J. W. Bijlsma, F. Berenbaum, and F. P. Lafeber, Osteoarthritis: an update with relevance for clinical practice, The Lancet, vol.377, issue.9783, pp.2115-2126, 2011.
DOI : 10.1016/S0140-6736(11)60243-2

P. G. Conaghan, M. Kloppenburg, G. Schett, and J. W. Bijlsma, Osteoarthritis research priorities: a report from a EULAR ad hoc expert committee, Annals of the Rheumatic Diseases, vol.72, issue.(7 Suppl), pp.1442-1445, 2014.
DOI : 10.1136/annrheumdis-2012-202745

D. J. Steger, DOT1L/KMT4 Recruitment and H3K79 Methylation Are Ubiquitously Coupled with Gene Transcription in Mammalian Cells, Molecular and Cellular Biology, vol.28, issue.8, pp.2825-2839, 2008.
DOI : 10.1128/MCB.02076-07

A. T. Nguyen and Y. Zhang, The diverse functions of Dot1 and H3K79 methylation, Genes & Development, vol.25, issue.13, pp.1345-1358, 2011.
DOI : 10.1101/gad.2057811

Q. Feng, Methylation of H3-Lysine 79 Is Mediated by a New Family of HMTases without a SET Domain, Current Biology, vol.12, issue.12, pp.1052-1058, 2002.
DOI : 10.1016/S0960-9822(02)00901-6

C. Betancourt and M. C. , Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis, Proc. Natl Acad. Sci, pp.8218-8223, 2012.
DOI : 10.1006/meth.2001.1261

M. C. Castaño-betancourt, Novel Genetic Variants for Cartilage Thickness and Hip Osteoarthritis, PLOS Genetics, vol.24, issue.10, p.1006260, 2016.
DOI : 10.1371/journal.pgen.1006260.s021

B. Ma, Gene expression profiling of dedifferentiated human articular chondrocytes in??monolayer culture, Osteoarthritis and Cartilage, vol.21, issue.4, pp.599-603, 2013.
DOI : 10.1016/j.joca.2013.01.014

P. D. Benya, S. R. Padilla, and M. E. Nimni, Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture, Cell, vol.15, issue.4, pp.1313-1321, 1978.
DOI : 10.1016/0092-8674(78)90056-9

R. F. Loeser, S. R. Goldring, C. R. Scanzello, and M. B. Goldring, Osteoarthritis: A disease of the joint as an organ, Arthritis & Rheumatism, vol.216, issue.6, pp.1697-1707, 2012.
DOI : 10.1111/j.1469-7580.2009.01186.x

M. Zhu, Activation of ??-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult ??-Catenin Conditional Activation Mice, Journal of Bone and Mineral Research, vol.908, issue.1, pp.12-21, 2009.
DOI : 10.1002/art.23614

R. J. Lories, -knockout mice, Arthritis & Rheumatism, vol.20, issue.12, pp.4095-4103, 2007.
DOI : 10.1007/BF03327364

R. J. Lories, M. Corr, and N. Lane, To Wnt or not to Wnt: the bone and joint health dilemma, Nature Reviews Rheumatology, vol.19, issue.6, pp.328-339, 2013.
DOI : 10.1016/j.joca.2011.04.014

K. Hovanes, Beta-catenin-sensitive isoforms of lymphoid enhancer factor-1 are selectively expressed in colon cancer, Nat. Genet, vol.28, pp.53-57, 2001.

J. Roose, Synergy Between Tumor Suppressor APC and the -Catenin-Tcf4 Target Tcf1, Science, vol.285, issue.5435, pp.1923-1926, 1999.
DOI : 10.1126/science.285.5435.1923

T. He, Identification of c-MYC as a Target of the APC Pathway, Science, vol.281, issue.5382, pp.1509-1512, 1998.
DOI : 10.1126/science.281.5382.1509

M. M. Sun, -. Beier, and F. , Chondrocyte hypertrophy in skeletal development, growth, and disease, Birth Defects Research Part C: Embryo Today: Reviews, vol.26, issue.11, pp.74-82, 2014.
DOI : 10.1002/jbmr.502

M. Mohan, Linking H3K79 trimethylation to Wnt signaling through a novel Dot1-containing complex (DotCom), Genes & Development, vol.24, issue.6, pp.574-589, 2010.
DOI : 10.1101/gad.1898410

D. Mueller, A role for the MLL fusion partner ENL in transcriptional elongation and chromatin modification, Blood, vol.110, issue.13, pp.4445-4454, 2007.
DOI : 10.1182/blood-2007-05-090514

Y. Okada, hDOT1L Links Histone Methylation to Leukemogenesis, Cell, vol.121, issue.2, pp.167-178, 2005.
DOI : 10.1016/j.cell.2005.02.020

URL : https://doi.org/10.1016/j.cell.2005.05.021

E. Bitoun, M. J. Finelli, P. L. Oliver, S. Lee, and K. Davies, AF4 Is a Critical Regulator of the IGF-1 Signaling Pathway during Purkinje Cell Development, Journal of Neuroscience, vol.29, issue.49
DOI : 10.1523/JNEUROSCI.5188-09.2009

M. F. Niedzielski, R. Hopewell, Z. Ismail, and M. C. Estable, MCEF is localized to the nucleus by protein sequences encoded within three distinct exons, where it represses HIV-1 Tat-transactivation of LTR-directed transcription, International Journal of Biological Sciences, vol.3, pp.225-236, 2007.
DOI : 10.7150/ijbs.3.225

A. J. Deshpande, AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes, Cancer Cell, vol.26, issue.6, pp.896-908, 2014.
DOI : 10.1016/j.ccell.2014.10.009

G. Park, Z. Gong, J. Chen, and J. Kim, Characterization of the DOT1L Network: Implications of Diverse Roles for DOT1L, The Protein Journal, vol.281, issue.26, pp.213-223, 2010.
DOI : 10.1042/bj20030839

M. W. Mcburney, K. V. Clark-knowles, A. Z. Caron, and D. A. Gray, SIRT1 is a Highly Networked Protein That Mediates the Adaptation to Chronic Physiological Stress, Genes & Cancer, vol.4, issue.3-4, pp.125-134, 2013.
DOI : 10.1177/1947601912474893

E. M. Stein and M. S. Tallman, Mixed lineage rearranged leukaemia, Current Opinion in Hematology, vol.22, issue.2, pp.92-96, 2015.
DOI : 10.1097/MOH.0000000000000123

N. J. Waters, Preclinical Pharmacokinetics and Pharmacodynamics of Pinometostat (EPZ-5676), a First-in-Class, Small Molecule S-Adenosyl Methionine Competitive Inhibitor of DOT1L, European Journal of Drug Metabolism and Pharmacokinetics, vol.7, issue.6, pp.13318-13335, 2017.
DOI : 10.1021/acsmedchemlett.6b00167

H. Lango-allen, Hundreds of variants clustered in genomic loci and biological pathways affect human height, Nature, vol.42, issue.7317, pp.832-838, 2010.
DOI : 10.1002/ajmg.a.31483

URL : https://hal.archives-ouvertes.fr/cea-00904990

E. Evangelou, rs12982744 polymorphism is associated with osteoarthritis of the hip with genome-wide statistical significance in males, Annals of the Rheumatic Diseases, vol.19, issue.7, pp.1264-1265, 2013.
DOI : 10.1016/j.joca.2010.10.027

Y. Zhou, F. Bi, G. Yang, and J. Chen, Association Between Single Nucleotide Polymorphisms of DOT1L Gene and Risk of Knee Osteoarthritis in a Chinese Han Population, Cell Biochemistry and Biophysics, vol.73, issue.Suppl 1, pp.1677-1682, 2014.
DOI : 10.1097/BRS.0b013e318287fcfd

T. Mahmoudi, The Leukemia-Associated Mllt10/Af10-Dot1l Are Tcf4/??-Catenin Coactivators Essential for Intestinal Homeostasis, PLoS Biology, vol.3, issue.11, p.1000539, 2010.
DOI : 10.1371/journal.pbio.1000539.s012

G. S. Gibbons, S. R. Owens, E. R. Fearon, and Z. Nikolovska-coleska, Regulation of Wnt Signaling Target Gene Expression by the Histone Methyltransferase DOT1L, ACS Chemical Biology, vol.10, issue.1, pp.109-114, 2015.
DOI : 10.1021/cb500668u

M. Zhu, Inhibition of ?????catenin signaling in articular chondrocytes results in articular cartilage destruction, Arthritis & Rheumatism, vol.16, issue.7, pp.2053-2064, 2008.
DOI : 10.1016/S1476-5586(04)80048-4

G. Nalesso, WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis, Annals of the Rheumatic Diseases, vol.280, issue.(Suppl 3), pp.218-226, 2017.
DOI : 10.1074/jbc.M414275200

C. Soria-valles, NF-??B activation impairs somatic cell reprogramming in ageing, Nature Cell Biology, vol.17, issue.8, pp.1004-1013, 2015.
DOI : 10.1038/ng.471

H. Vlaming and F. Van-leeuwen, The upstreams and downstreams of H3K79 methylation by DOT1L, Chromosoma, vol.20, issue.4, pp.593-605, 2016.
DOI : 10.1016/j.molcel.2005.09.025

H. Vlaming, Flexibility in crosstalk between H2B ubiquitination and H3 methylation in vivo, EMBO reports, vol.15, issue.10, pp.1077-1084, 2014.
DOI : 10.15252/embr.201438793

J. N. Feige and J. Auwerx, Transcriptional targets of sirtuins in the coordination of mammalian physiology, Current Opinion in Cell Biology, vol.20, issue.3, pp.303-309, 2008.
DOI : 10.1016/j.ceb.2008.03.012

URL : https://hal.archives-ouvertes.fr/inserm-00311100

C. Chen, DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia, Nature Medicine, vol.7, issue.4, pp.335-343, 2015.
DOI : 10.1371/journal.pone.0031690

D. Zhang, S. Li, P. Cruz, and B. C. Kone, Transcription in Collecting Duct, Journal of Biological Chemistry, vol.28, issue.31, pp.20917-20926, 2009.
DOI : 10.1681/ASN.2006090975

M. Dvir-ginzberg, A. Mobasheri, and A. Kumar, The Role of Sirtuins in Cartilage Homeostasis and Osteoarthritis, Current Rheumatology Reports, vol.152, issue.12, p.43, 2016.
DOI : 10.1210/en.2011-1128

O. Gabay, Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model, Arthritis & Rheumatism, vol.119, issue.Suppl 3, pp.159-166, 2013.
DOI : 10.1172/JCI38902

O. Gabay, Increased apoptotic chondrocytes in articular cartilage from adult heterozygous SirT1 mice, Annals of the Rheumatic Diseases, vol.71, issue.4, pp.613-616, 2012.
DOI : 10.1136/ard.2011.200504

T. Matsuzaki, Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice, Annals of the Rheumatic Diseases, vol.54, issue.7, pp.1397-1404, 2014.
DOI : 10.1002/hep.24471

W. Li, L. Cai, Y. Zhang, L. Cui, and G. Shen, Intra-articular resveratrol injection prevents osteoarthritis progression in a mouse model by activating SIRT1 and thereby silencing HIF-2??, Journal of Orthopaedic Research, vol.29, issue.7, pp.1061-1070, 2015.
DOI : 10.1523/JNEUROSCI.1779-09.2009

H. J. Kim, H. J. Braun, and J. L. Dragoo, The effect of resveratrol on normal and osteoarthritic chondrocyte metabolism, Bone and Joint Research, vol.3, issue.3, pp.51-59, 2014.
DOI : 10.1302/2046-3758.33.2000226

M. C. Motta, Mammalian SIRT1 Represses Forkhead Transcription Factors, Cell, vol.116, issue.4, pp.551-563, 2004.
DOI : 10.1016/S0092-8674(04)00126-6

URL : https://doi.org/10.1016/s0092-8674(04)00126-6

S. P. Henry, Generation of aggrecan-CreERT2 knockin mice for inducible Cre activity in adult cartilage, genesis, vol.58, issue.Pt 12, pp.805-814, 2009.
DOI : 10.7150/ijbs.4.283

G. Testa, A reliable lacZ expression reporter cassette for multipurpose, knockout-first alleles, genesis, vol.18, issue.3, pp.151-158, 2004.
DOI : 10.1128/MCB.12.8.3636

A. Basavapathruni, Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor, Biopharmaceutics & Drug Disposition, vol.56, issue.22, pp.237-252, 2014.
DOI : 10.1021/jm4007752

W. Yang, X. Mu, and X. Li, XAV939 Inhibits Vascular Remodeling by Reducing Vascular Smooth Muscle Cells Proliferation in Hypertensive Rats, Journal of Biomaterials and Tissue Engineering, vol.5, issue.12
DOI : 10.1166/jbt.2015.1402

H. Oh, Reciprocal regulation by hypoxia-inducible factor-2?? and the NAMPT-NAD + -SIRT axis in articular chondrocytes is involved in osteoarthritis, Osteoarthritis and Cartilage, vol.23, issue.12, pp.2288-2296, 2015.
DOI : 10.1016/j.joca.2015.07.009

S. S. Glasson, M. G. Chambers, W. B. Van-den-berg, and C. B. Little, The OARSI histopathology initiative ??? recommendations for histological assessments of osteoarthritis in the mouse, Osteoarthritis and Cartilage, vol.18, pp.17-23, 2010.
DOI : 10.1016/j.joca.2010.05.025

S. Thysen, F. P. Luyten, and R. J. Lories, Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis, Osteoarthritis and Cartilage, vol.23, issue.2, pp.275-279, 2015.
DOI : 10.1016/j.joca.2014.10.010

M. Geyer, Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology, Osteoarthritis and Cartilage, vol.17, issue.3, pp.328-335, 2009.
DOI : 10.1016/j.joca.2008.07.010

J. N. Beresford, J. A. Gallagher, J. W. Poser, and R. G. Russell, Production of osteocalcin by human bone cells in vitro(OH)2D3, parathyroid hormone, and glucocorticoids, Metab. Bone Dis. Relat. Res, vol.125, issue.5, pp.25-229, 1984.

D. W. Huang, DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists, Nucleic Acids Research, vol.33, issue.suppl_2, pp.169-175, 2007.
DOI : 10.1093/nar/gki031

J. Chen, E. E. Bardes, B. J. Aronow, and A. G. Jegga, ToppGene Suite for gene list enrichment analysis and candidate gene prioritization, Nucleic Acids Research, vol.18, issue.8, pp.305-311, 2009.
DOI : 10.1093/hmg/ddp041

H. Mi, PANTHER version 11: expanded annotation data from Gene Ontology and Reactome pathways, and data analysis tool enhancements, Nucleic Acids Research, vol.45, issue.D1, pp.183-189, 2017.
DOI : 10.1093/bioinformatics/btq028

URL : https://academic.oup.com/nar/article-pdf/45/D1/D183/8846980/gkw1138.pdf