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Contributions of pharmacogenetics and transcriptomics to the understanding of the hypersensitivity drug reactions

Abstract : Hypersensitivity drug reactions (HDRs) represent a large and important health problem, affecting many patients and leading to a variety of clinical entities, some of which can be life‐threatening. The culprit drugs include commonly used medications including antibiotics and NSAIDs. Nontherapeutical agents, such as contrast media, are also involved. Because the pathophysiological mechanisms are not well known and the current diagnostic procedures are somewhat insufficient, new approaches are needed for understanding the complexity of HDRs.
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https://hal.univ-lorraine.fr/hal-01687750
Contributor : Ngere Ul <>
Submitted on : Thursday, January 18, 2018 - 5:01:19 PM
Last modification on : Tuesday, October 13, 2020 - 10:47:38 AM

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T. Fernandez, C. Mayorga, J. Gueant, M. Blanca, J. Cornejo-García. Contributions of pharmacogenetics and transcriptomics to the understanding of the hypersensitivity drug reactions. Allergy, Wiley, 2014, 69 (2), pp.150 - 158. ⟨10.1111/all.12304⟩. ⟨hal-01687750⟩

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