G. Cartron, R. U. Trappe, P. Solal-celigny, and M. Hallek, Interindividual variability of response to rituximab: from biological origins to individualized therapies, Clin Cancer Res, vol.17, pp.19-30, 2011.

G. Cartron, L. Dacheux, G. Salles, P. Solal-celigny, P. Bardos et al., Therapeutic activity of humanized anti-CD20 monoclonal antibody and polymorphism in IgG Fc receptor FcgammaRIIIa gene, Blood, vol.99, pp.754-758, 2002.

T. Matsushita, K. Yanaba, J. D. Bouaziz, M. Fujimoto, and T. F. Tedder, Regulatory B cells inhibit EAE initiation in mice while other B cells promote disease progression, J Clin Invest, vol.118, pp.3420-3430, 2008.

K. Yanaba, J. D. Bouaziz, K. M. Haas, J. C. Poe, M. Fujimoto et al., A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses, Immunity, vol.28, pp.639-650, 2008.

Y. Iwata, T. Matsushita, M. Horikawa, D. J. Dilillo, K. Yanaba et al., Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells, Blood, vol.117, pp.530-541, 2011.

D. J. Dilillo, J. B. Weinberg, A. Yoshizaki, M. Horikawa, J. M. Bryant et al., Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function, Leukemia, vol.27, pp.170-182, 2013.

M. Hallek, B. D. Cheson, D. Catovsky, F. Caligaris-cappio, G. Dighiero et al., Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines, Blood, vol.111, pp.5446-5456, 2008.

S. Lepretre, R. Letestu, C. Dartigeas, H. Maisonneuve, T. Aurran et al., Results of a Phase II Randomizing Intensified Rituximab Pre-Phase Followed By Standard FCR Vs Standard FCR in Previously Untreated Patients with Active B-Chronic Lymphocytic Leukemia (B-CLL). CLL2010FMP (for fit medically patients): A Study of the French Cooperative Group on CLL and WM (FCGCLL/MW) and the "Groupe Ouest-Est d'Etudes Des Leucémies Aigües Et Autres Maladies Du sang, 56th ASH Annual Meeting, p.3329, 2014.

V. Goede, K. Fischer, R. Busch, A. Engelke, B. Eichhorst et al., Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions, N Engl J Med, vol.370, pp.1101-1110, 2014.

M. Horikawa, V. Minard-colin, T. Matsushita, and T. F. Tedder, Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice, J Clin Invest, vol.121, pp.4268-4280, 2011.

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