M. Karvonen, PHD for the Diabetes Mondiale (DiaMond) Incidence of Childhood Type 1 Diabetes Worldwide, Project Group Disclosures Diabetes Care, vol.23, 2000.

H. King, R. Aubert, and W. Herman, Global Burden of Diabetes, 1995-2025: Prevalence, numerical estimates, and projections, Diabetes Care, vol.21, issue.9, pp.1414-1431, 1998.
DOI : 10.2337/diacare.21.9.1414

B. Popkin and C. Doak, The Obesity Epidemic Is a Worldwide Phenomenon, Nutrition Reviews, vol.3, issue.2, pp.106-114, 1998.
DOI : 10.1002/j.1550-8528.1995.tb00451.x

A. Green, E. Gale, and C. Patterson, Incidence of childhood-onset insulin-dependent diabetes mellitus: the EURODIAB ACE study, The Lancet, vol.339, issue.8798, pp.905-909, 1992.
DOI : 10.1016/0140-6736(92)90938-Y

A. Fagot-campagna, D. Pettitt, and M. Engelgau, Type 2 diabetes among North adolescents: An epidemiologic health perspective, The Journal of Pediatrics, vol.136, issue.5, pp.664-672, 2000.
DOI : 10.1067/mpd.2000.105141

P. Saker, A. Hattersley, and B. Barrow, High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population, Diabetologia, vol.39, issue.11
DOI : 10.1007/s001250050577

A. Green and C. Patterson, Trends in the incidence of childhood-onset diabetes in Europe 1989???1998, Diabetologia, vol.44, issue.S3, p.3, 2001.
DOI : 10.1007/PL00002950

M. Charkaluk, P. Czernichow, and C. Lévy-maréchal, Incidence data of childhood-onset type 1

A. Weill, N. Wallier, and P. Ricordeau, Incidence medico-sociale du diabète en France : quelles evolutions entre 1990 et 2002? Quelles disparités spatiales ? Diabetes Metab, pp.1-9, 2004.

P. Onkamo, S. Väänänen, M. Karvonen, and J. Tuomilheto, Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends, Diabetologia, vol.42, issue.12, pp.1395-1403, 1999.
DOI : 10.1007/s001250051309

L. Quotidien-du-pharmacien, Le diabète de type 1 augmente de 5 pour cent par an chez l'enfant, pp.17-2013

M. Charkaluk, P. Czernichow, and C. Lévy-marchal, Incidence data of childhood-onset type 1

J. Dorman, Molecular Epidemiology of Insulin-dependent Diabetes Mellitus, Epidemiologic Reviews, vol.19, issue.1, pp.91-98, 1997.
DOI : 10.1093/oxfordjournals.epirev.a017950

J. Dorman, R. Laporte, R. Stone, and M. Trucco, Worldwide differences in the incidence of type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain., Proceedings of the National Academy of Sciences, vol.87, issue.19, pp.7370-7374, 1990.
DOI : 10.1073/pnas.87.19.7370

G. Dahlquist, L. Blom, and T. Tuvemo, The Swedish cildhood diabetes study. Results from a nine year case register and a one year case-referent study indicating that type 1 (insulindependent ) diabetes mellitus is associate with both type 2 (non-insulino-dependent) diabetes mellitus and auto-immune disorders, Diabetologia, vol.32, pp.2-6, 1989.

H. Dosch, J. Martin, and B. Robinson, An Immunological Basis for Disproportionate Diabetes Risks in Children With a Type I Diabetic Mother or Father, Diabetes Care, vol.16, issue.6, pp.949-951, 1993.
DOI : 10.2337/diacare.16.6.949

G. Dahlquist, The aetiologyof type 1 diabetes : an epidemiological perspective, Acta Paediatr, vol.425, pp.5-10, 1998.

P. Onkamo, S. Väänänen, M. Karvonen, and J. Tuomilehto, Worldwide increase in incidence of Type I diabetes - the analysis of the data on published incidence trends, Diabetologia, vol.42, issue.12, pp.1395-1403, 1999.
DOI : 10.1007/s001250051309

A. Green and C. Patterson, Trends in the incidence of childhood-onset diabetes in Europe 1989???1998, Diabetologia, vol.44, issue.S3, pp.3-8, 2001.
DOI : 10.1007/PL00002950

A. Green and E. Gale, Etiologie et pathogénie du diabète insulin-dépendant. Approche épidémiologique, Le diabète en Europe. Paris, les Editions INSERM/John Libbey, pp.15-31, 1994.

J. Karjalalainen, J. Martin, and M. Knip, A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes Mellitus, New England Journal of Medicine, vol.327, issue.5, pp.302-307, 1992.
DOI : 10.1056/NEJM199207303270502

A. Ziegler, S. Schmid, D. Huber, M. Hummel, and E. Bonifacio, Early Infant Feeding and Risk of Developing Type 1 Diabetes???Associated Autoantibodies, JAMA, vol.290, issue.13, pp.1721-1728, 2003.
DOI : 10.1001/jama.290.13.1721

T. Helgason and M. Jonasson, EVIDENCE FOR A FOOD ADDITIVE AS A CAUSE OF KETOSIS-PRONE DIABETES, The Lancet, vol.318, issue.8249, pp.716-720, 1981.
DOI : 10.1016/S0140-6736(81)91048-5

E. Barrett-connor, Is Insulin-Dependent Diabetes Mellitus Caused by Coxsackievirus B Infection? A Review of the Epidemiologic Evidence, Clinical Infectious Diseases, vol.7, issue.2, pp.207-215, 1985.
DOI : 10.1093/clinids/7.2.207

C. Patterson, G. Dahlquist, and G. Soltessz, Is childhood-onset Type I diabetes a wealth-related disease? An ecological analysis of European incidence rates, Diabetologia, vol.44, issue.S3, pp.9-16, 2001.
DOI : 10.1007/PL00002961

R. Leslie and R. Elliott, Early Environmental Events as a Cause of IDDM: Evidence and Implications, Diabetes, vol.43, issue.7, pp.843-850, 1994.
DOI : 10.2337/diab.43.7.843

A. Du, relatif à la radiation des pompes externes à insuline programmables à l'achat inscrites au chapitre 1er du titre Ier de la liste des produits et prestations remboursables prévue à l'article 165-1 du code de la sécurité sociale, p.7325, 2009.

S. Shalitin, M. Gil, R. Nimri, L. De-vries, M. Gavan et al., Predictors of glycaemic control in patients with Type 1 diabetes commencing continuous subcutaneous insulin infusion therapy, Diabetic Medicine, vol.8, issue.3, pp.339-347, 2010.
DOI : 10.1111/j.1464-5491.2009.02925.x

R. Hoogma, P. Hammond, R. Gomis, D. Kerr, D. Bruttomesso et al., Comparison of the effects of continuous subcutaneous insulin infusion (CSII) and NPH-based multiple daily insulin injections (MDI) on glycaemic control and quality of life: results of the 5-nations trial, Diabetic Medicine, vol.22, issue.2, pp.141-147, 2006.
DOI : 10.1046/j.1464-5491.2002.00750.x

R. Nuboer, G. Borsboom, J. Zoethout, H. Koot, and J. Bruining, Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison, Pediatric Diabetes, vol.23, issue.4pt1, pp.291-296, 2008.
DOI : 10.1111/j.1399-5448.2008.00396.x

E. Muller-godeffroy, S. Treichel, and V. Wagner, Investigation of quality of life and family burden issues during insulin pump therapy in children with Type 1 diabetes mellitus-a large-scale multicentre pilot study, Diabetic Medicine, vol.32, issue.5, pp.493-501, 2009.
DOI : 10.1515/JPEM.2005.18.1.83

K. Fuld, B. Conrad, B. Buckingham, and D. Wilson, Insulin Pumps in Young Children, Diabetes Technology & Therapeutics, vol.12, issue.S1, pp.67-71, 2010.
DOI : 10.1089/dia.2009.0182

B. Guerci, M. Benichou, M. Floriot, P. Bohme, S. Fougnot et al., Accuracy of an Electrochemical Sensor for Measuring Capillary Blood Ketones by Fingerstick Samples During Metabolic Deterioration After Continuous Subcutaneous Insulin Infusion Interruption in Type 1 Diabetic Patients, Diabetes Care, vol.26, issue.4, pp.1137-1141, 2003.
DOI : 10.2337/diacare.26.4.1137

R. Hanas and J. Ludvigsson, Hypoglycemia and ketoacidosis with insulin pump therapy in children and adolescents, Pediatric Diabetes, vol.17, issue.s4, pp.32-38, 2006.
DOI : 10.1001/jama.287.19.2511

R. Hanas, F. Lindgren, and B. Lindblad, A 2-yr national population study of pediatric ketoacidosis in Sweden: predisposing conditions and insulin pump use, Pediatric Diabetes, vol.28, issue.Suppl. 5, pp.33-37, 2009.
DOI : 10.3928/0090-4481-19990901-09

R. Hanas and P. Adolfsson, Insulin pumps in pediatric routine care improve long-term metabolic control without increasing the risk of hypoglycemia, Pediatric Diabetes, vol.38, issue.1, pp.25-31, 2006.
DOI : 10.1111/j.1442-200X.1996.tb03528.x

L. Fox, L. Buckloh, S. Smith, T. Wysocki, and N. Mauras, A Randomized Controlled Trial of Insulin Pump Therapy in Young Children With Type 1 Diabetes, Diabetes Care, vol.28, issue.6, pp.1277-1281, 2005.
DOI : 10.2337/diacare.28.6.1277

E. Schober and B. Rami, Dermatological side effects and complications of continuous subcutaneous insulin infusion in preschool-age and school-age children, Pediatric Diabetes, vol.95, issue.3, pp.198-201, 2009.
DOI : 10.1111/j.1464-5491.2007.02311.x

S. Clavel, B. Guerci, H. Hanaire, V. Lassman-vague, R. Leroy et al., Quand et comment traiter un patient diab??tique par pompe ?? insuline externe???, M??decine des Maladies M??taboliques, vol.3, issue.2, pp.219-227, 2009.
DOI : 10.1016/S1957-2557(09)71649-9

F. Pattou, GLP-1???Receptor Scanning for Imaging of Human Beta Cells Transplanted in Muscle, New England Journal of Medicine, vol.363, issue.13
DOI : 10.1056/NEJMc1004547

M. Vantyghem, Primary Graft Function, Metabolic Control, and Graft Survival After Islet Transplantation, Diabetes Care, vol.32, issue.8, pp.1473-1478, 2009.
DOI : 10.2337/dc08-1685

D. The and . Group, Diabetes Control and Complications Trial (DCCT): The Effect of Intensive Treatment of Diabetes on the Development and Progression of Long-Term Complications in Insulin Dependant Diabetes Mellitus, NEJM, vol.329, pp.977-986, 1993.

J. Beltrand, P. Cornillon, and E. Matzner-lober, Enquête sur les traitements du diabète de type 1 chez l'adulte en France: existe-t-il encore des patients à l'écart des moyens thérapeutiques optimaux? Infusystemes France, pp.1-6, 2007.

B. Bode, R. Steed, and P. Davidson, Reduction in severe hypoglycemia with long-term continuous subcutaneous insulin infusion in type 1 diabetes. Diabetes Care, 1996.

S. Bott, U. Bott, and M. Berger, Intensified insulin therapy and the risk of severe hypoglycaemia, Diabetologia, vol.40, issue.8, pp.926-958, 1997.
DOI : 10.1007/s001250050769

. Ronsin-0, M. Jannot-lamotte, and P. Vague, Lassman-Vague V. Factors related to CSII compliance. Diabetes Metab, Feb, vol.31, issue.1, pp.90-95, 2005.

D. Vries, J. Snoek, F. Heine, and R. , Persistent poor glycaemic control in adultType 1 diabetes. A closer look at the prob1em, Diabet Med, vol.21, issue.12, pp.1263-1271, 2004.

L. Président:-mme-brigitte, P. Directeur, :. M. Jacques, L. , M. Juges-mme-amélie et al., 2'. 0 i! . 'to\'i Doyen de la Faculté de Pharmacie de l, Joël COULON, pp.1-4