M. Dimatteo, Variations in Patients??? Adherence to Medical Recommendations, Medical Care, vol.42, issue.3
DOI : 10.1097/01.mlr.0000114908.90348.f9

M. Dimatteo, P. Giordani, H. Lepper, and T. Croghan, Patient Adherence and Medical Treatment Outcomes A Meta-Analysis. Med Care. 1 sept, pp.794-811, 2002.

D. Hershman, T. Shao, L. Kushi, D. Buono, W. Tsai et al., Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer, Breast Cancer Research and Treatment, vol.44, issue.5, pp.529-566, 2011.
DOI : 10.1097/01.mlr.0000207817.32496.cb

L. Martin, S. Williams, K. Haskard, and M. Dimatteo, The challenge of patient adherence, Ther Clin Risk Manag. sept, vol.1, issue.3, pp.189-99, 2005.

M. Dimatteo, H. Lepper, and T. Croghan, Depression Is a Risk Factor for Noncompliance With Medical Treatment, Archives of Internal Medicine, vol.160, issue.14, pp.2101-2108, 2000.
DOI : 10.1001/archinte.160.14.2101

N. Rieckmann, W. Gerin, I. Kronish, M. Burg, W. Chaplin et al., Course of Depressive Symptoms and Medication Adherence After Acute Coronary Syndromes, Journal of the American College of Cardiology, vol.48, issue.11, pp.2218-2240, 2006.
DOI : 10.1016/j.jacc.2006.07.063

M. Chabrier, O. Bezy, M. Mouret, J. Bay, and I. Jalenques, Impact of depressive disorders on adherence to oral anti-cancer treatment, Bull Cancer (Paris). oct, vol.100, issue.10, pp.1017-1039, 2013.

L. Campos, M. Guimaraes, and R. Remien, Anxiety and depression symptoms as risk factors for non-adherence to antiretroviral therapy in Brazil Nel A, Kagee A. The relationship between depression, anxiety and medication adherence among patients receiving antiretroviral treatment in South Africa, AIDS Behav. avr AIDS Care, vol.1425, issue.118, pp.289-99948, 2010.

F. Baekeland and L. Lundwall, Dropping out of treatment: A critical review., Psychological Bulletin, vol.82, issue.5
DOI : 10.1037/h0077132

M. Mitchell, M. R. Psych, . Alex, M. Selmes, and C. B. Thomas, A Comparative Survey of Missed Initial and Follow-Up Appointments to Psychiatric Specialties in the United Kingdom, Psychiatric Services, vol.58, issue.6, pp.868-71, 2007.
DOI : 10.1176/ps.2007.58.6.868

M. Stark, Dropping out of substance abuse treatment: A clinically oriented review, Clinical Psychology Review, vol.12, issue.1
DOI : 10.1016/0272-7358(92)90092-M

C. Coulson, F. Ng, M. Geertsema, S. Dodd, and M. Berk, Client-reported reasons for non-engagement in drug and alcohol treatment, Drug and Alcohol Review, vol.82, issue.4, pp.372-380, 2009.
DOI : 10.1111/j.1465-3362.2009.00054.x

A. Mclellan, M. Chalk, and J. Bartlett, Outcomes, performance, and quality???What's the difference?, Journal of Substance Abuse Treatment, vol.32, issue.4, pp.331-371, 2007.
DOI : 10.1016/j.jsat.2006.09.004

J. Mckellar, J. Kelly, A. Harris, and R. Moos, Pretreatment and during treatment risk factors for dropout among patients with substance use disorders, Addictive Behaviors, vol.31, issue.3, pp.450-60, 2006.
DOI : 10.1016/j.addbeh.2005.05.024

M. Elbreder, R. Silva, . De-s-e, S. Pillon, and R. Laranjeira, Alcohol Dependence: Analysis of Factors Associated with Retention of Patients in Outpatient Treatment, Alcohol and Alcoholism, vol.27, issue.8
DOI : 10.1016/S0212-6567(01)78859-2

J. Mertens and C. Weisner, Predictors of Substance Abuse Treatment Retention Among Women and Men in an HMO, Alcoholism: Clinical and Experimental Research, vol.6, issue.10, pp.1525-1558, 2000.
DOI : 10.1001/jama.268.14.1872

R. Gainey, E. Wells, J. Hawkins, and R. Catalano, Predicting Treatment Retention among Cocaine Users, International Journal of the Addictions, vol.68, issue.1, pp.487-505, 1993.
DOI : 10.1080/02791072.1990.10472539

A. King and S. Canada, Client-related predictors of early treatment drop-out in a substance abuse clinic exclusively employing individual therapy, 25. Beynon CM, McMinn AM, Marr AJ. Factors predicting drop out from, and retention in, specialist drug treatment services: A case control study in the North West of England, pp.189-95, 2004.
DOI : 10.1016/S0740-5472(03)00210-1

D. Rees, H. Beech, and B. Hore, Some Factors Associated with Compliance in the Treatment of Alcoholism, BMC Public Health Alcohol Alcohol. 1 janv, vol.819, issue.4, pp.149-26303, 1984.

C. Filho, M. J. Baltieri, and D. , Psychosocial and Clinical Predictors of Retention in Outpatient Alcoholism Treatment, Revista Brasileira de Psiquiatria, vol.34, issue.4, pp.413-434, 2012.
DOI : 10.1016/j.rbp.2012.03.003

J. Kathryn, The Impact of Depression on the Outcome of Addictions Treatment, J Subst Abuse Treat. mars, vol.15, issue.2, pp.123-153, 1998.

J. Hättenschwiler, P. Rüesch, and J. Modestin, Comparison of four groups of substance-abusing in-patients with different psychiatric comorbidity, Acta Psychiatrica Scandinavica, vol.154, issue.1, pp.59-65, 2001.
DOI : 10.1176/ajp.154.11.1610

A. Kokkevi, N. Stefanis, E. Anastasopoulou, and C. Kostogianni, Personality disorders in drug abusers, Addictive Behaviors, vol.23, issue.6, pp.841-53, 1998.
DOI : 10.1016/S0306-4603(98)00071-9

L. Araujo, P. Goldberg, J. Eyma, S. Madhusoodanan, D. Buff et al., The effect of anxiety and depression on completion/withdrawal status in patients admitted to substance abuse detoxification program, Journal of Substance Abuse Treatment, vol.13, issue.1, pp.61-67, 1996.
DOI : 10.1016/0740-5472(95)02043-8

S. Reiss, R. Peterson, D. Gursky, and R. Mcnally, Anxiety sensitivity, anxiety frequency and the prediction of fearfulness, Behaviour Research and Therapy, vol.24, issue.1, pp.1-8, 1986.
DOI : 10.1016/0005-7967(86)90143-9

C. Lejuez, M. Zvolensky, S. Daughters, M. Bornovalova, A. Paulson et al., Anxiety sensitivity: A unique predictor of dropout among inner-city heroin and crack/cocaine users in residential substance use treatment, Behaviour Research and Therapy, vol.46, issue.7, pp.811-819, 2008.
DOI : 10.1016/j.brat.2008.03.010

L. Ministère-de and . Santé, Suivi des objectifs annexés à la loi de Santé Publique Disponible sur: http://www.sante.gouv.fr/IMG/pdf/Etat_sante-population_2011.pdf 35. Guérin S, Laplanche A, Dunant A, Hill C. Mortalité attribuable à l'alcool en France en, pp.16-17, 2009.

M. Naassila, . Alcool, and . Santé, bilan et perspectives Alcool et santé : bilan et perspectives Disponible sur: http://www.inserm.fr/thematiques/neurosciences-sciences- cognitives-neurologie-psychiatrie/dossiers-d-information/alcool-et-sante-bilan-et-perspectives 37. Grant BF. Prevalence and correlates of drug use and DSM-IV drug dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey, J Subst Abuse, vol.8, issue.2, pp.195-210, 1996.

R. Schwan, Usage nocif d'alcool. Traité d'Addictologie. Médecine-Sciences Flammarion, pp.361-366, 2006.

P. Martin, The epidemiology of anxiety disorders: a review, Dialogues Clin Neurosci

D. Regier, M. Farmer, D. Rae, B. Locke, S. Keith et al., Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study, JAMA: The Journal of the American Medical Association, vol.264, issue.19, pp.2511-2519, 1990.
DOI : 10.1001/jama.264.19.2511

D. Hasin, R. Goodwin, F. Stinson, and B. Grant, Epidemiology of Major Depressive Disorder, Archives of General Psychiatry, vol.62, issue.10, pp.1097-106, 2005.
DOI : 10.1001/archpsyc.62.10.1097

R. Kessler, P. Berglund, and O. Demler, The Epidemiology of Major Depressive Disorder, JAMA, vol.289, issue.23, pp.3095-105, 2003.
DOI : 10.1001/jama.289.23.3095

R. Kessler, R. Crum, L. Warner, C. Nelson, J. Schulenberg et al., Lifetime Co-occurrence of DSM-III-R Alcohol Abuse and Dependence With Other Psychiatric Disorders in the National Comorbidity Survey, Archives of General Psychiatry, vol.54, issue.4, pp.313-334, 1997.
DOI : 10.1001/archpsyc.1997.01830160031005

J. Boden and D. Fergusson, Alcohol and depression, Addiction, vol.62, issue.5, pp.906-920, 2011.
DOI : 10.1037/a0014414

S. Gilman, H. Abraham, B. Grant, and T. Harford, A longitudinal study of the order of onset of alcohol dependence and major depression Comorbidity between DSM-IV alcohol use disorders and major depression: results of a national survey, Drug Alcohol Depend. 1 août Drug Alcohol Depend. oct, vol.6339, issue.463, pp.277-86197, 1995.

M. Reynaud, Quelques éléments pour une approche commune des addictions. Traité d'Addictologie. Médecine-Sciences Flammarion, pp.7-9, 2006.

J. Tassin, Uncoupling between noradrenergic and serotonergic neurons as a molecular basis of stable changes in behavior induced by repeated drugs of abuse, Biochemical Pharmacology, vol.75, issue.1, pp.85-97, 2008.
DOI : 10.1016/j.bcp.2007.06.038

S. Stahl, Les troubles de la récompense, abus de drogues et leurs traitements

P. Pickering, Conduites d'alcoolisation et pathologie psychiatrique. Traité d'Addictologie. Médecine-Sciences Flammarion, pp.343-350, 2006.

M. Kushner, K. Abrams, and C. Borchardt, The relationship between anxiety disorders and alcohol use disorders A review of major perspectives and findings, Clinical Psychology Review, vol.20, issue.2, pp.149-71, 2000.
DOI : 10.1016/S0272-7358(99)00027-6

F. Quitkin, A. Rifkin, J. Kaplan, and D. Klein, Phobic Anxiety Syndrome Complicated by Drug Dependence and Addiction, Archives of General Psychiatry, vol.27, issue.2, pp.159-62, 1972.
DOI : 10.1001/archpsyc.1972.01750260013002

K. Merikangas, R. Mehta, B. Molnar, E. Walters, J. Swendsen et al., Comorbidity of substance use disorders with mood and anxiety disorders, Addictive Behaviors, vol.23, issue.6, pp.893-907, 1998.
DOI : 10.1016/S0306-4603(98)00076-8

S. Richa, F. Kazour, and C. Baddoura, Comorbidit?? des troubles anxieux avec l???alcoolisme, Annales M??dico-psychologiques, revue psychiatrique, vol.166, issue.6
DOI : 10.1016/j.amp.2006.09.018

M. Driessen, S. Meier, A. Hill, T. Wetterling, W. Lange et al., The course of anxiety, depression and drinking behaviours after completed detoxification in alcoholics with and without comorbid anxiety and depressive disorders, Alcohol and Alcoholism, vol.36, issue.3, pp.249-55, 2001.
DOI : 10.1093/alcalc/36.3.249

J. Bolton, J. Robinson, J. Sareen, D. Brook, J. Brook et al., Self-medication of mood disorders with alcohol and drugs in the National Epidemiologic Survey on Alcohol and Related Conditions Drug use and the risk of major depressive disorder, alcohol dependence, and substance use disorders Quality of Life in alcohol-dependent subjects ? a review, J Affect Disord. juin Arch Gen Psychiatry. nov Qual Life Res. 1 mai, vol.115598, issue.583, pp.367-751039, 1999.

E. Sihvola, R. Rose, D. Dick, L. Pulkkinen, M. Marttunen et al., Early-onset depressive disorders predict the use of addictive substances in adolescence: a prospective study of adolescent Finnish twins, Addiction, vol.28, issue.1, pp.2045-53, 2008.
DOI : 10.15288/jsa.1994.55.149

T. Paljärvi, M. Koskenvuo, K. Poikolainen, J. Kauhanen, L. Sillanmäki et al., Binge drinking and depressive symptoms: a 5-year population-based cohort study, Addiction, vol.22, issue.7, pp.1168-78, 2009.
DOI : 10.1093/oxfordjournals.epirev.a017974

R. Mceachin, B. Keller, E. Saunders, and M. Mcinnis, Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach, BioData Mining, vol.45, issue.10, 2008.
DOI : 10.4065/82.9.1065

C. Prescott, S. Aggen, and K. Kendler, Sex-Specific Genetic Influences on the Comorbidity of Alcoholism and Major Depression in a Population-Based Sample of US Twins, Archives of General Psychiatry, vol.57, issue.8
DOI : 10.1001/archpsyc.57.8.803

K. Kendler, A. Heath, M. Neale, R. Kessler, and L. Eaves, Alcoholism and Major Depression in Women, Archives of General Psychiatry, vol.50, issue.9, pp.690-698, 1993.
DOI : 10.1001/archpsyc.1993.01820210024003

P. Kuo, M. Neale, D. Walsh, D. Patterson, R. B. Prescott et al., Genome-wide linkage scans for major depression in individuals with alcohol dependence, Journal of Psychiatric Research, vol.44, issue.9, pp.616-625, 2010.
DOI : 10.1016/j.jpsychires.2009.12.005

X. Luo, H. Kranzler, L. Zuo, S. Wang, H. Blumberg et al., CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case???control structured association study, Human Molecular Genetics, vol.14, issue.16, pp.2421-2455, 2005.
DOI : 10.1093/bioinformatics/16.2.182

J. Wang, A. Hinrichs, H. Stock, J. Budde, R. Allen et al., Evidence of common and specific genetic effects: association of the muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol dependence and major depressive syndrome, Human Molecular Genetics, vol.13, issue.17
DOI : 10.1093/hmg/ddh194

G. Deatherage, Effects of housing density on alcohol intake in the rat, Physiology & Behavior, vol.9, issue.1, pp.55-62, 1972.
DOI : 10.1016/0031-9384(72)90264-8

G. Deehan, M. Palmatier, M. Cain, and S. Kiefer, Differential rearing conditions and alcohol-preferring rats: Consumption of and operant responding for ethanol., Behavioral Neuroscience, vol.125, issue.2, pp.184-93, 2011.
DOI : 10.1037/a0022627

U. Zimmermann, D. Blomeyer, M. Laucht, and K. Mann, How gene???stress???behavior interactions can promote adolescent alcohol use: The roles of predrinking allostatic load and childhood behavior disorders, Pharmacology Biochemistry and Behavior, vol.86, issue.2, pp.246-62, 2007.
DOI : 10.1016/j.pbb.2006.09.024

M. Kuria, D. Ndetei, I. Obot, L. Khasakhala, B. Bagaka et al., The Association between Alcohol Dependence and Depression before and after Treatment for, Alcohol Dependence. ISRN Psychiatry, vol.2012, p.482802, 2012.

S. Greenfield, R. Weiss, and L. Muenz, The Effect of Depression on Return to Drinking, Archives of General Psychiatry, vol.55, issue.3, pp.259-65, 1998.
DOI : 10.1001/archpsyc.55.3.259

H. Wilcox, K. Conner, E. Caine, M. Teesson, O. Neill et al., Association of alcohol and drug use disorders and completed suicide: an empirical review of cohort studies Drug Alcohol Depend The impact of comorbid anxiety and depression on alcohol treatment outcomes The hospital anxiety and depression scale, Addiction. juin Acta Psychiatr, vol.76100, issue.6, pp.787-96, 2004.

A. Mcpherson and C. Martin, Is the Hospital Anxiety and Depression Scale (HADS) an appropriate screening tool for use in an alcohol-dependent population?, Journal of Clinical Nursing, vol.67, issue.11-12, pp.11-121507, 2011.
DOI : 10.1111/j.1600-0447.1983.tb09716.x

A. Lorraine, Les Consultations Jeunes Consommateurs (CJC) en Lorraine, 2012.