. Haute-autorité-de-santé, Maladie d'Alzheimer et maladies apparentées : suivi médical des aidants naturels. Recommandation 2010 Disponible sur : < http

C. Handicap, Chartre européenne de l'aidant (en ligne) Bruxelles Disponible sur : < http, 2009.

P. Thomas, Le rôle déterminant de l'entourage familial dans la prise en charge de la maladie. Etude PIXEL. France Alzheimer, 2001.

F. Novartis, Les aidants familiaux en France. Panel national des aidants familiaux BVA, Disponible sur : < www.aidautonomie.fr/IMG/pdf, 2008.

R. Schulz, Caregiving as a Risk Factor for Mortality, JAMA, vol.282, issue.23, pp.2215-2224, 1999.
DOI : 10.1001/jama.282.23.2215

C. Mc, . Sm, R. Logsdon, L. Teri, and M. Vitiello, Sleep disturbances in caregivers of persons with dementia: contributing factors and treatment implications, Sleep Med Rev, vol.11, issue.2, pp.143-53, 2007.

I. Aidants-familiaux, Alzheimer-INPES Disponible sur : < http, 2009.

C. Ferri, M. Prince, C. Brayne, H. Brodaty, and L. Fratiglioni, Global prevalence of dementia, Alzheimer's & Dementia, vol.5, issue.4, pp.2112-2119, 2005.
DOI : 10.1016/j.jalz.2009.05.374

M. Duée and C. Rebillard, La dépendance des personnes âgées : une projection en 2040. Données sociales. La société française, pp.613-618, 2006.

N. Bienart, J. Weinman, and J. Wade, Caregiver burden and psychoeducational interventions in Alzheimer's disease: a review, pp.638-686, 2012.

P. Thomas, Entrée en institution des déments. Service universitaire de psychogériatrie Esquirol Limoges, Gérontologie et société, pp.141-156, 2005.

P. Thomas, P. Etude, and . France-alzheimer, Qualité de vie de l'aidant du malade Alzheimer à domicile. Etude PIXEL III. France Alzheimer, 2003.

C. Schölzel-dorenbos, I. Draskovic, M. Vernooij-dassen, O. Rikkert, and M. , Quality of Life and Burden of Spouses of Alzheimer Disease Patients, Alzheimer Disease & Associated Disorders, vol.23, issue.2, pp.171-178, 2009.
DOI : 10.1097/WAD.0b013e318190a260

R. Hébert, G. Bravo, and D. Girouard, Fid??lit?? de la traduction fran??aise de trois instruments d'??valuation des aidants naturels de malades d??ments, Canadian Journal on Aging / La Revue canadienne du vieillissement, vol.29, issue.03, pp.324-337
DOI : 10.1093/geront/29.4.438

S. Andrieu, L. Balardy, S. Gillette-guyonnet, H. Bocquet, C. Cantet et al., Charge ressentie par les aidants informels de patients atteintsde la maladie d' Alzheimer au sein de l'??tude REAL.FR m??thode de mesure et facteurs associ??s, La Revue de M??decine Interne, vol.24, issue.3, pp.351-359, 2003.
DOI : 10.1016/S0248-8663(03)80695-1

J. Cummings, M. Mega, K. Gray, S. Rosenberg-thompson, D. Carusi et al., The Neuropsychiatric Inventory: Comprehensive assessment of psychopathology in dementia, Neurology, vol.44, issue.12, pp.2308-2322, 1994.
DOI : 10.1212/WNL.44.12.2308

P. Robert, I. Médecin, P. Staccini, and S. Goni, Inventaire neuropsychiatrique : validation de la version française d'un instrument destiné à évaluer les troubles du comportement chez les sujets déments. L'année gérontologique. Maladie d'Alzheimer, pp.63-87, 1998.

S. Mohamed, R. Rosenheck, C. Lyketsos, and L. Schneider, Caregiver Burden in Alzheimer Disease: Cross-Sectional and Longitudinal Patient Correlates, The American Journal of Geriatric Psychiatry, vol.18, issue.10, pp.917-944, 2010.
DOI : 10.1097/JGP.0b013e3181d5745d

C. Sevilla, J. Cabanello, P. Alfonso, V. Gonzales-adalid, and M. , Current Treatments of Alzheimer Disease: Are Main Caregivers Satisfied with the Drug Treatments Received by Their Patients?, Dementia and Geriatric Cognitive Disorders, vol.28, issue.3, pp.196-205, 2009.
DOI : 10.1159/000236015

P. Thomas, Motivations des aidants informels pour l'institutionnalisation des malades vivant jusque-là à domicile. Etude PIXEL II. France Alzheimer, 2002.
DOI : 10.1016/j.npg.2008.05.004

R. Hébert, G. Bravo, and M. Preville, Reliability, Validity and Reference Values of the Zarit Burden Interview for Assessing Informal Caregivers of Community-Dwelling Older Persons with Dementia, Canadian Journal on Aging / La Revue canadienne du vieillissement, vol.45, issue.04, pp.494-507, 2000.
DOI : 10.1093/geronj/45.5.P181

J. Razani, B. Kakos, C. Orieta-barbalace, J. Wong, R. Casas et al., Predicting Caregiver Burden from Daily Functional Abilities of Patients with Mild Dementia, Journal of the American Geriatrics Society, vol.34, issue.9, pp.1415-1435, 2007.
DOI : 10.1093/geront/29.6.798

G. Choi, T. Tirrito, and F. J. Mills, Caregiver's Spirituality and Its Influence on Maintaining the Elderly and Disabled in a Home Environment, Journal of Gerontological Social Work, vol.42, issue.3-4, pp.3-4247, 2008.
DOI : 10.1093/geront/42.2.224

W. Group and . Development, Rationale and current status, International Journal of Mental Health, issue.23, pp.24-56, 1993.

P. Thomas, Entrée en institution des déments Gérontologie et société 1, pp.141-156, 2005.

P. Thomas, Pronostic de la rupture du domicile pour les patients atteints d'une maladie d'Alzheimer ou apparentée, pp.589-596, 2006.

K. Yaffe, P. Fox, R. Newcomer, K. Lindquist, K. Dane et al., Patient and Caregiver Characteristics and Nursing Home Placement in Patients With Dementia, JAMA, vol.287, issue.16, pp.2090-2097, 2002.
DOI : 10.1001/jama.287.16.2090

O. , B. Drachman, D. Drachman, A. Barnes, and H. , Incontinence and troublesome behaviors predict institutionalization in dementia, J Geriatr Psychiat Neurol, vol.5, issue.1, pp.45-52, 1992.

T. Hope, J. Keene, and K. Gedlingk, Predictors of institutionalization for people with dementia living at home with a carer, International Journal of Geriatric Psychiatry, vol.26, issue.10, pp.682-90, 1998.
DOI : 10.1093/geront/26.3.260

L. Clyburn, M. J. Stones, and T. Had-jistavropoulos, Predicting caregiver burden and depression in Alzheimer's disease, J Gerontol B Psychol Sci Soc Sci, 2000.

D. Wilson, Urinary incontinence in stroke: results from the UK National Sentinel Audits of stroke, Age Ageing, vol.37, issue.5, 1998.

M. Mittelman, S. Ferris, and E. Shulman, A family intervention to delay nursing home placement of patients with Alzheimer disease. A randomized controlled trial, JAMA: The Journal of the American Medical Association, vol.276, issue.21, pp.1725-1756, 1996.
DOI : 10.1001/jama.276.21.1725

A. Selwood, K. Johnson, C. Katona, C. Lyketsios, and G. Livingstone, Systematic review of the effect of psychological interventions on family caregivers of people with dementia, Journal of Affective Disorders, vol.101, issue.1-3, pp.75-89, 2007.
DOI : 10.1016/j.jad.2006.10.025

M. Boucharlat, C. Montani, M. Myslinski, and A. Franco, Pour un soutien pychoth??rapique ?? domicile du couple patient/aidant, L'Enc??phale, vol.32, issue.1, pp.92-98, 2006.
DOI : 10.1016/S0013-7006(06)76141-3

C. Boutoleau and M. Vercelletto, Fardeau de l'aidant dans la pathologie démentielle : lien avec les activités de la vie quotidienne et les troubles psycho-comportementaux

S. Beach, R. Schulz, J. Yee, and S. Jackson, Negative and positive health effects of caring for a disabled spouse: Longitudinal findings from the Caregiver Health Effects Study., Psychology and Aging, vol.15, issue.2, pp.259-71, 2000.
DOI : 10.1037/0882-7974.15.2.259

. A. Prévenir-la-iatrogénèse-médicamenteuse-chez-le-sujet-agé, Disponible sur : < http://ansm.sante.fr/S-informer/Presse-Communiques-Points-presse/Prevenir- les-effets-indesirables-des-medicaments-chez-les-personnes- agees, 2005.

S. Legrain, Améliorer la prescription médicamenteuse chez le sujet âgé. HAS. Mai Disponible sur :<www.has-sante, pp.2008-2015, 2008.

J. Ankri, Le risque iatrog??ne m??dicamenteux chez le sujet ??g??, G??rontologie et soci??t??, vol.25, issue.4, pp.93-93, 2002.
DOI : 10.3917/gs.103.0093

G. Bujega, G. Kumara, and A. Kumara, Exclusion of elderly people from clinical research: a descriptive study of published report, Br Med J, vol.315, issue.7115, p.1059, 1997.

J. Doucet, Les effets indésirables des médicaments chez le sujet âgé. Pubmed, Oct, vol.2328, issue.32, pp.1789-93, 1999.

P. Queneau, Rapport de mission sur la iatrogénie médicamenteuse et sa prévention, Disponible sur, 1998.

J. Lazarou, B. Pomeranz, and P. Corey, Incidence of Adverse Drug Reactions in Hospitalized Patients, JAMA, vol.279, issue.15, pp.1200-1205, 1998.
DOI : 10.1001/jama.279.15.1200

B. Bégaud, Does age increase the risk of adverse drug reaction ?, Br J Clin Pharmacol, vol.54, issue.5, pp.550-552, 2002.

C. Wu, C. Bell, and W. Wodchis, Incidence and Economic Burden of Adverse Drug Reactions among Elderly Patients in Ontario Emergency Departments, Drug Safety, vol.33, issue.11, pp.769-81, 2012.
DOI : 10.1345/aph.19036

S. Legrain, Consommation médicamenteuse chez le sujet âgé. HAS Disponible sur : < www.has-sante.fr/portail, 2005.

B. Tangiisuran, J. Davies, J. Wright, and C. Rajkumar, Adverse drug reactions in a population of hospitalized very elderly patients. Malaysia. Drugs Aging, Aug, vol.129, issue.8, pp.669-79, 2012.

D. Mandavi, . Cruz, A. Sachdey, and P. Tiwari, Adverse drug reactions and their risk factors among indian ambulatory elderly patients, Indian J Med Res, vol.136, issue.3, pp.404-414, 2012.

B. Bongue, M. Laroche, S. Gutton, A. Colvez, R. Guéguen et al., Potentially inappropriate drug prescription in the elderly in France: a population-based study from the French National Insurance Healthcare system, European Journal of Clinical Pharmacology, vol.363, issue.3, pp.1291-1300, 2011.
DOI : 10.1056/NEJMsa0910881

P. Queneau, G. Bouvenot, J. Montastruc, and D. Bontoux, La prescription des médicaments chez la personne âgée, Bulletin.Académie

S. Tessier, Colloque Observance thérapeutique chez les personnes âgées Synthèse documentaire. La Mutualité Française, 2001.

D. Morrow, V. Leirer, and J. Sheikh, Adherence and medication instructions : review and recommendations. Journal of the american geriatrics society, pp.1147-60, 1988.

S. Leger, P. Bedouch, and A. B. Eger-s, Culture pharmaceutique, perception du traitement médicamenteux et difficultés de consommation des médicaments chez le sujet âgé, Journal pharmaceutique clinique, vol.20, pp.110-113, 2001.

J. Anandamanoharan, P. Druai, and P. Clerc, Observance et médecine générale : peut-on dépister les problèmes d'observance chez les patients atteints de pathologies chroniques ? Thèse de médecine générale, 2012.

S. De-bosschere-libessart, Les personnes âgées connaissent-elles leur ordonnance? Thèse de doctorat en médecine, 2007.

T. Kojima, M. Akishita, Y. Kameyama, K. Yamaguchi, H. Yamamoto et al., High risk of adverse drug reactions in elderly patients taking six or more drugs: Analysis of inpatient database, Geriatrics & Gerontology International, vol.36, issue.4, 2012.
DOI : 10.3143/geriatrics.36.181

L. Auvray and C. Sermet, Consommations et prescriptions pharmaceutiques chez les personnes âgées. Un état des lieux, Gérontologie et société, vol.4, pp.13-27, 2002.
DOI : 10.3917/gs.103.0013

I. Scott, L. Gray, J. Martin, and C. Mitchell, Effects of a drug minimization guide on prescribing intentions in elderly persons with polypharmacy. Australia. Drugs Aging, Aug, vol.129, issue.8, pp.659-67, 2012.

R. Pretorius, G. Gataric, S. Swedlund, and J. Miller, Reducing the risk of adverse drug events in older adults, Am Fam Physician, vol.87, issue.5, pp.331-337, 2013.

J. Kiecolt-glasser, R. Glaser, S. Gravenstein, W. Malarkey, and J. Sheridan, Chronic stress alters the immune response to influenza virus vaccine in older adults., Proceedings of the National Academy of Sciences, vol.93, issue.7, pp.3043-3050, 1996.
DOI : 10.1073/pnas.93.7.3043

J. Kiecolt-glaser, J. Dura, C. Speicher, O. Trask, and R. Glaser, Spousal caregivers of dementia victims: longitudinal changes in immunity and health., Psychosomatic Medicine, vol.53, issue.4, 1991.
DOI : 10.1097/00006842-199107000-00001

R. Glaser and J. Kiecolt-glaser, Chronic stress modulates the virus-specific immune response to latent herpes simplex virus Type 1, Annals of Behavioral Medicine, vol.272, issue.2, pp.78-82, 1997.
DOI : 10.1007/978-1-4757-2093-8_25

G. Rodriguez, D. Leo, C. Girtler, N. Vitali, P. Grossi et al., Psychological and social aspects in management of Alzheimer???s patients: an inquiry among caregivers, Neurological Sciences, vol.24, issue.5, pp.329-364, 2003.
DOI : 10.1007/s10072-003-0184-1

C. Mc and T. L. Sm, Sleep disturbance in elderly caregivers of dementia patients, Clin Gerontol, vol.16, pp.51-66, 1995.

R. Pruchno and S. Potashnik, Caregiving Spouses Physical and Mental Health in Perspective, Journal of the American Geriatrics Society, vol.35, issue.8, pp.697-705, 1989.
DOI : 10.1111/j.1532-5415.1987.tb04680.x

J. Yee and R. Schultz, Gender Differences in Psychiatric Morbidity Among Family Caregivers, The Gerontologist, vol.40, issue.2, pp.147-64, 2000.
DOI : 10.2307/3350059

C. Aggar, S. Ronaldson, and I. Cameron, Reactions to caregiving of frail, older persons predict depression, International Journal of Mental Health Nursing, vol.67, issue.6, pp.409-424, 2010.
DOI : 10.1093/geronj/46.4.P181

L. Garand, M. Dew, L. Eazor, S. Dekosky, and C. Reynolds, Caregiving burden and psychiatric morbidity in spouses of persons with mild cognitive impairment, International Journal of Geriatric Psychiatry, vol.32, issue.6, pp.512-534, 2005.
DOI : 10.1093/geront/32.5.665

J. Son, A. Erno, D. Shea, E. Femia, S. Zarit et al., The Caregiver Stress Process and Health Outcomes, Journal of Aging and Health, vol.44, issue.7, pp.871-87, 2007.
DOI : 10.1207/s15327558ijbm1302_9

C. Seigle, La consultation conjointe en médecine générale, Thèse médecine générale Nancy, 2011.

N. Christakis and P. Allison, Mortality after the Hospitalization of a Spouse, New England Journal of Medicine, vol.354, issue.7, pp.719-749, 2006.
DOI : 10.1056/NEJMsa050196

L. Stephanie, D. M. Brown, R. Smith, M. U. Schulz, and . Kabeto, Caregiving Behavior Is Associated With Decreased Mortality Risk Psychol Sci, 2009.

P. Vitaliano, J. Zhang, and J. Scanlan, Is Caregiving Hazardous to One's Physical Health? A Meta-Analysis., Psychological Bulletin, vol.129, issue.6, pp.946-72, 2003.
DOI : 10.1037/0033-2909.129.6.946

L. Fredman, J. Cauley, S. Satterfield, E. Simonsick, S. Spencer et al., Caregiving, Mortality, and Mobility Decline<subtitle>The Health, Aging, and Body Composition (Health ABC) Study</subtitle>, Archives of Internal Medicine, vol.168, issue.19, pp.2154-62, 2008.
DOI : 10.1001/archinte.168.19.2154

O. Reilly, D. Connolly, S. Rosato, M. Patterson, and C. , Is caring associated with an increased risk of mortality? A longitudinal study, Social Science & Medicine, vol.67, issue.8, pp.1282-90, 2008.
DOI : 10.1016/j.socscimed.2008.06.025