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Master thesis

Intérêt de la radiofréquence dans la prise en charge conservatrice du placenta accreta: évaluation in vitro et sur modèle animal

Abstract : Objective : Retained trophoblast (in cases of cesarean scar or cornual implantation), or retained placenta (in cases of conservative treatment for placenta accreta or percreta) are at high risk for hemorrhage or systemic infection. The objective of this preliminary study was to evaluate radiofrequency (RF) efficiency and safety for trophoblast or placenta ablation. Methods : Several RF procedures (RITA medical systems, Starbust SDE) were tested on 50 pregnant ewe placental units in order to define 2 optimal procedures. Reproducibility of these 2 optimal procedures was then evaluated on 20 others pregnant ewe placental units. Each procedure was also tested twice on 10 human terro placenta placed in an in vitro model after normal delivery.Results : When tested on pregnant ewe, low power (100 Watts) and low target temperatures (80 and 60 ° C) had to be applied in order to obtain homogenous tissular destruction, without any myometrial lesion. Reproducibility of these two procedures was excellent for the 20 others pregnant ewe. No bleeding was observed for any of the 70 procedures. Lesions displayed the same pattern when RF was applied on human placenta. The ablation volume is correlated with the tines deployment, and thus can be correctly targeted. Conclusion : RF seems to be an adequate method for ablation of retained trophoblast or placenta, with an optimal control of tissular destruction.
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Master thesis
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https://hal.univ-lorraine.fr/hal-01733826
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Elise Monceau. Intérêt de la radiofréquence dans la prise en charge conservatrice du placenta accreta: évaluation in vitro et sur modèle animal. Sciences du Vivant [q-bio]. 2007. ⟨hal-01733826⟩

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