. Dans-le and . De, 9% (9-27.7) par secteur, de 294% (15.1-47.5) par lobe et de 455% (24.4-67.8) par patient Dans le bras sans diffusion

. Dans-le and . De, 2% (84-95.9) par secteur, de 83.3% (62.6- 95.3) par lobe et de 85.7% (42.1-99.6) par patient Dans le bras sans diffusion, pp.90-96

. Graphe and . Tableau, VPP et VPN de chaque bras, gold standard biopsies b. En comparaison aux prostatectomies i

. Dans-le and 8. De, 4-91.9) par secteur, de 100% (61.5-100) par lobe et de 100% (51.7-100) par patient Dans le bras sans diffusion, p.80

. Dans-le and 7. De, 6-87.3) par secteur, pp.60-74

. Par and . De, 2% (15-44.9), celle de la séquence de perfusion de 18% (7.5-33.5) et celle de la séquence de diffusion de 30

. Par and . De, 5% (32.2-75.6), celle de la séquence de perfusion de 27.3% (10.7-50.2) et celle de la séquence de diffusion de 46, pp.100-142

. Graphe and . Tableau, VPP et VPN de chaque paire (gold standard biopsies) 2) Gold standard : prostatectomie a. Sensibilité, spécificité

A. Jemal, T. Murray, E. Ward, A. Samuels, R. Tiwari et al., Cancer Statistics, 2005, CA: A Cancer Journal for Clinicians, vol.55, issue.1, pp.10-30, 2005.
DOI : 10.3322/canjclin.55.1.10

A. Belot, P. Grosclaude, N. Bossard, E. Jougla, E. Benhamou et al., Cancer incidence and mortality in France over the period 1980???2005, Revue d'??pid??miologie et de Sant?? Publique, vol.56, issue.3, pp.159-75, 2008.
DOI : 10.1016/j.respe.2008.03.117

URL : https://hal.archives-ouvertes.fr/inserm-00338335

A. Villers, J. Mcneal, F. Freiha, and T. Stamey, Multiple cancers in the prostate. Morphologic features of clinically recognized versus incidental tumors, Cancer, vol.147, issue.9, pp.2313-2321, 1992.
DOI : 10.1002/1097-0142(19921101)70:9<2313::AID-CNCR2820700917>3.0.CO;2-T

D. Byar and F. Mostofi, Carcinoma of the prostate: Prognostic evaluation of certain pathologic features in 208 radical prostatectomies, Cancer, vol.16, issue.1, pp.5-13, 1972.
DOI : 10.1001/jama.1956.02960450020005

Y. Choi, J. Kim, N. Kim, K. Kim, E. Choi et al., Functional MR Imaging of Prostate Cancer, RadioGraphics, vol.27, issue.1, pp.63-75, 2007.
DOI : 10.1148/rg.271065078

A. Ouzzane, P. Coloby, J. Mignard, J. Allegre, M. Soulie et al., Recommandations pour la bonne pratique des biopsies prostatiques, Progr??s en Urologie, vol.21, issue.1, pp.18-28, 2011.
DOI : 10.1016/j.purol.2010.07.001

G. Andriole, E. Crawford, R. Grubb, S. Buys, D. Chia et al., Mortality Results from a Randomized Prostate-Cancer Screening Trial, New England Journal of Medicine, vol.360, issue.13, pp.1310-1319, 2009.
DOI : 10.1056/NEJMoa0810696

F. Schroder, J. Hugosson, M. Roobol, T. Tammela, S. Ciatto et al., Screening and Prostate-Cancer Mortality in a Randomized European Study, New England Journal of Medicine, vol.360, issue.13, pp.1320-1328, 2009.
DOI : 10.1056/NEJMoa0810084

L. Salmi, O. Scemama, C. Rumeau-pichon, M. Phillips, H. Kressel et al., Dépistage du cancer de la prostate: analyse critique des articles issus des études ERSPC et PLCO publiés en mars 2009. HAS 2010 Prostatic disorders: MR imaging at 1.5 T, Radiology, vol.12164, issue.2, pp.386-92, 1987.

C. Carrol, F. Sommer, J. Mcneal, and T. Stamey, The abnormal prostate: MR imaging at 1.5 T with histopathologic correlation., Radiology, vol.163, issue.2, pp.521-526, 1987.
DOI : 10.1148/radiology.163.2.2436253

H. Hricak, G. Dooms, R. Jeffrey, A. Avallone, D. Jacobs et al., Prostatic carcinoma: staging by clinical assessment, CT, and MR imaging., Radiology, vol.162, issue.2, pp.331-337, 1987.
DOI : 10.1148/radiology.162.2.3797645

H. Hricak, S. White, D. Vigneron, J. Kurhanewicz, A. Kosco et al., Carcinoma of the prostate gland: MR imaging with pelvic phased-array coils versus integrated endorectal--pelvic phased-array coils., Radiology, vol.193, issue.3, pp.703-712, 1994.
DOI : 10.1148/radiology.193.3.7972810

T. Tamada, T. Sone, J. Y. Yamamoto, A. Yamashita, T. Egashira et al., Prostate Cancer: Relationships between Postbiopsy Hemorrhage and Tumor Detectability at MR Diagnosis, Radiology, vol.248, issue.2, pp.531-540, 2008.
DOI : 10.1148/radiol.2482070157

P. Puech, D. Huglo, G. Petyt, L. Lemaitre, and A. Villers, Imaging of organ-confined prostate cancer: functional ultrasound, MRI and PET/computed tomography, Current Opinion in Urology, vol.19, issue.2, pp.168-76, 2009.
DOI : 10.1097/MOU.0b013e328323f5ed

J. Kurhanewicz, D. Vigneron, P. Carroll, F. Coakley, A. Tanimoto et al., Multiparametric Magnetic Resonance Imaging of Prostate Cancer at 3T, Curr Opin Urol J Magn Reson Imaging, vol.150, issue.11, pp.71-7146, 2007.
DOI : 10.1016/j.juro.2006.08.007

T. Franiel, Multiparametrische Magnetresonanztomografie der Prostata ??? Technik und klinische Anwendungen, R??Fo - Fortschritte auf dem Gebiet der R??ntgenstrahlen und der bildgebenden Verfahren, vol.183, issue.07, pp.607-617, 2011.
DOI : 10.1055/s-0029-1246055

S. Heijmink, J. Futterer, T. Hambrock, S. Takahashi, T. Scheenen et al., Prostate Cancer: Body-Array versus Endorectal Coil MR Imaging at 3 T???Comparison of Image Quality, Localization, and Staging Performance, Radiology, vol.244, issue.1, pp.184-95, 2007.
DOI : 10.1148/radiol.2441060425

R. Henkelman, Does IVIM measure classical perfusion?, Magnetic Resonance in Medicine, vol.5, issue.3, pp.470-475, 1990.
DOI : 10.1161/01.RES.16.4.309

L. Bihan, D. Turner, and R. , The capillary network: a link between ivim and classical perfusion, Magnetic Resonance in Medicine, vol.1, issue.1, pp.171-179, 1992.
DOI : 10.1148/radiology.178.2.1987621

URL : https://hal.archives-ouvertes.fr/hal-00350065

R. Mulkern, A. Barnes, S. Haker, Y. Hung, F. Rybicki et al., Biexponential characterization of prostate tissue water diffusion decay curves over an extended b-factor range, Magnetic Resonance Imaging, vol.24, issue.5, pp.563-571, 2006.
DOI : 10.1016/j.mri.2005.12.008

Y. Chen, Y. Pu, S. Chueh, C. Shun, W. Chu et al., Diffusion MRI predicts transrectal ultrasound biopsy results in prostate cancer detection, Journal of Magnetic Resonance Imaging, vol.179, issue.Pt 1, pp.356-63, 2011.
DOI : 10.1016/j.juro.2008.01.017

C. Li, M. Chen, S. Li, X. Zhao, C. Zhang et al., Diffusion tensor imaging of prostate at 3

C. Reischauer, B. Wilm, J. Froehlich, A. Gutzeit, L. Prikler et al., High-resolution diffusion tensor imaging of prostate cancer using a reduced FOV technique, European Journal of Radiology, vol.80, issue.2, 2010.
DOI : 10.1016/j.ejrad.2010.06.038

P. Kozlowski, S. Chang, R. Meng, B. Madler, R. Bell et al., Combined prostate diffusion tensor imaging and dynamic contrast enhanced MRI at 3T ??? quantitative correlation with biopsy, Magnetic Resonance Imaging, vol.28, issue.5, pp.621-629, 2010.
DOI : 10.1016/j.mri.2010.03.011

J. Xu, P. Humphrey, A. Kibel, A. Snyder, V. Narra et al., Magnetic resonance diffusion characteristics of histologically defined prostate cancer in humans, Magnetic Resonance in Medicine, vol.5, issue.4, pp.842-50, 2009.
DOI : 10.1148/radiology.179.3.2028002

Y. Takayama, R. Kishimoto, S. Hanaoka, H. Nonaka, S. Kandatsu et al., ADC value and diffusion tensor imaging of prostate cancer: Changes in carbon-ion radiotherapy, Journal of Magnetic Resonance Imaging, vol.22, issue.suppl 2, pp.1331-1336, 2008.
DOI : 10.1148/radiology.201.3.8939209

B. Gurses, N. Kabakci, A. Kovanlikaya, Z. Firat, A. Bayram et al., Diffusion tensor imaging of the normal prostate at 3 Tesla, European Radiology, vol.61, issue.4, pp.716-737, 2008.
DOI : 10.1007/s00330-007-0795-7

K. Kitajima, Y. Kaji, Y. Fukabori, K. Yoshida, N. Suganuma et al., Prostate cancer detection with 3 T MRI: Comparison of diffusion-weighted imaging and dynamic contrast-enhanced MRI in combination with T2-weighted imaging, Journal of Magnetic Resonance Imaging, vol.21, issue.3, pp.625-656, 2010.
DOI : 10.1148/radiology.202.3.9051019

C. Roy, R. Pasquali, A. Matau, G. Bazille, and H. Lang, R??le de l???IRM de diffusion pour la d??tection du cancer de la prostate avant ponction biopsie : ??tude multiparam??trique de 111 patients ?? 3 Tesla, Journal de Radiologie, vol.91, issue.11, pp.1121-1129, 2010.
DOI : 10.1016/S0221-0363(10)70157-8

M. Haider, T. Van-der-kwast, J. Tanguay, A. Evans, A. Hashmi et al., Combined T2-weighted and diffusion-weighted MRI for localization of prostate cancer323-8. 36. Team RDC. R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing Multiparametric MRI is helpful to predict tumor focality, stage, and size in patients diagnosed with unilateral low-risk prostate cancer Prostate Cancer Prostatic Dis, AJR Am J Roentgenol Austria Vienna, vol.1893, issue.2, 2007.

T. Yoshizako, A. Wada, T. Hayashi, K. Uchida, M. Sumura et al., Usefulness of diffusion-weighted imaging and dynamic contrast-enhanced magnetic resonance imaging in the diagnosis of prostate transition-zone cancer, Acta Radiologica, vol.49, issue.10, pp.1207-1220, 2008.
DOI : 10.1080/02841850802508959

K. Yoshimitsu, K. Kiyoshima, H. Irie, T. Tajima, Y. Asayama et al., Usefulness of apparent diffusion coefficient map in diagnosing prostate carcinoma: Correlation with stepwise histopathology, Journal of Magnetic Resonance Imaging, vol.42, issue.1, pp.132-141, 2008.
DOI : 10.1148/radiology.195.2.7724756

M. Roethke, A. Anastasiadis, M. Lichy, M. Werner, P. Wagner et al., MRI-guided prostate biopsy detects clinically significant cancer: analysis of a cohort of 100 patients after previous negative TRUS biopsy, World Journal of Urology, vol.15, issue.Suppl 1, 2011.
DOI : 10.1007/s00330-004-2458-2

H. Miao, H. Fukatsu, and T. Ishigaki, Prostate cancer detection with 3-T MRI: Comparison of diffusion-weighted and T2-weighted imaging, European Journal of Radiology, vol.61, issue.2, pp.297-302, 2007.
DOI : 10.1016/j.ejrad.2006.10.002

H. Vargas, O. Akin, T. Franiel, Y. Mazaheri, J. Zheng et al., Diffusion-weighted Endorectal MR Imaging at 3 T for Prostate Cancer: Tumor Detection and Assessment of Aggressiveness, Radiology, vol.259, issue.3, pp.775-84, 2011.
DOI : 10.1148/radiol.11102066

S. Verma, A. Rajesh, H. Morales, L. Lemen, G. Bills et al., Assessment of Aggressiveness of Prostate Cancer: Correlation of Apparent Diffusion Coefficient With Histologic Grade After Radical Prostatectomy, American Journal of Roentgenology, vol.196, issue.2, pp.374-81, 2011.
DOI : 10.2214/AJR.10.4441

A. Rastinehad, A. Baccala, J. Chung, P. Proano, J. Kruecker et al., D'Amico Risk Stratification Correlates With Degree of Suspicion of Prostate Cancer on Multiparametric Magnetic Resonance Imaging, The Journal of Urology, vol.185, issue.3, pp.815-835, 2011.
DOI : 10.1016/j.juro.2010.10.076

T. Shimizu, A. Nishie, T. Ro, T. Tajima, A. Yamaguchi et al., Prostate cancer detection: the value of performing an MRI before a biopsy, Acta Radiologica, vol.50, issue.9, pp.1080-1088, 2009.
DOI : 10.3109/02841850903216718

A. Villers, P. Puech, D. Mouton, X. Leroy, C. Ballereau et al., Dynamic Contrast Enhanced, Pelvic Phased Array Magnetic Resonance Imaging of Localized Prostate Cancer for Predicting Tumor Volume: Correlation With Radical Prostatectomy Findings, The Journal of Urology, vol.176, issue.6, pp.2432-2439, 2006.
DOI : 10.1016/j.juro.2006.08.007

S. Isebaert, D. Keyzer, F. Haustermans, K. Lerut, E. Roskams et al., Evaluation of semi-quantitative dynamic contrast-enhanced MRI parameters for prostate cancer in correlation to whole-mount histopathology, European Journal of Radiology, vol.81, issue.3, 2011.
DOI : 10.1016/j.ejrad.2011.01.107

A. Padhani, C. Harvey, and D. Cosgrove, Angiogenesis imaging in the management of prostate cancer, Nature Clinical Practice Urology, vol.233, issue.12, pp.596-607, 2005.
DOI : 10.2214/ajr.178.1.1780097

L. Dickinson, H. Ahmed, C. Allen, J. Barentsz, B. Carey et al., Magnetic Resonance Imaging for the Detection, Localisation, and Characterisation of Prostate Cancer: Recommendations from a European Consensus Meeting, European Urology, vol.59, issue.4, pp.477-94, 2011.
DOI : 10.1016/j.eururo.2010.12.009

T. Hambrock, J. Futterer, H. Huisman, C. Hulsbergen-vandekaa, J. Van-basten et al., Thirty-Two-Channel Coil 3T Magnetic Resonance-Guided Biopsies of Prostate Tumor Suspicious Regions Identified on Multimodality 3T Magnetic Resonance Imaging: Technique and Feasibility, Investigative Radiology, vol.43, issue.10, pp.686-94, 2008.
DOI : 10.1097/RLI.0b013e31817d0506

A. Ouzzane, P. Puech, L. Lemaitre, X. Leroy, P. Nevoux et al., Combined Multiparametric MRI and Targeted Biopsies Improve Anterior Prostate Cancer Detection, Staging, and Grading, Urology, vol.78, issue.6, 2011.
DOI : 10.1016/j.urology.2011.06.022

C. Kim, B. Park, J. Han, T. Kang, and H. Lee, Diffusion-Weighted Imaging of the Prostate at 3 T for Differentiation of Malignant and Benign Tissue in Transition and Peripheral Zones, Journal of Computer Assisted Tomography, vol.31, issue.3, pp.449-54, 2007.
DOI : 10.1097/01.rct.0000243456.00437.59

C. Sato, S. Naganawa, T. Nakamura, H. Kumada, S. Miura et al., Differentiation of noncancerous tissue and cancer lesions by apparent diffusion coefficient values in transition and peripheral zones of the prostate, Journal of Magnetic Resonance Imaging, vol.48, issue.3, pp.258-62, 2005.
DOI : 10.2214/ajr.170.2.9456953

K. Latchamsetty, L. Borden, J. Porter, C. Lacrampe, M. Vaughan et al., Experience improves staging accuracy of endorectal magnetic resonance imaging in prostate cancer: what is the learning curve?, Can J Urol, vol.14, issue.1, pp.3429-3463, 2007.

J. Haffner, L. Lemaitre, P. Puech, G. Haber, X. Leroy et al., Role of magnetic resonance imaging before initial biopsy: comparison of magnetic resonance imaging-targeted and systematic biopsy for significant prostate cancer detection, BJU International, vol.241, issue.8b, 2011.
DOI : 10.1148/radiol.2412051866

T. Franiel, C. Stephan, A. Erbersdobler, E. Dietz, A. Maxeiner et al., Areas Suspicious for Prostate Cancer: MR???guided Biopsy in Patients with at Least One Transrectal US-guided Biopsy with a Negative Finding???Multiparametric MR Imaging for Detection and Biopsy Planning, Radiology, vol.259, issue.1, pp.162-72, 2011.
DOI : 10.1148/radiol.10101251

T. Hambrock, D. Somford, C. Hoeks, S. Bouwense, H. Huisman et al., Magnetic Resonance Imaging Guided Prostate Biopsy in Men With Repeat Negative Biopsies and Increased Prostate Specific Antigen, The Journal of Urology, vol.183, issue.2, pp.520-527, 2010.
DOI : 10.1016/j.juro.2009.10.022

N. Lawrentschuk, M. Haider, N. Daljeet, A. Evans, A. Toi et al., ???Prostatic evasive anterior tumours???: the role of magnetic resonance imaging, BJU International, vol.99, issue.9, pp.1231-1237, 2009.
DOI : 10.1016/S1078-1439(03)00031-0

K. Berg, B. Toft, M. Roder, K. Brasso, B. Vainer et al., Prostate needle biopsies: interobserver variation and clinical consequences of histopathological re-evaluation, APMIS, vol.103, issue.4-5, pp.4-5239, 2011.
DOI : 10.1111/j.1464-410X.2008.08255.x

A. Singh, J. Kruecker, S. Xu, N. Glossop, P. Guion et al., Initial clinical experience with real-time transrectal ultrasonography-magnetic resonance imaging fusion-guided prostate biopsy, BJU International, vol.8752, issue.7, pp.841-846, 2008.
DOI : 10.1016/j.eururo.2006.03.007

P. Pinto, P. Chung, A. Rastinehad, A. Baccala, J. Kruecker et al., Magnetic Resonance Imaging/Ultrasound Fusion Guided Prostate Biopsy Improves Cancer Detection Following Transrectal Ultrasound Biopsy and Correlates With Multiparametric Magnetic Resonance Imaging Advances in magnetic resonance imaging: how they are changing the management of prostate cancer, J Urol Eur Urol, vol.59, issue.6, pp.962-77, 2011.

R. Berglund, T. Masterson, K. Vora, S. Eggener, J. Eastham et al., Pathological Upgrading and Up Staging With Immediate Repeat Biopsy in Patients Eligible for Active Surveillance, The Journal of Urology, vol.180, issue.5, pp.1964-1971, 2008.
DOI : 10.1016/j.juro.2008.07.051

S. Porten, J. Whitson, J. Cowan, M. Cooperberg, K. Shinohara et al., Changes in Prostate Cancer Grade on Serial Biopsy in Men Undergoing Active Surveillance, Journal of Clinical Oncology, vol.29, issue.20, pp.2795-800, 2011.
DOI : 10.1200/JCO.2010.33.0134

L. Klotz, L. Zhang, A. Lam, R. Nam, A. Mamedov et al., Clinical Results of Long-Term Follow-Up of a Large, Active Surveillance Cohort With Localized Prostate Cancer, Journal of Clinical Oncology, vol.28, issue.1, pp.126-157, 2010.
DOI : 10.1200/JCO.2009.24.2180

V. Morgan, S. Riches, K. Thomas, N. Vanas, C. Parker et al., Diffusion-weighted magnetic resonance imaging for monitoring prostate cancer progression in patients managed by active surveillance, The British Journal of Radiology, vol.186, issue.997, pp.31-38, 2011.
DOI : 10.1001/jama.294.4.440

O. Raz, M. Haider, S. Davidson, U. Lindner, E. Hlasny et al., Real-Time Magnetic Resonance Imaging???Guided Focal Laser Therapy in Patients with Low-Risk Prostate Cancer, European Urology, vol.58, issue.1, pp.173-180, 2010.
DOI : 10.1016/j.eururo.2010.03.006

A. Kirkham, M. Emberton, I. Hoh, R. Illing, A. Freeman et al., MR Imaging of Prostate after Treatment with High-Intensity Focused Ultrasound, Radiology, vol.246, issue.3, pp.833-877, 2008.
DOI : 10.1148/radiol.2463062080