Y. , K. Jz-r, T. R. , C. V. , L. M. Verin et al., Dopaminergicneurons intrinsic to the primate striatum, Anatomy of the dopamine system in the basal ganglia Aspects cliniques et thérapeutiques de la maladie de Parkinson HERRERO MT et coll. Re-evaluation of the functional anatomy of the basal ganglia in normal and Parkinson states, pp.28-33, 1997.

B. T. , B. E. , B. B. , and G. Ce, From single extracellular unit recording in experimental and human parkinsonism to the development of a functinal concept of the role played by the basal ganglia in motor control, Prog Neurobiol, vol.66, pp.265-283, 2002.

G. I. Bergman-h, Stepping out of the box : Information processing in the neural networks of the basal ganglia, Curr Opin Neurobiol, vol.11, pp.689-695, 2001.

B. , B. P. , C. Jr, and G. C. , Fonctions motrices, pp.17-19, 2004.

J. Op, The mysterious motor functionof the basal ganglia : the Robert Wartemberg lecture, L. VERIN M. Op. cit 61 NIEOULLON A. Op.cit 62 EBADI M. PFEIFFER RF. Parkinson s disease, pp.514-539, 1982.

. Ibid, G. Hornykiewicz-o-e, A. Am, and . Ya, Biochemical aspects of Parkinson mical aspects of Parkinson s disease Melanized dopaminergic neurons are differencially susceptible to degeneration in Parkinson s disease, Neurology Nature, vol.51, issue.334, pp.2-9, 1988.

P. Rg, A role for alpha-synuclein in the regulation of dopamine biosynthesis Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system, 3090. 73 EBADI M. Op. cit. 74 ABELIOVICH A M. Op. cit. 76 ZAGNOLI F. Op. cit. P14 77 Ibid, pp.239-252, 2002.

G. , W. Ac, and M. Sp, Chronic Parkinsonism secondary to intravenous injection of meperidine analogues, Psychiatry Res, vol.1, pp.249-254, 1979.

M. , E. M. Mankodi, and A. , Acute and reversible parkinsonism due to organophosphate pesticide intoxication five cases, Neurology, vol.52, pp.1467-1471, 1999.

B. , M. Sa, and T. K. , Occupational and environmental risk factors for Parkinson s disease, Parkinsonism Rel Disord Nature Reviews Neuroscience, vol.8, issue.4, pp.297-309, 2002.

T. Cm, Parkinson Disease in twins : an etiology study, JAMA, vol.281, 1999.

J. Quevauvilliers-g and D. L. , Dictionnaire médical de poche Trouble de la marche dans la maladie de Parkinson, Press Med, vol.30, pp.443-468, 2001.

E. , U. Hbm, and H. Pv, A 100 % increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson s disease, Mov Disord, vol.19, pp.687-692, 2004.

E. , B. Bf, and S. Mh, Rapid eye movement sleep behaviour disorder : demographic, clinicaland laboratory finding in 93 cases, Brain, vol.123, pp.331-339, 2000.

. P. Ibid, P. J. Marsden-cd, and F. S. Marsden-cd, Fluctuations of disability in Parkinson s disease : clinical aspects, 105 DEFEBVRE L, VERIN M. Op. cit. p52, pp.104-96, 1982.

L. , K. S. , and C. Tn, Classification of fluctuations in patientswith Parkinson s disease Pathophysiology of motor reponse complications in Parkinson s disease ; hypotheses on the only why, where and what, NP Neurology Mov Disord, vol.51, issue.15, pp.25-29, 1998.

D. L. , V. M. Op, W. Cit, and S. G. , Hallucinations in Parkinsonian motor fluctuations, Behav Neurol, vol.5, pp.83-86, 1992.

G. F. , C. F. , and G. Mp, Motor and cognitive performance of parkinsonian patients in the on and off phases of the disease, J Neurol Neurosurg Psychiatr, vol.49, pp.657-660, 1986.

P. , V. M. , V. M. Op, M. Sharpless-ns, and T. Gm, Dyskinésies provoquées par la L-dopa Patterns of dystonia (« I-D-I » and « D-I-D ») in response to L-dopa therapy for Parkinson s disease, Rev Neurol Mayo Clin. Proc, vol.158, issue.52, pp.7-92, 1997.

V. , Z. W. , A. C. , D. L. , and V. M. Op, Balance control in Parkinson s disease, Gait Post, vol.1, issue.116, pp.77-84, 1993.

L. , P. Rf, and Q. Emm, Gastrointestinal symptoms in Parkinson disease, Mov Disord, vol.6, pp.151-156, 1991.

L. , Q. Emm, and P. Rf, Gastrointestinal dysfunction in Parkinson s disease : frequency and physiopathology, P. Op. cit. p672 124 Ibid p670 125 SENARD JM. Troubles tensionnels au cours de la Maladie de Parkinson, pp.726-732, 1992.

P. Guide-pratique-des-médicaments, O. T. Kitahara-m, K. S. Bonnet, P. J. Am, and V. M. , 28 ème édition) p588 128 ARAKI I Voiding dysfunction and Parkinson s disease : urodynamic abnormalities and urinary symptoms Urinary disturbances in striatonigral degeneration and Parkinson s disease : clinical and urodynamic aspects, J Urol Mov Disord, vol.164, issue.12, pp.1640-1643, 1997.

D. Sphincter, E. Rg, J. M. , Q. N. , and M. Cd, Sexual dysfunction in patients with Parkinson s Disease and their partners, Mov Disord J Neurol Neurosurg Psichiatr, vol.16, issue.53, pp.600-607, 1990.

C. , W. Wj, S. , and A. M. , Sexual function in patients with Parkinson s Disease, J Neurol Neurosurg Psichiatr, vol.10, p.942, 1991.

M. , R. Dm, and M. Cr, Dimensions of sexual dysfunction in Parkinson s Disease, An J Geriatr Psychiatry, vol.12, pp.221-226, 2004.

A. , B. Jh, and P. Bj, Survival study of Parkinson disease in Olmstead County, Minesota, Arch Neurol, vol.60, pp.91-96, 2003.

K. , B. Mmb, and H. C. , Prognosis with Parkinson s disease in Europe : a collaborative sutdy of population-based cohorts, Neurology, vol.54, issue.suppl5, pp.24-27, 2000.

H. A. Bogaard-jm, M. Jd, . Van-der-meche, and . Fga, Pulmonary function in Parkinson s disease, J Neurol Neurosurg Psychiatr, vol.52, pp.329-333, 1989.

M. M. , S. F. , and T. Sr, Alterations of thermoregulation in Parkinson s disease, Funct Neurol, vol.6, pp.279-283, 1991.

L. and S. A. Viswanathanr, Sweating dysfunction in Parkinson s disease, Mov Disord, vol.12, pp.1459-1463, 2003.

C. , T. Cm, and L. M. , Pain in Parkinson s disease, Mov Disord, vol.1, pp.45-49, 1986.

R. , B. Cr, and I. Rp, Pain and sensory symptoms in Parkinson s disease, Int J Neurosci, vol.39, pp.15-25, 1988.

P. , C. Db, S. A. , and F. J. , A review of normal sleep and its disturbances in Parkinson s disease, Parkinsonism Rel Disord, vol.5, pp.1-17, 1999.

R. , D. A. Findley-l, and W. Sc, The Parkinson fatigue scale, Parkinsonism Relat Disord, vol.11, pp.49-55, 2005.

L. , M. A. , and W. Wj, The effect of pregnancy in Parkinson disease, Mov Disord, vol.15, pp.132-135

R. , M. Cd-defebvre-l, V. M. Op, K. Van-den-wildenberg, S. Wp et al., Internal versus external cues and the control of attention in Parkinson s disease Neurocognitive mecanisms of cognitive control : the role of prefrontal cortex in action selection, response inhibition, performance, monitoring, and reward-based learning, Brain Brain Cogn, vol.111, issue.56, pp.323-345, 1988.

D. L. , V. M. Op, A. K. , and L. Jp, Cognitive dysfunction in Parkinson s disease : the role of frontostriatal circuitry Prevalence and characteristics of dementia in Parkinson disease : an 8-year propective study, AM Neuroscientist Arch Neurol, vol.10, issue.60, pp.525-537, 2003.

I. Mckeith, G. D. , and K. K. , Consensus guidelines for the clinical and pathologic diagnosis of dementia with Lewy bodies (DLB): Report of the consortium on DLB international workshop, Neurology, vol.47, issue.5, pp.1113-1124, 1996.
DOI : 10.1212/WNL.47.5.1113

L. Afg, E. Van-der-akker-m, and . Ktjl, Higher incidence of depression preceding the onset of Parkinson s disease : a register study, Mov disord, vol.18, pp.414-418, 2003.

A. , V. Der-akker-m, and E. Ktjl, Increased risk of Parkonson s diseas after depression. A retrospective cohort study, Neurology, vol.58, pp.1501-1504, 2002.

A. Walshk, B. G. , K. R. , and P. D. , Depression in Parkinson s disease : conceptual issues and clinical challenges Parkinson s disease and anxiety Punding in Parkinson s disease : ist relation to the dopamine dysregulation syndrome, J Gériatr Psychiatry Neurol Postgrad Med J Mov Disord, vol.17, issue.19, pp.120-126, 2001.

W. and L. Aj, The relevance of Lewy body to the pathogenesis of idiopathic Parkinson s disease, J Neurol Neurosurg Psychiatry, vol.51, pp.745-752, 1988.

Z. Zx and R. Cg, CM Epidemiology of Parkinson s disease Worldwilde occurrence of Parkinson s disease : an updated review, Neurol Clin Neuroepidemiology, vol.10, issue.12, pp.317-329, 1992.

R. Mc, L. Lj, and . Berger-k, Prevalence of Parkinson s disease in Europe : a collaborative study of population-based cohorts, Neurology, vol.54, issue.5, pp.21-23, 2000.

F. , D. Jf, D. F. , R. Mc, and L. Lj, Prevalence of the Parkinson s disease in the Elderly : a population study in Gironde France Prevalence of the Parkinson s disease in the Elderly : a population study in Gironde France Systematic review of incidence studies of Parkinson s disease, CM. Op. cit. 178 DE, pp.110-115, 1994.

A. , B. Jh, and P. Bj, Survival study of Parkinson disease in Olmstead County, Minesota, Arch Neurol, vol.60, pp.91-96, 2003.

P. , S. As, and . Fredrickson-m, Survival time, mortality, and cause of death in elderly patients with Parkinson s Disease : a 9-year follow up, Mov Disord, vol.18, pp.1312-1316, 2003.

B. Berger-k and H. C. Mmb, Prognosis with Parkinson s disease in Europe : a collaborative sutdy of population-based cohorts, Neurology, vol.54, issue.suppl5, pp.24-27, 2000.

H. , M. Rj, and C. P. , Selegiline : an appraisal of it pharmacoeconomics and quality of life benefits in Parkinson s disease, Pharmacoeconomics, vol.2, pp.118-136, 1992.

. Landry-y, . Op, O. Cit, B. Dj, K. Ad et al., A five year study of incidence of dyskinésia in patients with early pParkinson s disease who were treated with ropinirole or levodopa Parkinson study group. Pramipexole versus levodopa as initial treatement for Parkinson disease a 4 year randomized control trial, F. Op. cit. P78 204 Ibid. 205 Ibid 206 Ibid, pp.1484-1491, 1992.

U. , L. Jp, and S. A. , Entocapone enhance the restponse to levodopa in parkinsonian patients with motor fluctuation, Neurology, vol.51, pp.1309-1314, 1998.

M. , A. Ch, and H. Ms, Tolcapone improved motor function and reduces levodopa requirement in patients with Parkinson s disease experiencing motor fluctuation : a multicenter double-blind randomized placebo-controlled trial, Neurology, vol.48, pp.81-87, 1997.

R. , E. Acj, and P. Dc, Amantadine in the treatment of Parkinson s disease, J Am Med Assoc, vol.208, pp.1168-1170, 1969.

P. , K. S. , and C. Tn, Amantadine reduces Levodopa-induced dyskinesias in parkinsonian monkeys, Mov Disord, vol.13, pp.798-802, 1998.

O. , B. Dj, and K. Ad, A five year study of incidence of dyskinésia in patients with early pParkinson s disease who were treated with ropinirole or levodopa, N Engl J M, vol.342, pp.1484-1491, 2000.

G. , W. H. , and M. Rm, Core assessment program for surgical interventional therapies in Parkinson s disease (CAPSIT-PD), Mov Disord, vol.14, pp.572-584, 1999.

V. , H. Jl, L. C. , L. , V. M. Op et al., Résultats cliniques et économiques de la stimulation du noyau sous thalamique dans la maladie de Pakinson Introduction to the programming of deep brain stimulators, Rev Neurol (Paris) Mov Disord, vol.161, issue.17 3, pp.15-16, 2002.

D. L. , V. M. Op, P. , B. Da, B. Pm et al., A comparison of continuous thalamic stimulation and thalatomiy for suppression of severe tremor Cell remplacement therapy for Parkinson s disease Transplanted adrenal chromaffin cells in rat brain reduce lesion-induced rotational behaviour, N. Engl. J. Med. Biochim. Biophys Acta Nature, vol.342, issue.292, pp.461-468, 1981.

W. , P. M. Becker, K. W. Olanow-cw, G. Cg, S. Gt et al., Intracerebral adrenal medulla grafts : a review Autologous transplantation of adrenal medulla in Parkinson s disease. 18 month results Putative chromaffin cel survival and enhanced hostderived TH-fiber innervation following a functional adrenal medulla autograft for Parkinson s disease Clinical outcome of cotransplantation of peripherial nerve and adrenal medulla in patients with parkinson s disease. Clinica Puerta de Hierro Neural Transplantation Group, Exp. Neurol. Arch. Neurol. Ann. Neurol. J. Neurosurg, vol.110, issue.90, pp.139-166, 1990.

. Ainsi-que:-howel, B. Ll, and . Ld, Behavioral Evaluation of Hemiparkinsonian MPTP Monkeys following Dopamine Pharmacological Manipulation and Adrenal Co-Graft Transplantation, Cell Transplantation, vol.654, issue.5, pp.609-622, 2000.
DOI : 10.1111/j.1749-6632.1992.tb25967.x

L. , B. Eo, and E. T. Freedman-r, Intraputaminal infusion of nerve growth factor to support adrenal medullary autografts in Parkinson s disease. One year follow-up of first clinical trial, Arch. Neurol, vol.48, pp.373-381, 1991.

E. Ef and . Montoro-rj, Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell agregates Autotransplantation of human carotid body cell aggregates for treatment of Parkinson s disease s Disease : a clinical and positron emission tomography study, Neuron. Neurosurgery J Neurol Neurosurg Psychiatry, vol.20, issue.78, pp.197-206, 1998.

S. and P. Gr, Direct infusion of glial cell line-derived neurotrophic factor in Parkinson disease, Nat. Med, vol.9, pp.589-595, 2003.

B. Mckay and . Goodman-b, Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: Results from an in vitro model system, Experimental Neurology, vol.201, issue.1, pp.234-243, 2006.
DOI : 10.1016/j.expneurol.2006.04.016

J. Poirier, Service d'Histologie -Embryologie

. Subramanian-d, Striatalxénotransplantation of human retinal pigment epithelial cells attached to microcarriers in hemiparkinsonian rats ameliorates behavioral deficits without provoking a host immune response, Cell Transplant, vol.11, pp.207-214, 2002.

. Spheramine, titanpharm.com/products-trials.php. 248 PERLOW MJ and al. Brain grafts reduce motor abnormalities produced by destruction of nigro-striatal dopamin system, Science, vol.204, pp.643-647, 1979.

F. Cr, Transplantation of embryonic dopamine neurons for severe Parkinson s disease, N. Engl. J. Med, vol.344, pp.710-719, 2001.

E. and L. Jy, Lewy bodies in grafted neurons in subjects with Parkinson s disease suggesting host-to-graft disease propagation, Nat. Med, vol.14, pp.501-503, 2008.

A. Jp, Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease, J. Biol. Chem, vol.281, pp.29739-29752, 2006.

P. Xenografts and G. Press-release, asp ; http///www.genvec.com/go.cfm?do=Press.View&prid=141 264 GOSS RJ. Principles of regeneration 265 NOTTEBOHM F. « The road we travelled : discovery, choregraphy, and significance of brain remplaceable neurons, Ann. N. Y. Acad Sci, vol.1016, pp.628-658, 1969.

A. Kirn-jr and N. F. , Birth of projection neurons in adult avian brain may be related to perceptual or motor learning, Science, vol.249, issue.4975, pp.1444-1446, 1990.

. Sa, 3H-Thymidine-radiographic Studies of neurogenesis in the rat olfactory bulb, Exp. Brain Res, vol.50, pp.329-340, 1983.

G. , C. H. Mclean, H. , C. G. , V. Jd et al., Importance of newly generated neurons in the adult olfactory bulb for odor discrimination, pp.1823-1828, 2000.
URL : https://hal.archives-ouvertes.fr/hal-00122237

R. C. Gheusi, . Vincent, D. N. Lledo-pm, E. Op, T. P. et al., Enrichied odor-exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory Tenascin-R mediates activity dependant recruitment of neuroblast in the adult mouse forebrain, J. Neurosci. Biol. Psychiatry. Nature Reviews Neuroscice. Nature Neuroscience, vol.22, issue.74, pp.2679-2689, 1999.

S. , L. Br, M. Jd-a, C. T. , K. K. et al., Introduction of neurogenesis in the neocortex of adult mice Neuronal remplacement from endogenous precursors in the adult brain after stroke, Nature Nat. Med, vol.405, issue.8, pp.951-955, 2000.

C. Ma, Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension, Science, vol.315, issue.5816, pp.1243-1246, 2007.

L. Pm and S. A. Thomson-ja, Integrating new neurons into the adult olfactory bulb: joining the network, life death decisions, and the effects of sensory experience Embryonic stem cell lines derived from human blastocysts, TRENDS in Neurosciences Science, vol.26, issue.282, pp.248-254, 1998.

R. Be, Neural progénitors from human embryonic stem cells, Nat. Biotechnol, vol.19, pp.1134-1140, 2001.

S. Tc, Differentiation of human embryonic stem cells to dopaminergic neurons in serum-free suspension culture, Stem Cells, vol.22, pp.1218-1238, 2004.

R. Ns, Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortelized midbrain astrocytes, Nat. Med, vol.12, pp.1259-1268, 2006.

S. Temple, The development of neural stem cells, Nature, vol.414, issue.6859, pp.112-117, 2001.
DOI : 10.1038/35102174

S. Cn, term survival of human central nervous system progénitors cells transplanted into a rat model of Parkinson s disease, Exp. Neurol, vol.148, pp.135-146, 1997.

J. Altman, Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats, The Journal of Comparative Neurology, vol.43, issue.3, pp.319-335, 1965.
DOI : 10.1177/10.3.269

R. Ba, Generation of neurons and astrocytes from isolated cells of the adult mammalian central nervous system, Science, vol.255, pp.1707-1710, 1992.

K. Hg, Neurogenesis in the rat dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation, J.Neurosci, vol.16, pp.2027-2033, 1996.

. Td, Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS, J. Neurosci, vol.19, pp.8487-8497, 1999.

. Td, 2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain, Mol. Cell Neurosci, vol.6, pp.474-486, 1995.

. Td, Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS, J. Neurosci, vol.19, pp.8487-8497, 1999.

M. and K. H. Hoshino-m, Specific induction of neuronal cells from bone marrow stromal cells and application for autologous transplantation, J. Clin. Invest, vol.113, pp.1701-1710, 2004.