H. M. Straif-k, T. D. Morgenstern-h, and G. S. Zhang-z, Epidemiologic review of marijuana use and cancer risk, Alcohol, vol.35, issue.3, pp.265-275, 2005.

B. A. Cerfolio-r, Differences in epidemiology, histology, and survival between cigarette smokers and never-smokers who develop non-small cell lung cancer, Chest, vol.132, issue.1, pp.185-192, 2007.

K. S. Stampfer-m, R. B. , and C. G. , Smoking and smoking cessation in relation to mortality in women, JAMA, vol.299, issue.17, pp.2037-2047, 2008.

C. Vignaud-j.-m, B. O. Stoufflet-a, G. A. Thiberville-l, . Grosdidier-g, . Martinet-y et al., Characteristics of never smoker lung cancer including environmental and occupational risk factors, Lung Cancer, vol.67, issue.2, pp.144-150, 2010.

R. R. Moran-t, . Queralt-c, C. F. Porta-r, C. C. Majem-m, I. G. Lopez-vivanco et al., Screening for epidermal growth factor receptor mutations in lung cancer, N Engl J Med, vol.361, issue.10, pp.958-967, 2009.

T. L. and D. L. Edelman-m, Lung cancer in women: emerging differences in epidemiology, biology, and therapy, Chest, vol.128, issue.1, pp.370-381, 2005.

F. J. Hedelin-g, L. M. Purohit-a, and . Velten-m, Specific features of non-small cell lung cancer in women: a retrospective study of 1738 cases diagnosed in Bas-Rhin between, J Thorac Oncol, vol.2, issue.6, pp.466-474, 1982.

J. A. , T. W. Tarone-r, T. L. , and D. S. , Lung cancer rates convergence in young men and women in the United States: analysis by birth cohort and histologic type, Int J Cancer, vol.105, issue.1, pp.101-107, 2003.

W. Q. Cheng-l, A. C. , W. L. Guo-z, H. W. , and S. M. , Repair of tobacco carcinogen-induced DNA adducts and lung cancer risk: a molecular epidemiologic study, J Natl Cancer Inst, vol.92, issue.21, pp.1764-1772, 2000.

B. M. Brambilla-e and T. W. , The 2004 World Health Organization classification of lung tumors, Semin Roentgenol, vol.40, issue.2, pp.90-97, 2005.

V. E. Sheperd-f, C. J. Van-houtte-p, C. P. Postmus-p-goldstraw, C. K. Giroux-d, G. P. Rami-porta et al., The IASLC Lung Cancer Staging Project The IASLC Lung Cancer Staging Project: proposals for the revision of the TNM stage groupings in the forthcoming (seventh) edition of the TNM Classification of malignant tumours, Journal of thoracic oncology J Thorac Oncol, vol.2, issue.8, pp.706-714, 2007.

R. D. , Z. J. , O. S. , G. D. Anton-culver-h, J. D. Thomas et al., Natural history of stage I non-small cell lung cancer: implications for early detection, Chest, Practical issues in the surgical treatment of non-small cell lung cancer. Recommendations from the French Society of Thoracic and Cardiovascular Surgery], pp.1031-1036, 2007.

S. W. , H. J. , and F. S. Movsas-b, Treatment of non-small cell lung cancer stage I and stage II: ACCP evidence-based clinical practice guidelines, Chest, vol.132, pp.234-242, 2007.

N. N. , G. L. , W. J. , H. R. Cohen-d, and . V. Vinh-hung, Can stereotactic fractionated radiation therapy become the standard of care for early stage non-small cell lung carcinoma, Cancer Treat Rev, vol.34, issue.8, pp.719-727, 2008.

A. N. Flores-r, Video-assisted thoracic surgery (VATS) lobectomy: the evidence base, JSLS, vol.11, issue.3, pp.368-374, 2007.

B. A. , C. A. Bolliger-c, R. G. , S. J. Varela-g, F. M. Licker-m et al., ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy), Eur Respir J, vol.34, issue.1, pp.17-41, 2009.

C. M. Sarna-l, K. J. , L. J. , J. M. Green-s, and . Bueno-r, Smoking cessation is challenging even for patients recovering from lung cancer surgery with curative intent, Lung Cancer, vol.66, issue.2, pp.218-225, 2009.

C. G. Shafazand-s, G. J. , and K. R. Bolliger-c, Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidenced-based clinical practice guidelines, Chest, pp.161-177, 2007.

C. L. and W. W. Van-meerbeeck, Early stage and locally advanced (non-metastatic) non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up, Ann Oncol, vol.21, pp.103-115, 2010.

R. L. , R. J. Wagner-h, and J. W. Stevens-c, Treatment of non-small cell lung cancer-stage IIIA: ACCP evidencebased clinical practice guidelines, Chest, 2007.

J. J. Schild-s and K. R. Kesler-k, Treatment of nonsmall cell lung cancer, stage IIIB: ACCP evidence-based clinical practice guidelines, Chest, vol.132, pp.266-276, 2007.

P. J. , D. E. Scalzetti-e, and B. J. , Treatment advances for medically inoperable non-small-cell lung cancer: emphasis on prospective trials, Lancet Oncol, vol.10, issue.9, pp.885-894, 2009.

S. C. Dupuy-d, . A. Dipetrillo-t, . P. Safran-h, . A. Grieco-c, . Ng-t et al., Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients, Radiology, vol.243, issue.1, pp.268-275, 2007.

L. R. , C. L. , C. R. Suh-r, G. D. , R. D. Helmberger-t et al., Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study), Lancet Oncol, vol.9, issue.7, pp.621-628, 2008.

F. J. , T. W. Fenwick-j, and . P. Mehta-m, A challenge to traditional radiation oncology, Int J Radiat Oncol Biol Phys, vol.60, issue.4, pp.1241-1256, 2004.

Q. X. Tullgren-o, . Lax-i, . Sirzen-f, and . Lewensohn-r, The role of radiotherapy in treatment of stage I non-small cell lung cancer, Lung Cancer, vol.41, issue.1, pp.1-11, 2003.

U. A. Koolen-m, . M. Van-os-r, . Koedooder-k, . Van-de-kar-m, . R. Pieters-b et al., Accelerated high-dose radiotherapy alone or combined with either concomitant or sequential chemotherapy; treatments of choice in patients with Non-Small Cell Lung Cancer A randomised phase III study of accelerated or standard fraction radiotherapy with or without concurrent carboplatin in inoperable non-small cell lung cancer: Final report of an Australian multicentre trial, radiotherapy and oncology, Radiat Oncol, vol.2, issue.52, pp.129-136, 1999.

R. K. , F. J. Yorke-e, A. H. , J. A. Rusch-v, K. M. et al., Results of a phase I doseescalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma, Cancer, pp.2118-2127, 2005.

H. J. Martel-m and . K. Haken-r, Dose Escalation in Non? Small-Cell Lung Cancer Using Three-Dimensional Conformal Radiation Therapy: Update of a Phase I Trial, J Clin Oncol, vol.19, issue.1, pp.127-136, 2001.

F. K. , P. T. Trotti-a, S. U. Jones-c, . L. Phillips-t, R. S. Garden-a et al., A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003, Int J Radiat Oncol Biol Phys, vol.48, issue.1, pp.7-16, 2000.

S. M. , D. S. , B. A. , and H. A. Griffiths-g, Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer: mature data from the randomised multicentre trial, CHART Steering committee Radiother Oncol, vol.52, issue.2, pp.137-148, 1999.

B. J. Hodgson-l, . L. Seagren-s, W. W. Blackstock-a, T. A. Lenox-r, R. J. 3rd et al., Phase I study of accelerated conformal radiotherapy for stage I non-small-cell lung cancer in patients with pulmonary dysfunction: CALGB 39904, J Clin Oncol, vol.28, issue.2, pp.202-206, 2010.

D. De, R. D. Van-baardwijk, Y. S. Rao-b, and . Lambin-p, The importance of patient characteristics for the prediction of radiation-induced lung toxicity, Radiother Oncol, vol.91, issue.3, pp.421-426, 2009.

P. L. Timmerman-r, Hypofractionation in radiation therapy and its impact, Med Phys, vol.35, issue.1, pp.112-118, 2008.

G. , P. F. Cordon-cardo, L. D. , R. S. Haimovitz-friedman-a, and . Fuks-z, Tumor response to radiotherapy regulated by endothelial cell apoptosis, Science, vol.300, issue.5622, pp.1155-1159, 2003.

B. N. Bernier-v, A. R. Picard-l, . Marchal-c, . Buchheit-i, . Metayer-c et al., Radiochirurgie des malformations artério-veineuse : proposition d'un algorithme de prescription The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery, Cancer Radiother Semin Radiat Oncol, vol.13, issue.4, pp.240-243, 2008.

T. R. Galvin-j, M. J. Straube-w, M. E. Ibbott-g, . Abdulrahman-r, F. J. Swann-s et al., Accreditation and quality assurance for Radiation Therapy Oncology Group: Multicenter clinical trials using Stereotactic Body Radiation Therapy in lung cancer, Acta Oncol, vol.45, issue.7, pp.779-786, 2006.

L. R. , B. J. Howes-t, M. J. Dill-j, and . L. Meeks-s, Optimal number of beams for stereotactic body radiotherapy of lung and liver lesions 58 LAX I. Target dose versus extratarget dose in stereotactic radiosurgery, Int J Radiat Oncol Biol Phys Acta Oncol, vol.66, issue.4, pp.906-912, 1993.

H. C. , C. J. Lagerwaard-f, W. J. Van-der, H. U. , S. D. Senan-s-hara et al., Recommendations for implementing stereotactic radiotherapy in peripheral stage IA non-small cell lung cancer: report from the Quality Assurance Working Party of the randomised phase III ROSEL study Stereotactic single high dose irradiation of lung tumors under respiratory gating, Radiat Oncol Radiother Oncol, vol.4, issue.2, pp.159-163, 2002.

O. R. Shirato-h, . Shimizu-s, . Kitamura-k, . Xu-b, C. T. Fukumoto-s et al., Tolerance of organs at risk in smallvolume , hypofractionated, image-guided radiotherapy for primary and metastatic lung cancers, Int J Radiat Oncol Biol Phys, vol.56, issue.1, pp.126-135, 2003.

N. J. Prevost-j, P. J. Hoogeman-m, . J. Van-klaveren-r, . C. Levendag-p, and . M. Pattynama-p, Lung tumor tracking during stereotactic radiotherapy treatment with the CyberKnife: Marker placement and early results, Acta Oncol, vol.45, issue.7, pp.961-965, 2006.

B. J. Prevost-b, M. X. Dansin-e, . Lacornerie-t, and . Dubus-f, Radiothérapie stéréotaxique du cancer du poumon: suivi tumoral non invasif par tracking, Cancer Radiother, vol.14, issue.8, pp.690-697, 2010.

F. A. Mcgarry-r, Y. C. Papiez-l, W. M. , and H. M. Timmerman-r, Stereotactic body radiation therapy for early-stage non-small-cell lung carcinoma: four-year results of a prospective phase II study, Int J Radiat Oncol Biol Phys, vol.75, issue.3, pp.677-682, 2009.

T. R. Mcgarry-r, Y. C. Papiez-l, T. K. , D. J. Ewing-m, . Abdulrahman-r et al., Excessive toxicity when treating central tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung cancer, J Clin Oncol, vol.24, issue.30, pp.4833-4839, 2006.

M. M. , C. Y. Katz-a, P. A. Schell-m, and . Okunieff-p, Central thoracic lesions treated with hypofractionated stereotactic body radiotherapy, Radiother Oncol, vol.91, issue.3, pp.301-306, 2009.

T. A. Sanuki-n, . Kunieda-e, . Ohashi-t, . Oku-y, . Takeda-t et al., Stereotactic body radiotherapy for primary lung cancer at a dose of 50 Gy total in five fractions to the periphery of the planning target volume calculated using a superposition algorithm, Int J Radiat Oncol Biol Phys, vol.73, issue.2, pp.442-448, 2009.

N. Y. Takayama-k, . Matsuo-y, . Norihisa-y, . Mizowaki-t, . Sakamoto-t et al., Clinical outcomes of a phase I/II study of 48 Gy of stereotactic body radiotherapy in 4 fractions for primary lung cancer using a stereotactic body frame, Int J Radiat Oncol Biol Phys, vol.63, issue.5, pp.1427-1431, 2005.

K. M. Takai-y, . Ogawa-y, . Matsushita-h, . Takeda-k, . Takahashi-c et al., A phase II study on stereotactic body radiotherapy for stage I non-small cell lung cancer, Radiother Oncol, vol.85, issue.3, pp.429-434, 2007.

B. P. , N. J. Hoyer-m, . Wennberg-b, . Gagliardi-g, . Lax-i et al., Outcome in a prospective phase II trial of medically inoperable stage I nonsmall-cell lung cancer patients treated with stereotactic body radiotherapy, J Clin Oncol, vol.27, issue.20, pp.3290-3296, 2009.

L. F. Haasbeek-c, . F. Smit-e, . J. Slotman-b, and . Senan-s, Outcomes of risk-adapted fractionated stereotactic radiotherapy for stage I non-small-cell lung cancer, Int J Radiat Oncol Biol Phys, vol.70, issue.3, pp.685-692, 2008.

S. D. , B. S. , C. R. , C. T. , and C. M. Schmidt-ullrich-r, Stereotactic body radiation therapy of lung tumors: preliminary experience using normal tissue complication probabilitybased dose limits, Am J Clin Oncol, vol.28, issue.6, pp.591-596, 2005.

O. H. , A. T. Shirato-h, . Nagata-y, . Hiraoka-m, . Gomi-k et al., Stereotactic hypofractionated high-dose irradiation for stage I nonsmall cell lung carcinoma: clinical outcomes in 245 subjects in a Japanese multiinstitutional study, Cancer, vol.101, issue.7, pp.1623-1631, 2004.

X. Y. Papiez-l, . Paulus-r, . Timmerman-r, . L. Straube-w, M. R. Bosch-w et al., Dosimetric evaluation of heterogeneity corrections for RTOG 0236: stereotactic body radiotherapy of inoperable stage I-II non-small-cell lung cancer, Int J Radiat Oncol Biol Phys, vol.73, issue.4, pp.1235-1242, 2009.

H. M. Matsuo-y, Stereotactic body radiation therapy (SBRT) for early-stage lung cancer, Cancer Radiother, vol.11, pp.1-2, 2007.

S. O. Sandhu-t, C. B. Lattin-p, L. C. Groshko-g, and . J. Lattin-c, Once-weekly, high-dose stereotactic body radiotherapy for lung cancer: 6-year analysis of 60 early-stage, 42 locally advanced, and 7 metastatic lung cancers, Int J Radiat Oncol Biol Phys, vol.72, issue.3, pp.707-715, 2008.

M. R. Papiez-l, W. M. Whitford-t, and . D. Timmerman-r, Stereotactic body radiation therapy of early-stage nonsmall-cell lung carcinoma: phase I study, Int J Radiat Oncol Biol Phys, vol.63, issue.4, pp.1010-1015, 2005.

B. P. , N. J. Lax-i, F. S. Hoyer-m, J. S. Rehn, . Ekberg-l et al., Factors important for efficacy of stereotactic body radiotherapy of medically inoperable stage I lung cancer. A retrospective analysis of patients treated in the Nordic countries, Acta Oncol, vol.45, issue.7, pp.787-795, 2006.

C. J. , T. J. Benezery-k, P. B. , D. D. Venissac-n, O. J. Poudenx-m et al., Feasibility and efficacy of cyberknife radiotherapy for lung cancer: early results], Cancer Radiother, vol.12, issue.8, pp.793-799, 2008.

T. R. Papiez-l, . Mcgarry-r, . Likes-l, . Desrosiers-c, . Frost-s et al., Extracranial stereotactic radioablation: results of a phase I study in medically inoperable stage I non-small cell lung cancer, Chest, vol.124, issue.5, pp.1946-1955, 2003.

L. E. , M. X. Prevost-b, . Lacornerie-t, . Dubus-f, and . Sarrazin-t, Extracranial stereotactic radiotherapy: preliminary results with the CyberKnife, Onkologie, vol.32, issue.4, pp.209-215, 2009.

O. C. Verbakel-w, C. J. Slotman-b, . J. Lagerwaard-f, and . Senan-s, Stereotactic radiotherapy for peripheral lung tumors: A comparison of volumetric modulated arc therapy with 3 other delivery techniques, Radiother Oncol, vol.97, issue.3, pp.437-442, 2010.

N. A. and T. S. Wong-v, Hypofractionated stereotactic radiotherapy for medically inoperable stage I non-small cell lung cancer-report on clinical outcome and dose to critical organs, Radiother Oncol, vol.87, issue.1, pp.24-28, 2008.

C. A. Liao-z, . P. Nguyen-n, . Xu-j, and . Stea-b, Systemic review of the patterns of failure following stereotactic body radiation therapy in early-stage non-small-cell lung cancer: clinical implications, Radiother Oncol, vol.94, issue.1, pp.1-11, 2010.

B. J. , A. S. Bedford-j, . Nioutsikou-e, . Partridge-m, and . Brada-m, Review of hypofractionated small volume radiotherapy for earlystage non-small cell lung cancer, Clin Oncol (R Coll Radiol), vol.20, issue.9, pp.666-676, 2008.

T. S. , J. H. , W. X. , W. S. Martel-m, K. R. Liu-h et al., Impact of toxicity grade and scoring system on the relationship between mean lung dose and risk of radiation pneumonitis in a large cohort of patients with non-small cell lung cancer, Int J Radiat Oncol Biol Phys, vol.77, issue.3, pp.691-698, 2010.

B. P. , N. J. Hoyer-m, . Gagliardi-g, . Lax-i, . Wennberg-b et al., Stereotactic body radiotherapy for medically inoperable patients with stage I non-small cell lung cancer -a first report of toxicity related to COPD/CVD in a non-randomized prospective phase II study Fractionated stereotactic body radiation therapy for medically inoperable stage I lung cancer adjacent to central large bronchus, Radiother Oncol Lung Cancer, vol.88, issue.1, pp.359-367, 2008.

I. T. Shimizu-s, T. A. Onimaru-r, . Onishi-h, . Nagata-y, . Kimura-t et al., Clinical outcomes of stereotactic body radiotherapy for small lung lesions clinically diagnosed as primary lung cancer on radiologic examination, Int J Radiat Oncol Biol Phys, vol.75, issue.3, pp.683-687, 2009.

B. S. Gevaert-t, . Linthout-n, C. C. Versmessen-h, . Engels-b, E. H. Verdries-d et al., Risk-Adapted Strategy of Stereotactic Body Radiotherapy for Early-Stage Non-Small-Cell Lung Cancer: Results of a Phase II Trial Exceptionally high incidence of symptomatic grade 2-5 radiation pneumonitis after stereotactic radiation therapy for lung tumors Coil spring fiducial markers placed safely using navigation bronchoscopy in inoperable patients allows accurate delivery of CyberKnife stereotactic radiosurgery, Int J Radiat Oncol Biol Phys Radiat Oncol J Thorac Cardiovasc Surg, vol.2, issue.5, pp.1137-1142, 2007.

Z. F. , G. H. Schill-s, . Thamm-r, . Nieder-c, and . Schratzenstaller-u, Stereotactic hypofractionated radiotherapy in stage I (T1-2 N0 M0) non-small-cell lung cancer (NSCLC), Acta Oncol, vol.45, issue.7, pp.796-801, 2006.

C. K. Al-lozi, B. I. El, . R. Olsen-j, . J. Parikh-p, . E. Drzymala-r et al., Dosimetric Prediction of Chest Wall Toxicity after Lung SBRT, International Journal of Radiation OncologyBiologyPhysics, vol.78, issue.3, pp.181-182, 2010.

T. T. , T. A. Kunieda-e, I. A. Takemasa-k, . Shimada-k, . Yamamoto-s et al., Radiation injury after hypofractionated stereotactic radiotherapy for peripheral small lung tumors: serial changes on CT, AJR Am J Roentgenol, vol.182, issue.5, pp.1123-1128, 2004.

S. K. Djemil-t, G. A. Reddy-c, . Kolar-m, . Machuzak-m, . Mazzone-p et al., Comprehensive analysis of pulmonary function Test (PFT) changes after stereotactic body radiotherapy (SBRT) for stage I lung cancer in medically inoperable patients, J Thorac Oncol, vol.4, issue.7, pp.838-844, 2009.

T. A. Kunieda-e, . Takeda-t, . Tanaka-m, . Sanuki-n, . Fujii-h et al., Possible misinterpretation of demarcated solid patterns of radiation fibrosis on CT scans as tumor recurrence in patients receiving hypofractionated stereotactic radiotherapy for lung cancer, Int J Radiat Oncol Biol Phys, vol.70, issue.4, pp.1057-1065, 2008.

A. T. Nagata-y, . Negoro-y, M. T. Takayama-k, . Kokubo-m, . Oya-n et al., Evaluation of lung injury after three-dimensional conformal stereotactic radiation therapy for solitary lung tumors: CT appearance, Radiology, vol.230, issue.1, pp.101-108, 2004.

O. H. Shirato-h, . Nagata-y, . Hiraoka-m, . Fujino-m, N. Y. Gomi-k et al., Hypofractionated stereotactic radiotherapy (HypoFXSRT) for stage I non-small cell lung cancer: updated results of 257 patients in a Japanese multi-institutional study, J Thorac Oncol, vol.2, issue.7, pp.94-100, 2007.

W. J. Haedinger-u, T. W. Oppitz-u, and . Mueller-g, Stereotactic radiotherapy for primary lung cancer and pulmonary metastases: a noninvasive treatment approach in medically inoperable patients, Int J Radiat Oncol Biol Phys, vol.60, issue.1, pp.186-196, 2004.

B. H. Lax-i, . Naslund-i, and . Svanstrom-r, Stereotactic high dose fraction radiation therapy of extracranial tumors using an accelerator. Clinical experience of the first thirty-one patients, Acta Oncol, vol.34, issue.6, pp.861-870, 1995.

O. R. Fujino-m, Y. K. Onodera-y, T. H. , K. N. Hommura-f, . Oizumi-s et al., Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy, Int J Radiat Oncol Biol Phys, vol.70, issue.2, pp.374-381, 2008.

V. Der, . C. Van-zyp-n, . S. Hoogeman-m, . S. Van-de-water, . C. Levendag-p et al., Clinical introduction of Monte Carlo treatment planning: a different prescription dose for non-small cell lung cancer according to tumor location and size, Radiother Oncol, vol.96, issue.1, pp.55-60, 2010.

B. F. Shibamoto-y, . Ogino-h, . Murata-r, I. H. Sugie-c, . Otsuka-s et al., Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size, Cancer stem cells and the ontogeny of lung cancer, pp.2883-2889, 2008.

C. M. Pompei-p, A. K. , and M. C. , A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, vol.40, issue.5, pp.373-383, 1987.

K. N. Paludan-m, . Petersen-j, . T. Hansen-a, . Grau-c, and . Hoyer-m, Co-morbidity index predicts for mortality after stereotactic body radiotherapy for medically inoperable early-stage non-small cell lung cancer, Radiother Oncol, vol.93, issue.3, pp.402-407, 2009.

C. J. Balter-p, D. L. , Y. Q. Liao-z, . Jeter-m, . K. Bucci-m et al., Stereotactic body radiation therapy in centrally and superiorly located stage I or isolated recurrent non-small-cell lung cancer, Int J Radiat Oncol Biol Phys, vol.72, issue.4, pp.967-971, 2008.

T. R. Paulus-r, M. J. Galvin-j, B. J. Straube-w, F. A. Bezjak-a, . Videtic-g et al., Stereotactic body radiation therapy for inoperable early stage lung cancer, JAMA, vol.303, issue.11, pp.1070-1076, 2010.

H. M. Mcgarry-r, Y. C. , F. A. , H. D. , and W. M. Timmerman-r, Baseline pulmonary function as a predictor for survival and decline in pulmonary function over time in patients undergoing stereotactic body radiotherapy for the treatment of stage I non-small-cell lung cancer, Int J Radiat Oncol Biol Phys, vol.72, issue.2, pp.404-409, 2008.

T. A. Ohashi-t, . Kunieda-e, . Enomoto-t, . Sanuki-n, . Takeda-t et al., Early graphical appearance of radiation pneumonitis correlates with the severity of radiation pneumonitis after stereotactic body radiotherapy (SBRT) in patients with lung tumors, Int J Radiat Oncol Biol Phys, vol.77, issue.3, pp.685-690, 2010.

B. R. , F. J. , B. J. , A. D. Shapiro-r, H. M. Johnstone-p et al., A Dose-Volume Analysis of Radiation Pneumonitis in Non-Small Cell Lung Cancer Patients Treated with Stereotactic Body Radiation Therapy, Int J Radiat Oncol Biol Phys, 2010.

P. M. , T. A. Hansen, . Petersen-j, . Grau-c, and . Hoyer-m, Aggravation of dyspnea in stage I non-small cell lung cancer patients following stereotactic body radiotherapy: Is there a dose-volume dependency?, Acta Oncol, vol.45, issue.7, pp.818-822, 2006.

C. B. Timmerman-r, Stereotactic body radiation therapy: a comprehensive review, Am J Clin Oncol, vol.30, issue.6, pp.637-644, 2007.

M. T. and C. L. Okunieff-p, Normal tissue toxicity after small field hypofractionated stereotactic body radiation, Radiat Oncol, vol.3, p.36, 2008.

J. M. Salter-b and . Papanikolaou-n, Stereotactic body radiation therapy for centrally located lung lesions, Acta Oncol, vol.45, issue.7, pp.802-807, 2006.

H. A. Sibata-c and A. R. , Isodose-based methodology for minimizing the morbidity and mortality of thoracic hypofractionated radiotherapy, Radiother Oncol, vol.91, issue.3, pp.369-378, 2009.

O. T. , T. A. Shigematsu-n, I. A. Kunieda-e, F. J. , D. H. Kawaguchi-o et al., Differences in pulmonary function before vs. 1 year after hypofractionated stereotactic radiotherapy for small peripheral lung tumors, Int J Radiat Oncol Biol Phys, vol.62, issue.4, pp.1003-1008, 2005.

F. J. Fakiris-a, . D. Timmerman-r, . S. Lo-s, . M. Perkins-s, . C. Mcgarry-r et al., Brachial plexopathy from stereotactic body radiotherapy in early-stage NSCLC: dose-limiting toxicity in apical tumor sites, Radiother Oncol, vol.93, issue.3, pp.408-413, 2009.

N. J. and J. K. Hulten-u, Stereotactic hypofractionated radiotherapy for stage I non-small cell lung cancer--mature results for medically inoperable patients, Lung Cancer, vol.51, issue.1, pp.97-103, 2006.

D. N. , C. J. Biedermann-g, Y. W. , B. S. Sheng-k, . E. Schefter-t et al., Chest wall volume receiving >30 Gy predicts risk of severe pain and/or rib fracture after lung stereotactic body radiotherapy, Int J Radiat Oncol Biol Phys, vol.76, issue.3, pp.796-801, 2009.

V. J. , H. A. , D. M. Purdy-t, . N. Franks-k, . Pearson-s et al., Chest wall pain and rib fracture after stereotactic radiotherapy for peripheral non-small cell lung cancer, J Thorac Oncol, vol.4, issue.8, pp.1035-1037, 2009.

H. W. Guiou-m, L. N. Dublin-a, . Narayan-s, P. J. Vijayakumar-s, and C. A. , Development and Validation of a Standardized Method for Contouring the Brachial Plexus: Preliminary Dosimetric Analysis Among Patients Treated With IMRT for Head-and-Neck Cancer, International Journal of Radiation Oncology*Biology*Physics, vol.72, issue.5, pp.1362-1367, 2008.

K. F. Ritter-t, Q. D. Senan-s, G. L. Komaki-r, . W. Hurkmans-c, . Timmerman-r et al., Consideration of Dose Limits for Organs at Risk of Thoracic Radiotherapy: Atlas for Lung, European Journal of Cancer, pp.228-247, 2009.

O. H. Kuriyama-k, K. T. Tanaka-s, . Sano-n, I. S. Marino-k, and A. T. , Clinical outcomes of stereotactic radiotherapy for stage I non-small cell lung cancer using a novel irradiation technique: patient self-controlled breath-hold and beam switching using a combination of linear accelerator and CT scanner, Lung Cancer, vol.45, issue.1, pp.45-55, 2004.

G. I. Mangona-v, W. R. , C. G. Mcinerney-e, M. S. , W. J. et al., Outcomes after stereotactic lung radiotherapy or wedge resection for stage I non-smallcell lung cancer, J Clin Oncol, vol.28, issue.6, pp.928-935, 2010.

V. Der, . C. Van-zyp-n, . B. Prevost-j, . Van-der-holt-b, . Braat-c et al., Quality of Life after Stereotactic Radiotherapy for Stage I Non-Small-Cell Lung Cancer, Int J Radiat Oncol Biol Phys, 2009.

M. M. Paradis-c, M. R. Houck-p, R. A. Stack-j, R. C. Mulsant-b, and 3. , Rating chronic medical illness burden in geropsychiatric practice and research: application of the Cumulative Illness Rating Scale, Psychiatry Res, vol.41, issue.3, pp.237-248, 1992.

E. A. Esterni-b, C. A. Mozziconacci-m, A. C. , C. D. Puig-b, G. J. et al., Comorbidity is an independent predictor of complete remission in elderly patients receiving induction chemotherapy for acute myeloid leukemia, Cancer, pp.1376-1383, 2007.

V. Der, . C. Van-zyp-n, . B. Prevost-j, P. S. Hoogeman-m, . Van-der-holt-b et al., Stereotactic radiotherapy with real-time tumor tracking for non-small cell lung cancer: clinical outcome, Radiother Oncol, vol.91, issue.3, pp.296-300, 2009.

C. Y. Guo-w and L. Y. Zou-b, Dose-individualized stereotactic body radiotherapy for T1-3N0 non-small cell lung cancer: long-term results and efficacy of adjuvant chemotherapy, Radiother Oncol, vol.88, issue.3, pp.351-358, 2008.

G. M. Heilman-k, W. J. Mueller-g, and . Beckmann-g, Pulmonary injury and tumor response after stereotactic body radiotherapy (SBRT): results of a serial follow-up CT study, Radiother Oncol, vol.85, issue.3, pp.435-442, 2007.

P. D. Senan-s, . T. Brown-w, . Wu-x, F. J. Fayad-f, A. B. et al., Stereotactic radiation therapy: changing treatment paradigms for stage I nonsmall cell lung cancer CyberKnife radiosurgery for stage I lung cancer: results at 36 months, Clin Lung Cancer, Curr Opin Oncol, vol.8, issue.8, pp.488-492, 2007.

M. F. , P. J. , and D. J. Bolla-m, Système d'évaluation des effets tardifs des radiations sur les tissus normaux: l'échelle SOMA- LENT, Cancer Radiother, vol.1, pp.622-627, 1997.

M. Y. Shibuya-k, N. Y. Takayama-k, N. Y. Mizowaki-t, . Narabayashi-m, . Sakanaka-k et al., Prognostic factors in stereotactic body radiotherapy for non-small-cell lung cancer, Int J Radiat Oncol Biol Phys, vol.79, issue.4, pp.1104-1111, 2011.

P. D. Senan-s, . J. Haasbeek-c, and V. F. Verbakel-w, Radiological and Clinical Pneumonitis after Stereotactic Lung Radiotherapy: A Matched Analysis of Three-dimensional Conformal and Volumetric-modulated Arc Therapy Techniques, Int J Radiat Oncol Biol Phys, 2010.

C. S. Fisher-p, C. J. Kirkbride-p, and . Q. Hatton-m, The use of lung dose-volume histograms in predicting post-radiation pneumonitis after non-conventionally fractionated radiotherapy for thoracic carcinoma, Clin Oncol (R Coll Radiol), vol.17, issue.8, pp.599-603, 2005.

F. S. Shirato-h, O. S. Shimzu-s, . Onimaru-r, Y. K. Kitamura-k, M. K. Nishimura-m et al., Small-volume image-guided radiotherapy using hypofractionated, coplanar, and noncoplanar multiple fields for patients with inoperable Stage I nonsmall cell lung carcinomas, Cancer, pp.1546-1553, 2002.

C. B. Erickson-k, R. C. , C. S. Gagnon-g, D. S. Mcrae-d, Y. S. Zhang-y et al., Radical stereotactic radiosurgery with real-time tumor motion tracking in the treatment of small peripheral lung tumors Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results, Radiat Oncol Radiat Oncol, vol.2, issue.4, p.15, 2007.

H. B. Laser-b, F. V. Kowalski-a, . Pena-greenberg-e, L. D. Yorke-e, H. M. et al., Acute skin toxicity following stereotactic body radiation therapy for stage I non-small-cell lung cancer: who's at risk?, Int J Radiat Oncol Biol Phys, vol.72, issue.5, pp.1283-1286, 2008.

C. M. Hayman-j, H. R. Ten, T. D. , and F. S. Kong-f, Long-term results of high-dose conformal radiotherapy for patients with medically inoperable T1-3N0 non-small-cell lung cancer: is low incidence of regional failure due to incidental nodal irradiation?, Int J Radiat Oncol Biol Phys, vol.64, issue.1, pp.120-126, 2006.

L. A. Rodrigues-g, . Hannouf-m, P. D. Lagerwaard-f, . S. Zaric-g, . Haasbeek-c et al., Withholding stereotactic radiotherapy in elderly patients with stage I non-small cell lung cancer and co-existing COPD is not justified: Outcomes of a markov model analysis, Radiotherapy and Oncology, 2011.

A. C. and S. F. Vens-c, Strategies to improve radiotherapy with targeted drugs, Nature Reviews Cancer, vol.11, issue.4, pp.239-253, 2011.

B. J. Harari-p, G. J. , A. N. , S. D. Cohen-r, . U. Jones-c et al., Radiotherapy plus cetuximab for squamous-cell carcinoma of the head and neck, N Engl J Med, vol.354, issue.6, pp.567-578, 2006.

P. D. , S. Y. Kraus-d, . L. Wolden-s, A. T. Lis-e, . J. Zahalsky-a et al., Concurrent cetuximab, cisplatin, and concomitant boost radiotherapy for locoregionally advanced, squamous cell head and neck cancer: a pilot phase II study of a new combined-modality paradigm, J Clin Oncol, vol.24, issue.7, pp.1072-1078, 2006.

M. J. Sempoux-c, C. J. Scalliet-p, . Humblet-y, K. J. Van-cutsem-e, C. J. Peeters-m et al., Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer, Ann Oncol, vol.18, issue.4, pp.738-744, 2007.

K. J. Packer-s, . L. Vu-h, S. E. Schwartz-m, . G. Stock-r, . C. Lo-y et al., Phase 1 study of concurrent sunitinib and image-guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: acute toxicity and preliminary response, Cancer, pp.3571-3580, 2009.

K. K. , C. K. , G. L. Albain-k, J. J. Ung-y, C. H. Lau-d et al., Phase III trial of maintenance gefitinib or placebo after concurrent chemoradiotherapy and docetaxel consolidation in inoperable stage III non-small-cell lung cancer: SWOG S0023, J Clin Oncol, vol.26, issue.15, pp.2450-2456, 2008.

K. B. Timmerman-r, Stereotactic body radiation therapy. Lippincott, 2005.

V. W. Senan-s, C. J. Slotman-b, and . J. Lagerwaard-f, Rapid delivery of stereotactic radiotherapy for peripheral lung tumors using volumetric intensity-modulated arcs, Radiother Oncol, vol.93, issue.1, pp.122-124, 2009.

W. J. Hollander-m, U. J. Bolt-r, and L. J. , Optimizing dose prescription in stereotactic body radiotherapy for lung tumours using Monte Carlo dose calculation, Radiother Oncol, vol.94, issue.1, pp.42-46, 2010.

H. U. Krieger-t and . Flentje-m, Influence of calculation model on dose distribution in stereotactic radiotherapy for pulmonary targets, Int J Radiat Oncol Biol Phys, vol.61, issue.1, pp.239-249, 2005.

W. E. Daskalov-g, L. H. Shumway-r, and C. M. Kaplan-b, Comparison of planned dose distributions calculated by Monte Carlo and Ray-Trace algorithms for the treatment of lung tumors with cyberknife: a preliminary study in 33 patients, Int J Radiat Oncol Biol Phys, vol.77, issue.1, pp.277-284, 2010.

R. D. De, . Faivre-finn-c, . Nestle-u, . W. Hurkmans-c, P. A. Le-pechoux-c et al., European organisation for research and treatment of cancer recommendations for planning and delivery of highdose , high-precision radiotherapy for lung cancer, J Clin Oncol, vol.28, issue.36, pp.5301-5310, 2010.

K. M. , T. H. Voges, . Hoevels-m, . Sturm-v, and . P. Muller-r, Computer simulation of cytotoxic and vascular effects of radiosurgery in solid and necrotic brain metastases, Radiother Oncol, vol.54, issue.2, pp.149-156, 2000.

T. M. , A. D. Bourguignon-m, C. J. Bourhis, C. J. Favaudon-v, . M. Gardès-albert et al., radiobiologie, radiothérapie et radioprotection: bases fondamentales. Hermann/Médecine, p.502, 2008.

L. T. Renner-w, G. A. Hofmann-g, . M. Thurner-e, and . S. Kapp-k, Association between single nucleotide polymorphisms in the gene for XRCC1 and radiationinduced late toxicity in prostate cancer patients, Radiotherapy and oncology, vol.98, pp.387-393, 2011.

Y. M. Zhang-l, N. B. , W. J. , W. T. Lujun-z, L. W. Dianke-y et al., association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy, int J Radiation Oncology Phys, vol.79, issue.5, pp.1402-1407, 2011.

O. M. Crompton-n, G. S. Kramar-a, L. L. Shi-y, Z. J. Sozzi-w, and . O. Mirimanoff-r, CD4 and CD8 T-lymphocyte apoptosis can predict radiation-induced late toxicity: a prospective study in 399 patients, Clin Cancer Res, vol.11, issue.20, pp.7426-7433, 2005.

H. P. Jones-l and C. B. , Modeling late effects in hypofractionated stereotactic radiotherapy, Int J Radiat Oncol Biol Phys, vol.43, issue.1, pp.199-210, 1999.

U. M. Shioda-a, . Suda-a, . Fukui-t, . Ozeki-y, . Hama-y et al., Computed tomography-guided frameless stereotactic radiotherapy for stage I non-small cell lung cancer: a 5-year experience, Int J Radiat Oncol Biol Phys, vol.51, issue.3, pp.666-670, 2001.

B. J. Badine-e, M. D. El-sayah, . Friscia-p, . Silverman-p, and . Terjanian-t, Stereotactic body radiation therapy for nonmetastatic lung cancer: an analysis of 75 patients treated over 5 years, Int J Radiat Oncol Biol Phys, vol.65, issue.1, pp.100-106, 2006.

R. U. , G. A. Mantovani-c, and C. P. Giglioli-f, Stereotactic body radiation therapy for early non-small cell lung cancer: experience at the University of Turin, J Thorac Oncol, vol.2, p.47, 2007.

J. H. Hansen-o, . Hjelm-hansen-m, and . Brink-c, Inter-and intrafractional movement of the tumour in extracranial stereotactic radiotherapy of NSCLC, Acta Oncol, vol.47, issue.7, pp.1432-1437, 2008.

M. M. , H. J. Brusasco-v, C. R. Burgos-f, . Coates-a, . Crapo-r et al., Standardisation of spirometry, Eur Respir J, vol.26, issue.2, pp.319-338, 2005.

B. E. , T. W. , C. T. , and C. B. Shimosato-y, The new World Health Organization classification of lung tumours, Eur Respir J, vol.18, issue.6, pp.1059-1068, 2001.