M. Althuser, ??chographie f??tale de d??pistage, EMC - Obst??trique, vol.2, issue.2, 2007.
DOI : 10.1016/S0246-0335(07)41880-4

. Arrêté-du-1ier and . Juillet, modifiant l'arrêté du 27 mai 1997 fixant les conditions particulières d'évaluation et d'utilisation des réactifs de dosage des marqueurs sériques prédictifs de la trisomie 21, Journal Officiel de la République Française, 2005.

A. Du, modifiant l'arrêté du 23 juin 2009 relatif à l'information, à la demande et au consentement de la femme enceinte à la réalisation du prélèvement et des analyses en vue d'établir un diagnostic prénatal in utero prévues à l'article R.2131-1 du code de la santé publique, Journal Officiel de la République Française, 2010.

M. Bernard and F. Muller, D??pistage de la trisomie 21 f??tale par les marqueurs s??riques maternels, Revue Francophone des Laboratoires, vol.2009, issue.411, pp.31-37, 2009.
DOI : 10.1016/S1773-035X(09)72562-6

N. Bersinger, F. Vanderlick, M. Birkhäuser, P. Janecek, and D. Wunder, First trimester serum concentrations of placental proteins in singleton and multiple IVF pregnancies: implications for Down syndrome screening, Immuno-analyse & Biologie Sp??cialis??e, vol.20, issue.1, pp.21-27, 2005.
DOI : 10.1016/j.immbio.2004.11.006

J. Bestwick, W. Huttly, and N. Wald, First trimester Down's syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free ?? human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency, Journal of Medical Screening, vol.110, issue.4, pp.204-206, 2008.
DOI : 10.1002/pd.1446

J. L. Bidart, hormone chorionique gonadotrope (hCG) et ses formes moléculaires
DOI : 10.1016/0923-2532(96)88055-0

M. Bogart, M. Pandian, and O. Jones, Abnormal maternal serum chorionic gonadotropin levels in pregnancies with fetal chromosome abnormalities, Prenatal Diagnosis, vol.98, issue.9, pp.623-730, 1987.
DOI : 10.1016/0002-9378(84)90530-1

P. Bouizegarène, N. Ameziane, M. Bogard, J. Deybach, and J. Lamoril, D??tection de la trisomie 21 par l?????tude de l???ADN, Immuno-analyse & Biologie Sp??cialis??e, vol.23, issue.1, pp.1-10, 2008.
DOI : 10.1016/j.immbio.2007.11.002

P. Bourgeot, Echographie du 1 er trimestre : apport au diagnostic aux embryopathies et des anomalies chromosomiques, Feuillet de Radiologie, vol.42, issue.5, pp.374-383, 2002.

M. Briard and N. Morichon-delvallez, Anomalies chromosomiques, EMC Pédiatrie, vol.4, 2006.
DOI : 10.1016/s1634-6939(06)75588-0

C. Brochet, A. Bakkouch, E. Guillerm, and M. Bernard, La pregnancy-associated plasma protein A (PAPP-A), Immuno-analyse & Biologie Sp??cialis??e, vol.25, issue.4, pp.212-218, 2010.
DOI : 10.1016/j.immbio.2010.05.006

B. Broussin and M. Sarramon, La clarté nucale : technique de mesure et signification, J Radiol, vol.83, pp.1891-1898, 2002.

L. Bussières, P. Rozenberg, J. Bault, and Y. Ville, Programme de d??pistage de la trisomie 21 dans les Yvelines par mesure ??chographique de la clart?? nucale et mesure des marqueurs s??riques maternels au 1er trimestre de la grossesse, Journal de Gyn??cologie Obst??trique et Biologie de la Reproduction, vol.33, issue.1
DOI : 10.1016/S0368-2315(04)96667-7

J. Canick, G. Knight, G. Palomaki, J. Haddow, H. Cuckle et al., Low second trimester maternal serum unconjugated oestriol in pregnancies with Down's syndrome, BJOG: An International Journal of Obstetrics and Gynaecology, vol.95, issue.4, pp.330-333, 1988.
DOI : 10.1111/j.1471-0528.1988.tb06602.x

X. Capelle, J. Schaaps, and J. Foidart, Nouvelles méthodes d'évaluation du risqué de trisomie 21 en consultation prénatale, Rev Med Liege, vol.63, issue.2, pp.82-86, 2008.

N. Cowans, A. Stamatopoulou, J. Hellström, M. Mäkelä, and K. Spencer, Xpress systems, Prenatal Diagnosis, vol.101, issue.Pt 5, pp.127-132, 2010.
DOI : 10.1111/j.1471-0528.1994.tb13123.x

H. Cuckle, K. Spencer, and K. Nicolaides, Down syndrome screening marker levels in women with a previous aneuploidy pregnancy, Prenatal Diagnosis, vol.9, issue.1, pp.47-50, 2005.
DOI : 10.1002/pd.1082

H. Cuckle, N. Wald, and S. Thompson, Estimation a woman's risk of having a pregnancy associated with Down's syndrome using her age and serum alpha-foetopreotein level, Br J

O. Dedeystère, Int??r??t du dosage de la sous-unit?? ?? libre d'HCG dans le d??pistage pr??natal de la trisomie 21, Immuno-analyse & Biologie Sp??cialis??e, vol.8, issue.3, pp.177-179, 1993.
DOI : 10.1016/S0923-2532(05)80116-4

D. Dibie-krajcman, Trisomie??21??: les nouvelles r??gles institu??es par les arr??t??s du 23??juin 2009, La Revue Sage-Femme, vol.8, issue.6, pp.347-356, 2009.
DOI : 10.1016/j.sagf.2009.10.006

B. Dingeon, C. Lebrun, and C. Doche, Marqueurs s??riques maternels d'anomalies f??tales, EMC - Biologie m??dicale, vol.2, issue.2
DOI : 10.1016/S2211-9698(07)71366-3

M. Engels, M. Kooij, R. Schats, J. Twisk, M. Blankenstein et al., Firsttrimester serum marker distribution in singleton pregnancies conceived with assisted reproduction, Prenat Diagn, vol.30, pp.372-377, 2010.

M. I. Evans, K. David, A. , H. Terrence, W. et al., Meta-analysis of first trimester Down syndrome screening studies: free ??-human chorionic gonadotropin significantly outperforms intact human chorionic gonadotropin in a multimarker protocol, American Journal of Obstetrics and Gynecology, vol.196, issue.3, pp.198-205, 2007.
DOI : 10.1016/j.ajog.2006.08.001

C. Fallet, Les différentes formes d'hCG circulantes : de leur source de production aux applications cliniques, J Gynécol Obstet Biol Reprod, vol.39, pp.11-12, 2010.

R. Favre and G. Moutel, Échographie du 1er trimestre de la grossesse : Le consentement des patientes à cet examen est-il réellement « éclairé » ?, Médecine, vol.4, issue.4, pp.186-190, 2008.

M. Flori and J. Goffette, Réflexions éthiques sur le dépistage du risque de trisomie 21 par les marqueurs sériques, La revue Exercer, vol.75, pp.126-129, 2005.

S. Ghosh, E. Feingold, and S. Dey, Etiology of Down syndrome: Evidence for consistent association among altered meiotic recombination, nondisjunction, and maternal age across populations, American Journal of Medical Genetics Part A, vol.141, issue.7, pp.1415-1420, 2009.
DOI : 10.1002/ajmg.a.32932

A. Gjerris, A. Loft, A. Pinborg, M. Christiansen, and A. Tabor, First-trimester screening markers are altered in pregnancies conceived after IVF/ICSI, Ultrasound in Obstetrics and Gynecology, vol.28, issue.1, pp.8-17, 2009.
DOI : 10.1016/S0015-0282(16)58508-2

G. Grange, E. Pannier, F. Goffinet, J. Zorn, and D. Cabrol, Précision de la biométrie de datation à l'échographie du premier trimestre dans la pratique courante, J Gynecol Obstet Biol Reprod, vol.32, issue.3, pp.221-226, 2003.

G. Grange, J. Tantau, N. Acuna, G. Viot, F. Narcy et al., Fr??quence des malformations associ??es ?? la trisomie 21, Journal de Gyn??cologie Obst??trique et Biologie de la Reproduction, vol.35, issue.5, pp.477-482, 2006.
DOI : 10.1016/S0368-2315(06)76420-1

A. Graulet, Informations R??actifs : AFP, Immuno-analyse & Biologie Sp??cialis??e, vol.15, issue.4, pp.286-293, 2000.
DOI : 10.1016/S0923-2532(00)80029-0

D. Porquet and F. Muller, Physiopathologie de l'hormone chorionique gonadotrope humaine (hCG) dans la trisomie 21, Immunoanal Biol Spec, vol.17, issue.1, pp.2-10, 2002.

A. Herman, E. Dreazen, A. Herman, C. Batukan, W. Holzgreve et al., Bedside estimation of Down syndrome risk during first-trimester ultrasound screening, Ultrasound in Obstetrics and Gynecology, vol.347, issue.5, pp.468-475, 2002.
DOI : 10.1046/j.1469-0705.2001.00454.x

A. Herman, R. Maymon, E. Dreazen, E. Caspi, I. Bukovsky et al., Nuchal translucency audit: a novel image-scoring method, Ultrasound in Obstetrics and Gynecology, vol.12, issue.6, pp.398-403, 1998.
DOI : 10.1046/j.1469-0705.1998.12060398.x

E. Hook, Down syndrome frequency in human population and factors pertinent to variation in rates Mental retardation centers series, pp.3-67, 1981.

P. Hui, Y. Lam, M. Tang, N. Eh, W. Yeung et al., Maternal serum pregnancy-associated plasma protein-A and free ??-human chorionic gonadotrophin in pregnancies conceived with fresh and frozen-thawed embryos fromin vitro fertilization and intracytoplasmic sperm injection, Prenatal Diagnosis, vol.7, issue.5, pp.390-403, 2005.
DOI : 10.3310/hta7110

E. Iwarsson, On the origin of trisomy 21 Down syndrome, Mol Cytogenet, vol.1, pp.21-31, 2008.

W. Huttly, A. Rudnicka, and N. Wald, Second-trimester prenatal screening markers for Down syndrome in women with insulin-dependent diabetes mellitus, Prenatal Diagnosis, vol.16, issue.10, pp.804-807, 2004.
DOI : 10.1111/j.1471-0528.1997.tb14356.x

J. Ingrand, Gonadotrophine chorionique (hCG) et sa sous-unité bêta libre, EMC Encyclopédie Médico-Biologique, pp.90-100, 2007.
DOI : 10.1016/s2211-9698(07)71380-8

K. Kagan, D. Wright, K. Spencer, F. Molina, and K. Nicolaides, First-trimester screening for trisomy 21 by free beta-human chorionic gonadotropin and pregnancy-associated plasma protein-A: impact of maternal and pregnancy characteristics, Ultrasound in Obstetrics and Gynecology, vol.108, issue.5, pp.493-502, 2008.
DOI : 10.1097/01.AOG.0000241095.19638.f2

K. Kogan, D. Wright, A. Etchegaray, Y. Zhou, and K. Nicolaides, Effect of deviation of nuchal translucency measurements on the performance of screening for trisomy 21

S. Kessler, Clart?? nucale : technique de mesure, Imagerie de la Femme, vol.18, issue.3, pp.153-156, 2008.
DOI : 10.1016/S1776-9817(08)77191-8

D. Krantz, T. Hallahan, V. Macri, and J. Macri, Maternal weight and ethnic adjustment within a first-trimester Down syndrome and trisomy 18 screening program, Prenatal Diagnosis, vol.16, issue.8, pp.635-640, 2005.
DOI : 10.1046/j.1471-0528.2003.02246.x

P. Kuhn, M. Brizot, P. Pandya, R. Snijders, and K. Nicolaides, Crown-rump length in chromosomally abnormal fetuses at 10 to 13 weeks' gestation, American Journal of Obstetrics and Gynecology, vol.172, issue.1, pp.32-35, 1995.
DOI : 10.1016/0002-9378(95)90080-2

T. Leung, K. Spencer, T. Leung, T. Fung, and T. Lau, Higher Median Levels of Free ??-hCG and PAPP-A in the First Trimester of Pregnancy in a Chinese Ethnic Group, Fetal Diagnosis and Therapy, vol.20, issue.1, pp.140-143, 2006.
DOI : 10.1046/j.1469-0705.1999.13040231.x

R. Levy, J. Arfi, and F. Daffos, Techniques de pr??l??vements f??taux, Gyn??cologie Obst??trique & Fertilit??, vol.31, issue.6, pp.550-555, 2003.
DOI : 10.1016/S1297-9589(03)00136-X

T. Lin, S. Galbert, D. Kiefer, S. Wn, and S. Gall, Characterization of four human pregnancy-associated plasma proteins, American Journal of Obstetrics and Gynecology, vol.118, issue.2, pp.223-236, 1974.
DOI : 10.1016/0002-9378(74)90553-5

J. Jr, Maternal serum Down syndrome screening: free beta-protein is a more effective marker than human chorionic gonadotropin, Am J Obstet Gynecol, vol.163, issue.4, pp.1248-1253, 1990.

I. Merkatz, H. Nitowsky, J. Macri, and W. Johnson, An association between low maternal serum ??-fetoprotein and fetal chromosomal abnormalities, American Journal of Obstetrics and Gynecology, vol.148, issue.7, pp.886-894, 1984.
DOI : 10.1016/0002-9378(84)90530-1

M. Moineau, D. Guenet, J. Codet, and J. Morin, Estimation du risque de trisomie 21 foetale par les marqueurs sériques maternels, Principe du calcul de risque. Médecine foetale et échographie en Gynécologie, pp.13-17, 2005.
DOI : 10.1016/j.immbio.2005.07.004

N. Morichon-delvallez, Cytog??n??tique pr??natale, EMC - Obst??trique, vol.1, issue.2, pp.31-46, 2006.
DOI : 10.1016/S0246-0335(06)41354-5

F. Muller, D??pistage de la trisomie 21 par les marqueurs s??riques, EMC - Gyn??cologie-Obst??trique, vol.2, issue.3, pp.209-216, 2005.
DOI : 10.1016/j.emcgo.2005.04.002

K. Nicolaides, Nuchal translucency and other first-trimester sonographic markers of chromosomal abnormalities, American Journal of Obstetrics and Gynecology, vol.191, issue.1, pp.45-67, 2004.
DOI : 10.1016/j.ajog.2004.03.090

K. Nicolaides, R. Snijders, and H. Cuckle, Letter. Correct estimation of parameters for ultrasound nuchal translucency screening, Prenatal Diagnosis, vol.17, issue.5, pp.519-523, 1998.
DOI : 10.1111/j.1471-0528.1995.tb10902.x

G. Palomaki, D. Wright, A. Summers, L. Neveux, C. Meier et al., Repeated measurement of pregnancy-associated plasma protein-A (PAPP-A) in Down syndrome screening: A validation study, Prenatal Diagnosis, vol.24, issue.8, pp.730-739, 2006.
DOI : 10.1111/j.1471-0528.2004.00343.x

P. Pandya, D. Altman, M. Brizot, H. Pettersen, and K. Nicolaides, Repeatability of measurement of fetal nuchal translucency thickness, Ultrasound in Obstetrics and Gynecology, vol.5, issue.5, pp.334-337, 1995.
DOI : 10.1046/j.1469-0705.1995.05050334.x

L. Penrose, The relative effects of paternal and maternal age in mongolism, Journal of Genetics, vol.60, issue.2, pp.219-224, 1933.
DOI : 10.1007/BF02984413

M. Perona, G. Mancini, D. Dall-'amico, V. Guaraldo, and A. Carbonara, Influence of smoking habits on Down???s syndrome risk evaluation at mid-trimester through biochemical screening, International Journal of Clinical & Laboratory Research, vol.24, issue.3
DOI : 10.1007/BF02592410

Y. Giovangrandi, F. Muller, D. Evain-brion, and J. Frendo, Reasons of increased level of hCG in the serum of the mothers bearing a trisomic foetus, Immunoanal Biol Spéc, vol.21, pp.91-98, 2006.

F. Poloce and C. Boisson-gaudin, Marqueurs sériques maternels d'anomalies foetales (trisomie 21, anomalies chromosomiques, spina bifida,?) Revue Francophone des, Laboratoires, vol.421, pp.59-68, 2010.
DOI : 10.1016/s1773-035x(10)70466-4

H. Robinson and J. Fleming, A CRITICAL EVALUATION OF SONAR "CROWN-RUMP LENGTH" MEASUREMENTS, BJOG: An International Journal of Obstetrics and Gynaecology, vol.4, issue.9, pp.702-712, 1975.
DOI : 10.1002/aja.1000230206

N. Roizen and D. Patterson, Down's syndrome, The Lancet, vol.361, issue.9365, pp.1281-1289, 2003.
DOI : 10.1016/S0140-6736(03)12987-X

T. Rousseau, C. Ferdynus, C. Thauvin-robinet, J. Gouyon, and P. Sagot, Impact des variations de distribution de l'âge maternel sur la prévalence attendue à la naissance de la trisomie 21 en
DOI : 10.1016/j.jgyn.2010.03.001

P. Rozenberg, Dépistage de la trisomie 21 par échographie, Immunoanal Biol Spéc, vol.20, issue.2, pp.103-109, 2005.
DOI : 10.1016/j.immbio.2005.01.003

L. Salomon, M. Bernard, R. Amarsy, J. Bernard, and Y. Ville, The impact of crown-rump length measurement error on combined Down syndrome screening: a simulation study, Ultrasound in Obstetrics and Gynecology, vol.36, issue.5
DOI : 10.1016/j.jgyn.2006.12.021

A. Scott, Mesure de la claret nucale dans le dépistage du syndrome de Down au premier trimester, Agence canadienne

M. Senat, P. Rozenberg, J. Bernard, and Y. Ville, Trisomy 21 screening: value of ultrasound and serum markers in a combined approach, J Gynecol Obstet Biol Reprod, vol.30, issue.1, pp.11-27, 2001.

R. Snijders, P. Noble, N. Sebire, A. Souka, and K. Nicolaides, UK multicentre project on assessment of risk of trisomy 21 by maternal age and fetal nuchal-translucency thickness at 10-14 weeks of gestation. Fetal Medicine Foundation First Trimester Screening Group

K. Spencer, Evaluation of an assay of the free beta-subunit of choriogonadotropin and its potential value in screening for Down's syndrome, Clin Chem, vol.37, issue.6, pp.809-814, 1991.

K. Spencer, E. Coombes, A. Mallard, and A. Ward, Free Beta Human Choriogonadotropin in Down's Syndrome Screening: A Multicentre Study of its Role Compared with other Biochemical Markers, Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine, vol.29, issue.5, pp.506-518, 1992.
DOI : 10.1177/000456329202900504

K. Spencer, R. Bindra, and K. Nicolaides, Maternal weight correction of maternal serum PAPP-A and free ?-hCG MoM when screening for trisomy 21 in the first trimester of pregnancy, Prenatal Diagnosis, vol.18, issue.10, pp.851-855, 2003.
DOI : 10.1002/(SICI)1097-0223(199808)18:8<842::AID-PD339>3.0.CO;2-G

K. Spencer, S. Cicero, A. Atzei, C. Otigbah, and K. Nicolaides, The influence of maternal insulin-dependent diabetes on fetal nuchal translucency thickness and first-trimester maternal serum biochemical markers of aneuploidy, Prenatal Diagnosis, vol.22, issue.10, pp.927-929, 2005.
DOI : 10.1046/j.1471-0528.2003.02246.x

K. Spencer, V. Heath, A. El-sheikhah, C. Ong, and K. Nicolaides, Ethnicity and the need for correction of biochemical and ultrasound markers of chromosomal anomalies in the first trimester: a study of Oriental, Asian and Afro-Caribbean populations, Prenatal Diagnosis, vol.16, issue.5, pp.365-369, 2005.
DOI : 10.1046/j.1471-0528.2003.02246.x

K. Spencer, I. Staboulidou, D. J. Cruz, J. Karagiannis, G. Nicolaides et al., Maternal serum screening marker levels in women with a previous aneuploidy pregnancy, Prenatal Diagnosis, vol.31, issue.13, pp.1242-1243, 2009.
DOI : 10.1002/pd.2395

M. Vekemans, Âge maternel et autres facteurs de risque de la trisomie 21, C, vol.61, issue.4, pp.497-499, 2003.

N. Wald, H. Cuckle, J. Densem, K. Nanchahal, P. Royston et al., Maternal serum screening for Down's syndrome in early pregnancy., BMJ, vol.297, issue.6653, pp.883-887, 1988.
DOI : 10.1136/bmj.297.6653.883

N. Wald, D. Smith, and A. Kennard, Biparietal diameter and crown-rump lenght in fetuses with Down's syndrome : implications for antenatal serum screening for Down's syndrome

W. Fuhrman, First trimester concentrations of pregnancy associated plasma protein A and placental protein 14 in Down's syndrome, Brit Med J, vol.28, p.305, 1992.

J. Wisser and P. Dirsheld, Estimation of gestational age by transvaginal sonographic measurement of greatest embryonic length in dated human embryos, Ultrasound in Obstetrics and Gynecology, vol.4, issue.6, pp.457-462, 1994.
DOI : 10.1046/j.1469-0705.1994.04060457.x