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Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation

Abstract : Background: The umbilical cord is becoming a notable alternative to bone marrow (BM) as a source of mesenchymal stromal cells (MSC). Although age-dependent variations in BM-MSC are well described, less data are available for MSC isolated from Wharton's jelly (WJ-MSC). We initiated a study to identify whether obstetric factors influenced MSC properties. We aimed to evaluate the correlation between a large number of obstetric factors collected during pregnancy and until peripartum (related to the mother, the labor and delivery, and the newborn) with WJ-MSC proliferation and chondrogenic differentiation parameters.
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https://hal.univ-lorraine.fr/hal-01715233
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Submitted on : Thursday, February 22, 2018 - 2:58:22 PM
Last modification on : Friday, April 9, 2021 - 9:18:05 AM
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Léonore Avercenc-Leger, Philippe Guerci, Jean-Marc Virion, Ghislaine Cauchois, Sebastien Hupont, et al.. Umbilical cord-derived mesenchymal stromal cells: predictive obstetric factors for cell proliferation and chondrogenic differentiation. Stem Cell Research and Therapy, BioMed Central, 2017, 8 (1), ⟨10.1186/s13287-017-0609-z⟩. ⟨hal-01715233⟩

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