B. Lubamba, B. Dhooghe, S. Noel, and T. Leal, Cystic fibrosis: Insight into CFTR pathophysiology and pharmacotherapy, Clinical Biochemistry, vol.45, issue.15, pp.1132-1176, 2012.
DOI : 10.1016/j.clinbiochem.2012.05.034

M. Britto, U. Kotagal, R. Hornung, H. Atherton, J. Tsevat et al., Impact of Recent Pulmonary Exacerbations on Quality of Life in Patients With Cystic Fibrosis, Chest, vol.121, issue.1, pp.64-72, 2002.
DOI : 10.1378/chest.121.1.64

A. Hauser, M. Jain, M. Bar-meir, and S. Mccolley, Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis, Clinical Microbiology Reviews, vol.24, issue.1, pp.29-70, 2011.
DOI : 10.1128/CMR.00036-10

E. Vanderhelst, D. Meirleir, L. Verbanck, S. Piérard, D. Vincken et al., Prevalence and impact on FEV1 decline of chronic methicillin-resistant Staphylococcus aureus (MRSA) colonization in patients with Cystic Fibrosis, Journal of Cystic Fibrosis, vol.11, issue.1, pp.2-7
DOI : 10.1016/j.jcf.2011.08.006

M. Parkins and R. Floto, Emerging bacterial pathogens and changing concepts of bacterial pathogenesis in cystic fibrosis, Journal of Cystic Fibrosis, vol.14, issue.3, pp.293-304
DOI : 10.1016/j.jcf.2015.03.012

M. Muhlebach, S. Heltshe, E. Popowitch, M. Miller, V. Thompson et al., Multicenter Observational Study on Factors and Outcomes Associated with Different MRSA Types in Children with Cystic Fibrosis, 2015.

E. Champion, M. Miller, E. Popowitch, M. Hobbs, L. Saiman et al., Antimicrobial susceptibility and molecular typing of MRSA in cystic fibrosis, Pediatric Pulmonology, vol.52, issue.3, pp.230-237, 2014.
DOI : 10.1128/AAC.01395-07

B. Kahl, Impact of Staphylococcus aureus on the pathogenesis of chronic cystic fibrosis lung disease, International Journal of Medical Microbiology, vol.300, issue.8, pp.514-523, 2010.
DOI : 10.1016/j.ijmm.2010.08.002

V. Eiff, C. Peters, G. Becker, and K. , The small colony variant (SCV) concept???the role of staphylococcal SCVs in persistent infections, Injury, vol.37, issue.2, pp.26-33, 2006.
DOI : 10.1016/j.injury.2006.04.006

A. Rivier, Intérêt d'un milieu chromogène pour la détection des variants à petites colonies de Staphylococcus aureus Epidémiologie bactérienne des patients atteints de mucoviscidose suivis au Centre de Ressources et de Compétences de la Mucoviscidose de Nancy en 1997 et en, 2007.

S. Besier, C. Smaczny, C. Von-mallinckrodt, A. Krahl, H. Ackermann et al., Prevalence and Clinical Significance of Staphylococcus aureus Small-Colony Variants in Cystic Fibrosis Lung Disease, Journal of Clinical Microbiology, vol.45, issue.1, pp.168-72, 2007.
DOI : 10.1128/JCM.01510-06

D. Wolter, J. Emerson, S. Mcnamara, A. Buccat, X. Qin et al., Staphylococcus aureus Small-Colony Variants Are Independently Associated With Worse Lung Disease in Children With Cystic Fibrosis, Clinical Infectious Diseases, vol.74, issue.3, pp.384-91, 2013.
DOI : 10.1159/000098405

URL : https://hal.archives-ouvertes.fr/pasteur-01133166

P. Morelli, A. De-alessandri, G. Manno, A. Marchese, M. Bassi et al., Characterization of Staphylococcus aureus small colony variant strains isolated from Italian patients attending a regional cystic fibrosis care centre, New Microbiol. 2015, vol.38, issue.2, pp.235-278

G. Doring, S. Conway, H. Heijerman, M. Hodson, N. Hoiby et al., Antibiotic therapy against Pseudomonas aeruginosa in cystic fibrosis: a European consensus, European Respiratory Journal, vol.16, issue.4, pp.749-67, 2000.
DOI : 10.1034/j.1399-3003.2000.16d30.x

B. Rosenstein and G. Cutting, WHAT IS A CYSTIC FIBROSIS DIAGNOSIS?, Clinics in Chest Medicine, vol.19, issue.3, pp.589-95, 1998.
DOI : 10.1016/S0272-5231(05)70091-5

C. Demko, P. Byard, and P. Davis, Gender differences in cystic fibrosis: Pseudomonas aeruginosa infection, Journal of Clinical Epidemiology, vol.48, issue.8, pp.1041-1050, 1995.
DOI : 10.1016/0895-4356(94)00230-N

S. Lanng, B. Thorsteinsson, J. Nerup, and C. Koch, Influence of the development of diabetes mellitus on clinical status in patients with cystic fibrosis, European Journal of Pediatrics, vol.727, issue.Suppl 1, pp.684-691, 1992.
DOI : 10.1007/BF01957574

K. Mohan, K. Israel, H. Miller, R. Grainger, M. Ledson et al., Long-Term Effect of Insulin Treatment in Cystic Fibrosis-Related Diabetes, Respiration, vol.51, issue.2, pp.181-187, 2008.
DOI : 10.1136/bmj.311.7006.655

E. Mckone, C. Goss, and M. Aitken, CFTR Genotype as a Predictor of Prognosis in Cystic Fibrosis, Chest, vol.130, issue.5, pp.1441-1448, 2006.
DOI : 10.1378/chest.130.5.1441

J. Broeck, D. Willie, and N. Younger, The World Health Organization child growth standards: expected implications for clinical and epidemiological research, European Journal of Pediatrics, vol.2, issue.2, pp.247-51, 2008.
DOI : 10.1017/PHN20062005

F. Counil, C. Karila, L. Bourgeois, M. Matecki, S. Lebras et al., Cystic fibrosis: how to use pulmonary function tests]. Rev Mal Respir, pp.691-701, 2007.

P. Quanjer, S. Stanojevic, T. Cole, X. Baur, G. Hall et al., Multi-ethnic reference values for spirometry for the 3?95 year age range: the global lung function 2012 equations, Eur Respir J, p.2012

S. Française-de-microbiologie, Infections broncho-pulmonaires et mucoviscidose, Rémic. 5ème édition, p.370, 2015.

P. Y. Allouch, O. Bajolet, E. Bingen, G. Chabanon, J. P. Flandrois et al., Recommandations pour l'analyse bactériologique des prélèvements d'expectorations chez les patients atteints de mucoviscidose, pp.99-104

L. Miall, N. Mcginley, K. Brownlee, and S. Conway, Methicillin resistant Staphylococcus aureus (MRSA) infection in cystic fibrosis, Archives of Disease in Childhood, vol.84, issue.2, pp.160-162, 2001.
DOI : 10.1136/adc.84.2.160

URL : http://adc.bmj.com/content/archdischild/84/2/160.full.pdf

G. Sawicki, L. Rasouliyan, D. Pasta, W. Regelmann, J. Wagener et al., detection on pulmonary function in cystic fibrosis, Pediatric Pulmonology, vol.43, issue.11, pp.1117-1140, 2008.
DOI : 10.1128/JCM.43.7.3341-3345.2005

E. Dasenbrook, C. Merlo, M. Diener-west, N. Lechtzin, and M. Boyle, Decline in Cystic Fibrosis, American Journal of Respiratory and Critical Care Medicine, vol.178, issue.8, pp.814-835, 2008.
DOI : 10.1164/rccm.200403-404OC

E. Dasenbrook, W. Checkley, C. Merlo, M. Konstan, N. Lechtzin et al., Association between respiratory tract methicillin-resistant Staphylococcus aureus and survival in cystic fibrosis, 2010.
DOI : 10.1001/jama.2010.791

J. Cogen, J. Emerson, D. Sanders, C. Ren, M. Schechter et al., Risk factors for lung function decline in a large cohort of young cystic fibrosis patients, Pediatric Pulmonology, vol.28, issue.8, pp.763-70, 2015.
DOI : 10.1002/(SICI)1099-0496(199911)28:5<321::AID-PPUL3>3.0.CO;2-V

C. Ren, W. Morgan, M. Konstan, M. Schechter, J. Wagener et al., Presence of methicillin resistantStaphylococcus aureus in respiratory cultures from cystic fibrosis patients is associated with lower lung function, Pediatric Pulmonology, vol.126, issue.6, pp.513-521, 2007.
DOI : 10.1164/ajrccm/144.2.331

K. Nadesalingam, S. Conway, and M. Denton, Risk factors for acquisition of methicillin-resistant Staphylococcus aureus (MRSA) by patients with cystic fibrosis, Journal of Cystic Fibrosis, vol.4, issue.1, pp.49-52, 2005.
DOI : 10.1016/j.jcf.2004.09.002

J. Zobell, K. Epps, D. Young, M. Montague, J. Olson et al., Utilization of antibiotics for methicillin-resistant Staphylococcus aureus infection in cystic fibrosis: Survey of Anti-MRSA Antibiotics in CF, Pediatr Pulmonol, 2015.

D. Lo, M. Hurley, M. Muhlebach, and A. Smyth, Interventions for the eradication of meticillin-resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis, Cochrane Database of Systematic Reviews, vol.43, issue.2, p.9650, 2015.
DOI : 10.1002/14651858.CD009650.pub2

M. Schneider, K. Mühlemann, S. Droz, S. Couzinet, C. Casaulta et al., Clinical Characteristics Associated with Isolation of Small-Colony Variants of Staphylococcus aureus and Pseudomonas aeruginosa from Respiratory Secretions of Patients with Cystic Fibrosis, Journal of Clinical Microbiology, vol.46, issue.5, 2008.
DOI : 10.1128/JCM.00361-08

S. Yagci, G. Hascelik, D. Dogru, U. Ozcelik, and B. Sener, Prevalence and genetic diversity of Staphylococcus aureus small-colony variants in cystic fibrosis patients, Clinical Microbiology and Infection, vol.19, issue.1, pp.77-84, 2013.
DOI : 10.1111/j.1469-0691.2011.03742.x