une dose correspondant à 50 mg d'harpagoside, 25 mg soit la moitié sera disponible pour la résorption intestinale ,
8 à 200 mg. La demie-vie plasmatique est courte (entre 3,7 et 6,4 heures) et les auteurs signalent qu'un taux mesurable d'harpagoside sanguin n'est atteint que ,
harpagophytum procumbens est jugée très faible. À ce jour, il n'y a pas eu d'effets secondaires rapportés suite à son utilisation. Une étude toxicologique sur les rats a conclu qu ,
état des connaissances actuelles sur ce sujet, la supplémentation en cuivre dans les compléments alimentaires est très souvent recommandée et a lieu à très petite dose très loin des doses toxiques (0,5 mg, ou des doses létales ,
agirait en enrayant le processus inflammatoire (anti-IL1), et en augmentant la quantité d'antioxydants par son action ,
Pathophysiologie et diagnostic de l'ostéoarthroseLes Affections Articulaire, pp.199-201, 1995. ,
Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage, Ostearthritis Cartilage, vol.1, pp.613-622, 2003. ,
Arthrose : physio-pathologie et aspects actuels des traitements, pp.185-193, 1996. ,
Cytokines: inflammatory mediators of joint disease, Equine Veterinary Journal, vol.24, pp.78-80, 1992. ,
Dietary vitamins and selenium diminish the development of mechanically induced osteoarthritis and increase the expression of antioxidative enzymes in the knee joint of STR/1N mice, Ostearthritis Cartilage, vol.10, pp.119-126, 2001. ,
Nutraceuticals: challenges and opportunities for the new millennium that affect consumers and healthcare professionals who use and recommend nutraceuticals, pp.6-10, 1999. ,
La glucosamine dans le traitement de l'ostéoarthrose. Revue bibliographique, pp.31-36, 2000. ,
Nutraceuticals: challenges and opportunities for the new millennium that affect consumers and healthcare professionals who use and recommend nutraceuticals, pp.6-10, 1999. ,
Degenerative joint disease, Disease Mechanisms in Small Animal Surgery, pp.727-736, 1993. ,
General pathobiology of the joint and response to injury. Joint Disease in the Horse, p.70, 1996. ,
Glucosamine and chondroïtine sulfates in the treatment of osteoarthritis: a survey, Prog. Drug. Res, vol.55, pp.81-103, 2000. ,
Changes in proteoglycane turnover in experimental canine osteoarthritic cartilage, Matrix, vol.12, p.137, 1992. ,
Glucosamine and chondroitin sulfates in the treatment of osteoarthritis : a survey, Prog. Drug. Res, vol.55, pp.81-103, 2000. ,
Evidence of the oral absorption of chondroitin sulfate as determined by total disaccharide content after oral and IV administration to horses, pp.43-44, 2001. ,
Effects of oral intramuscular use of chondroïtine sulfate in induced equine aseptic arthritis, J. Equine Vet. Sci, vol.18, pp.548-555, 1998. ,
Biochemical basis of the pharmacological action of chondroitin sulfates on the osteoarticular system, Arthritis and Rheumatism, vol.31, pp.58-68, 2001. ,
Avocado/soybean unsaponifiables prevent the inhibitory effect of osteoarthritic subchondral osteoblasts on aggrecan and type II collagen synthesis by chondrocytes, pp.1668-78, 2006. ,
Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes, pp.31-40, 1998. ,
Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, three-month, randomized, double-blind, placebo-controlled trial, pp.76-84, 2004. ,
A study of the absorption Methylsulfonylmethane in horses, Proc 17e Physiol Nutr Soc Equine, pp.141-142 ,
Toxicity of methylsulfonylmethane in rats ,
Suppressive effect of methylsulfonylmethane (MSM) on Type-II collagen induced arthritis in SBA/1J mice, Jpn Pharmacol Ther, vol.32, pp.421-428, 2004. ,
Assessment of Methylsulfonylmethane (MSM) on the developement of osteoarthritis (OA): An animal study FASEB J, pp.109-110, 2008. ,
Efficacy of methylsulfonyl-methane (MSM) in osteoarthritis pain of the knee : a pilot clinical atrial, Osteoarthritis and Cartilage, vol.14, pp.286-94, 2006. ,
Assistant Clinical Professor UCLA School of Medicine Professeur adjoint de clinique UCLA School of Medicine Methylsulfonylmethane (MSM) a double-blind study of its use of degenerative arthritis, Int J Anti-Aging Med, vol.1, p.50, 1998. ,
Plantes thérapeutiques, pratique officinale, science et thérapeutique, pp.248-50, 2002. ,
Prescription et conseil en phytothérapie, pp.196-204, 2005. ,
antimicrobial, antiulcer and analgesic activities of nettle (Urtica dioica L.), J-Ethnopharmacol, vol.90, pp.2-3, 2004. ,
Urinary and fecal excretion and absorption of large supplement of selenium: superiority of selenate over selenite, J. Clin. Nut, vol.44, pp.659-663, 1986. ,
Un point sur le sélénium, Bulletin des GTV, pp.35-47, 1998. ,
Sélénium : rôle physiologique et intérêt en pathologie humaine, Path. Biol, issue.8, pp.36-1017, 1988. ,
Un point sur le sélénium, Bulletin des GTV, vol.5, pp.35-47, 1998. ,
Dietary iodine and selenium interact to affect thyroid hormone metabolism of rats, Journal of Nutrition, issue.6, pp.127-1214, 1997. ,
Sélénium : rôle physiologique et intérêt en pathologie humaine, Path. Biol, issue.8, pp.36-1017, 1988. ,
-Circadian rhythms of seven heavy metals in plasma, erythrocytes and urine in men: observation in metal workers, Industrial Health, vol.38, pp.205-217, 2000. ,
Evaluation du cuivre dans le traitement symptomatique de la gonarthrose, Réflexions Rhumatologiques, vol.28, pp.3-6, 2000. ,
The role of glucosamine and chondroitin sulphate in treatment for and prevention of osteoarthritis in animals, J. Am. Vet. Med. Assoc, vol.226, pp.1079-1088, 2005. ,
Effects of glucosamine and chondroitine sulphate on mediators of osteoarthritis in cultured equine chondrocytes stimulated by use of recombinant equine interleukin-1beta, Am. J.Vet.Res, vol.66, pp.1861-1869, 2005. ,
Effect of unsaponifiable extracts of avocado and soybean (Piascledine) on the collagenolytic action of cultures of human rheumatoid synoviocytes and rabbit articular chondrocytes treated with interleukin-1, Rev. Rhum. Mal. Osteoartic, vol.58, issue.4, pp.241-246, 1991. ,
Medicinal plants of the world, pp.34-35, 2004. ,
DOI : 10.1079/9781786393258.0000
Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil's claw (Harpagophytum procumbens DC.). Phytother Res, pp.1165-72, 2003. ,
Antiinflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens, Planta Medica, vol.58, pp.117-123, 1992. ,
Evaluation of acute and chronic treatments with Harpagophytum procumbens on Freund???s adjuvant-induced arthritis in rats, Journal of Ethnopharmacology, vol.91, issue.2-3, pp.2-3, 2004. ,
DOI : 10.1016/j.jep.2004.01.003
Effect of a Harpagophytum procumbens DC extract on matrix metalloproteinases in human chondrocytes in vitro, Arzneimittel-Forschung, vol.54, issue.4, pp.213-233, 2004. ,
Interleukin-10 modulates pro-apoptotic effects of TNF-alpha in human articular chondrocytes in vitro, Cytokine, vol.40, issue.3, pp.226-260, 2007. ,
Effects of the antirheumatic remedy hox alpha--a new stinging nettle leaf extract--on matrix Metalloproteinases in human chondrocytes in vitro, Histol Histopathol, vol.17, issue.2, pp.477-485, 2002. ,
Antinociceptive and antiinflammtory properties of the hydroalcoholic extract of stem from Equisetum arvense L. in mice, Pharmacol rem, pp.239-282, 2004. ,
Boswellia serrata, common name : Frankincense, Alternative Medicine Review, pp.22-24, 1998. ,
Selenium, glutathione peroxidase, peroxides and platelet functions ; Annales de biologie clinique, pp.54-181, 1996. ,
Antiinflammatory and analgesic effects of an aqueous extract of Harpagophytum procumbens, Planta Medica, vol.58, pp.117-123, 1992. ,
Investigations on the pharmacokinetic properties in humans of Harpagophytum extracts and their effects on eicosanoid biosynthesis in vitro and ex vivo, Clinical Pharmacology and Therapeutics, vol.69, issue.5, pp.356-364, 2001. ,