1 ± 1,5 mm puis celui-ci va passer à 6,3 ± 1,8 mm et 6,2 ± 1,7 mm à 1 et 5 ans respectivement Donc à 1 an, on aura gagné 3,8 ± 1,9 mm et à 5 ans, 4,1 ± 1,6 mm. Pour ce traitement, on note une petite progression du niveau d'attache jusqu'à 5 ans mais de l ,
os enregistrées sont faites à partir de radiographies Initialement et à 1 an, 10 sujets sont présents mais, au bout de 5 ans, il n'en reste que plus que 8. La moyenne de la profondeur des lésion infra-osseuses initiale est de 10,4 ± 2,5 mm puis, à 1 an, elle est de 5,6 ± 1,5 mm et enfin, à 5 ans, 2000. ,
Enamel Matrix Derivative versus bioactive ceramic filler in the treatment of intrabony defects : 12-month results, J. Periodontol, pp.219-227, 1980. ,
GTR treatment of degree III furcation defects following application of enamel matrix proteins. An experimental study in dogs, Journal of Clinical Periodontology, vol.2, issue.6, pp.524-530, 1925. ,
DOI : 10.1111/j.1365-2818.1973.tb04629.x
Leuchine-rich amelogenin Peptide: a candidate signaling molecule during cementogenesis, J . Periodontol, pp.1126-1136, 1975. ,
Primary flap closure combined with Emdogain® and Cerasorb® in the treatment of intrabony defects, J. Clin. Periodontol, pp.885-893, 1933. ,
Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels, Journal of Clinical Periodontology, vol.86, issue.(Suppl. 1), pp.87-105, 2008. ,
DOI : 10.1902/jop.1976.47.5.249
Comparison of ready-to-use Emdogain®-gel and Emdogain® in patients with chronic adult periodontitis ( a multicenter clinical study ), J. Clin. Periodontol, pp.923-929, 1928. ,
A controlled re-entry study on the effectiveness of bovine porous bone mineral used in combination with a collagen membrane of porcine origin in the treatment of intrabony defects in humans, Journal of Clinical Periodontology, vol.27, issue.12, pp.889-896, 2000. ,
DOI : 10.1034/j.1600-051x.2000.027012889.x
Treatment of deep and shallow intrabony defects ( a multicentrer randomized controlled clinical trial ), J. Clin. Periodontol, pp.981-987, 1925. ,
Treatment of intrabony defects using Guided Tissue Regeneration or Enamel Matrix Derivative : a 3 year prospective randomized clinical study, J. Periodontol, pp.2281-2289, 1979. ,
Wound healing of degree III furcation involvements following Guided Tissue Regeneration and / or Emdogain® ( a histologic study ), J. Clin. Periodontol, pp.1061-1068, 1930. ,
Enamel Matrix Proteins in the treatment of intrabony defects ( a prospective 24 -month clinical trial ), J. Clin. Periodontol, pp.52-59, 1931. ,
Osteoprotegerin and Receptor Activator of Nuclear Factor-Kappa B Ligand Modulation by Enamel Matrix Derivative in Human Alveolar Osteoblasts, Journal of Periodontology, vol.25, issue.7 ,
DOI : 10.1111/j.1600-0501.2004.01088.x
In vitro studies on periodontal ligament cells and enamel matrix derivative, Journal of Clinical Periodontology, vol.34, issue.9, pp.685-692, 1924. ,
DOI : 10.1016/0092-8674(93)90678-J
In Vitro Biologic Response of Human Bone Marrow Stromal Cells to Enamel Matrix Derivative, Journal of Periodontology, vol.3, issue.3, pp.2190-2196, 1978. ,
DOI : 10.1902/jop.2002.73.5.543
Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins, Journal of Clinical Periodontology, vol.30, issue.9, pp.669-677, 1924. ,
DOI : 10.1902/jop.1959.30.1.17
Amelogenin-mediated Regulation of Osteoclastogenesis, and Periodontal Cell Proliferation and Migration, Journal of Dental Research, vol.85, issue.2, pp.144-149, 1985. ,
DOI : 10.1016/S0945-053X(01)00155-X
Enamel Matrix Derivative ( Emdogain® ) in the treatment of inrtabony periodontal defects, J. Clin. Periodontol, pp.705-714, 1924. ,
Enamel matrix derivative induces connective growth factor expression inhuman osteoblastic cells, J. Periodontol, pp.2369-2379, 1978. ,
Clinical Evaluation of Demineralized Freeze-Dried Bone Allograft With and Without Enamel Matrix Derivative for the Treatment of Periodontal Osseous Defects in Humans, Journal of Periodontology, vol.20, issue.12, pp.792273-2280, 2008. ,
DOI : 10.1902/jop.2003.74.9.1282
Noggin blocks osteoinductive activity of porcine enamel extracts, J. Dent. Res, issue.81, pp.387-391, 2002. ,
Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivative: A Literature Review, Journal of Periodontology, vol.20, issue.11, pp.198-201, 2002. ,
DOI : 10.1034/j.1600-051x.2002.290102.x
Healing following Guided Tissue Regenerative treatment of intrabony defects distal to mandibular second molars using resorbable and non-resorbable barriers, J. Clin. Periodontol, pp.27333-340, 2000. ,
Effect of an oily hydroxyde suspension ( Osteoinductals ) on human periodontal fibroblasts. An in vitro study, Eur. J. Med. Res, issue.12, pp.268-272, 2007. ,
Cytostatic action of enamel matrix derivative (EMDOGAINR) on human oral squamous cell carcinoma-derived SCC25 epithelial cells, Journal of Periodontal Research, vol.35, issue.5, pp.291-300, 2000. ,
DOI : 10.1034/j.1600-0765.2000.035005291.x
Enamel matrix derivative ( Emdogain® ) rapidly stimulates phophorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells, J. Periodontal Res, issue.36, pp.367-376, 2001. ,
Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation, Journal of Periodontal Research, vol.37, issue.4, pp.37255-262, 2002. ,
DOI : 10.1034/j.1600-0765.2002.01615.x
In vitro assessment of motility and proliferation of human osteogenic cells on different isolated extracellular matrix components compared with enamel matrix derivative by continuous single-cell observation, Clinical Oral Implants Research, vol.14, issue.1, pp.40-45, 2007. ,
DOI : 10.1034/j.1600-0501.2001.012004332.x
Enamel matrix derivative alone or in combination with a bioactive glass in wide intrabony defects, Clinical Oral Investigations, vol.74, issue.3, pp.227-234, 2006. ,
DOI : 10.1902/jop.1982.53.12.726
Guided tissue regeneration/deproteinized bovine bone mineral or papilla preservation flaps alone for treatment of intrabony defects. II: radiographic predictors and outcomes, Journal of Clinical Periodontology, vol.64, issue.5, pp.33351-358, 2006. ,
DOI : 10.1016/0030-4220(51)90084-9
Periodontal tissue alterations following Emdogain® treatment of periodontal sites with angular bone defects ( a series of case reports ), J. Clin. Periodontol, issue.26, pp.855-860, 1999. ,
Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative, Journal of Clinical Periodontology, vol.35, issue.2, pp.181-188, 1928. ,
DOI : 10.1083/jcb.120.1.253
Possible involvement of extracellular signal-regulatedkinase 1 ,
Effects of a topical enamel matrix derivative on skin wound healing. Wound Repair Regen, pp.100-108, 2004. ,
Porcine enamel protein fractions contain transforming growth factor-b1, J.Periodontol, issue.77, pp.1688-1694, 2006. ,
DOI : 10.1902/jop.2006.050352
Atlas clinique de chirurgie parodontale, Paris : Quintescence international, vol.447, 2002. ,
The Influence of Enamel Matrix Derivative Associated With Insulin-Like Growth Factor-I on Periodontal Ligament Fibroblasts, Journal of Periodontology, vol.17, issue.4, pp.75498-504, 2004. ,
DOI : 10.1902/jop.2000.71.8.1287
Effect of Enamel Matrix Derivative on the Differentiation of C2C12 Cells, Journal of Periodontology, vol.265, issue.5, pp.543-550, 2002. ,
DOI : 10.1083/jcb.105.2.949
Participation of endogenous IGF-1 and TGF-?1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells, J. Periodontal Res, pp.1-9, 1938. ,
Clinical and radiographic findings following application of enamel matrix derivative in the treatment of intrabony defects. A series of case reports, Journal of Clinical Periodontology, vol.27, issue.9 ,
DOI : 10.1034/j.1600-051x.2000.027009705.x
Gene Expression Profiles of Periodontal Ligament Cells Treated With Enamel Matrix Proteins In Vitro: Analysis Using cDNA Arrays, Journal of Periodontology, vol.66, issue.11, pp.751539-1546, 2004. ,
DOI : 10.1177/00220345010800030701
Treatment of intrabony defects with resorbable materials, nonresorbable materials and flap debridement, J. Clin. Periodontol, pp.169-178, 1927. ,
A comparative study on the use of Bio-Oss® and Enamel Matrix Derivative ( Emdogain® ) in the treatment of periodontal bone defects, J. Clin. Periodontol, issue.109, pp.178-181, 2001. ,
Effects of an enamel matrix deriative on human osteoblasts and PDL cells grown in organoid cultures, Oral Surg. Oral Med., Oral Pathol., Oral Radiol, vol.1, pp.2551-557, 2006. ,
Clinical evaluation of Bio-Oss® : a bovine-derived xenograft for the treatment of periodontal osseous defects in humans, J. Clin. Periodontol, issue.26, pp.421-428, 1999. ,
Enhanced proliferation, attachment and osteopontine expression by porcine periodontal cells exposed to Emdogain®, Arch. Oral biol, pp.1047-1054, 1950. ,
Effects of enamel matrix derivative and transforming growth factor-b1 on human periodontal ligament fibroblasts, J.Clin.Periodontol, pp.514-522, 1934. ,
In Vitro Effects of Enamel Matrix Derivative on Microvascular Cells, Journal of Periodontology, vol.7, issue.1, pp.141-151, 1978. ,
DOI : 10.1034/j.1600-0765.2003.00690.x
Porcine Fetal Enamel Matrix Derivative Stimulates Proliferation But Not Differentiation of Pre-Osteoblastic 2T9 Cells, Inhibits Proliferation and Stimulates Differentiation of Osteoblast-Like MG63 Cells, and Increases Proliferation and Differentiation of Normal Human Osteoblast NHOst Cells, Journal of Periodontology, vol.122, issue.8, pp.711287-1296, 2000. ,
DOI : 10.1002/jcb.240500411
Healing of human intrabony defects following treatment with enamel matrix proteins or guided tissue regeneration, Journal of Periodontal Research, vol.22, issue.6, pp.310-322, 1934. ,
DOI : 10.1111/j.1600-051X.1987.tb00956.x
Treatment of intrabony defects with guided tissue regeneration and enamel-matrix-proteins. An experimental study in monkeys, Journal of Clinical Periodontology, vol.27, issue.7, pp.27466-472, 2000. ,
DOI : 10.1034/j.1600-051x.2000.027007466.x
Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study, Journal of Clinical Periodontology, vol.18, issue.5, pp.397-403, 1928. ,
DOI : 10.1902/jop.1998.69.11.1183
Healing of intrabony defects following treatment with a bovinederived xenograft and collagen membrane ( a controlled clinical study ), J. Clin ,
Five year results following treatment of intrabony defects with Enamel Matrix Proteins and Guidee Tissus Regeneration, J. Clin. Periodontol, pp.545-549, 1927. ,
Healing of human intrabony defects following regenerative periodontal therapy with an enamel matrix protein derivative alone or combined with a bioactive glass. A controlled clinical study, Journal of Clinical Periodontology, vol.73, issue.1, pp.32111-117, 2005. ,
DOI : 10.1034/j.1600-051X.2002.290508.x
Ten year result after treatment of intrabony defects with an 127 ,
Ten year result following treatment of intrabony defects with Enamel Matrix Proteins and Guided Tissue Regeneration, J. Clin. Periodontol, pp.817-824, 1935. ,
The combined use of Enamel Matrix Proteins and a tetracyclinecoated expanted polytetrafluoroethylene barrier membrane in the treatment of intra-osseous defects, J. Clin. Periodontol, pp.32765-772, 2005. ,
Five-year results of guided tissue regeneration in combination with deproteinized bovine bone (Bio-Oss) in the treatment of intrabony periodontal defects: a case series report, Clinical Oral Investigations, vol.22, issue.4, pp.271-277, 2005. ,
DOI : 10.1111/j.1600-0528.1994.tb02050.x
Bovine bone mineral ( Bio-Oss® ) in the treatment of intrabony periodonal defects : 6-year results from a randomized-controlled clinical trial, J ,
Amelogenins regulate expression of genes associated with cementoblasts in vitro, European Journal of Oral Sciences, vol.44, issue.s1, pp.239-243, 2006. ,
DOI : 10.1016/0003-9969(91)90101-Y
Enamel Factors Regulate Expression of Genes Associated With Cementoblasts, Journal of Periodontology, vol.106, issue.12, pp.1829-1839, 2000. ,
DOI : 10.1111/j.1600-0722.1998.tb02188.x
Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects, Journal of Clinical Periodontology, vol.29, issue.3, pp.311092-1098, 2004. ,
DOI : 10.1902/jop.1993.64.10.934
Baseline radiographic defect angle of the intrabony defect as a prognosic indicator in regenerative periodontal surgery with Enamal Matrix Derivative, J ,
Clinical outcomes following treatment of human intrabony defects with GTR/bone replacement material or access flap alone. A multicenter randomized controlled clinical trial, Journal of Clinical Periodontology, vol.22, issue.3, pp.31770-776, 2004. ,
DOI : 10.1034/j.1600-051X.2002.290407.x
Improved wound stability with a modified minimally invasive surgical technique in the regenerative treatment of isolated interdental intrabony defects, J ,
Autogenous bone graft in conjunction with enamel matrix derivative in the treatment of deep periodontal intra-osseous defects: a report of 13 consecutively treated patients, Journal of Clinical Periodontology, vol.74, issue.3, pp.3369-75, 2006. ,
DOI : 10.1902/jop.2000.71.5.752
The effect of Emdogain on the growth and differentiation of rat bone marrow cells, J. Periodontal Res, pp.471-476, 1941. ,
Enamel-matrix-derived proteins stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor ?1 release of periodontal ligament and gingival fibroblasts, J. Periodontol, pp.7131-7174, 2000. ,
Amelogenin: A Potential Regulator of Cementum-Associated Genes, Journal of Periodontology, vol.5, issue.10, pp.1423-1431, 2003. ,
DOI : 10.1006/jsbi.1994.1011
Guided Tissue Regeneration in intrabony periodontal deects 129 following treatment with two bioabsorbable membranes in combination with bovine bone mineral graft ( a clinical and radiographic study ), J. Clin. Periodontol, pp.31908-917, 2004. ,
Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: a controlled clinical study, Journal of Clinical Periodontology, vol.68, issue.6, pp.496-504, 1930. ,
DOI : 10.1902/jop.1997.68.10.996
The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect, Journal of Periodontal Research, vol.275, issue.3, pp.333-342, 1938. ,
DOI : 10.1016/S0934-8832(11)80080-6
Enamel matrix derivative exhibits angiogenic effect in vitro and in a murine model, Journal of Clinical Periodontology, vol.73, issue.8, pp.732-738, 1930. ,
DOI : 10.1902/jop.2002.73.7.701
ERK, Journal of Dental Research, vol.86, issue.1, pp.41-46, 2007. ,
DOI : 10.1002/cyto.990030503
Enamel matrix derivative protects human gingival fibroblasts from TNF-induced apoptosis by inhibiting caspase activation, Journal of Cellular Physiology, vol.86, issue.3, pp.750-758, 0213. ,
DOI : 10.1177/00220345740530020101