<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01663032</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-22T07:11:41+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper</title>
            <author role="aut">
              <persName>
                <forename type="first">C.</forename>
                <surname>Mayorga</surname>
              </persName>
              <email type="md5">c6d2e6b46c6e9075198db7f7a2157af6</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1003982</idno>
              <idno type="halauthorid" notation="string">1148381-1003982</idno>
              <affiliation ref="#struct-568111"/>
              <affiliation ref="#struct-488872"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">G.</forename>
                <surname>Celik</surname>
              </persName>
              <email type="md5">80cae21d5f99e9f0242bfc088a879e96</email>
              <email type="domain">gmail.com</email>
              <idno type="idhal" notation="numeric">1003974</idno>
              <idno type="halauthorid" notation="string">1148376-1003974</idno>
              <affiliation ref="#struct-523908"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Rouzaire</surname>
              </persName>
              <idno type="halauthorid">1278877-0</idno>
              <affiliation ref="#struct-195701"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Whitaker</surname>
              </persName>
              <idno type="halauthorid">1278878-0</idno>
              <affiliation ref="#struct-523909"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Bonadonna</surname>
              </persName>
              <email type="md5">e4c64f08aadd0ea22d014e3f98b389a8</email>
              <email type="domain">ospedaleuniverona.it</email>
              <idno type="idhal" notation="numeric">1003983</idno>
              <idno type="halauthorid" notation="string">1148382-1003983</idno>
              <affiliation ref="#struct-488890"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Rodrigues-Cernadas</surname>
              </persName>
              <idno type="halauthorid">1278879-0</idno>
              <affiliation ref="#struct-523910"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Vultaggio</surname>
              </persName>
              <idno type="halauthorid">1278880-0</idno>
              <affiliation ref="#struct-523913"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">K.</forename>
                <surname>Brockow</surname>
              </persName>
              <idno type="halauthorid">210049-0</idno>
              <affiliation ref="#struct-214784"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Caubet</surname>
              </persName>
              <idno type="halauthorid">1278881-0</idno>
              <affiliation ref="#struct-523915"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Makowska</surname>
              </persName>
              <idno type="halauthorid">1278882-0</idno>
              <affiliation ref="#struct-523917"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">A.</forename>
                <surname>Nakonechna</surname>
              </persName>
              <idno type="halauthorid">1278883-0</idno>
              <affiliation ref="#struct-523918"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Romano</surname>
              </persName>
              <idno type="halauthorid">94752-0</idno>
              <affiliation ref="#struct-380289"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M. I.</forename>
                <surname>Montañez</surname>
              </persName>
              <idno type="halauthorid">1278884-0</idno>
              <affiliation ref="#struct-488873"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Laguna</surname>
              </persName>
              <idno type="halauthorid">1278885-0</idno>
              <affiliation ref="#struct-523919"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">G.</forename>
                <surname>Zanoni</surname>
              </persName>
              <idno type="halauthorid">1227867-0</idno>
              <affiliation ref="#struct-542958"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Gueant</surname>
              </persName>
              <idno type="halauthorid">1278886-0</idno>
              <affiliation ref="#struct-409232"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">H.</forename>
                <surname>Oude Elberink</surname>
              </persName>
              <idno type="halauthorid">1278887-0</idno>
              <affiliation ref="#struct-352384"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">J.</forename>
                <surname>Fernandez</surname>
              </persName>
              <idno type="halauthorid">62763-0</idno>
              <affiliation ref="#struct-523922"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">S.</forename>
                <surname>Viel</surname>
              </persName>
              <idno type="idhal" notation="numeric">763011</idno>
              <idno type="halauthorid" notation="string">483830-763011</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-9554-4059</idno>
              <affiliation ref="#struct-157369"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">P.</forename>
                <surname>Demoly</surname>
              </persName>
              <email type="md5">23f02926435bb7bfb08293ddfbbdc588</email>
              <email type="domain">inserm.fr</email>
              <idno type="idhal" notation="string">pascal-demoly</idno>
              <idno type="idhal" notation="numeric">754222</idno>
              <idno type="halauthorid" notation="string">410632-754222</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/Y-9938-2019</idno>
              <idno type="IDREF">https://www.idref.fr/03442959X</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7827-7964</idno>
              <idno type="GOOGLE SCHOLAR">http://scholar.google.fr/citations?user=So_kniIAAAAJ&amp;hl=fr</idno>
              <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Y-9938-2019</idno>
              <affiliation ref="#struct-454982"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">M. J.</forename>
                <surname>Torres</surname>
              </persName>
              <idno type="halauthorid">1276720-0</idno>
              <affiliation ref="#struct-488872"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>NGERE</forename>
                <surname>UL</surname>
              </persName>
              <email type="md5">4716635d06f9bcffb1f71d811e4e18dd</email>
              <email type="domain">univ-lorraine.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2017-12-13 16:29:48</date>
              <date type="whenModified">2026-02-07 05:14:23</date>
              <date type="whenReleased">2017-12-13 16:29:48</date>
              <date type="whenProduced">2016-08</date>
              <ref type="externalLink" target="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/all.12886"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="557320">
                <persName>
                  <forename>NGERE</forename>
                  <surname>UL</surname>
                </persName>
                <email type="md5">4716635d06f9bcffb1f71d811e4e18dd</email>
                <email type="domain">univ-lorraine.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01663032</idno>
            <idno type="halUri">https://hal.univ-lorraine.fr/hal-01663032</idno>
            <idno type="halBibtex">mayorga:hal-01663032</idno>
            <idno type="halRefHtml">&lt;i&gt;Allergy&lt;/i&gt;, 2016, 71 (8), pp.1103 - 1134. &lt;a target="_blank" href="https://dx.doi.org/10.1111/all.12886"&gt;&amp;#x27E8;10.1111/all.12886&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">Allergy, 2016, 71 (8), pp.1103 - 1134. &amp;#x27E8;10.1111/all.12886&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="HCL">Hospices Civils de Lyon</idno>
            <idno type="stamp" n="PRES_CLERMONT">Université de Clermont</idno>
            <idno type="stamp" n="UNIV-CLERMONT1" corresp="PRES_CLERMONT">Université d'Auvergne - Clermont-Ferrand I</idno>
            <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno>
            <idno type="stamp" n="CHLS" corresp="HCL">Centre Hospitalier Lyon Sud</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="IMOST" corresp="PRES_CLERMONT">Imagerie Moléculaire et Stratégies Théranostiques</idno>
            <idno type="stamp" n="NGERE-UL">NGERE - Nutrition-génétique et exposition aux risques environnementaux</idno>
            <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno>
            <idno type="stamp" n="SU-INF-2018" corresp="SORBONNE-UNIVERSITE">SORBONNE université &lt;2018</idno>
            <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Santé de Sorbonne Université</idno>
            <idno type="stamp" n="SU-MED" corresp="SORBONNE-UNIVERSITE">Médecine - Sorbonne Université</idno>
            <idno type="stamp" n="BMS-UL">Pôle scientifique Biologie, Médecine, Santé de l'Université de Lorraine</idno>
            <idno type="stamp" n="SU-TI">Sorbonne Université - Texte Intégral</idno>
            <idno type="stamp" n="ALLIANCE-SU"> Alliance Sorbonne Université</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">In vitro tests for drug hypersensitivity reactions: an ENDA/EAACI Drug Allergy Interest Group position paper</title>
                <author role="aut">
                  <persName>
                    <forename type="first">C.</forename>
                    <surname>Mayorga</surname>
                  </persName>
                  <email type="md5">c6d2e6b46c6e9075198db7f7a2157af6</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1003982</idno>
                  <idno type="halauthorid" notation="string">1148381-1003982</idno>
                  <affiliation ref="#struct-568111"/>
                  <affiliation ref="#struct-488872"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">G.</forename>
                    <surname>Celik</surname>
                  </persName>
                  <email type="md5">80cae21d5f99e9f0242bfc088a879e96</email>
                  <email type="domain">gmail.com</email>
                  <idno type="idhal" notation="numeric">1003974</idno>
                  <idno type="halauthorid" notation="string">1148376-1003974</idno>
                  <affiliation ref="#struct-523908"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Rouzaire</surname>
                  </persName>
                  <idno type="halauthorid">1278877-0</idno>
                  <affiliation ref="#struct-195701"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Whitaker</surname>
                  </persName>
                  <idno type="halauthorid">1278878-0</idno>
                  <affiliation ref="#struct-523909"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Bonadonna</surname>
                  </persName>
                  <email type="md5">e4c64f08aadd0ea22d014e3f98b389a8</email>
                  <email type="domain">ospedaleuniverona.it</email>
                  <idno type="idhal" notation="numeric">1003983</idno>
                  <idno type="halauthorid" notation="string">1148382-1003983</idno>
                  <affiliation ref="#struct-488890"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Rodrigues-Cernadas</surname>
                  </persName>
                  <idno type="halauthorid">1278879-0</idno>
                  <affiliation ref="#struct-523910"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Vultaggio</surname>
                  </persName>
                  <idno type="halauthorid">1278880-0</idno>
                  <affiliation ref="#struct-523913"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">K.</forename>
                    <surname>Brockow</surname>
                  </persName>
                  <idno type="halauthorid">210049-0</idno>
                  <affiliation ref="#struct-214784"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Caubet</surname>
                  </persName>
                  <idno type="halauthorid">1278881-0</idno>
                  <affiliation ref="#struct-523915"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Makowska</surname>
                  </persName>
                  <idno type="halauthorid">1278882-0</idno>
                  <affiliation ref="#struct-523917"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">A.</forename>
                    <surname>Nakonechna</surname>
                  </persName>
                  <idno type="halauthorid">1278883-0</idno>
                  <affiliation ref="#struct-523918"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Romano</surname>
                  </persName>
                  <idno type="halauthorid">94752-0</idno>
                  <affiliation ref="#struct-380289"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M. I.</forename>
                    <surname>Montañez</surname>
                  </persName>
                  <idno type="halauthorid">1278884-0</idno>
                  <affiliation ref="#struct-488873"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Laguna</surname>
                  </persName>
                  <idno type="halauthorid">1278885-0</idno>
                  <affiliation ref="#struct-523919"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">G.</forename>
                    <surname>Zanoni</surname>
                  </persName>
                  <idno type="halauthorid">1227867-0</idno>
                  <affiliation ref="#struct-542958"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Gueant</surname>
                  </persName>
                  <idno type="halauthorid">1278886-0</idno>
                  <affiliation ref="#struct-409232"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">H.</forename>
                    <surname>Oude Elberink</surname>
                  </persName>
                  <idno type="halauthorid">1278887-0</idno>
                  <affiliation ref="#struct-352384"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">J.</forename>
                    <surname>Fernandez</surname>
                  </persName>
                  <idno type="halauthorid">62763-0</idno>
                  <affiliation ref="#struct-523922"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">S.</forename>
                    <surname>Viel</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">763011</idno>
                  <idno type="halauthorid" notation="string">483830-763011</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-9554-4059</idno>
                  <affiliation ref="#struct-157369"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">P.</forename>
                    <surname>Demoly</surname>
                  </persName>
                  <email type="md5">23f02926435bb7bfb08293ddfbbdc588</email>
                  <email type="domain">inserm.fr</email>
                  <idno type="idhal" notation="string">pascal-demoly</idno>
                  <idno type="idhal" notation="numeric">754222</idno>
                  <idno type="halauthorid" notation="string">410632-754222</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/Y-9938-2019</idno>
                  <idno type="IDREF">https://www.idref.fr/03442959X</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7827-7964</idno>
                  <idno type="GOOGLE SCHOLAR">http://scholar.google.fr/citations?user=So_kniIAAAAJ&amp;hl=fr</idno>
                  <idno type="RESEARCHERID">http://www.researcherid.com/rid/http://www.researcherid.com/rid/Y-9938-2019</idno>
                  <affiliation ref="#struct-454982"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">M. J.</forename>
                    <surname>Torres</surname>
                  </persName>
                  <idno type="halauthorid">1276720-0</idno>
                  <affiliation ref="#struct-488872"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">10340</idno>
                <idno type="issn">0105-4538</idno>
                <idno type="eissn">1398-9995</idno>
                <title level="j">Allergy</title>
                <imprint>
                  <publisher>Wiley</publisher>
                  <biblScope unit="volume">71</biblScope>
                  <biblScope unit="issue">8</biblScope>
                  <biblScope unit="pp">1103 - 1134</biblScope>
                  <date type="datePub">2016-08</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1111/all.12886</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Basophil Activation Test</term>
                <term xml:lang="en">diagnosis</term>
                <term xml:lang="en">drug hypersensitivity</term>
                <term xml:lang="en">IgE</term>
                <term xml:lang="en">invitro</term>
                <term xml:lang="en">T cells</term>
                <term xml:lang="en">Stevens-Johnson-Syndrome</term>
                <term xml:lang="en">Lymphocyte-Transformation Test</term>
                <term xml:lang="en">Toxic Epidermal Necrolysis</term>
                <term xml:lang="en">Cetuximab-Induced Anaphylaxis</term>
                <term xml:lang="en">Generalized Exanthematous Pustulosis</term>
                <term xml:lang="en">Mast-Cell Tryptase</term>
                <term xml:lang="en">Neuromuscular Blocking-Agents</term>
                <term xml:lang="en">Nonsteroidal Antiinflammatory Drugs</term>
                <term xml:lang="en">Beta-Lactam Antibiotics</term>
              </keywords>
              <classCode scheme="halDomain" n="sdv">Life Sciences [q-bio]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>Drug hypersensitivity reactions (DHRs) are a matter of great concern, both for outpatient and in hospital care. The evaluation of these patients is complex, because invivo tests have a suboptimal sensitivity and can be time-consuming, expensive and potentially risky, especially drug provocation tests. There are several currently available invitro methods that can be classified into two main groups: those that help to characterize the active phase of the reaction and those that help to identify the culprit drug. The utility of these invitro methods depends on the mechanisms involved, meaning that they cannot be used for the evaluation of all types of DHRs. Moreover, their effectiveness has not been defined by a consensus agreement between experts in the field. Thus, the European Network on Drug Allergy and Drug Allergy Interest Group of the European Academy of Allergy and Clinical Immunology has organized a task force to provide data and recommendations regarding the available invitro methods for DHR diagnosis. We have found that although there are many invitro tests, few of them can be given a recommendation of grade B or above mainly because there is a lack of well-controlled studies, most information comes from small studies with few subjects and results are not always confirmed in later studies. Therefore, it is necessary to validate the currently available invitro tests in a large series of well-characterized patients with DHR and to develop new tests for diagnosis.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-568111" status="VALID">
          <orgName>Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina = Biomedical Research Institute of Málaga and Nanomedicine Platform</orgName>
          <orgName type="acronym">IBIMA Plataforma BIONAND</orgName>
          <date type="start">2012-03-19</date>
          <desc>
            <address>
              <addrLine>Málaga TechPark, C. Severo Ochoa, 35, 29590 Málaga</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://ibima.eu/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-488872" status="INCOMING">
          <orgName>Allergy Unit [Malaga, Spain]</orgName>
          <orgName type="acronym">National Network ARADyAL</orgName>
          <desc>
            <address>
              <addrLine>Plaza del Hospital Civil, 29009 Malaga.</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-488871" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-523908" status="INCOMING">
          <orgName>Division of Immunology and Allergy [Ankara, turkey]</orgName>
          <desc>
            <address>
              <country key="TR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-488881" type="direct"/>
            <relation active="#struct-488880" type="indirect"/>
            <relation active="#struct-495747" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-195701" status="OLD">
          <orgName>Equipe de recherche sur les traitements individualisés des cancers</orgName>
          <orgName type="acronym">ERTICa</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <addrLine>Centre Jean Perrin Service d'Anatomopathologie 58, rue Montalembert 63011 Clermont-Ferrand Faculté de Médecine Rez de chaussée R3 &amp; CBRV 28 place Henri-Dunant 63000 Clermont-Ferrand</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://ertica.u-clermont1.fr/</ref>
          </desc>
          <listRelation>
            <relation name="EA4677" active="#struct-300267" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-523909" status="INCOMING">
          <orgName>Regional Adult Cystic Fibrosis Unit [St James' Hospital Leeds]</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-545097" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-488890" status="INCOMING">
          <orgName>Allergy Unit [Verona, Italy]</orgName>
          <desc>
            <address>
              <addrLine>Piazzale Aristide Stefani, 1, 37126 Verona VR.</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-488889" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-523910" status="INCOMING">
          <orgName>Immunoallergology Department [Hospital de São João]</orgName>
          <desc>
            <address>
              <country key="PT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-347026" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-523913" status="INCOMING">
          <orgName>Immunoallergology Unit [Careggi Hospital]</orgName>
          <desc>
            <address>
              <addrLine>Firenze</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-523912" type="direct"/>
            <relation active="#struct-523911" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-214784" status="INCOMING">
          <orgName>Department of Dermatology and Allergy Biederstein</orgName>
          <desc>
            <address>
              <addrLine>Walther-Meißner-Straße 3, 85748 Garching</addrLine>
              <country key="DE"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-132871" type="direct"/>
          </listRelation>
        </org>
        <org type="researchteam" xml:id="struct-523915" status="INCOMING">
          <orgName>Pediatric Allergy Unit [Geneva University Hospitals]</orgName>
          <desc>
            <address>
              <addrLine>Genève</addrLine>
              <country key="CH"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-523914" type="direct"/>
            <relation active="#struct-300992" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-523917" status="INCOMING">
          <orgName>Department of Immunology, Rheumatology and Allergy [Medical University of Łódź]</orgName>
          <desc>
            <address>
              <country key="PL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-523916" type="direct"/>
            <relation active="#struct-328083" type="indirect"/>
          </listRelation>
        </org>
        <org type="regrouplaboratory" xml:id="struct-523918" status="INCOMING">
          <orgName>Allergy and Immunology Clinic [Royal Liverpool and Broadgreen University Hospital]</orgName>
          <desc>
            <address>
              <addrLine>Liverpool</addrLine>
              <country key="GB"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-301526" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-380289" status="VALID">
          <orgName>Istituto di Ricovero e Cura a Carattere Scientifico</orgName>
          <orgName type="acronym">IRCCS</orgName>
          <desc>
            <address>
              <addrLine>Via Conte Ruggiero, 73, 94018 Troina EN</addrLine>
              <country key="IT"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-488873" status="INCOMING">
          <orgName>The Andalusian Center for Nanomedicine and Biotechnology</orgName>
          <orgName type="acronym">BIONAND</orgName>
          <desc>
            <address>
              <addrLine>Calle Severo Ochoa, 35, 29590 Málaga.</addrLine>
              <country key="ES"/>
            </address>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-523919" status="INCOMING">
          <orgName>Allergy Unit [Cruz Roja-Madrid]</orgName>
          <desc>
            <address>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-545648" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-542958" status="VALID">
          <orgName>Università degli studi di Verona = University of Verona</orgName>
          <orgName type="acronym">UNIVR</orgName>
          <desc>
            <address>
              <addrLine>Università degli Studi di Verona,Via dell'Artigliere, 8 - 37129, Verona</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.univr.it/en/</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-409232" status="VALID">
          <idno type="IdRef">172251281</idno>
          <idno type="ISNI">000000040383051X</idno>
          <idno type="RNSR">200919208U</idno>
          <idno type="IdUnivLorraine">[UL]RNJ--</idno>
          <idno type="ROR">https://ror.org/053d03003</idno>
          <orgName>Nutrition-Génétique et Exposition aux Risques Environnementaux</orgName>
          <orgName type="acronym">NGERE</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Université de Lorraine, Faculté de Médecine, 9 avenue de la Forêt de Haye, 54500 Vandoeuvre-les-Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">https://ngere.univ-lorraine.fr/</ref>
          </desc>
          <listRelation>
            <relation name="UMRS954/UMRS1256" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-352384" status="INCOMING">
          <orgName>Groningen Research Institute for Asthma and COPD (GRIAC)</orgName>
          <desc>
            <address>
              <country key="NL"/>
            </address>
          </desc>
        </org>
        <org type="researchteam" xml:id="struct-523922" status="INCOMING">
          <orgName>Allergy Section [Alicante]</orgName>
          <desc>
            <address>
              <addrLine>Alicante</addrLine>
              <country key="ES"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-25448" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-157369" status="VALID">
          <orgName>Service d'immunologie [Centre Hospitalier Lyon Sud - HCL]</orgName>
          <desc>
            <address>
              <addrLine>165, chemin du Grand-Revoyet, 69495 Pierre-Bénite, France</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-353860" type="direct"/>
            <relation active="#struct-300074" type="indirect"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-454982" status="VALID">
          <orgName>CHU Saint-Antoine [AP-HP]</orgName>
          <desc>
            <address>
              <addrLine>184, rue du Faubourg Saint-Antoine 75571 Paris cedex 12</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.aphp.fr/contenu/hopital-saint-antoine-1</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300068" type="direct"/>
            <relation active="#struct-413221" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-488871" status="VALID">
          <orgName>Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain]</orgName>
          <date type="start">1956-04-30</date>
          <desc>
            <address>
              <addrLine>Malaga</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.hospitalregionaldemalaga.es/</ref>
          </desc>
        </org>
        <org type="department" xml:id="struct-488881" status="INCOMING">
          <orgName>Department of Chest Diseases [Ankara, Turkey]</orgName>
          <desc>
            <address>
              <addrLine>06100 Sihhiye, Ankara.</addrLine>
              <country key="TR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-488880" type="direct"/>
            <relation active="#struct-495747" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-488880" status="INCOMING">
          <orgName>Division of Immunology and Allergy [Ankara, Turkey]</orgName>
          <desc>
            <address>
              <addrLine>06100 Sihhiye, Ankara.</addrLine>
              <country key="TR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-495747" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-495747" status="VALID">
          <orgName>Ankara University School of Medicine [Turkey]</orgName>
          <desc>
            <address>
              <addrLine>Hacettepe Mahallesi A.Adnan Saygun Cad. No: 35  06100 Altndağ/Ankara/Turkey</addrLine>
              <country key="TR"/>
            </address>
            <ref type="url">http://medicine.en.ankara.edu.tr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-300267" status="OLD">
          <orgName>Université d'Auvergne - Clermont-Ferrand I</orgName>
          <orgName type="acronym">UdA</orgName>
          <date type="end">2016-12-31</date>
          <desc>
            <address>
              <addrLine>49, Boulevard François-Mitterrand / CS 60032 / 63001 Clermont-Ferrand Cedex 1</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.u-clermont1.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-545097" status="INCOMING">
          <orgName>St James‘s University Hospital</orgName>
          <desc>
            <address>
              <country key="GB"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-488889" status="INCOMING">
          <orgName>Azienda ospedaliera universitaria integrata di Verona [Italy]</orgName>
          <desc>
            <address>
              <addrLine>Piazzale Aristide Stefani, 1, 37126 Verona VR.</addrLine>
              <country key="IT"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-347026" status="VALID">
          <orgName>Hospital de São João [Porto]</orgName>
          <desc>
            <address>
              <addrLine>Alameda Prof. Hernâni Monteiro4200–319 Porto</addrLine>
              <country key="PT"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-523912" status="INCOMING">
          <orgName>Department of Biomedicine [Careggi Hospital]</orgName>
          <desc>
            <address>
              <addrLine>Firenze</addrLine>
              <country key="IT"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-523911" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-523911" status="VALID">
          <orgName>Azienda Ospedaliero Universitaria Careggi [Firenze] = Careggi University Hospital [Florence, Italy]</orgName>
          <orgName type="acronym">AOUC</orgName>
          <desc>
            <address>
              <addrLine>Largo Brambilla, 3, 50134 Firenze FI</addrLine>
              <country key="IT"/>
            </address>
            <ref type="url">https://www.aou-careggi.toscana.it</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-132871" status="VALID">
          <idno type="IdRef">031660150</idno>
          <idno type="ISNI">0000000123369749</idno>
          <idno type="ROR">https://ror.org/02kkvpp62</idno>
          <idno type="Wikidata">Q157808</idno>
          <orgName>Technische Universität Munchen = Technical University Munich = Université Technique de Munich</orgName>
          <orgName type="acronym">TUM</orgName>
          <date type="start">1868-01-01</date>
          <desc>
            <address>
              <addrLine>Arcisstrasse 21, D- 80333 München</addrLine>
              <country key="DE"/>
            </address>
            <ref type="url">https://www.tum.de</ref>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-523914" status="INCOMING">
          <orgName>Department of Child and Adolescent [Geneva University Hospitals]</orgName>
          <desc>
            <address>
              <addrLine>Genève</addrLine>
              <country key="CH"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300992" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300992" status="VALID">
          <idno type="IdRef">194001806</idno>
          <idno type="ISNI">0000000107219812</idno>
          <idno type="ROR">https://ror.org/01m1pv723</idno>
          <idno type="Wikidata">Q3145370</idno>
          <orgName>Hôpitaux Universitaires de Genève = University Hospital of Geneva [Genève]</orgName>
          <orgName type="acronym">HUG</orgName>
          <date type="start">1995-01-01</date>
          <desc>
            <address>
              <addrLine>Rue Gabrielle-Perret-Gentil 4,1205 Genève</addrLine>
              <country key="CH"/>
            </address>
            <ref type="url">https://www.hug-ge.ch/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-523916" status="INCOMING">
          <orgName>Healthy Ageing Research Center [Medical University of Łódź]</orgName>
          <orgName type="acronym">HARC</orgName>
          <desc>
            <address>
              <country key="PL"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-328083" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-328083" status="VALID">
          <orgName>Medical University of Łódź</orgName>
          <orgName type="acronym">MUL</orgName>
          <date type="start">2002</date>
          <desc>
            <address>
              <addrLine>aleja Tadeusza Kościuszki 4, 90-419 Łódź,</addrLine>
              <country key="PL"/>
            </address>
            <ref type="url">http://studymed.umed.pl/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-301526" status="VALID">
          <orgName>Royal Liverpool and Broadgreen University Hospital NHS Trust</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="institution" xml:id="struct-545648" status="VALID">
          <idno type="ISNI">0000 0004 1767 4079</idno>
          <orgName>Hospital Central de la Cruz Roja San José y Santa Adela</orgName>
          <date type="start">1913-01-01</date>
          <desc>
            <address>
              <addrLine>Av. de la Reina Victoria, 22-26, Tetuán, 28003 Madrid, Espagne</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">https://www.comunidad.madrid/hospital/cruzroja/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-413289" status="VALID">
          <idno type="IdRef">157040569</idno>
          <idno type="IdUnivLorraine">[UL]100--</idno>
          <idno type="ROR">https://ror.org/04vfs2w97</idno>
          <orgName>Université de Lorraine</orgName>
          <orgName type="acronym">UL</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lorraine.fr/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-25448" status="VALID">
          <idno type="ROR">https://ror.org/05t8bcz72</idno>
          <orgName>Universidad de Alicante</orgName>
          <desc>
            <address>
              <addrLine>Carretera San Vicente del Raspeig s/n 03690 San Vicente del Raspeig - Alicante</addrLine>
              <country key="ES"/>
            </address>
            <ref type="url">http://www.ua.es</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-353860" status="VALID">
          <idno type="ROR">https://ror.org/023xgd207</idno>
          <orgName>Centre Hospitalier Lyon Sud [CHU - HCL]</orgName>
          <orgName type="acronym">CHLS</orgName>
          <desc>
            <address>
              <addrLine>165 Chemin du Grand Revoyet69495 Pierre-Bénite</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/centre-hospitalier-lyon-sud</ref>
          </desc>
          <listRelation>
            <relation active="#struct-300074" type="direct"/>
          </listRelation>
        </org>
        <org type="regroupinstitution" xml:id="struct-300074" status="VALID">
          <idno type="IdRef">026534657</idno>
          <idno type="ROR">https://ror.org/01502ca60</idno>
          <orgName>Hospices Civils de Lyon</orgName>
          <orgName type="acronym">HCL</orgName>
          <desc>
            <address>
              <addrLine>3 Quai des Célestins69002 Lyon</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-lyon.fr/fr/hospices-civils-de-lyon-hcl</ref>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-300068" status="VALID">
          <idno type="ROR">https://ror.org/00pg5jh14</idno>
          <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName>
          <orgName type="acronym">AP-HP</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="regroupinstitution" xml:id="struct-413221" status="VALID">
          <idno type="IdRef">221333754</idno>
          <idno type="ROR">https://ror.org/02en5vm52</idno>
          <orgName>Sorbonne Université</orgName>
          <orgName type="acronym">SU</orgName>
          <date type="start">2018-01-01</date>
          <desc>
            <address>
              <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.sorbonne-universite.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>