M. Airola and Y. Hannun, Sphingolipid Metabolism and Neutral Sphingomyelinases, Handb Exp Pharmacol, vol.215, pp.57-76, 2013.
DOI : 10.1007/978-3-7091-1368-4_3

URL : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043343/pdf

T. Hla and A. Dannenberg, Sphingolipid Signaling in Metabolic Disorders, Cell Metabolism, vol.16, issue.4, pp.420-434, 2012.
DOI : 10.1016/j.cmet.2012.06.017

URL : https://doi.org/10.1016/j.cmet.2012.06.017

X. Jiang, F. Paultre, T. Pearson, R. Reed, C. Francis et al., Plasma Sphingomyelin Level as a Risk Factor for Coronary Artery Disease, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.20, issue.12, pp.2614-2618, 2000.
DOI : 10.1161/01.ATV.20.12.2614

S. Summers and D. Nelson, A Role for Sphingolipids in Producing the Common Features of Type 2 Diabetes, Metabolic Syndrome X, and Cushing's Syndrome, Diabetes, vol.54, issue.3, pp.591-602, 2005.
DOI : 10.2337/diabetes.54.3.591

U. Ortegren, M. Karlsson, N. Blazic, M. Blomqvist, F. Nystrom et al., Lipids and glycosphingolipids in caveolae and surrounding plasma membrane of primary rat adipocytes, European Journal of Biochemistry, vol.32, issue.10, pp.2028-2036, 2004.
DOI : 10.1074/jbc.272.47.29947

K. Huitema, J. Van-den-dikkenberg, J. Brouwers, and J. Holthuis, Identification of a family of animal sphingomyelin synthases, The EMBO Journal, vol.23, issue.1, pp.33-44, 2004.
DOI : 10.1038/sj.emboj.7600034

Y. Hannun, The sphingomyelin cycle and the second messenger function of ceramide, J Biol Chem, vol.269, pp.3125-3128, 1994.

U. Kintscher and R. Law, PPAR??-mediated insulin sensitization: the importance of fat versus muscle, American Journal of Physiology-Endocrinology and Metabolism, vol.288, issue.2, pp.287-291, 2005.
DOI : 10.1073/pnas.0403652101

N. Marchesini and Y. Hannun, Acid and neutral sphingomyelinases: roles and mechanisms of regulation, Biochemistry and Cell Biology, vol.20, issue.42, pp.27-44, 2004.
DOI : 10.1128/MCB.20.5.1507-1514.2000

R. Cutler and M. Mattson, Sphingomyelin and ceramide as regulators of development and lifespan, Mechanisms of Ageing and Development, vol.122, issue.9, pp.895-908, 2001.
DOI : 10.1016/S0047-6374(01)00246-9

J. Ohanian and V. Ohanian, Sphingolipids in mammalian cell signalling, Cellular and Molecular Life Sciences, vol.58, issue.14, pp.2053-2068, 2001.
DOI : 10.1007/PL00000836

N. Zeghari, H. Vidal, M. Younsi, O. Ziegler, P. Drouin et al., Adipocyte membrane phospholipids and PPAR-?? expression in obese women: relationship to hyperinsulinemia, American Journal of Physiology-Endocrinology and Metabolism, vol.52, issue.4, pp.736-743, 2000.
DOI : 10.1016/0003-2697(69)90017-7

N. Al-makdissy, A. Bianchi, M. Younsi, E. Picard, P. Valet et al., Down-regulation of peroxisome proliferator-activated receptor-?? gene expression by sphingomyelins, FEBS Letters, vol.56, issue.2-3, pp.75-79, 2001.
DOI : 10.1016/0024-3205(94)00953-8

W. Shao and P. Espenshade, Expanding Roles for SREBP in Metabolism, Cell Metabolism, vol.16, issue.4, pp.414-419, 2012.
DOI : 10.1016/j.cmet.2012.09.002

J. Horton, I. Shimomura, M. Brown, R. Hammer, J. Goldstein et al., Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2., Journal of Clinical Investigation, vol.101, issue.11, pp.2331-2339, 1998.
DOI : 10.1172/JCI2961

M. León, N. Torres, N. Tovar, and A. , Mechanism of action of sterol regulatory element binding proteins (SREBPs) in cholesterol and fatty-acid biosynthesis, Rev Invest Clin, vol.54, pp.145-153, 2002.

T. Williams and M. Lisanti, The Caveolin genes: from cell biology to medicine, Annals of Medicine, vol.276, issue.8, pp.584-595, 2004.
DOI : 10.1152/ajpcell.00006.2003

F. Galbiati, D. Volonte, J. Engelman, G. Watanabe, R. Burk et al., Targeted downregulation of caveolin-1 is sufficient to drive cell transformation and hyperactivate the p42/44 MAP kinase cascade, The EMBO Journal, vol.17, issue.22, pp.6633-6648, 1998.
DOI : 10.1093/emboj/17.22.6633

J. Kotzka, D. Müller-wieland, G. Roth, L. Kremer, M. Munck et al., Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade, J Lipid Res, vol.41, pp.99-108, 2000.

J. Stephens, J. Lee, and P. Pilch, Tumor Necrosis Factor-??-induced Insulin Resistance in 3T3-L1 Adipocytes Is Accompanied by a Loss of Insulin Receptor Substrate-1 and GLUT4 Expression without a Loss of Insulin Receptor-mediated Signal Transduction, Journal of Biological Chemistry, vol.267, issue.2, pp.971-976, 1997.
DOI : 10.1074/jbc.271.22.13018

M. Resh, Development of insulin responsiveness of the glucose transporter and the (Na+,K +)-adenosine triphosphatase during in vitro adipocyte differentiation, J Biol Chem, vol.257, pp.6978-6986, 1982.

E. Smart, Y. Ying, C. Mineo, and R. Anderson, A detergent-free method for purifying caveolae membrane from tissue culture cells., Proceedings of the National Academy of Sciences, vol.92, issue.22, pp.10104-10108, 1995.
DOI : 10.1073/pnas.92.22.10104

H. Rose and M. Oklander, Improved procedure for the extraction of lipids from human erythrocytes, J Lipid Res, vol.6, pp.428-431, 1965.

A. Zlatkis and Z. B. , Study of a new cholesterol reagent, Analytical Biochemistry, vol.29, issue.1, pp.143-148, 1969.
DOI : 10.1016/0003-2697(69)90017-7

I. Popa, L. Thuy, B. Colsch, D. Pin, H. Gatto et al., Analysis of free and protein-bound ceramides by tape stripping of stratum corneum from dogs, Archives of Dermatological Research, vol.236, issue.9, pp.639-644, 2010.
DOI : 10.1016/0925-4439(93)90135-N

J. Bodennec, O. Koul, I. Aguado, G. Brichon, G. Zwingelstein et al., A procedure for fractionation of sphingolipid classes by solid-phase extraction onto aminopropyl cartridges, J Lipid Res, vol.41, pp.1524-1531, 2000.

M. Naoi, Y. Lee, and S. Roseman, Rapid and sensitive determination of sphingosine bases and sphingolipids with fluorescamine, Analytical Biochemistry, vol.58, issue.2, pp.571-577, 1974.
DOI : 10.1016/0003-2697(74)90226-7

E. Kean, Separation of gluco-and galactocerebrosides by means of borate thin-layer chromatography, J Lipid Res, vol.7, pp.449-452, 1966.

N. Pham, M. Gal, R. Bagshaw, A. Mohr, B. Chue et al., A comparative study of cytoplasmic granules imaged by the real-time microscope, Nile Red and Filipin in fibroblasts from patients with lipid storage diseases, Journal of Inherited Metabolic Disease, vol.348, issue.Pt 3, pp.991-1024, 2005.
DOI : 10.1016/0005-2760(79)90035-3

N. Al-makdissy, M. Younsi, S. Pierre, O. Ziegler, and M. Donner, Sphingomyelin/cholesterol ratio: an important determinant of glucose transport mediated by GLUT-1 in 3T3-L1 preadipocytes, Cellular Signalling, vol.15, issue.11, pp.1019-1030, 2003.
DOI : 10.1016/S0898-6568(03)00070-6

D. Daviaud, J. Boucher, S. Gesta, C. Dray, C. Guigne et al., TNF?? up-regulates apelin expression in human and mouse adipose tissue, The FASEB Journal, vol.20, issue.9, pp.1528-1530, 2006.
DOI : 10.1096/fj.05-5243fje

O. Masson, C. Chavey, C. Dray, A. Meulle, D. Daviaud et al., LRP1 Receptor Controls Adipogenesis and Is Up-Regulated In Human and Mouse Obese Adipose Tissue, PLoS ONE, vol.118, issue.6, 2009.
DOI : 10.1371/journal.pone.0007422.g009

URL : https://hal.archives-ouvertes.fr/inserm-00431065

Z. Li, H. Zhang, J. Liu, C. Liang, Y. Li et al., Reducing Plasma Membrane Sphingomyelin Increases Insulin Sensitivity, Molecular and Cellular Biology, vol.31, issue.20, pp.4205-4218, 2011.
DOI : 10.1128/MCB.05893-11

URL : http://mcb.asm.org/content/31/20/4205.full.pdf

Y. Landry, M. Denis, S. Nandi, S. Bell, A. Vaughan et al., ATP-binding Cassette Transporter A1 Expression Disrupts Raft Membrane Microdomains through Its ATPase-related Functions, Journal of Biological Chemistry, vol.17, issue.47, pp.36091-36101, 2006.
DOI : 10.1021/bi0004192

URL : http://www.jbc.org/content/281/47/36091.full.pdf

K. Nagao, K. Takahashi, K. Hanada, N. Kioka, M. Matsuo et al., Enhanced ApoA-I-dependent Cholesterol Efflux by ABCA1 from Sphingomyelin-deficient Chinese Hamster Ovary Cells, Journal of Biological Chemistry, vol.267, issue.20, pp.14868-14874, 2007.
DOI : 10.1194/jlr.M500546-JLR200

URL : http://www.jbc.org/content/282/20/14868.full.pdf

V. Puri, J. Jefferson, R. Singh, C. Wheatley, D. Marks et al., Sphingolipid Storage Induces Accumulation of Intracellular Cholesterol by Stimulating SREBP-1 Cleavage, Journal of Biological Chemistry, vol.12, issue.23, pp.20961-20970, 2003.
DOI : 10.1016/S1388-1981(00)00006-8

B. Liu and Y. Hannun, Inhibition of the Neutral Magnesium-dependent Sphingomyelinase by Glutathione, Journal of Biological Chemistry, vol.249, issue.26, pp.16281-16287, 1997.
DOI : 10.1016/0003-2697(76)90527-3

R. Grigsby and R. Dobrowsky, Inhibition of Ceramide Production Reverses TNF-Induced Insulin Resistance, Biochemical and Biophysical Research Communications, vol.287, issue.5, pp.1121-1124, 2001.
DOI : 10.1006/bbrc.2001.5694

N. Zeghari, M. Younsi, L. Meyer, M. Donner, P. Drouin et al., Adipocyte and erythrocyte plasma membrane phospholipid composition and hyperinsulinemia: a study in nondiabetic and diabetic obese women, International Journal of Obesity, vol.14, issue.Suppl 1, pp.1600-1607, 2000.
DOI : 10.1016/S0005-2736(96)00192-7

H. Zhang, C. Koo, J. Stebbing, and G. Giamas, The dual function of KSR1: a pseudokinase and beyond: Figure 1, Biochemical Society Transactions, vol.61, issue.4, pp.1078-82, 2013.
DOI : 10.1371/journal.pone.0029304

Y. Zhang, B. Yao, S. Delikat, S. Bayoumy, X. Lin et al., Kinase Suppressor of Ras Is Ceramide-Activated Protein Kinase, Cell, vol.89, issue.1, pp.63-72, 1997.
DOI : 10.1016/S0092-8674(00)80183-X

P. Scherer, R. Lewis, D. Volonte, J. Engelman, F. Galbiati et al., Cell-type and Tissue-specific Expression of Caveolin-2, Journal of Biological Chemistry, vol.268, issue.46, pp.29337-29346, 1997.
DOI : 10.1074/jbc.272.4.2437

C. Luberto, D. Hassler, P. Signorelli, Y. Okamoto, H. Sawai et al., Inhibition of Tumor Necrosis Factor-induced Cell Death in MCF7 by a Novel Inhibitor of Neutral Sphingomyelinase, Journal of Biological Chemistry, vol.1452, issue.43, pp.41128-41139, 2002.
DOI : 10.1038/35069004

J. Lehmann, L. Moore, T. Smith-oliver, W. Wilkison, T. Willson et al., An Antidiabetic Thiazolidinedione Is a High Affinity Ligand for Peroxisome Proliferator-activated Receptor ?? (PPAR??), Journal of Biological Chemistry, vol.55, issue.22, pp.12953-12956, 1995.
DOI : 10.2337/diab.43.11.1271

B. Spiegelman, PPAR-gamma: adipogenic regulator and thiazolidinedione receptor, Diabetes, vol.47, issue.4, pp.507-514, 1998.
DOI : 10.2337/diabetes.47.4.507

L. Fajas, K. Schoonjans, L. Gelman, J. Kim, J. Najib et al., Regulation of Peroxisome Proliferator-Activated Receptor ?? Expression by Adipocyte Differentiation and Determination Factor 1/Sterol Regulatory Element Binding Protein 1: Implications for Adipocyte Differentiation and Metabolism, Molecular and Cellular Biology, vol.19, issue.8, pp.5495-5503, 1999.
DOI : 10.1128/MCB.19.8.5495

J. Oliner, J. Andresen, S. Hansen, S. Zhou, and R. Tjian, SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein., Genes & Development, vol.10, issue.22, pp.2903-2911, 1996.
DOI : 10.1101/gad.10.22.2903

J. Chrivia, R. Kwok, N. Lamb, M. Hagiwara, M. Montminy et al., Phosphorylated CREB binds specifically to the nuclear protein CBP, Nature, vol.365, issue.6449, pp.855-859, 1993.
DOI : 10.1038/365855a0

W. Xu, L. Kasper, S. Lerach, T. Jeevan, and P. Brindle, Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanisms, The EMBO Journal, vol.102, issue.12, pp.2890-2903, 2007.
DOI : 10.1128/MCB.18.4.2218

J. Cardinaux, J. Notis, Q. Zhang, N. Vo, J. Craig et al., Recruitment of CREB Binding Protein Is Sufficient for CREB-Mediated Gene Activation, Molecular and Cellular Biology, vol.20, issue.5, pp.1546-1552, 2000.
DOI : 10.1128/MCB.20.5.1546-1552.2000

S. Prattes, G. Hörl, A. Hammer, A. Blaschitz, W. Graier et al., Intracellular distribution and mobilization of unesterified cholesterol in adipocytes: triglyceride droplets are surrounded by cholesterol-rich ER-like surface layer structures, J Cell Sci, vol.113, pp.2977-89, 2000.

H. Ohvo-rekilä, B. Ramstedt, P. Leppimäki, and J. Slotte, Cholesterol interactions with phospholipids in membranes, Progress in Lipid Research, vol.41, issue.1, pp.66-97, 2002.
DOI : 10.1016/S0163-7827(01)00020-0

M. Murata, J. Peränen, R. Schreiner, F. Wieland, T. Kurzchalia et al., VIP21/caveolin is a cholesterol-binding protein., Proceedings of the National Academy of Sciences, vol.92, issue.22, pp.10339-10343, 1995.
DOI : 10.1073/pnas.92.22.10339

URL : http://www.pnas.org/content/92/22/10339.full.pdf

L. Lay, S. Krief, S. Farnier, C. Lefrère, I. et al., Cholesterol, a Cell Size-dependent Signal That Regulates Glucose Metabolism and Gene Expression in Adipocytes, Journal of Biological Chemistry, vol.7, issue.20, pp.16904-16910, 2001.
DOI : 10.1073/pnas.94.9.4300

H. Kempen, M. Vermeer, E. De-wit, and L. Havekes, Vastatins inhibit cholesterol ester accumulation in human monocyte- derived macrophages, Arteriosclerosis, Thrombosis, and Vascular Biology, vol.11, issue.1, pp.146-153, 1991.
DOI : 10.1161/01.ATV.11.1.146

URL : http://atvb.ahajournals.org/content/atvbaha/11/1/146.full.pdf

J. Lawler, M. Yin, A. Diehl, E. Roberts, and S. Chatterjee, Tumor Necrosis Factor-?? Stimulates the Maturation of Sterol Regulatory Element Binding Protein-1 in Human Hepatocytes through the Action of Neutral Sphingomyelinase, Journal of Biological Chemistry, vol.259, issue.9, pp.5053-5059, 1998.
DOI : 10.1016/S0092-8674(00)80169-5

S. Scheek, M. Brown, and J. Goldstein, Sphingomyelin depletion in cultured cells blocks proteolysis of sterol regulatory element binding proteins at site 1, Proceedings of the National Academy of Sciences, vol.77, issue.1, pp.11179-11183, 1997.
DOI : 10.1016/0092-8674(94)90234-8

H. Shimano, I. Shimomura, R. Hammer, J. Herz, J. Goldstein et al., Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene., Journal of Clinical Investigation, vol.100, issue.8, pp.2115-2124, 1997.
DOI : 10.1172/JCI119746

M. Czarny, J. Liu, P. Oh, and J. Schnitzer, Transient Mechanoactivation of Neutral Sphingomyelinase in Caveolae to Generate Ceramide, Journal of Biological Chemistry, vol.42, issue.7, pp.4424-4430, 2003.
DOI : 10.1161/01.RES.83.3.334

M. Raines, R. Kolesnick, and D. Golde, Sphingomyelinase and ceramide activate mitogen-activated protein kinase in myeloid HL-60 cells, J Biol Chem, vol.268, pp.14572-14575, 1993.

M. Cobb and E. Goldsmith, How MAP Kinases Are Regulated, Journal of Biological Chemistry, vol.3, issue.25, pp.14843-14846, 1995.
DOI : 10.1126/science.8052857

URL : http://www.jbc.org/content/270/25/14843.full.pdf

D. Botolin, Y. Wang, B. Christian, and D. Jump, Docosahexaneoic acid (22:6,n-3) regulates rat hepatocyte SREBP-1 nuclear abundance by Erk- and 26S proteasome-dependent pathways, Journal of Lipid Research, vol.134, issue.1, pp.181-192, 2006.
DOI : 10.1074/jbc.M005425200

URL : http://www.jlr.org/content/47/1/181.full.pdf

J. Kim, H. Wright, M. Wright, and B. Spiegelman, ADD1/SREBP1 activates PPAR?? through the production of endogenous ligand, Proceedings of the National Academy of Sciences, vol.101, issue.1, pp.4333-4337, 1998.
DOI : 10.1172/JCI1411

S. Ait-si-ali, D. Carlisi, S. Ramirez, L. Upegui-gonzalez, A. Duquet et al., Phosphorylation by p44 MAP Kinase/ERK1 Stimulates CBP Histone Acetyl Transferase Activity in Vitro, Biochemical and Biophysical Research Communications, vol.262, issue.1, pp.157-162, 1999.
DOI : 10.1006/bbrc.1999.1132

L. Qi, M. Saberi, E. Zmuda, Y. Wang, J. Altarejos et al., Adipocyte CREB Promotes Insulin Resistance in Obesity, Cell Metabolism, vol.9, issue.3, pp.277-286, 2009.
DOI : 10.1016/j.cmet.2009.01.006

URL : https://doi.org/10.1016/j.cmet.2009.01.006

J. Reusch, L. Colton, and D. Klemm, CREB Activation Induces Adipogenesis in 3T3-L1 Cells, Molecular and Cellular Biology, vol.20, issue.3, pp.1008-1020, 2000.
DOI : 10.1128/MCB.20.3.1008-1020.2000

URL : http://mcb.asm.org/content/20/3/1008.full.pdf

T. Park, R. Panek, S. Mueller, J. Hanselman, W. Rosebury et al., Inhibition of Sphingomyelin Synthesis Reduces Atherogenesis in Apolipoprotein E-Knockout Mice, Circulation, vol.110, issue.22, pp.3465-3471, 2004.
DOI : 10.1161/01.CIR.0000148370.60535.22

F. Kummerow, L. Cook, E. Wasowicz, and H. Jelen, Changes in the phospholipid composition of the arterial cell can result in severe atherosclerotic lesions, The Journal of Nutritional Biochemistry, vol.12, issue.10, pp.602-607, 2001.
DOI : 10.1016/S0955-2863(01)00181-4

P. Subbaiah and R. Sargis, Sphingomyelin: a natural modulator of membrane homeostasis and inflammation, Medical Hypotheses, vol.57, issue.2, pp.135-138, 2001.
DOI : 10.1054/mehy.2001.1336

D. Müller-wieland and J. Kotzka, SREBP-1: Gene Regulatory Key to Syndrome X?, Annals of the New York Academy of Sciences, vol.275, issue.Suppl. 1, pp.19-27, 2002.
DOI : 10.1161/01.ATV.20.7.1777

V. Catalán, J. Gómez-ambrosi, A. Rodríguez, C. Silva, F. Rotellar et al., Expression of caveolin-1 in human adipose tissue is upregulated in obesity and obesity-associated type 2 diabetes mellitus and related to inflammation, Clinical Endocrinology, vol.50, issue.0, pp.213-222, 2008.
DOI : 10.1073/pnas.250406797

G. Frühbeck, M. López, and C. Diéguez, Role of caveolins in body weight and insulin resistance regulation, Trends in Endocrinology & Metabolism, vol.18, issue.5, pp.177-82, 2007.
DOI : 10.1016/j.tem.2007.04.001

L. Méndez-giménez, A. Rodríguez, I. Balaguer, and G. Frühbeck, Role of aquaglyceroporins and caveolins in energy and metabolic homeostasis, Molecular and Cellular Endocrinology, vol.397, issue.1-2, pp.78-92, 2014.
DOI : 10.1016/j.mce.2014.06.017

H. Thorn, K. Stenkula, M. Karlsson, U. Ortegren, F. Nystrom et al., Cell Surface Orifices of Caveolae and Localization of Caveolin to the Necks of Caveolae in Adipocytes, Molecular Biology of the Cell, vol.14, issue.10, pp.3967-76, 2003.
DOI : 10.1091/mbc.E03-01-0050