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P. Concernant-le, Process Analytical Technology) et la QbD (Quality by Design) énoncent qu'une opération unitaire faisant partie de la production d'une forme pharmaceutique doit être parfaitement comprise et maîtrisée

D. Toutefois and . Le-cas-de-la-granulation-humide, de nombreux aspects sont connus qualitativement mais n'ont fait l'objet que de peu d'études quantitatives Ce travail propose une description moderne du procédé de granulation humide en mélangeur-granulateur haute vitesse en le décomposant en trois étapes. Les techniques de suivi en ligne du procédé sont abordées et l'influence des paramètres physicochimiques est discutée. L'importance de la nature du liquide de mouillage est notamment mise en lumière. Ce paramètre ayant été peu étudié dans la littérature, un travail expérimental a été mené pour approfondir l'influence de la composition du liquide de mouillage sur la cinétique de granulation et la qualité des grains produits. Ce projet s'est focalisé plus particulièrement sur l