H. Plauchu and S. Dupuis-girod, Hereditary hemorrhagic telangiectasia]. Rev Prat, pp.899-903, 2009.
URL : https://hal.archives-ouvertes.fr/hal-00443253

G. Brunet, G. Lesca, E. Génin, S. Dupuis-girod, A. Bideau et al., Trente ans d'??tude de la maladie de Rendu-Osler en France??: d??mographie historique, g??n??tique des populations et biologie mol??culaire, Population, vol.64, issue.2, pp.305-330, 2009.
DOI : 10.3917/popu.902.0305

K. Mcallister, K. Grogg, D. Johnson, C. Gallione, M. Baldwin et al., Endoglin, a TGF-?? binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1, Nature Genetics, vol.23, issue.4, pp.345-51, 1994.
DOI : 10.1101/gr.2.3.234

P. Vincent, H. Plauchu, J. Hazan, S. Fauré, J. Weissenbach et al., A third locus for hereditary haemorrhagic telangiectasia maps to chromosome 12q, Human Molecular Genetics, vol.4, issue.5, pp.945-954, 1995.
DOI : 10.1093/hmg/4.5.945

C. Shovlin, Molecular defects in rare bleeding disorders: hereditary haemorrhagic telangiectasia, Thromb Haemost, vol.78, issue.1, pp.145-50, 1997.

S. Bailly, S. Dupuis-girod, and H. Plauchu, Rendu-Osler disease: clinical and molecular update]. Médecine Sci MS, pp.855-60, 2010.

P. Duffau, E. Lazarro, and J. Viallard, Hereditary hemorrhagic telangiectasia]. Rev Médecine Interne Fondée Par Société Natl Francaise Médecine Interne, pp.21-28, 2014.

V. Cottin, S. Dupuis-girod, G. Lesca, and J. Cordier, Pulmonary Vascular Manifestations of Hereditary Hemorrhagic Telangiectasia (Rendu-Osler Disease), Respiration, vol.31, issue.4, pp.361-78, 2007.
DOI : 10.1111/j.1365-2796.2005.01555.x

P. Bayrak-toydemir, J. Mcdonald, B. Markewitz, S. Lewin, F. Miller et al., Genotypephenotype correlation in hereditary hemorrhagic telangiectasia: mutations and manifestations, Am J Med Genet A, vol.140, issue.5, pp.463-70, 2006.
DOI : 10.1002/ajmg.a.31101

M. Piskorz, C. Waldbaum, M. Volpacchio, and J. Sordá, Liver involvement in hereditary hemorrhagic telangiectasia], Acta Gastroenterol Latinoam, vol.41, issue.3, pp.225-234, 2011.

D. Flieger, S. Hainke, and W. Fischbach, Dramatic improvement in hereditary hemorrhagic telangiectasia after treatment with the vascular endothelial growth factor (VEGF) antagonist bevacizumab, Annals of Hematology, vol.90, issue.9, pp.631-633, 2006.
DOI : 10.1007/s00277-006-0147-8

S. Dheyauldeen, Ø. Geirdal, A. Osnes, T. Vartdal, L. Dollner et al., Bevacizumab in hereditary hemorrhagic telangiectasia-associated epistaxis: Effectiveness of an injection protocol based on the vascular anatomy of the nose, The Laryngoscope, vol.268, issue.6, 2012.
DOI : 10.1007/s00405-011-1677-9

J. Fleagle, R. Bobba, C. Kardinal, and C. Freter, Iron Deficiency Anemia Related to Hereditary Hemorrhagic Telangiectasia: Response to Treatment With Bevacizumab, The American Journal of the Medical Sciences, vol.343, issue.3, pp.249-51, 2012.
DOI : 10.1097/MAJ.0b013e3182429866

T. Karnezis and T. Davidson, Efficacy of intranasal Bevacizumab (Avastin) treatment in patients with hereditary hemorrhagic telangiectasia-associated epistaxis. The Laryngoscope, pp.636-644, 2011.

S. Dupuis-girod, I. Ginon, J. Saurin, D. Marion, E. Guillot et al., Bevacizumab in Patients With Hereditary Hemorrhagic Telangiectasia and Severe Hepatic Vascular Malformations and High Cardiac Output, JAMA, vol.307, issue.9, pp.948-55, 2012.
DOI : 10.1001/jama.2012.250

B. Maron, Hemodynamics Should Be the Primary Approach to Diagnosing, Following, and Managing Pulmonary Arterial Hypertension, Canadian Journal of Cardiology, vol.31, issue.4, 2014.
DOI : 10.1016/j.cjca.2014.09.021

G. Simonneau, M. Gatzoulis, I. Adatia, D. Celermajer, C. Denton et al., Updated Clinical Classification of Pulmonary Hypertension, J Am Coll Cardiol, vol.62, pp.25-34, 2013.

A. Seferian and G. Simonneau, [Pulmonary hypertension: definition, diagnostic and new classification]. Presse Médicale Paris Fr 1983, pp.935-979, 2014.

M. Held, M. Linke, and J. B. , Echocardiography and right heart catheterization in pulmonal hypertension], Dtsch Med Wochenschr, vol.139, issue.30, pp.1511-1518, 1946.

D. Armstrong, G. Tsimiklis, and M. Matangi, Factors influencing the echocardiographic estimate of right ventricular systolic pressure in normal patients and clinically relevant ranges according to age, Canadian Journal of Cardiology, vol.26, issue.2, pp.35-44, 2010.
DOI : 10.1016/S0828-282X(10)70004-0

O. Sitbon, L. Savale, X. Jaïs, D. Montani, M. Humbert et al., Traitement de l'hypertension artérielle pulmonaire. Presse Médicale, pp.981-93, 2014.

J. Vachiéry, Y. Adir, J. Barberà, H. Champion, J. Coghlan et al., Pulmonary Hypertension Due to Left Heart Diseases, Journal of the American College of Cardiology, vol.62, issue.25, pp.25-100, 2013.
DOI : 10.1016/j.jacc.2013.10.033

O. Minai, A. Chaouat, and S. Adnot, Pulmonary hypertension in copd: Epidemiology, significance, and management: pulmonary vascular disease: the global perspective. Chest, pp.39-51, 2010.

V. Cottin, Hypertension pulmonaire au cours des maladies respiratoires chroniques. Presse Médicale, pp.945-56, 2014.
DOI : 10.1016/j.lpm.2014.07.006

D. Jenkins, M. Madani, E. Mayer, K. Kerr, N. Kim et al., Surgical treatment of chronic thromboembolic pulmonary hypertension, European Respiratory Journal, vol.41, issue.3, pp.735-777, 2013.
DOI : 10.1183/09031936.00058112

H. Ghofrani, D. Armini, A. Grimminger, F. Hoeper, M. Jansa et al., Riociguat for the Treatment of Chronic Thromboembolic Pulmonary Hypertension, New England Journal of Medicine, vol.369, issue.4, pp.319-348, 2013.
DOI : 10.1056/NEJMoa1209657

M. Delcroix, Chronic post-embolic pulmonary hypertension: a new target for medical therapies?, European Respiratory Review, vol.22, issue.129, pp.258-64, 2009.
DOI : 10.1183/09059180.00003513

O. Mercier, É. Fadel, S. Mussot, D. Fabre, F. Ladurie et al., Traitement chirurgical de l'hypertension pulmonaire post-embolique. Presse Médicale, pp.994-1007, 2014.
DOI : 10.1016/j.lpm.2014.07.007

M. Faughnan, J. Granton, and L. Young, The pulmonary vascular complications of hereditary haemorrhagic telangiectasia, European Respiratory Journal, vol.33, issue.5, pp.1186-94, 2009.
DOI : 10.1183/09031936.00061308

E. Trell, B. Johansson, F. Linell, and J. Ripa, Familial pulmonary hypertension and multiple abnormalities of large systemic arteries in Osler's disease, The American Journal of Medicine, vol.53, issue.1, pp.50-63, 1972.
DOI : 10.1016/0002-9343(72)90115-5

C. Olivieri, L. Lanzarini, F. Pagella, L. Semino, S. Corno et al., Echocardiographic screening discloses increased values of pulmonary artery systolic pressure in 9 of 68 unselected patients affected with hereditary hemorrhagic telangiectasia, Genetics in Medicine, vol.47, issue.3, pp.183-90, 2006.
DOI : 10.1203/00006450-200001000-00008

B. Girerd, D. Montani, F. Coulet, B. Sztrymf, A. Yaici et al., ) Mutation, American Journal of Respiratory and Critical Care Medicine, vol.181, issue.8, pp.851-61, 2010.
DOI : 10.1161/01.CIR.0000154543.07679.08

R. Harrison, J. Flanagan, M. Sankelo, S. Abdalla, J. Rowell et al., Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia, Journal of Medical Genetics, vol.40, issue.12, pp.865-71, 2003.
DOI : 10.1136/jmg.40.12.865

R. Trembath, J. Thomson, R. Machado, N. Morgan, C. Atkinson et al., Clinical and Molecular Genetic Features of Pulmonary Hypertension in Patients with Hereditary Hemorrhagic Telangiectasia, New England Journal of Medicine, vol.345, issue.5, pp.325-359, 2001.
DOI : 10.1056/NEJM200108023450503

Y. Chen, Q. Yang, D. Liu, Q. Liu, M. Eyries et al., Clinical and genetic characteristics of Chinese patients with hereditary haemorrhagic telangiectasia-associated pulmonary hypertension, European Journal of Clinical Investigation, vol.36, issue.Suppl 3, pp.1016-1040, 2013.
DOI : 10.1111/j.1365-2362.2006.01683.x

S. Abdalla, C. Gallione, R. Barst, E. Horn, J. Knowles et al., Primary pulmonary hypertension in families with hereditary haemorrhagic telangiectasia, European Respiratory Journal, vol.23, issue.3, pp.373-380, 2004.
DOI : 10.1183/09031936.04.00085504

R. Harrison, R. Berger, S. Haworth, R. Tulloh, C. Mache et al., Transforming Growth Factor-? Receptor Mutations and Pulmonary Arterial Hypertension in Childhood. Circulation, pp.435-476, 2005.
DOI : 10.1161/01.cir.0000153798.78540.87

URL : http://circ.ahajournals.org/content/circulationaha/111/4/435.full.pdf

A. Chaouat, F. Coulet, C. Favre, G. Simonneau, E. Weitzenblum et al., Endoglin germline mutation in a patient with hereditary haemorrhagic telangiectasia and dexfenfluramine associated pulmonary arterial hypertension, Thorax, vol.59, issue.5, pp.446-454, 2004.
DOI : 10.1136/thx.2003.11890

M. Nasim, T. Ogo, M. Ahmed, R. Randall, H. Chowdhury et al., Molecular genetic characterization of SMAD signaling molecules in pulmonary arterial hypertension. Hum Mutat, pp.1385-1394, 2011.

D. Bonderman, R. Nowotny, N. Skoro-sajer, C. Adlbrecht, and I. Lang, Bosentan therapy for pulmonary arterial hypertension associated with hereditary haemorrhagic telangiectasia, European Journal of Clinical Investigation, vol.36, issue.s3, pp.71-73, 2006.
DOI : 10.1183/09031936.05.00054804

S. Chang, S. Jang, C. Ki, I. Kang, and D. Kim, Successful bosentan therapy for pulmonary arterial hypertension associated with hereditary hemorrhagic telangiectasia. Heart Vessels, pp.231-235, 2011.
DOI : 10.1007/s00380-010-0079-z

I. Ginon, E. Decullier, G. Finet, J. Cordier, D. Marion et al., Hereditary hemorrhagic telangiectasia, liver vascular malformations and cardiac consequences, European Journal of Internal Medicine, vol.24, issue.3, pp.35-44, 2013.
DOI : 10.1016/j.ejim.2012.12.013

S. Dupuis?girod, A. Chesnais, I. Ginon, J. Dumortier, J. Saurin et al., Long?term outcome of patients with hereditary hemorrhagic telangiectasia and severe hepatic involvement after orthotopic liver transplantation: A single?center study, Liver Transpl, vol.16, issue.3, pp.340-347, 2010.

E. Ayala, K. Kudelko, F. Haddad, R. Zamanian, J. De et al., The Intersection of Genes and Environment, Chest, vol.141, issue.6, pp.1598-600, 2012.
DOI : 10.1378/chest.11-1402

R. Naeije, J. Vachiery, P. Yerly, and R. Vanderpool, The transpulmonary pressure gradient for the diagnosis of pulmonary vascular disease, European Respiratory Journal, vol.41, issue.1, pp.217-240, 2013.
DOI : 10.1183/09031936.00074312

E. Buscarini, C. Danesino, C. Olivieri, G. Lupinacci, D. Grazia et al., Doppler Ultrasonographic Grading of Hepatic Vascular Malformations in Hereditary Hemorrhagic Telangiectasia - Results of Extensive Screening, Ultraschall in der Medizin - European Journal of Ultrasound, vol.25, issue.05, 1980.
DOI : 10.1055/s-2004-813549

E. Bossone, D. Andrea, A. , D. Alto, M. Citro et al., Echocardiography in Pulmonary Arterial Hypertension: from Diagnosis to Prognosis, Journal of the American Society of Echocardiography, vol.26, issue.1, pp.1-14, 2013.
DOI : 10.1016/j.echo.2012.10.009

E. Hachulla, V. Gressin, L. Guillevin, P. Carpentier, E. Diot et al., Early detection of pulmonary arterial hypertension in systemic sclerosis: A French nationwide prospective multicenter study, Arthritis & Rheumatism, vol.351, issue.12, pp.3792-800, 2005.
DOI : 10.1164/ajrccm.164.2.2006129

J. Coghlan, C. Denton, E. Grünig, D. Bonderman, O. Distler et al., Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: the DETECT study, Annals of the Rheumatic Diseases, vol.65, issue.Suppl 1, pp.1340-1349
DOI : 10.1002/art.37838

L. Savale, F. Lador, X. Jais, D. Montani, G. Simonneau et al., L???hypertension art??rielle pulmonaire associ??e au VIH, Revue des Maladies Respiratoires, vol.29, issue.4, pp.491-500
DOI : 10.1016/j.rmr.2011.09.050

O. Sitbon, C. Lascoux-combe, J. Delfraissy, P. Yeni, F. Raffi et al., Prevalence of HIV-related Pulmonary Arterial Hypertension in the Current Antiretroviral Therapy Era, American Journal of Respiratory and Critical Care Medicine, vol.177, issue.1, pp.108-121, 2008.
DOI : 10.1016/j.ehj.2004.09.014

M. Hayes, A. Vedamurthy, G. George, R. Dweik, E. Klings et al., Pulmonary Hypertension in Sickle Cell Disease, Annals of the American Thoracic Society, vol.11, issue.9, pp.1488-1497, 2014.
DOI : 10.1001/jama.2012.358

M. Caughey, A. Hinderliter, S. Jones, S. Shah, and K. Ataga, Hemodynamic Characteristics and Predictors of Pulmonary Hypertension in Patients With Sickle Cell Disease, The American Journal of Cardiology, vol.109, issue.9, pp.1353-1360, 2012.
DOI : 10.1016/j.amjcard.2011.11.067

F. Parent, D. Bachir, J. Inamo, F. Lionnet, F. Driss et al., A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease, New England Journal of Medicine, vol.365, issue.1, pp.44-53, 2011.
DOI : 10.1056/NEJMoa1005565

URL : https://hal.archives-ouvertes.fr/inserm-00609555

J. Calderón-colmenero, J. Sandoval-zárate, B. Gámez, and M. , Pulmonary hypertension associated with congenital heart disease and Eisenmenger syndrome]. Arch Cardiol México, pp.32-49, 2015.

S. Abdalla and M. Letarte, Hereditary haemorrhagic telangiectasia: current views on genetics and mechanisms of disease, Journal of Medical Genetics, vol.43, issue.2, pp.97-110, 2006.
DOI : 10.1136/jmg.2005.030833

N. Bhuachalla, C. , O. Connor, T. Murphy, M. Colwell et al., Experience of the Irish National Centre for hereditary haemorrhagic telangiectasia, Respir Med, 2003.

P. Bayrak-toydemir, J. Mcdonald, B. Markewitz, S. Lewin, F. Miller et al., Genotypephenotype correlation in hereditary hemorrhagic telangiectasia: mutations and manifestations, Am J Med Genet A, vol.140, issue.5, pp.463-70, 2006.
DOI : 10.1002/ajmg.a.31101