Bacteriology, vol.172, issue.8, pp.24138-4142, 1990.
DOI : 10.1128/jb.172.8.4138-4142.1990

A. Dary, N. Bourget, J. M. Simonet, and B. Decaris, The amplification of a specific DNA sequence reversibly prevents spiramycin production in Streptomyces ambqfaciens RPI81110, Res. Microbiol, pp.143-99, 1992.

P. Demuyter, D. Schneider, P. Leblond, J. M. Simonet, and B. Decaris, A chromosomal hotspot for multiple rearrangements associated with genetic instability of Streptomyces ambofaciens DSM 40697, Journal of General Microbiology, vol.137, issue.3, pp.491-499, 19911.
DOI : 10.1099/00221287-137-3-491

S. E. Fishman and C. L. Hershberger, Amplified DNA in Strepmmj'ces ji'adiae, J. Bacteriol, vol.155, pp.459-466, 19831.

Y. Fujita and Y. Miwa, Identification of an operator sequence for the" Bacillus suhtilis grit operon, J. Biol. Chem, vol.264, pp.4201-4206, 1989.

D. A. Hopwood, M. J. Bibb, K. F. Chatcr, G. R. Janssen, F. Malpartida et al., Regulation ofgene expression in antibiotic-producing Streptomyces Regulation of Gent Expression, Society for General Microbiology, pp.251-276, 1986.

K. P. Koller and G. Riess, Heterologous expression of the alpha-amylase inhibitor gene cloned from an amplified genomic sequence in Streptom.vces temhte, J. Bacteriol. !, vol.71, pp.4953-4957, 1989.

P. Leblond, P. Demuyter, L. Moutier, M. Laakel, B. Decaris et al., Hypervariability, a new phenomenon of genetic instability , related to DNA amplification in Streptooo'ces amhqfacieos, J. Bacteriol, pp.171-419, 19891.

P. Leblond, P. Demuyter, J. M. Simonel, and B. Decaris, Genetic instability and hypervariability in Streptomyces ambofaciens: towards an understanding of a mechanism of genome plasticity, Molecular Microbiology, vol.95, issue.5, pp.707-714, 1990.
DOI : 10.1016/0014-5793(87)81547-8

URL : https://hal.archives-ouvertes.fr/hal-01658674

P. Leblond, F. X. Francou, J. M. Simonet, and B. Dccaris, Pulsed-field gel analysis of the genome of StrelmmO't'es amhohtcieos strains, FEMS Microbiol. Lett, pp.72-79, 1990.

. P. Leblond, P. Demuyter, J. M. Simonet, and B. Decaris, Genetic instability and associated genomic plasticity in StrelmmO'ces ambt!facieos: PFG E evidence for large alterations in a limited genomic region, J. Bacteriol, pp.173-4229, 19911.

P. Lejeune and A. Danchin, Mutations in the hglY gene increase the fi'equency of spontaneous deletions in b.~'cherichia coil K-12

D. J. Lipman and W. R. Pearson, Rapid and sensitive protein similarity searches, Science, vol.227, issue.4693, pp.1435-1441, 1985.
DOI : 10.1126/science.2983426

T. G. Pridham, P. Anderson, C. Foley, L. A. Lindenfelser, C. Hesseltine et al., A selection of media for maintenance and taxonomic study of Streptoooz'es. Antibiotic Annual, pp.947-953, 1956.

M. A. Richardson, S. Kuhstoss, M. L. Huber, L. Ford, O. Godfrey et al., Cloning of spiramycin biosynthetic genes and their use in constructuing Sn'ept,mn'ces ambq]'aciens mutants defective in spiramycin biosynthesis, J. Bacterioi, pp.172-3790, 1990.

B. Simonet, A. Dary, B. Decaris, and J. M. Simonet, Characterization of a family of multimcric ccc molecules of amplified chromosomal DNA in Strepmoo'ces ambqhtcieos DSM40697

T. Smokvina, . F. Francou, and M. Luzzati, Genetic analysis in Strepwno'ces ambofaciens, J. Gen. Microbiol, vol.134, pp.395-402, 1988.