44 a) Tableau récaptilatif des propositions individuelles 44 b) Tableau récapitulatif après votes individuels45 c) Analyse des votes, ., p.46 ,
47 a) Guideline français, 47 b) Les recommandations européennes....... 47 c) Les recommandations internationales, p.47 ,
Asia???Pacific consensus guidelines on gastric cancer prevention, Journal of Gastroenterology and Hepatology, vol.19, issue.2, pp.351-65, 2008. ,
DOI : 10.1016/j.bpg.2006.11.001
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2008.05314.x/pdf
Combination of gastric atrophy, reflux symptoms and histological subtype indicates two distinct aetiologies of gastric cardia cancer, Gut, vol.57, issue.3, pp.298-305, 2008. ,
DOI : 10.1136/gut.2007.137364
Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial Current concepts in the management of Helicobacter pylori infection: Maastrischt III Consensus report, 12?20. 15. Malfertheiner P1, pp.772-81, 2004. ,
Early Helicobacter pylori Eradication Decreases Risk of Gastric Cancer in Patients With Peptic Ulcer Disease, Gastroenterology, vol.137, issue.5, pp.1641-1649, 2009. ,
DOI : 10.1053/j.gastro.2009.07.060
Effect of a Community Screening for Helicobacter pylori: A 5-Yr Follow-Up Study, The American Journal of Gastroenterology, vol.316, issue.5, pp.1106-1119, 2008. ,
DOI : 10.1053/j.gastro.2005.07.028
Effect of eradication of Helicobacter pylori on incidence of metachronous gastric carcinoma after endoscopic resection of early gastric cancer: an open-label, randomised controlled trial, The Lancet, vol.372, issue.9636, pp.392-399, 2008. ,
DOI : 10.1016/S0140-6736(08)61159-9
Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy, Gut, vol.46, issue.5, pp.615-636, 2000. ,
DOI : 10.1136/gut.46.5.615
Effects of eradication of Helicobacter pylori infection in patients with immune thrombocytopenic purpura: a systematic review, Blood, vol.113, issue.6, pp.1231-1271, 2009. ,
DOI : 10.1182/blood-2008-07-167155
Effects of Helicobacter pylori and Nonsteroidal Anti-Inflammatory Drugs on Peptic Ulcer Disease: A Systematic Review, Clinical Gastroenterology and Hepatology, vol.4, issue.2, pp.130-172, 2006. ,
DOI : 10.1016/j.cgh.2005.10.006
Relationship between Helicobacter pylori infection and gastric atrophy and the stages of the oesophageal inflammation, metaplasia, adenocarcinoma sequence: results from the FINBAR case-control study, Gut, vol.57, issue.6, pp.734-743, 2008. ,
DOI : 10.1136/gut.2007.132662
eradication in aspirin or non-steroidal anti-inflammatory drug users, World Journal of Gastroenterology, vol.11, issue.25, pp.3811-3817, 2005. ,
DOI : 10.1053/gast.2002.36013
Role of Helicobacter pylori infection and nonsteroidal anti-inflammatory drugs in peptic-ulcer disease: a meta-analysis ,
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans, IARC Monogr Eval Carcinog Risks Hum World Health Organ Int Agency Res Cancer, vol.61, pp.1-241, 1994. ,
Survival of cancer patients in Europe: the EUROCARE-2 Study, IARC Sci Publ, vol.151, 1999. ,
Symptom Response and Healing of Erosive Esophagitis with Proton-Pump Inhibitors in Patients with Helicobacter pylori Infection, The American Journal of Gastroenterology, vol.115, issue.1, pp.1437-1478, 2004. ,
DOI : 10.1111/j.1572-0241.2001.05263.x
The effect of Helicobacter pylori and its eradication on gastro-oesophageal reflux disease in patients with duodenal ulcers or reflux oesophagitis, Alimentary Pharmacology and Therapeutics, vol.16, issue.1, pp.733-777, 2004. ,
DOI : 10.1046/j.1365-2036.2002.01169.x
There is no difference in the disease severity of gastro-oesophageal reflux disease between patients infected and not infected with Helicobacter pylori, Alimentary Pharmacology and Therapeutics, vol.45, issue.1, pp.761-769, 2004. ,
DOI : 10.1007/BF00191963
13C-Urea Breath Test for Diagnosis of Helicobacter pylori Infection in the Elderly, Digestive Diseases and Sciences, vol.110, issue.Suppl 1, pp.11-121840, 2004. ,
DOI : 10.1007/s10620-004-9581-4
An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews, The American Journal of Gastroenterology, vol.136, issue.2, pp.2621-2627, 2003. ,
DOI : 10.1136/gut.48.6.759
Infection in Patients with Reflux Esophagitis Treated with Omeprazole or Fundoplication, New England Journal of Medicine, vol.334, issue.16, pp.1018-1040, 1996. ,
DOI : 10.1056/NEJM199604183341603
Changes of gastric mucosal architecture during long-term omeprazole therapy: results of a randomized clinical trial, Alimentary Pharmacology and Therapeutics, vol.89, issue.186, pp.639-686, 2006. ,
DOI : 10.1080/00365520410003362
Changing Patterns of Helicobacter pylori Gastritis in Long-Standing Acid Suppression, Helicobacter, vol.45, issue.4, pp.206-220, 2000. ,
DOI : 10.1007/s004280050171
Chemoprevention of Gastric Dysplasia: Randomized Trial of Antioxidant Supplements and Anti-Helicobacter pylori Therapy, Journal of the National Cancer Institute, vol.92, issue.23, pp.1881-1889, 2000. ,
DOI : 10.1093/jnci/92.23.1881
Clinical trial: prolonged beneficial effect of Helicobacter pylori eradication on dyspepsia consultations - the Bristol Helicobacter Project, Alimentary Pharmacology & Therapeutics, vol.95, issue.3, pp.394-400, 2010. ,
DOI : 10.1111/j.1365-2036.2007.03500.x
URL : https://hal.archives-ouvertes.fr/hal-00552576
Diagnosis of Helicobacter pylori infection with a new non-in vasive antigen-based assay, The Lancet, vol.354, issue.9172, pp.30-33, 1999. ,
DOI : 10.1016/S0140-6736(98)08103-3
Effect of Helicobacter pylori eradication on chronic gastritis during omeprazole therapy, Gut, vol.46, issue.5, pp.615-636, 2000. ,
DOI : 10.1136/gut.46.5.615
Effects of Helicobacter pylori Eradication on Gastroesophageal Reflux Disease, Helicobacter, vol.17, issue.7, pp.255-65, 2011. ,
DOI : 10.1016/0197-2456(95)00134-4
Gastric extranodal marginal zone B-cell lymphoma of MALT, EGILS consensus report Gut. juin, vol.60, issue.6, pp.747-58, 2011. ,
Eradication of Helicobacter pylori Does Not Reduce the Incidence of Gastroduodenal Ulcers in Patients on Long-term NSAID Treatment: Double-Blind, Randomized, Placebo-Controlled Trial, Helicobacter, vol.34, issue.5, pp.477-85, 2007. ,
DOI : 10.1056/NEJMe020153
Factors predicting progression of gastric intestinal metaplasia: results of a randomised trial on Helicobacter pylori eradication, Gut, vol.53, issue.9, pp.1244-1253, 2004. ,
DOI : 10.1136/gut.2003.034629
Gastric Atrophy and Intestinal Metaplasia before and after <i>Helicobacter pylori</i> Eradication: A Meta-Analysis, Digestion, vol.99, issue.4, pp.253-60, 2011. ,
DOI : 10.1111/j.1572-0241.2004.40948.x
Gastric Cancer Risk in Patients With Premalignant Gastric Lesions: A Nationwide Cohort Study in the Netherlands, Gastroenterology, vol.134, issue.4, pp.945-52, 2008. ,
DOI : 10.1053/j.gastro.2008.01.071
Guidelines for the management of Helicobacter pylori infection, The American Journal of Gastroenterology, vol.113, issue.1, pp.2330-2338, 1998. ,
DOI : 10.1016/S0016-5085(97)80014-5
and Gastroesophageal Reflux Disease: A Case-Control Study, Helicobacter, vol.30, issue.Suppl. 1, pp.352-60, 2008. ,
DOI : 10.1093/oxfordjournals.bmb.a011663
Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China, JAMA, vol.291, issue.2, pp.187-94, 2004. ,
DOI : 10.1001/jama.291.2.187
Helicobacter pylori infection and chronic gastric acid hyposecretion, Gastroenterology, vol.113, issue.1, pp.15-24, 1997. ,
DOI : 10.1016/S0016-5085(97)70075-1
H. pylori eradication on the long-term incidence of recurrent ulcer bleeding in high-tisk aspirin users: a 10-year prospective cohort study, Gastroenterology, vol.140, pp.173-177, 2011. ,
URL : https://hal.archives-ouvertes.fr/pasteur-00614345
Is There an Increased Risk of GERD After Helicobacter pylori Eradication?: A Meta-Analysis, The American Journal of Gastroenterology, vol.10, issue.5, pp.1007-1020, 1014. ,
DOI : 10.1046/j.1365-2036.2000.00677.x
Lansoprazole for the prevention of recurrences of ulcer complications from long-term low-dose aspirin use Long-Term Follow-Up of Gastric MALT Lymphoma After Helicobacter Pylori Eradication, N Engl J Med. 27 juin J Clin Oncol. 11 janv, vol.34623, issue.2631, pp.8018-8042, 2002. ,
Long-term omeprazole treatment in resistant gastroesophageal reflux disease: Efficacy, safety, and influence on gastric mucosa, Gastroenterology, vol.118, issue.4, pp.661-670, 2000. ,
DOI : 10.1016/S0016-5085(00)70135-1
Long-term outcome following Helicobacter pylori eradication in a retrospective study of 105 patients with localized gastric marginal zone B-cell lymphoma of MALT type, Annals of Oncology, vol.56, issue.12, pp.1086-93, 2009. ,
DOI : 10.1136/gut.2006.096420
Predictors of long-term outcome of functional dyspepsia and duodenal ulcer after successful Helicobacter pylori eradication ??? a 7-year follow-up study, European Journal of Gastroenterology & Hepatology, vol.21, issue.4, pp.387-93, 2009. ,
DOI : 10.1097/MEG.0b013e3283069db0
Randomised controlled trial of Helicobacter pylori eradication in patients on non-steroidal anti-inflammatory drugs: HELP NSAIDs study, The Lancet, vol.352, issue.9133, pp.1016-1037, 1998. ,
DOI : 10.1016/S0140-6736(98)04206-8
Randomised trial of eradication of Helicobacter pylori before non-steroidal anti-inflammatory drug therapy to prevent peptic ulcers, The Lancet, vol.350, issue.9083, pp.975-984, 1997. ,
DOI : 10.1016/S0140-6736(97)04523-6
Regression of primary low-grade B-cell gastric lymphoma of mucosaassociated lymphoid tissue type after eradication of Helicobacter pylori Relationship between Helicobacter pylori infection and esophageal neoplasia: a metaanalysis, 575?7. 83. Rokkas T, pp.1413-1420, 1993. ,
Review article: Helicobacter pylori and gastro-oesophageal reflux disease-clinical implications and management, Alimentary Pharmacology and Therapeutics, vol.110, issue.2, pp.117-144, 1999. ,
DOI : 10.1053/gast.1996.v110.pm8566598
The health economics of Helicobacter pylori infection, Best Practice & Research Clinical Gastroenterology, vol.21, issue.2, pp.347-61, 2007. ,
DOI : 10.1016/j.bpg.2006.11.004
The role of endoscopy in dyspepsia, Gastrointestinal Endoscopy, vol.66, issue.6, pp.1071-1076, 2007. ,
DOI : 10.1016/j.gie.2007.07.007
The usefulness of the likelihood ratio in the diagnosis of dyspepsia and gastroesophageal reflux disease, The American Journal of Gastroenterology, vol.92, issue.11, pp.3122-3127, 1999. ,
DOI : 10.1016/S0002-9270(98)80009-9
Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment---Helicobacter pylori positive (CADET-Hp) randomised controlled trial, BMJ, vol.324, issue.7344, p.1012, 2002. ,
DOI : 10.1136/bmj.324.7344.1012
13C-urea breath test in the management of Helicobacter pylori infection, Digestive and Liver Disease, vol.37, issue.12, pp.899-906, 2005. ,
DOI : 10.1016/j.dld.2005.09.006
Accuracy of a monoclonal antibody-based stool antigen test in the diagnosis of Helicobacter pylori infection, Scandinavian Journal of Gastroenterology, vol.42, issue.2, pp.1073-1080, 2004. ,
DOI : 10.1128/JCM.42.3.1319-1321.2004
Positive Result by Serology Indicates ActiveHelicobacter pylori Infection in Patients with Atrophic Gastritis, J Clin Microbiol. 6 janv, vol.36, issue.6, pp.1808-1818, 1998. ,
Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection?a critical review Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors, Aliment Pharmacol Ther. Am J Gastroenterol. mai, vol.20, issue.985, pp.1005-1014, 2003. ,
Which test to use to detect Helicobacter pylori infection in patients with low-grade gastric mucosa-associated lymphoid tissue lymphoma?, The American Journal of Gastroenterology, vol.108, issue.2, pp.291-296, 2003. ,
DOI : 10.1002/(SICI)1096-9896(199808)185:4<409::AID-PATH121>3.0.CO;2-T
Second consultation, NICE guideline ,
Best practice in primary care pathology: review 1, Journal of Clinical Pathology, vol.58, issue.10, pp.1016-1040, 2005. ,
DOI : 10.1136/jcp.2004.025049
A trial of a test-and-treat strategy for Helicobacter pylori positive dyspeptic patients in general practice, Int J Clin Pract. sept, vol.53, issue.6, pp.413-419, 1999. ,
Current or recent proton pump inhibitor therapy markedly impairs the accuracy of the [14C]urea breath test, European Journal of Gastroenterology & Hepatology, vol.10, issue.9, pp.759-64, 1998. ,
DOI : 10.1097/00042737-199809000-00006
Diagnosis of Helicobacter pylori infection by stool antigen determination: a systematic review, The American Journal of Gastroenterology, vol.118, issue.1, pp.2829-2867, 2001. ,
DOI : 10.1111/j.1572-0241.2000.02193.x
Eradication therapy for peptic ulcer disease in Helicobacter pylori positive patients, Cochrane Database Syst Rev, issue.4, p.3840, 2003. ,
Evaluation of Commercially Available Helicobacter pylori Serology Kits: a Review, J Clin Microbiol. oct, vol.36, issue.10, pp.2803-2812, 1998. ,
False Negative Urea Breath Tests with H2-Receptor Antagonists: Interactions Between Helicobacter pylori Density and pH, Helicobacter, vol.91, issue.1, pp.17-27, 2004. ,
DOI : 10.1046/j.1365-2036.2002.01169.x
Randomised trial of endoscopy with testing for Helicobacter pylori compared with non-invasive H pylori testing alone in the management of dyspepsia, BMJ, vol.324, issue.7344, p.999, 2002. ,
DOI : 10.1136/bmj.324.7344.999
Systematic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia, BMJ, vol.321, issue.7262, pp.659-64, 2000. ,
DOI : 10.1136/bmj.321.7262.659
Test and treat for dyspepsia--but which test? BMJ. 15 janv Treating Helicobacter pylori infection in primary care patients with uninvestigated dyspepsia: the Canadian adult dyspepsia empiric treatment--Helicobacter pylori positive (CADET-Hp) randomised controlled trial, BMJ. 27 avr, vol.330324, issue.7344, p.1012, 2002. ,
Evidence-Based Recommendations for Short- and Long-Term Management of Uninvestigated Dyspepsia in Primary Care: An Update of the Canadian Dyspepsia Working Group (CanDys) Clinical Management Tool, Canadian Journal of Gastroenterology, vol.19, issue.5, pp.285-303, 2005. ,
DOI : 10.1155/2005/674607
13C-Urea breath tests are the noninvasive method of choice for Helicobacter pylori detection, Can J Gastroenterol, vol.13, pp.681-684, 1999. ,
ABSENCE OF ABDOMINAL PAIN IN ELDERLY PATIENTS WITH PEPTIC ULCER, Age and Ageing, vol.13, issue.2, pp.120-123, 1984. ,
DOI : 10.1093/ageing/13.2.120
A five-year follow-up study on the pathological changes of gastric mucosa after H. pylori eradication, Chin Med J (Engl). janv, vol.116, issue.1, pp.11-15, 2003. ,
A follow-up study of atrophic gastritis and intestinal metaplasia after eradication of Helicobacter pylori, Helicobacter. déc, vol.3, issue.4, pp.236-276, 1998. ,
Editorial: Can Therapy Ever Be Denied for Helicobacter pylori Infection?, Gastroenterology, vol.113, issue.6, pp.113-120, 1997. ,
DOI : 10.1016/S0016-5085(97)80023-6
Curing Helicobacter pylori infection in patients with duodenal ulcer may provoke reflux esophagitis, Gastroenterology, vol.112, issue.5, pp.1442-1449, 1997. ,
DOI : 10.1016/S0016-5085(97)70024-6
Current concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report, Gut, vol.56, issue.6, pp.772-81, 2007. ,
DOI : 10.1136/gut.2006.101634
Effect of population screening and treatment for Helicobacter pylori on dyspepsia and quality of life in the community: a randomised controlled trial, The Lancet, vol.355, issue.9216, pp.1665-1674, 2000. ,
DOI : 10.1016/S0140-6736(00)02236-4
Empirical prescribing for dyspepsia, European Journal of Gastroenterology & Hepatology, vol.15, issue.7, p.1118, 2003. ,
DOI : 10.1097/00042737-200307000-00022
Improvement of Gastric Atrophy After Helicobacter pylori Eradication Therapy, Journal of Clinical Gastroenterology, vol.36, issue.5, pp.405-415, 2003. ,
DOI : 10.1097/00004836-200305000-00009
Long-term Symptom Patterns, Endoscopic Findings, and Gastric Histology in Helicobacter pylori-Infected and -Uninfected Patients, Journal of Clinical Gastroenterology, vol.26, issue.2, pp.106-118, 1998. ,
DOI : 10.1097/00004836-199803000-00004
Meta-analysis: the relationship between Helicobacter pylori infection and gastro-oesophageal reflux disease, Alimentary Pharmacology and Therapeutics, vol.1, issue.0, pp.279-89, 2003. ,
DOI : 10.1016/S0140-6736(00)02236-4
and Pandora's Box, New England Journal of Medicine, vol.347, issue.26, pp.2162-2166, 2002. ,
DOI : 10.1056/NEJMe020153
Relation of upper gastrointestinal bleeding to non-steroidal anti-inflammatory drugs and aspirin: a case-control study., Gut, vol.32, issue.7, pp.730-734, 1991. ,
DOI : 10.1136/gut.32.7.730
Risk for serious gastrointestinal complications related to use of nonsteroidal antiinflammatory drugs. A meta-analysis ,
Short-term treatment of gastroesophageal reflux disease, Journal of General Internal Medicine, vol.160, issue.suppl, pp.755-63, 2003. ,
DOI : 10.1001/archinte.160.12.1810
Stratifying the risk of NSAID-related upper gastrointestinal clinical events: Results of a double-blind outcomes study in patients with rheumatoid arthritis, Gastroenterology, vol.123, issue.4, pp.1006-1018, 2002. ,
DOI : 10.1053/gast.2002.36013
Studies regarding the mechanism of false negative urea breath tests with proton pump inhibitors, The American Journal of Gastroenterology, vol.84, issue.5, pp.1005-1014, 2003. ,
DOI : 10.1046/j.1365-2036.2002.01192.x
The prevalence of Helicobacter pylori in peptic ulcer disease, Aliment Pharmacol Ther, vol.9, issue.2, pp.59-69, 1995. ,
American College of Gastroenterology Guideline on the Management of Helicobacter pylori Infection, The American Journal of Gastroenterology, vol.11, issue.2, pp.1808-1833, 2007. ,
DOI : 10.1111/j.1523-5378.2006.00436.x
in Patients with Nonulcer Dyspepsia, New England Journal of Medicine, vol.341, issue.15, pp.1106-1117, 1999. ,
DOI : 10.1056/NEJM199910073411502
Accuracy of breath tests using low doses of 13C-urea to diagnose Helicobacter pylori infection: a randomised controlled trial, Gut, vol.55, issue.4, pp.457-62, 2006. ,
DOI : 10.1136/gut.2005.078626
Accuracy of monoclonal stool antigen test for the diagnosis of H. pylori infection: a systematic review and meta-analysis Accuracy of the stool antigen test in the diagnosis of Helicobacter pylori infection before treatment and in patients on omeprazole therapy, 1921?30. 149. Manes G, pp.73-82, 2001. ,
Accurate Diagnosis of Helicobacter Pylori, Gastroenterology Clinics of North America, vol.29, issue.4, pp.895-902, 2000. ,
DOI : 10.1016/S0889-8553(05)70157-6
Accurate Diagnosis of Helicobacter pylori, Gastroenterology Clinics of North America, vol.29, issue.4, pp.853-62, 2000. ,
DOI : 10.1016/S0889-8553(05)70152-7
A comparison of three fingerstick, whole blood antibody tests for Helicobacter pylori infection: a United States, multicenter trial, The American Journal of Gastroenterology, vol.540, issue.6, pp.1512-1518, 1999. ,
DOI : 10.1016/S0002-9270(97)00003-8
A con-trolled, householdrandomized , open-label trial of the effect that treatment of Helicobacter pylori infection has on iron-de fi ciency in children in rural Alaska, J Infect Dis, issue.193, pp.537-583, 2006. ,
American Gastroenterological Association Medical Position Statement: Evaluation of Dyspepsia, Gastroenterology, vol.129, issue.5, pp.1753-1758, 2005. ,
DOI : 10.1053/j.gastro.2005.09.019
A meta-analysis comparing eradication, healing and relapse rates in patients with Helicobacter pylori -associated gastric or duodenal ul-cer, Aliment Pharmacol Ther, issue.15, 2001. ,
Antigen stool test for assessment of Helicobacter pylori infection in patients with upper gastrointestinal bleeding, Alimentary Pharmacology and Therapeutics, vol.120, issue.1, pp.1075-84, 2003. ,
DOI : 10.1016/S0210-5705(01)70125-2
An update of the Cochrane systematic review of Helicobacter pylori eradication therapy in nonulcer dyspepsia: resolving the discrepancy between systematic reviews, The American Journal of Gastroenterology, vol.136, issue.2, pp.2621-2627, 2003. ,
DOI : 10.1136/gut.48.6.759
Appropriate timing of the 14C-urea breath test to establish eradication of Helicobacter pylori infection, The American Journal of Gastroenterology, vol.38, issue.5, pp.1171-1175, 2000. ,
DOI : 10.1016/S0002-9270(99)00341-X
Comparison of stool immunoassay with standard methods for detection of Helicobacter pylori infection in patients with upper-gastrointestinal bleeding of peptic origin, European Journal of Gastroenterology & Hepatology, vol.15, issue.5, pp.525-534, 2003. ,
DOI : 10.1097/01.meg.0000059114.41030.a9
Do commercial serological kits for Helicobacter pylori infection differ in accuracy? A meta-analysis, Am J Gastroenterol. juin, vol.91, issue.6, pp.1138-1182, 1996. ,
Does He-licobacter pylori eradication affect symptoms in nonulcer dyspepsia: A 5-year follow-up study, Helicobacter, issue.7, pp.317-338, 2002. ,
Effect of Helicobacter pylori eradication on development of erosive esophagitis and gastroesophageal reflux disease symptoms: a post hoc analysis of eight double blind prospective studies, The American Journal of Gastroenterology, vol.35, issue.12, pp.2992-2999, 2002. ,
DOI : 10.1067/mge.2002.122617
Effects of acid suppression and bismuth medications on the performance of diagnostic tests for Helicobacter pylori infection, The American Journal of Gastroenterology, vol.107, issue.9, pp.2380-2383, 1999. ,
DOI : 10.1016/S0140-6736(87)90664-7
Effects of Helicobacter pylori and nonsteroidal anti-in fl ammatory drugs on peptic ulcer disease: A sys-tematic review, Clin Gastroenterol Hepatol, issue.4, pp.130-172, 2006. ,
Endemic Iron Deficiency Associated With Helicobacter pylori Infection Among School-Aged Children in Alaska, PEDIATRICS, vol.117, issue.3, pp.396-404, 2006. ,
DOI : 10.1542/peds.2005-1129
Endoscopic biopsy requirements for post-treatment diagnosis of Helicobacter pylori, Gastrointestinal Endoscopy, vol.51, issue.6, pp.664-673, 2000. ,
DOI : 10.1067/mge.2000.105776
Enzyme-Linked Immunosorbent Assay for Helicobacter pylori Needs Adjustment for the Population Investigated, Journal of Clinical Microbiology, vol.42, issue.2, pp.627-657, 2004. ,
DOI : 10.1128/JCM.42.2.627-630.2004
Eradication of Helicobacter pylori for non-ulcer dyspepsia, Cochrane Database Syst Rev, issue.1, p.2096, 2005. ,
Eradication of Heli-cobacter pylori prevents ulcer development in patients with ulcer-like functional dyspepsia, Aliment Pharmacol Ther, issue.15, pp.195-201, 2001. ,
Eradication of H. pylori affects symptoms in non-ulcer dyspepsia ,
Eradication Therapy in Helicobacter pylori Positive Peptic Ulcer Disease: Systematic Review and Economic Analysis, The American Journal of Gastroenterology, vol.312, issue.2, pp.1833-55, 2004. ,
DOI : 10.1136/bmj.312.7027.349
Evaluation of the Ez-HBT Helicobacter blood test to establish Helicobacter pylori eradication, Evaluation of the Helicobacter pylori stool antigen test for monitoring eradication therapy, 2005. ,
DOI : 10.1002/bms.1200111103
Guidelines for the Management of Dyspepsia, The American Journal of Gastroenterology, vol.10, issue.1, pp.2324-2361, 2005. ,
DOI : 10.1111/j.1365-2982.2004.00516.x
Guidelines for the manage-ment of Helicobacter pylori infection, Am J Gastroenterol, issue.93, pp.2330-2338, 1998. ,
Helicobacter pylori and MALT Lymphoma, Gastroenterology, vol.128, issue.6, pp.1579-605, 2005. ,
DOI : 10.1053/j.gastro.2005.03.083
Helicobacter pylori antigen stool test and 13C-urea breath test in patients after eradication treatments, The American Journal of Gastroenterology, vol.97, issue.11 ,
DOI : 10.1111/j.1572-0241.2002.07065.x
Helicobacter pylori Eradication and Gastric Preneoplastic Conditions: A Randomized, Double-Blind, Placebo-Controlled Trial, Cancer Epidemiology Biomarkers & Prevention, vol.13, issue.1, pp.4-10, 2004. ,
DOI : 10.1158/1055-9965.EPI-03-0124
Helicobac-ter pylori eradication is bene fi cial in the treatment of func-tional dyspepsia ,
Helicobacter py-lori eradication is superior to ulcer healing with or without maintenance therapy to prevent further ulcer haemorrhage ,
Helicobacter pylori stool antigen test in patients with bleeding peptic ulcers, Helicobacter, vol.19, issue.3, pp.663-671, 2004. ,
DOI : 10.1097/00042737-200104000-00013
How to Treat Heliobacter pylori, Gastroenterology Clinics of North America, vol.29, issue.4, pp.759-73, 2000. ,
DOI : 10.1016/S0889-8553(05)70145-X
H. Pylori and GERD: Is Less More?, The American Journal of Gastroenterology, vol.84, issue.7, pp.1222-1227, 2004. ,
DOI : 10.1111/j.1572-0241.2000.01970.x
pylori erad-ication therapy vs. antisecretory non-eradication therapy (with or without long-term maintenance antisecretory ther-apy) for the prevention of recurrent bleeding from peptic ulcer, Cochrane Database Syst Rev, 2004. ,
Improvement of complete blood count in patients with iron deficiency anemia and Helicobacter pylori infection after the eradication of Helicobacter pylori, Hepatogastroenterology. févr, vol.51, issue.55, pp.313-318, 2004. ,
Iron Deficiency and Helicobacter pylori Infection in the United States, American Journal of Epidemiology, vol.163, issue.2, pp.127-161, 2006. ,
DOI : 10.1146/annurev.nutr.22.120501.134539
Lack of accuracy of the noninvasive Helicobacter pylori stool antigen test in patients with gastroduodenal ulcer bleeding, The American Journal of Gastroenterology, vol.24, issue.2, pp.798-801, 2003. ,
DOI : 10.1136/adc.83.3.268
Infection in Patients with Nonulcer Dyspepsia, New England Journal of Medicine, vol.339, issue.26, pp.1875-81, 1998. ,
DOI : 10.1056/NEJM199812243392602
Long-term follow-up gastric MALT lymphoma after Helicobacter py-lori eradication, J Clin Oncol, issue.23, pp.8018-8042, 2001. ,
Long term follow up of patients treated for Helicobacter pylori infection, Gut, vol.54, issue.11, pp.1536-1576, 2005. ,
DOI : 10.1136/gut.2005.072009
Long-term results of anti-Helicobacter pylori therapy in early-stage gastric highgrade transformed MALT lymphoma, J Natl Cancer Inst, issue.97, pp.1345-53, 2005. ,
Maintenance Treatment Is Not Necessary After Helicobacter pylori Eradication and Healing of Bleeding Peptic Ulcer, Archives of Internal Medicine, vol.163, issue.17, pp.2020-2024, 2003. ,
DOI : 10.1001/archinte.163.17.2020
Meta-analysis: The relationship between Helicobacter pylori infection and gastrooesophageal re fl ux disease, Aliment Pharmacol Ther, issue.18, pp.279-89, 2003. ,
Noninvasive Helicobacter pylori Testing for the "Test-and-Treat" Strategy, Archives of Internal Medicine, vol.161, issue.17, pp.2129-2161, 2001. ,
DOI : 10.1001/archinte.161.17.2129
NSAID-Induced Peptic Ulcers and Helicobacter pylori Infection, Drug Safety, vol.17, issue.9, pp.287-300, 2005. ,
DOI : 10.2165/00002018-200528040-00002
Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro-oesophageal re fl ux disease in Western patients with non-ulcer dyspepsia, Aliment Pharmacol, issue.24, pp.55-63, 2006. ,
Pearls and pitfalls of assessing Helicobacter pylori status Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver Prevalence of Helicobacter pylori in patients with gastrooesophageal reflux disease: systematic review, juin BMJ. 5 avr, vol.35326, issue.67392, p.737, 2003. ,
Primary care physician perceptions of non-steroidal anti-in fl ammatory drug and aspirin-associated toxicity: Results of a national survey ,
Randomized Placebo-Controlled Trial of Helicobacter pylori Eradication for Iron-Deficiency Anemia in Preadolescent Children and Adolescents, Helicobacter, vol.34, issue.2, pp.135-144, 1999. ,
DOI : 10.1146/annurev.me.34.020183.000415
RECENT DEVELOPMENTS IN THE EPIDEMIOLOGY OF HELICOBACTER PYLORI, Gastroenterology Clinics of North America, vol.29, issue.3, pp.559-78, 2000. ,
DOI : 10.1016/S0889-8553(05)70130-8
Reproducibility of the 14C urea breath test repeated after 1 week, Am J Gastroenterol. déc, vol.90, issue.12, pp.2103-2108, 1995. ,
Eradication in Patients with Asymptomatic Gastritis, Annals of Internal Medicine, vol.131, issue.9, pp.668-72, 1999. ,
DOI : 10.7326/0003-4819-131-9-199911020-00006
Review article: 13C-urea breath test in the diagnosis of Helicobacter pylori infection - a critical review, Alimentary Pharmacology and Therapeutics, vol.15, issue.3, pp.1001-1018, 2004. ,
DOI : 10.1111/j.1083-4389.2004.00191.x
Risk factors for ulcer development in patients with non-ulcer dyspepsia: a prospective two year follow up study of 209 patients, Gut, vol.51, issue.1, pp.15-20, 2002. ,
DOI : 10.1136/gut.51.1.15
Role of Heli-cobacter pylori eradication in aspirin or non-steroidal anti-inflammatory drug users, pp.3811-3817, 2005. ,
Should We Eradicate Helicobacter pylori Before Prescribing an NSAID? Result of a Placebo-Controlled Study, The American Journal of Gastroenterology, vol.29, issue.6 ,
DOI : 10.1136/gut.51.3.329
Should we eradicate Helicobacter pylori in non-steroidal anti-inflammatory drug users? Aliment Pharma-Col Ther, pp.65-70, 2004. ,
Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection: a Systematic Review, Helicobacter, vol.47, issue.4, pp.347-68, 2004. ,
DOI : 10.1046/j.1365-2036.2001.00106.x
Symptomatic bene fi t from eradicating Helicobacter pylori infection in patients with nonulcer dyspepsia, N Engl J Med, issue.339, pp.1869-74, 1998. ,
Systematic review: The effect of Helicobacter pylori and its eradication on gastro-oesophageal re fl ux disease in patients with duodenal ulcers or re fl ux oesophagitis, Aliment Pharmacol Ther, issue.20, pp.733-777, 2004. ,
The 13C-urea blood test accurately detects active Helicobacter pylori infection: a United States, multicenter trial, The American Journal of Gastroenterology, vol.123, issue.6, pp.1522-1526, 1999. ,
DOI : 10.7326/0003-4819-123-4-199508150-00003
The cost-effectiveness of diagnostic testing strategies for Helicobacter pylori, The American Journal of Gastroenterology, vol.319, issue.8, pp.1691-1699, 2000. ,
DOI : 10.1046/j.1365-2036.2000.00677.x
The long-term effect of Helicobacter pylori eradication therapy on symptoms in dyspeptic patients with fundi atrophic gastritis, Aliment Pharmacol Ther, issue.18, pp.245-52, 2003. ,
after Eradication Therapy, Annals of Internal Medicine, vol.136, issue.4, pp.280-287, 2002. ,
DOI : 10.7326/0003-4819-136-4-200202190-00007
Treatment of gastric mucosa-associated lymphoid tissue lymphoma: Helicobacter py-lori eradication and beyond, Expert Rev Anticancer Ther, issue.6, pp.361-71, 2006. ,
Treatment of gastro-oesophageal reflux disease with rabeprazole in primary and secondary care: does Helicobacter pylori infection affect proton pump inhibitor effectiveness?, Alimentary Pharmacology and Therapeutics, vol.98, issue.4, pp.451-459, 2004. ,
DOI : 10.1016/S1590-8658(01)80100-6
Usefulness of a delayed test for the diagnosis of Helicobacter pylori infection in bleeding peptic ulcer, Alimentary Pharmacology and Therapeutics, vol.40, issue.1, pp.53-62, 2006. ,
DOI : 10.1053/j.gastro.2003.11.006
Validity of a modified 13C-urea breath test for pre- and posttreatment diagnosis of Helicobacter pylori infection in the routine clinical setting, The American Journal of Gastroenterology, vol.92, issue.2, pp.2100-2104, 1999. ,
DOI : 10.1042/cs0930003
Current concepts in the management of Helicobacter pylori infection-The Maastricht 2-2000 Consensus Report, Alimentary Pharmacology and Therapeutics, vol.13, issue.2, pp.167-80, 2002. ,
DOI : 10.1128/JCM.39.1.394-397.2001
guidelines on diagnosis and treatment of Helicobacter pylori infection in Italy, Cervia II Working Group Report Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. août, vol.39, issue.8, pp.782-791, 2006. ,
Accuracy of a new monoclonal stool antigen test in post-eradication assessment of Helicobacter pylori infection: comparison with the polyclonal stool antigen test and urea breath test. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver A negative rapid urease test is unreliable for exclusion of Helicobacter pylori infection during acute phase of ulcer bleeding. A prospective case control study, 751?5. 223. Schilling D, pp.217-238, 2003. ,
Antisecretory drugs, Helicobacter pylori infection and symptom relief in GORD: still an unexplored triangle. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, juill, vol.37, issue.7, pp.468-74, 2005. ,
???Cervia Working Group Report???: Guidelines on the diagnosis and treatment of Helicobacter pylori infection, Digestive and Liver Disease, vol.33, issue.1, pp.75-80, 2001. ,
DOI : 10.1016/S1590-8658(01)80139-0
Clinical and endoscopic presentation of primary gastric lymphoma: a multicentre study, Alimentary Pharmacology and Therapeutics, vol.20, issue.6, pp.721-727, 2006. ,
DOI : 10.3748/wjg.v11.i15.2354
Diagnosis of Helicobacter pylori infection in dyspeptic patients by stool antigen detection usefulness of a new monoclonal enzyme immunoassay test, Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. juill, vol.36, issue.7, pp.450-454, 2004. ,
Evaluation of a Novel Rapid One-Step Immunochromatographic Assay for Detection of Monoclonal Helicobacter pylori Antigen in Stool Samples from Children, Journal of Clinical Microbiology, vol.43, issue.6, pp.2598-601, 2005. ,
DOI : 10.1128/JCM.43.6.2598-2601.2005
Evidence based medicine and extradigestive manifestations of Helicobacter pylori):388?92. 230. Smith ML. Functional dyspepsia pathogenesis and therapeutic options-implications for management, Acta Gastro- Enterol Belg. déc Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. août, vol.6337, issue.48, pp.547-58, 2000. ,
Helicobacter pylori: diseases, tests and treatment, Digestive and Liver Disease, vol.33, issue.9, pp.788-94, 2001. ,
DOI : 10.1016/S1590-8658(01)80697-6
Helicobacter pylori eradication does not exacerbate gastro-oesophageal reflux disease, Gut, vol.53, issue.2, pp.312-315, 2004. ,
DOI : 10.1136/gut.2003.019836
URL : http://gut.bmj.com/content/gutjnl/53/2/312.full.pdf
Helicobacter pylori impairs iron absorption in infected individuals, Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver. juill, vol.36, issue.7, pp.455-60, 2004. ,
infection and antisecretory efficacy of proton-pump inhibitors in gastroesophageal reflux disease: A liaison dangereuse or an innocent interplay?, Scandinavian Journal of Gastroenterology, vol.21, issue.10, pp.1121-1126, 2006. ,
DOI : 10.1111/j.1365-2036.2005.02368.x
Helicobacter pylori Infection and Idiopathic Thrombocytopenic Purpura, International Journal of Hematology, vol.158, issue.2, pp.113-121, 2005. ,
DOI : 10.1532/IJH97.04161
Infection and the Development of Gastric Cancer, New England Journal of Medicine, vol.345, issue.11, pp.784-793, 2001. ,
DOI : 10.1056/NEJMoa001999
Helicobacter pylori infection and the prevention of peptic ulcer with proton pump inhibitors in elderly subjects taking low-dose aspirin, Digestive and Liver Disease, vol.36, issue.10, pp.666-70, 2004. ,
DOI : 10.1016/j.dld.2004.05.011
Helicobacter pylori infection in patients with liver cirrhosis: facts and fictions. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, mars, vol.35, issue.3, pp.197-205, 2003. ,
High incidence of primary gastric lymphoma in northeastern Italy, The Lancet, vol.339, issue.8797, pp.834-839, 1992. ,
DOI : 10.1016/0140-6736(92)90280-G
Noninvasive Helicobacter pylori diagnosis: stool or breath tests? Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, oct, vol.37, issue.10, pp.732-736, 2005. ,
Non-steroidal anti-inflammatory drugs: who should receive prophylaxis?, Alimentary Pharmacology and Therapeutics, vol.124, issue.s2, pp.59-64, 2004. ,
DOI : 10.1136/gut.52.1.16
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2036.2004.02042.x/pdf
Outcome of non-variceal acute upper gastrointestinal bleeding in relation to the time of endoscopy and the experience of the endoscopist: A two-year survey, World Journal of Gastroenterology, vol.11, issue.45, pp.7122-7152, 2005. ,
DOI : 10.7326/0003-4819-139-4-200308190-00005
Proton-pump inhibitors reduce the risk of uncomplicated peptic ulcer in elderly either acute or chronic users of aspirin/non-steroidal anti-inflammatory drugs, Alimentary Pharmacology and Therapeutics, vol.19, issue.10, pp.1091-1098, 2004. ,
DOI : 10.1046/j.1365-2036.2000.00804.x
Randomized Double-Blind Factorial Trial of Three Treatments To Reduce the Prevalence of Precancerous Gastric Lesions, JNCI: Journal of the National Cancer Institute, vol.98, issue.14, pp.974-83, 2006. ,
DOI : 10.1016/S0140-6736(04)17138-9
infection, Alimentary Pharmacology & Therapeutics, vol.95, issue.1, pp.16-23, 2002. ,
DOI : 10.1016/S0016-5085(01)80248-1
URL : https://hal.archives-ouvertes.fr/hal-00464770
Helicobacter pylori and reflux disease, Alimentary Pharmacology and Therapeutics, vol.19, issue.6, pp.297-305, 2003. ,
DOI : 10.1016/S0016-5085(98)70364-6
A Review Article, India Quarterly: A Journal of International Affairs, vol.129, issue.1, pp.1051-61, 2004. ,
DOI : 10.1177/097492848504100131
Review article: should NSAID/low-dose aspirin takers be tested routinely for H. pylori infection and treated if positive? Implications for primary risk of ulcer and ulcer relapse after initial healing ,
DOI : 10.1111/j.0953-0673.2004.01830.x
URL : http://onlinelibrary.wiley.com/doi/10.1111/j.0953-0673.2004.01830.x/pdf
Should we eradicate Helicobacter pylori in non-steroidal anti-inflammatory drug users?, Alimentary Pharmacology and Therapeutics, vol.39, issue.s2, pp.65-70, 2004. ,
DOI : 10.1046/j.1440-1746.2000.02267.x
Stool test for Helicobacter pylori. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, juill, vol.36, issue.7, pp.446-453, 2004. ,
The methodological quality of trials affects estimates of treatment efficacy in functional (non-ulcer) dyspepsia, Alimentary Pharmacology and Therapeutics, vol.40, issue.3, pp.631-672, 2004. ,
DOI : 10.1046/j.1365-2036.2002.01373.x
The stomach and iron deficiency anaemia: a forgotten link. Dig Liver Dis Off J Ital Soc Gastroenterol Ital Assoc Study Liver, avr, vol.35, issue.4, pp.288-95, 2003. ,
Trends in incidence rates of oesophagus and gastric cancer in Italy by subsite and histology, 1986. ,
Upper gastrointestinal bleeding associated with antiplatelet drugs, Alimentary Pharmacology and Therapeutics, vol.12, issue.56, pp.235-277, 2006. ,
DOI : 10.1161/01.STR.0000063141.24491.50
Variability in risk of gastrointestinal complications with individual non-steroidal antiinflammatory drugs: results of a collaborative meta-analysis, BMJ. 22 juin, vol.312, issue.7046, pp.1563-1569, 1996. ,
The relative contribution of NSAIDs and Helicobacter pylori to the aetiology of endoscopically-diagnosed peptic ulcer disease: observations from a tertiary referral hospital in the UK between 2005 and 2010, Alimentary Pharmacology & Therapeutics, vol.36, issue.Suppl. 12, pp.48-56, 2005. ,
DOI : 10.1016/S0889-8553(05)70152-7
Eradicating Helicobacter Pylori in Functional Dyspepsia, Gastroenterology, vol.142, issue.7, pp.1613-1617, 2012. ,
DOI : 10.1053/j.gastro.2012.04.022
Helicobacter pylori eradication in long-term proton pump inhibitor users in primary care: a randomized-controlled trial, Alimentary Pharmacology & Therapeutics, vol.90, issue.Suppl. 3, pp.585-92, 2007. ,
DOI : 10.1136/bmj.317.7156.452
testing and empirical therapy for the management of dyspepsia in primary care, Alimentary Pharmacology & Therapeutics, vol.336, issue.Suppl, pp.55-68, 2009. ,
DOI : 10.1017/CBO9780511625817.005
Risk factors associated with a decrease ???2??g/dL in haemoglobin and/or ???10% haematocrit in osteoarthritis patients taking celecoxib or a nonselective NSAID plus a PPI in a large randomised controlled trial (CONDOR), Alimentary Pharmacology & Therapeutics, vol.165, issue.Suppl. 1, pp.485-92, 2012. ,
DOI : 10.1001/archinte.165.19.2214
Etiological factors of duodenal and gastric ulcers, The Turkish Journal of Gastroenterology, vol.23, issue.2, pp.99-103, 2012. ,
DOI : 10.4318/tjg.2012.0435
Helicobacter pylori management in primary care, Intern Emerg Med. août, vol.7, issue.4, pp.297-305, 2012. ,
L'anémie par carence en vitamine B12 dans la région de Marrakech (Maroc) Rev DÉpidémiologie Santé Publique, févr, vol.61, issue.1, pp.78-81, 2013. ,
DOI : 10.1016/j.respe.2012.07.003
Cost-effectiveness of six strategies for Helicobacter pyloridiagnosis and management in uninvestigated dyspepsia assuming a high resource intensity practice pattern, BMC Health Services Research, vol.11, issue.3, p.344, 2010. ,
DOI : 10.1002/14651858.CD002096.pub4
Managing Dyspepsia in a Primary Care Setting, Clinical Medicine & Research, vol.4, issue.4, pp.337-379, 2006. ,
DOI : 10.3121/cmr.4.4.337
Disponible sur: http://www.inserm.fr/actualites/rubri ques/actualites- recherche/helicobacter-pylori-et- cancer-gastrique-un-des-mecanismes- elucide 268. afssaps, recommandations de bonnes pratiques: les antisécrétoires gastriques chez l'adulte [Internet]. [cité 8 oct 2013] Disponible sur: http://www.ansm.sante.fr/var/ansm_ site/storage/original/application/4eab 9fc78eba0b7b11e4fb6543dd65e2 GI-REASONS: A Novel 6-Month, Prospective, Randomized, Open-Label, Blinded Endpoint (PROBE) Trial time: an analysis of two large outcome trials, Am J Gastroenterol. mars Aliment Pharmacol Ther. 1 oct, vol.10834, issue.2707, pp.392-400808, 2011. ,
Improvement of Non-Steroidal Anti-Inflammatory Drug-Induced Gastrointestinal Symptoms during Proton Pump Inhibitor Treatment: Are G-Protein ??3 Subunit Genotype, <i>Helicobacter pylori</i> Status, and Environmental Factors Response Modifiers?, Digestion, vol.67, issue.4, pp.289-98, 2011. ,
DOI : 10.1136/ard.2008.092015
Interaction of Helicobacter pylori infection and lowdose aspirin in the upper gastrointestinal tract: Implications for clinical practice, Best Pract Res Clin Gastroenterol. avr, vol.26, issue.2, pp.163-72, 2012. ,
Commentary: changing aetiology of peptic ulcers, Alimentary Pharmacology & Therapeutics, vol.4, issue.3, pp.291-293, 2012. ,
DOI : 10.1038/ncpgasthep0769
The Influence of Etiologic Factors on Clinical Outcome in Patients with Peptic Ulcer Bleeding, Digestive Diseases and Sciences, vol.128, issue.234, pp.3195-204, 2012. ,
DOI : 10.1053/j.gastro.2005.03.026
Does Helicobacter pylori infection eradication modify peptic ulcer prevalence A 10 years' endoscopical survey, World Journal of Gastroenterology, vol.12, issue.15, pp.2398-401, 2006. ,
DOI : 10.1023/A:1012731614075
How to test for Helicobacter pylori in 2005., Cleveland Clinic Journal of Medicine, vol.72, issue.Suppl_2, p.8, 2005. ,
DOI : 10.3949/ccjm.72.Suppl_2.S8