Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation - Université de Lorraine Access content directly
Journal Articles Stem Cell Research and Therapy Year : 2017

Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

Abstract

Background: The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available for MSC isolated from Wharton's jelly (WJ-MSC). We initiated a study to identify whether obstetric factors influenced MSC properties. We aimed to evaluate the correlation between a large number of obstetric factors collected during pregnancy and until peripartum (related to the mother, the labor and delivery, and the newborn) with WJ-MSC proliferation and chondrogenic differentiation parameters.
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Dates and versions

hal-01715233 , version 1 (22-02-2018)

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Léonore Avercenc-Leger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sebastien Hupont, et al.. Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation. Stem Cell Research and Therapy, 2017, 8 (1), ⟨10.1186/s13287-017-0609-z⟩. ⟨hal-01715233⟩
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