60 D. Evaluation de la capacité fonctionnelle, p.62 ,
63 I, PARTIE, vol.3, p.63 ,
76 A. En pré-greffe, p.76 ,
113 1/ Facteurs explicatifs d'une infection bactérienne 113 2/ Facteurs explicatifs de la survenue d'une infection, p.115 ,
130 2/ La maladie du greffon contre l'hôte, p.131 ,
hémopathie maligne (p=0,05 à J100 et p=0,0009 à J360) et la survenue d'une GVHc extensive (p=0,02 à J360) ralentissent la RI des LT8. Le statut sérologique positif du donneur vis-à-vis du CMV semble amélioré à J180 la reconstitution des LT8 (p=0,06) Aucun facteur de risque en analyse multivariée n'a influencé la probabilité d ,
âge adulte (p=0,005 à J60 et p=0,001 J360), le diagnostique initial d'hémopathie maligne de type leucémie aiguë ou chronique (p=0,002 à J60), J360) et la survenue de GVHc extensive ,
les facteurs de risque diminuant la probabilité d'atteindre un taux de LB>200/l sont : l'âge> 18 ans (p = 0,002), le conditionnement myéloablatif (p=0,06), p.6 ,
Haematopoietic cell transplantation as immunotherapy, Nature, vol.411, issue.6835, pp.385-394, 2001. ,
DOI : 10.1038/35077251
Immunobiology of Allogeneic Hematopoietic Stem Cell Transplantation, Annual Review of Immunology, vol.25, issue.1, pp.139-70, 2007. ,
DOI : 10.1146/annurev.immunol.25.022106.141606
Graft-versus-leukemia reactions after bone marrow transplantation, Blood Feb, vol.175, issue.3, pp.555-62, 1990. ,
In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens, Nature Medicine, vol.6, issue.4, pp.410-414, 2002. ,
DOI : 10.1038/79573
Complete remission of accelerated phase chronic myeloid leukemia by treatment with leukemia-reactive cytotoxic T lymphocytes, Blood Aug, vol.1594, issue.4, pp.1201-1209, 1999. ,
Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant, Blood, vol.91, issue.10, pp.3671-80, 1998. ,
Invariant Valpha14 NKT lymphocytes: a doubleedged immuno-regulatory T cell population, Eur Cytokine Netw, vol.14, issue.1, pp.4-14, 2003. ,
TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and Paradoxes, Annual Review of Immunology, vol.23, issue.1, pp.877-900, 2005. ,
DOI : 10.1146/annurev.immunol.23.021704.115742
IL-4-producing NK T cells are biased towards IFN-?? production by IL-12. Influence of the microenvironment on the functional capacities of NK T cells, European Journal of Immunology, vol.103, issue.5, pp.1507-1522, 1998. ,
DOI : 10.1002/(SICI)1521-4141(199805)28:05<1507::AID-IMMU1507>3.0.CO;2-F
URL : http://onlinelibrary.wiley.com/doi/10.1002/(SICI)1521-4141(199805)28:05<1507::AID-IMMU1507>3.0.CO;2-F/pdf
Ligand-activated natural killer T lymphocytes promptly produce IL-3 and GM-CSF in vivo: relevance to peripheral myeloid recruitment, European Journal of Immunology, vol.32, issue.7, pp.1897-904, 2002. ,
DOI : 10.1002/1521-4141(200207)32:7<1897::AID-IMMU1897>3.0.CO;2-Y
In vivo activation of invariant V??14 natural killer T?cells by??-galactosylceramide sequentially induces Fas-dependent and -independent cytotoxicity, European Journal of Immunology, vol.34, issue.5, pp.1381-1389, 2004. ,
DOI : 10.1002/eji.200324828
NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs, Journal of Clinical Investigation, vol.115, issue.11, 2005. ,
DOI : 10.1172/JCI25249DS1
Effectiveness of Donor Natural Killer Cell Alloreactivity in Mismatched Hematopoietic Transplants, Science, vol.295, issue.5562, pp.2097-100, 2002. ,
DOI : 10.1126/science.1068440
Tolerance and chimerism, Transplantation May, vol.1575, issue.9, pp.26-31, 2003. ,
Cellular immunotherapy after allogeneic stem cell transplantation in hematologic malignancies, Current Opinion in Oncology, vol.16, issue.2, pp.167-73, 2004. ,
DOI : 10.1097/00001622-200403000-00015
Graft-versus-Leukemia and Graft-versus-Host Reactions after Donor Lymphocyte Infusion Are Initiated by Host-Type Antigen-Presenting Cells and Regulated by Regulatory T Cells in Early and Long-Term Chimeras, Biology of Blood and Marrow Transplantation, vol.12, issue.4, pp.397-407, 2006. ,
DOI : 10.1016/j.bbmt.2005.11.519
Mechanisms of the Graft‐versus‐Leukemia Reaction, Stem Cells, vol.81, issue.4, pp.248-58, 1997. ,
DOI : 10.1002/stem.150248
A retrospective analysis of therapy for acute graftversus-host disease: initial treatment National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. Diagnosis and staging working group report, Blood Biol Blood Marrow Transplant, vol.76, issue.21, pp.1464-72, 1990. ,
Mycophenolate mofetil for the prevention and treatment of graft-versus-host disease following stem cell transplantation: preliminary findings, Bone Marrow Transplantation, vol.22, issue.12, pp.1255-62, 2001. ,
DOI : 10.1097/00007691-199908000-00036
Graft-versus-host disease, Nature Reviews Immunology, vol.171, issue.5, pp.340-52, 2007. ,
DOI : 10.4049/jimmunol.171.3.1272
Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokines, Blood, vol.90, issue.8, pp.3204-3217, 1997. ,
High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism Identification of a graft versus host disease-associated human minor histocompatibility antigen, Blood Science, vol.110268, issue.75216, pp.2235-411476, 1995. ,
HLA DNA Typing and Transplantation, Immunity, vol.14, issue.4, 2001. ,
DOI : 10.1016/S1074-7613(01)00115-7
URL : https://doi.org/10.1016/s1074-7613(01)00115-7
Acute and Chronic Graft-Versus-Host Disease After Allogeneic Peripheral-Blood Stem-Cell and Bone Marrow Transplantation: A Meta-Analysis, Journal of Clinical Oncology, vol.19, issue.16, pp.3685-91, 2001. ,
DOI : 10.1200/JCO.2001.19.16.3685
Outcomes after Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia, New England Journal of Medicine, vol.351, issue.22, pp.2265-75, 2004. ,
DOI : 10.1056/NEJMoa041276
Pathophysiology of acute graft-versus-host disease: recent advances, Translational Research, vol.150, issue.4, pp.197-214, 2007. ,
DOI : 10.1016/j.trsl.2007.06.003
Absence of regulatory T-cell control of TH1 and TH17 cells is responsible for the autoimmune-mediated pathology in chronic graft-versus-host disease, Blood, vol.110, issue.10, pp.3804-3817, 2007. ,
DOI : 10.1182/blood-2007-05-091074
Autoimmunity following haematopoietic stem-cell transplantation, Best Practice & Research Clinical Haematology, vol.20, issue.2, pp.349-60, 2007. ,
DOI : 10.1016/j.beha.2006.09.008
Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations, Blood, vol.107, issue.7, pp.2993-3001, 2006. ,
DOI : 10.1182/blood-2005-09-3623
Antileukemic effect of graft-versus-host disease contributes to improved survival after allogeneic marrow transplantation, Transplant Proc, vol.13, issue.1, pp.248-51, 1981. ,
Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant, Annual Review of Medicine, vol.54, issue.1, pp.29-52, 2003. ,
DOI : 10.1146/annurev.med.54.101601.152339
Histopathologic Diagnosis of Chronic Graft-versus-Host Disease: National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: II. Pathology Working Group Report, Biology of Blood and Marrow Transplantation, vol.12, issue.1, pp.31-47, 2006. ,
DOI : 10.1016/j.bbmt.2005.10.023
CLINICAL MANIFESTATIONS OF GRAFT-VERSUS-HOST DISEASE IN HUMAN RECIPIENTS OF MARROW FROM HL-A-MATCHED SIBLING DONOR,S, Transplantation, vol.18, issue.4, pp.295-304, 1974. ,
DOI : 10.1097/00007890-197410000-00001
Chronic graft-versus-host syndrome in man. A long-term clinicopathologic study of 20 Seattle patients, Am J Med, 1980. ,
Hematopoietic stem cell transplantation: an overview of infection risks and epidemiology, Hematol Oncol Clin North Am, 2011. ,
Immune reconstitution after allogeneic transplantation and expanding options for immunomodulation: an update, Blood, vol.115, issue.19, pp.3861-3869, 2010. ,
DOI : 10.1182/blood-2009-12-234096
Controlled trial of filgrastim for acceleration of neutrophil recovery after allogeneic blood stem cell transplantation from human leukocyte antigen-matched related donors, Blood, vol.97, issue.11, pp.3405-3415, 2001. ,
DOI : 10.1182/blood.V97.11.3405
Allogeneic hematopoietic stem cell transplantation], Rev Prat Dec, vol.1558, pp.2111-2133, 2008. ,
URL : https://hal.archives-ouvertes.fr/inserm-00484234
Reconstitution of adaptive and innate immunity following allogeneic hematopoietic stem cell transplantation in humans, Cytotherapy, vol.8, issue.5, pp.427-463, 2006. ,
DOI : 10.1080/14653240600851938
An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation Reconstitution of NK cell receptor repertoire following HLA-matched hematopoietic cell transplantation, J Immunol Blood, vol.181101, issue.39, pp.2227-373730, 2003. ,
Monitoring human blood dendritic cell numbers in normal individuals and in stem cell transplantation, Blood, vol.93, issue.2, pp.728-764, 1999. ,
Immune reconstitution following haematopoietic stem cell transplantation, British Journal of Haematology, vol.95, issue.4, pp.407-427, 2004. ,
DOI : 10.1182/blood.V97.5.1458
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2141.2003.04767.x/pdf
Vaccination against infectious disease following hematopoietic stem cell transplantation, Biology of Blood and Marrow Transplantation, vol.7, issue.3, pp.171-83, 2001. ,
DOI : 10.1053/bbmt.2001.v7.pm11302551
URL : https://doi.org/10.1053/bbmt.2001.v7.pm11302551
Incompatibilit?? ABO et greffe allog??nique de cellules souches h??matopo????tiques ?? l?????re des conditionnements non my??loablatifs, Transfusion Clinique et Biologique, vol.14, issue.3, pp.327-360, 2007. ,
DOI : 10.1016/j.tracli.2007.03.002
Impact of nonmyeloablative conditioning regimens on the occurrence of pure red cell aplasia after ABO-incompatible allogeneic haematopoietic stem cell transplantation, Vox Sanguinis, vol.96, issue.1, pp.85-94, 2007. ,
DOI : 10.1111/j.1537-2995.2004.04106.x
Treatment of chronic graft-versus-host disease with anti-CD20 chimeric monoclonal antibody, Biology of Blood and Marrow Transplantation, vol.9, issue.8, pp.505-516, 2003. ,
DOI : 10.1016/S1083-8791(03)00216-7
Correlation between the numbers of naive T cells infused with blood stem cell allografts and the counts of naive T cells after transplantation, Biology of Blood and Marrow Transplantation, vol.9, issue.12, pp.781-785, 2003. ,
DOI : 10.1016/j.bbmt.2003.09.003
Quantitation of T-cell neogenesis in vivo after allogeneic bone marrow transplantation in adults, Blood, vol.98, issue.4, pp.1116-1137, 2001. ,
DOI : 10.1182/blood.V98.4.1116
Direct evidence for new T-cell generation by patients after either T-cell-depleted or unmodified allogeneic hematopoietic stem cell transplantations, Blood, vol.100, issue.6, pp.2235-2277, 2002. ,
High donor FOXP3-positive regulatory Tcell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT Immune reconstitution is preserved in hematopoietic stem cell transplant co-administered with regulatory T cells for GVHD prevention Protective conditioning for acute graft-versushost disease, Blood Blood N Engl J Med, vol.108353, issue.413, pp.1291-71321, 2005. ,
Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation, Blood, vol.98, issue.13, pp.3505-3517, 2001. ,
DOI : 10.1182/blood.V98.13.3505
Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL? Blood T-cell reconstitution after unmanipulated, CD8-depleted or CD34-selected nonmyeloablative peripheral blood stem-cell transplantation, Transplantation, vol.10776, issue.6012, pp.3430-51705, 2003. ,
Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen, Blood, vol.99, issue.3, pp.1071-1079, 2002. ,
DOI : 10.1182/blood.V99.3.1071
High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution, Blood, vol.99, issue.12, pp.4357-63, 2002. ,
DOI : 10.1182/blood.V99.12.4357
Kinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning, Blood, vol.104, issue.8, pp.2254-62, 2004. ,
DOI : 10.1182/blood-2004-04-1506
T cell immune reconstitution following lymphodepletion, Seminars in Immunology, vol.19, issue.5, pp.318-348, 2007. ,
DOI : 10.1016/j.smim.2007.10.004
URL : http://europepmc.org/articles/pmc2180244?pdf=render
Microbial contamination of hematopoietic progenitor cell products: clinical outcome, Bone Marrow Transplantation, vol.15, issue.4, 2007. ,
DOI : 10.1038/sj.bmt.1705731
Risk factors for lymphoproliferative disorders after allogeneic hematopoietic cell transplantation, Blood, vol.113, issue.20, pp.4992-5001, 2009. ,
DOI : 10.1182/blood-2008-09-178046
EBV reactivation and post transplant lymphoproliferative disorders following allogeneic SCT, Bone Marrow Transplantation, vol.330, issue.3, 2008. ,
DOI : 10.1038/bmt.2008.150
URL : http://www.nature.com/bmt/journal/v42/n3/pdf/bmt2008150a.pdf
Cytomegalovirus infection/disease after hematopoietic stem cell transplantation, International Journal of Hematology, vol.101, issue.4, pp.588-95, 2010. ,
DOI : 10.7326/0003-4819-109-10-783
Aspergillosis: The Most Common Community???Acquired Pneumonia with Gram???Negative Bacilli as Copathogens in Stem Cell Transplant Recipients with Graft???versus???Host Disease, Clinical Infectious Diseases, vol.15, issue.6, pp.659-64, 2002. ,
DOI : 10.1086/318133
Infectious morbidity in long-term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts, American Journal of Hematology, vol.333, issue.2, pp.131-139, 1997. ,
DOI : 10.1056/NEJM199509283331305
Radiosensitivity of thymic interleukin-7 production and thymopoiesis after bone marrow transplantation, Blood, vol.98, issue.5, pp.1601-1607, 2001. ,
DOI : 10.1182/blood.V98.5.1601
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets, The Journal of Experimental Medicine, vol.153, issue.7, pp.1701-1715, 2008. ,
DOI : 10.1016/0198-8859(96)00076-6
Thymopoiesis following allogeneic stem cell transplantation: new possibilities for improvement, Blood Reviews, vol.19, issue.2, pp.89-98, 2005. ,
DOI : 10.1016/j.blre.2004.04.001
The immunopathology of thymic GVHD, Seminars in Immunopathology, vol.105, issue.Suppl 1, pp.439-56, 2008. ,
DOI : 10.4049/jimmunol.175.4.2741
Assessment of thymic output in adults after haematopoietic stemcell transplantation and prediction of T-cell reconstitution, The Lancet, vol.355, issue.9218, pp.1875-81, 2000. ,
DOI : 10.1016/S0140-6736(00)02293-5
Interleukin-7 mediates the homeostasis of na??ve and memory CD8 T cells in vivo, Nature Immunology, vol.90, issue.5, 2000. ,
DOI : 10.1073/pnas.90.19.9125
Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation, Blood, vol.106, issue.3, pp.1123-1132, 2005. ,
DOI : 10.1182/blood-2005-01-0393
Immune Reconstitution following Stem Cell Transplantation, Leukemia & Lymphoma, vol.360, issue.6, pp.1093-101, 2004. ,
DOI : 10.1172/JCI17601
Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients Clinical implications of T cell receptor repertoire analysis after allogeneic stem cell transplantation, Blood Hematology, vol.105, issue.80, pp.886-93, 2004. ,
Human blood IgM "memory" B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire Molecular TCR diagnostics can be used to identify shared clonotypes after allogeneic hematopoietic stem cell transplantation, Blood Exp Hematol, vol.10432, issue.8210, pp.3647-541010, 2004. ,
Acute graft-versus-host disease: grade and outcome in patients with chronic myelogenous leukemia. Working Party Chronic Leukemia of the European Group for Blood and Marrow Transplantation, Blood, 1995. ,
A survey of diagnosis, management, and grading of chronic GVHD, Biology of Blood and Marrow Transplantation, vol.8, issue.1, pp.32-41, 2002. ,
DOI : 10.1053/bbmt.2002.v8.pm11846354
A COMPREHENSIVE DEFINITION OF THE MAJOR ANTIBODY SPECIFICITIES IN POLYCLONAL RABBIT ANTITHYMOCYTE GLOBULIN1, Transplantation, vol.57, issue.5, pp.685-94, 1994. ,
DOI : 10.1097/00007890-199403150-00010
Outcome of unrelated bone marrow donor searches in 174 children resulting in 45 patients transplanted in the HLA-matched and -mismatched situation, Bone Marrow Transplantation, vol.86, issue.1, pp.31-43, 2000. ,
DOI : 10.1097/00007890-199809150-00013
Mechanisms of immunosuppression induced by antithymocyte globulins and OKT3, J Heart Lung Transplant, vol.15, issue.5, pp.435-477, 1996. ,
ANTIBODIES AGAINST FUNCTIONAL LEUKOCYTE SURFACE MOLECULES IN POLYCLONAL ANTILYMPHOCYTE AND ANTITHYMOCYTE GLOBULINS, TRANSPLANTATION, vol.51, issue.3, pp.669-73, 1991. ,
DOI : 10.1097/00007890-199103000-00024
Antithymocyte Globulin Induces Ex Vivo and In Vivo Depletion of Myeloid and Plasmacytoid Dendritic Cells, Transplantation, vol.79, issue.3, pp.369-71, 2005. ,
DOI : 10.1097/01.TP.0000150210.77543.1B
Polyclonal rabbit antithymocyte globulin triggers Bcell and plasma cell apoptosis by multiple pathways, Transplantation Jun, vol.1579, issue.11, pp.1507-1522, 2005. ,
DOI : 10.1097/01.tp.0000164159.20075.16
URL : http://pdfs.journals.lww.com/transplantjournal/2005/06150/Polyclonal_Rabbit_Antithymocyte_Globulin_Triggers.8.pdf?token=method|ExpireAbsolute;source|Journals;ttl|1505080208689;payload|mY8D3u1TCCsNvP5E421JYK6N6XICDamxByyYpaNzk7FKjTaa1Yz22MivkHZqjGP4kdS2v0J76WGAnHACH69s21Csk0OpQi3YbjEMdSoz2UhVybFqQxA7lKwSUlA502zQZr96TQRwhVlocEp/sJ586aVbcBFlltKNKo+tbuMfL73hiPqJliudqs17cHeLcLbV/CqjlP3IO0jGHlHQtJWcICDdAyGJMnpi6RlbEJaRheGeh5z5uvqz3FLHgPKVXJzdGlb2qsojlvlytk14LkMXSHuoF62fy+5jTG3go+I9W8BHG7by6MKXPmCAznIvBmk1;hash|BfLtGbY7/3wJacwUVUSSng==
Antithymocyte globulin induces complement-dependent cell lysis and caspase-dependent apoptosis in myeloma cells, Experimental Hematology, vol.33, issue.12, pp.1531-1537, 2005. ,
DOI : 10.1016/j.exphem.2005.08.004
Rabbit Anti T-Lymphocyte Globulin Induces Apoptosis in Peripheral Blood Mononuclear Cell Compartments and Leukemia Cells, While Hematopoetic Stem Cells Are Apoptosis Resistant, Biology of Blood and Marrow Transplantation, vol.15, issue.2, 2009. ,
DOI : 10.1016/j.bbmt.2008.11.014
Monitoring anti-thymocyte globulin (ATG) in bone marrow recipients, Bone Marrow Transplantation, vol.23, issue.8, pp.779-81, 1999. ,
DOI : 10.1038/sj.bmt.1701645
Rabbit-immunoglobulin G levels in patients receiving thymoglobulin as part of conditioning before unrelated donor stem cell transplantation, Haematologica, vol.90, issue.7, pp.931-939, 2005. ,
Effects of anti-lymphocytes and antithymocytes globulin on human dendritic cells, Int Immunopharmacol, 2003. ,
Clinical impact of human Jurkat T-cell-line-derived antithymocyte globulin in multiple myeloma patients undergoing allogeneic stem cell transplantation, Haematologica, vol.93, issue.9, pp.1343-50, 2008. ,
DOI : 10.3324/haematol.12665
Antitumor effects of polyclonal antithymocyte globulins: focus on B-cell malignancies and multiple myeloma, Annals of Hematology, vol.103, issue.13, 2009. ,
DOI : 10.1097/00007890-199504270-00020
URL : https://hal.archives-ouvertes.fr/hal-00535027
The pharmacokinetics of antithymocyte globulin (ATG) following intravenous infusion in man, Clin Nephrol, 1996. ,
Pharmacokinetics and pharmacodynamics of anti-thymocyte globulin in recipients of partially HLA-matched blood hematopoietic progenitor cell transplantation, Biology of Blood and Marrow Transplantation, vol.9, issue.7, pp.460-71, 2003. ,
DOI : 10.1016/S1083-8791(03)00127-7
Second marrow transplants in patients with aplastic anemia rejecting the first graft: use of a conditioning regimen including cyclophosphamide and antithymocyte globulin, Blood, vol.70, issue.1, pp.116-137, 1987. ,
Cyclophosphamide combined with antithymocyte globulin in preparation for allogeneic marrow transplants in patients with aplastic anemia, Blood, vol.84, issue.3, pp.941-950, 1994. ,
ANTIHUMAN THYMOCYTE GLOBULIN FOR PROPHYLAXIS OF GRAFT-VERSUS-HOST DISEASE, Transplantation, vol.27, issue.4, pp.227-257, 1979. ,
DOI : 10.1097/00007890-197904000-00003
Treatment of severe acute graft-versus-host disease with anti-thymocyte globulin, Clinical Transplantation, vol.24, issue.6, 2001. ,
DOI : 10.1097/00007890-200102150-00017
A Randomized Study of the Prevention of Acute Graft-versus-Host Disease, New England Journal of Medicine, vol.306, issue.7, pp.392-399, 1982. ,
DOI : 10.1056/NEJM198202183060703
Reduced-intensity conditioning with busulfan and fludarabine with or without antithymocyte globulin in HLA-identical sibling transplantation ??? a retrospective analysis, Bone Marrow Transplantation, vol.100, issue.5, 2004. ,
DOI : 10.1038/sj.bmt.1703674
Antithymocyte globulin for graft-versus-host disease prophylaxis in transplants from unrelated donors: 2 randomized studies from Gruppo Italiano Trapianti Midollo Osseo (GITMO), Blood, vol.98, issue.10, pp.2942-2949, 2001. ,
DOI : 10.1182/blood.V98.10.2942
Prophylactic antithymocyte globulin reduces the risk of chronic graft-versus-host disease in alternative-donor bone marrow transplants, Biology of Blood and Marrow Transplantation, vol.8, issue.12, pp.656-61, 2002. ,
DOI : 10.1053/bbmt.2002.v8.abbmt080656
Thymoglobulin Prevents Chronic Graft-versus-Host Disease, Chronic Lung Dysfunction, and Late Transplant-Related Mortality: Long-Term Follow-Up of a Randomized Trial in Patients Undergoing Unrelated Donor Transplantation, Biology of Blood and Marrow Transplantation, vol.12, issue.5, pp.560-565, 2006. ,
DOI : 10.1016/j.bbmt.2005.12.034
Standard graft-versus-host disease prophylaxis with or without anti-T-cell globulin in haematopoietic cell transplantation from matched unrelated donors: a randomised, open-label, multicentre phase 3 trial, The Lancet Oncology, vol.10, issue.9, pp.855-64, 2009. ,
DOI : 10.1016/S1470-2045(09)70225-6
Association between pretransplant Thymoglobulin and reduced non-relapse mortality rate after marrow transplantation from unrelated donors, Bone Marrow Transplantation, vol.24, issue.5, pp.391-398, 2002. ,
DOI : 10.3109/10428199609045715
URL : http://www.nature.com/bmt/journal/v29/n5/pdf/1703374a.pdf
In vivo T cell depletion with pretransplant anti-thymocyte globulin reduces graft-versus-host disease without increasing relapse in good risk myeloid leukemia patients after stem cell transplantation from matched related donors, Bone Marrow Transplantation, vol.94, issue.8, pp.683-692, 2002. ,
DOI : 10.1038/sj.bmt.1701645
Unrelated donor BMT recipients given pretransplant low-dose antithymocyte globulin have outcomes equivalent to matched sibling BMT: a matched pair analysis, Bone Marrow Transplantation, vol.96, issue.10, pp.681-687, 2002. ,
DOI : 10.1200/JCO.1997.15.5.1767
Reduced incidence of acute and chronic graftversus-host disease with the addition of thymoglobulin to a targeted busulfan/cyclophosphamide regimen, Biol Blood Marrow Transplant, 2006. ,
Matched and Mismatched Allogeneic Stem-Cell Transplantation From Unrelated Donors Using Combined Graft-Versus-Host Disease Prophylaxis Including Rabbit Anti???T Lymphocyte Globulin, Journal of Clinical Oncology, vol.21, issue.3, pp.506-519, 2003. ,
DOI : 10.1200/JCO.2003.03.129
Anti-thymocyte globulin overcomes the negative impact of HLA mismatching in transplantation from unrelated donors, Experimental Hematology, vol.36, issue.8, pp.1047-54, 2008. ,
DOI : 10.1016/j.exphem.2008.03.011
HLA-Mismatched Unrelated Donors as an Alternative Graft Source for Allogeneic Stem Cell Transplantation after Antithymocyte Globulin-Containing Conditioning Regimen, Biology of Blood and Marrow Transplantation, vol.15, issue.4, 2009. ,
DOI : 10.1016/j.bbmt.2009.01.002
Antithymocyteglobulin as prophylaxis of graft failure and graft-versus-host disease in recipients of partially T-cell???depleted grafts from matched unrelated donors: A dose-finding study, Experimental Hematology, vol.31, issue.11, pp.1026-1056, 2003. ,
DOI : 10.1016/S0301-472X(03)00204-2
Comparison of Two Doses of Antithymocyte Globulin in Patients Undergoing Matched Unrelated Donor Allogeneic Stem Cell Transplantation, Biology of Blood and Marrow Transplantation, vol.14, issue.8, pp.913-922, 2008. ,
DOI : 10.1016/j.bbmt.2008.05.023
Dose-dependent effects of in vivo antithymocyte globulin during conditioning for allogeneic bone marrow transplantation from unrelated donors in patients with chronic phase CML, Bone Marrow Transplantation, vol.22, issue.Suppl. 1, pp.243-50, 2003. ,
DOI : 10.1182/blood-2002-03-0701
Mismatched T cell-depleted hematopoietic stem cell transplantation for children with high-risk acute leukemia, Bone Marrow Transplant, vol.22, issue.5, pp.29-32, 1998. ,
Effect of antithymocyte globulin on quantitative immune recovery and graft-versus-host disease after partially T-cell???depleted bone marrow transplantation: a comparison between recipients of matched related and matched unrelated donor grafts, Transplantation, vol.75, issue.11, pp.1910-1913, 2003. ,
DOI : 10.1097/01.TP.0000065737.60591.9D
Immune reconstitution following reduced-intensity transplantation with cladribine, busulfan and antithymocyte globulin: serial comparison with conventional myeloablative transplantation, Bone Marrow Transplantation, vol.48, issue.6, 2003. ,
DOI : 10.1111/j.1600-065X.1989.tb00544.x
Immune reconstitution after haematopoietic transplantation with two different doses of pre-graft antithymocyte globulin, Bone Marrow Transplantation, vol.73, issue.7, pp.421-427, 2002. ,
DOI : 10.1016/S1083-8791(00)70007-3
Influence of Anti-Thymocyte Globulin As Part of the Conditioning Regimen on Immune Reconstitution Following Matched Related Bone Marrow Transplantation, Journal of Hematotherapy & Stem Cell Research, vol.12, issue.2, pp.237-279, 2003. ,
DOI : 10.1089/152581603321628377
Suspected delayed immune recovery against cytomegalovirus after reduced-intensity stem cell transplantation using anti-thymocyte globulin, Bone Marrow Transplantation, vol.26, issue.3, pp.237-278, 2002. ,
DOI : 10.1038/sj.bmt.1702500
URL : http://www.nature.com/bmt/journal/v29/n3/pdf/1703351a.pdf
Detection of a novel specificity (CTLA-4) in ATG/TMG globulins and sera from ATG-treated leukemic patients1, Transplantation, vol.73, issue.8, pp.1295-302, 2002. ,
DOI : 10.1097/00007890-200204270-00019
Transplantation of Marrow from an Unrelated Donor to a Patient with Acute Leukemia, New England Journal of Medicine, vol.303, issue.10, pp.565-572, 1980. ,
DOI : 10.1056/NEJM198009043031007
Prospective evaluation of unrelated donor bone marrow transplantation. The International Marrow Unrelated Search and Transplant (IMUST) Study, Bone Marrow Transplant, 1993. ,
The outcome of matched unrelated donor bone marrow transplantation in patients with hematologic malignancies using molecular typing for donor selection and graft-versus-host disease prophylaxis regimen of cyclosporine, methotrexate, and prednisone, Blood, vol.86, issue.3, pp.1228-1262, 1995. ,
Antilymphocyte/thymocyte globulin for graft versus host disease prophylaxis: efficacy and side effects, Bone Marrow Transplantation, vol.100, issue.Suppl 1, pp.225-256, 2005. ,
DOI : 10.1182/blood-2001-12-0304
Use of a five-agent GVHD prevention regimen in recipients of unrelated donor marrow, Bone Marrow Transplantation, vol.23, issue.9, 1999. ,
DOI : 10.1038/sj.bmt.1701745
Influence of antithymocyte globulin dose on outcome in cytomegalovirus-seropositive recipients of partially T cell-depleted stem cell grafts from matched-unrelated donors, British Journal of Haematology, vol.153, issue.3, pp.473-479, 2003. ,
DOI : 10.1038/sj.bmt.1703513
Risk of lymphoproliferative disorders after bone marrow transplantation: a multi-institutional study, Blood, vol.94, issue.7, pp.2208-2224, 1999. ,
Risks of developing Epstein-Barr virus-related lymphoproliferative disorders after T-cell-depleted marrow transplants. CAMPATH Users, Blood, vol.91, issue.8, pp.3079-83, 1998. ,
Risk factors for developing EBV-related B cell lymphoproliferative disorders (BLPD) after non-HLA-identical BMT in children, Bone Marrow Transplant, vol.18, issue.2, pp.377-82, 1996. ,
Prevention of Epstein-Barr viruslymphoproliferative disease by molecular monitoring and preemptive rituximab in highrisk patients after allogeneic stem cell transplantation, Blood Jun, vol.1599, issue.12, pp.4364-4373, 2002. ,
CD8-depleted donor lymphocyte infusion as treatment for relapsed chronic myelogenous leukemia after allogeneic bone marrow transplantation, Blood, vol.86, issue.11, pp.4337-4380, 1995. ,
Antileukemic Effect of Chronic Graft-versus-Host Disease, New England Journal of Medicine, vol.304, issue.25, pp.1529-1562, 1981. ,
DOI : 10.1056/NEJM198106183042507
Morbidity and mortality of chronic GVHD after hematopoietic stem cell transplantation from HLA-identical siblings for patients with aplastic or refractory anemias, Biology of Blood and Marrow Transplantation, vol.8, issue.1, pp.47-56, 2002. ,
DOI : 10.1053/bbmt.2002.v8.pm11858190