12 1.1.1. Description des, Structure ,
89 3.1.3. Concentration Quelle innovation : Les Systèmes de Délivrance du Médicament (Drug Delivery Systems : DDS) ,
91 3.1.4.3. Choix d'un traitement local, p.96 ,
98 3.2.2. Propriété : molécule insoluble : passage faible, p.100 ,
110 3.3.1.4, p.110 ,
115 4.1. Le patient, la pathologie et le médicament : application à Loramyc ®, p.117 ,
emploi du posaconazole a été évaluée chez plus de 2400 patients et volontaires sains au cours des études cliniques et depuis la commercialisation. Les effets indésirables graves liés au traitement le plus fréquemment rapportés incluaient nausées, vomissements, diarrhée ,
Rapport de la Commission d'orientation sur le cancer Ministère de la santé, Disponible sur, 2003. ,
Oral candidiasis, Postgraduate Medical Journal, vol.78, issue.922, pp.455-464, 2002. ,
DOI : 10.1136/pmj.78.922.455
Ex vivo bioadhesion and in vivo testosterone bioavailability study of different bioadhesive formulations based on starch-g-poly(acrylic acid) copolymers and starch/poly(acrylic acid) mixtures, Journal of Controlled Release, vol.79, issue.1-3, pp.1-3173, 2002. ,
DOI : 10.1016/S0168-3659(01)00539-9
Informations-de-securite-Lettres-aux- professionnels-de-sante/NIZORAL-R-ketoconazole-comprime-a-200-mg-information-importante- sur-le-rapport-benefice-risque-Lettre-aux-professionnels-de-sante, 2012. ,
Candidiasis: pathogenesis, clinical characteristics, and treatment, J Calif Dent Assoc, vol.28, issue.12, pp.942-950, 2000. ,
Comparison of the efficacy and safety of miconazole 50-mg mucoadhesive buccal tablets with miconazole 500-mg gel in the treatment of oropharyngeal candidiasis, Cancer, vol.4, issue.1, pp.204-211, 2008. ,
DOI : 10.1002/cncr.23152
Oropharyngeal candidiasis in head and neck cancer patients treated with radiation: update 2011, Supportive Care in Cancer, vol.16, issue.Suppl 2, pp.737-744, 2011. ,
DOI : 10.1111/j.1601-0825.2009.01618.x
Pathologie de la muqueuse buccale. Rapport de la société Française d'ORL et de Chirurgie Cervico-Faciale, pp.183-190, 2009. ,
Candidiasis in cancer patients, Am J Med, vol.77, issue.4D, pp.13-22, 1984. ,
Epidemiology and antifungal susceptibilities of Candida spp. to six antifungal agents: results from a surveillance study on fungaemia in Germany from, J Antimicrob Chemother, 2004. ,
ABSTRACT, Applied and Environmental Microbiology, vol.77, issue.18, 2011. ,
DOI : 10.1128/AEM.05780-11
Prévalence des candidoses oropharyngées en gériatrie à propos d'une étude nationale multicentrique, 2000. ,
An epidemiologic study of yeasts in elderly denture wearers, Community Dentistry and Oral Epidemiology, vol.30, issue.3, pp.115-124, 1975. ,
DOI : 10.1177/00220345510300031901
Candida albicans drug resistance another way to cope with stress. Microbiology, Review, vol.153, pp.3211-3218, 2007. ,
DOI : 10.1099/mic.0.2007/010405-0
URL : http://mic.microbiologyresearch.org/deliver/fulltext/micro/153/10/3211.pdf?itemId=/content/journal/micro/10.1099/mic.0.2007/010405-0&mimeType=pdf&isFastTrackArticle=
Comparison of the pharmacokinetics of miconazole after administration via a bioadhesive slow release tablet and an oral gel to healthy male and female subjects, British Journal of Clinical Pharmacology, vol.43, issue.4, pp.345-351, 2004. ,
DOI : 10.1016/S0939-6411(96)00014-8
Cell wall and secreted proteins of Candida albicans: identification, function, and expression, Microbiol Mol Biol Rev. Review, vol.62, issue.1, pp.130-80, 1998. ,
Biofilm Formation by the Fungal Pathogen Candida albicans: Development, Architecture, and Drug Resistance, Journal of Bacteriology, vol.183, issue.18 ,
DOI : 10.1128/JB.183.18.5385-5394.2001
Safety, acceptability, and adhesion of a novel bioadhe-sive slow release tablet of miconazole in a phase I study, J Mycol Med, vol.13, pp.13-18, 2003. ,
gov/ct2/show/NCT01125644 : Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis ,
Management of oropharyngeal candidiasis with localized oral miconazole therapy: efficacy, safety, and patient acceptability, Patient Preference and Adherence, vol.5, pp.369-74, 2011. ,
DOI : 10.2147/PPA.S14047
Oral candidosis in patients with advanced cancer, Oral Oncology, vol.42, issue.7, pp.698-702, 2006. ,
DOI : 10.1016/j.oraloncology.2005.11.010
Prise en charge médicale des personnes infectées par le VIH, 2004. ,
Preparation and evaluation of a novel buccal adhesive system, AAPS PharmSciTech, vol.5, issue.3, p.35 ,
DOI : 10.1208/pt050335
Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms, Clinical Microbiology Reviews, vol.15, issue.2 ,
DOI : 10.1128/CMR.15.2.167-193.2002
Medical importance of biofilms in Candida infections, Rev Iberoam Micol, 2002. ,
Bioadhesion of solid oral dosage forms, why and how?, European Journal of Pharmaceutics and Biopharmaceutics, vol.44, issue.1, pp.15-23, 1997. ,
DOI : 10.1016/S0939-6411(97)00097-0
Consigny PH et al A pilot study evaluating the efficacy and safety of a bioadhesive buccal tablet of miconazole 50 mg (miconazole Lauriad ® ) in HIV positive patients with oropharyngeal candidiasis, 2004. ,
Utilisation des antifongiques topiques. Thérapie, Mai-Juin, vol.61, issue.3, pp.251-254, 2006. ,
DOI : 10.2515/therapie:2006041
Epidemiology of Candida species infections in critically ill non-immunosuppressed patients, The Lancet Infectious Diseases, vol.3, issue.11, pp.685-702, 2003. ,
DOI : 10.1016/S1473-3099(03)00801-6
Oral Candidal Infections and Antimycotics, Critical Reviews in Oral Biology & Medicine, vol.11, issue.2, pp.172-98, 2000. ,
DOI : 10.1177/106002809102500210
URL : http://journals.sagepub.com/doi/pdf/10.1177/10454411000110020301
Oropharyngeal Candidiasis: A Review of its Clinical Spectrum and Current Therapies1998 Clinical Therapeutics, pp.40-57, 1998. ,
Oral candidiasis in hematopoietic cell transplantation patients: an outcome-based analysis, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.96, issue.2, 2003. ,
DOI : 10.1016/S1079-2104(03)00296-8
Comparison of Visual 24-Hour and Spectrophotometric 48-Hour MICs to CLSI Reference Microdilution MICs of Fluconazole, Itraconazole, Posaconazole, and Voriconazole for Candida spp.: a Collaborative Study, Journal of Clinical Microbiology, vol.43, issue.9, pp.4535-4575, 2005. ,
DOI : 10.1128/JCM.43.9.4535-4540.2005
Predictive value of oral colonization by Candida yeasts for the onset of a nosocomial infection in elderly hospitalized patients, Journal of Medical Microbiology, vol.55, issue.2, pp.223-231, 2006. ,
DOI : 10.1099/jmm.0.46155-0
Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteers, Revista Espa??ola de Enfermedades Digestivas, vol.96, issue.11 ,
DOI : 10.4321/S1130-01082004001100005
Miconazole: a historical perspective, Expert Review of Anti-infective Therapy, vol.46, issue.2, pp.171-175, 2006. ,
DOI : 10.1128/AAC.46.10.3113-3117.2002
Candida and candidosis. Epidemiology, Diagnosis, and Therapeutic Management. Dental Clinics of North America, 1992. ,
Overview of medically important antifungal azole derivatives., Clinical Microbiology Reviews, vol.1, issue.2, pp.187-217, 1988. ,
DOI : 10.1128/CMR.1.2.187
Antifungal agents: chemotherapeutic targets and immunologic strategies, Antimicrob Agents Chemother. Feb, vol.40, issue.2, pp.279-91, 1996. ,
Antifungals: mechanism of action and resistance, established and novel drugs, Current Opinion in Microbiology, vol.1, issue.5, pp.547-57, 1998. ,
DOI : 10.1016/S1369-5274(98)80087-8
Antifungal agents: mode of action, mechanisms of resistance, and correlation of these mechanisms with bacterial resistance, Clin Microbiol Rev. Review, vol.12, issue.4, pp.501-518, 1999. ,
Repeated exposure of Candida spp. to miconazole demonstrates no development of resistance, Mycoses, vol.37, issue.4, pp.175-182, 2010. ,
DOI : 10.1016/S1567-1356(03)00240-X
Prevalence and Treatment Management of Oropharyngeal Candidiasis in Cancer Patients: Results of the French Candidoscope Study, International Journal of Radiation Oncology*Biology*Physics, vol.80, issue.2, pp.532-541, 2010. ,
DOI : 10.1016/j.ijrobp.2010.02.006
Effect of highly active antiretroviral therapy on frequency of oral warts, The Lancet, vol.357, issue.9266, pp.1411-1413, 2001. ,
DOI : 10.1016/S0140-6736(00)04578-5
Bioadhesive polymers in peptide drug delivery, Biomaterials, vol.11, issue.9, pp.652-660, 1990. ,
DOI : 10.1016/0142-9612(90)90023-J
ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.55, issue.10, pp.4543-51, 2011. ,
DOI : 10.1128/AAC.00366-11
Production of extracellular matrix by Candida albicans biofilms, Journal of Medical Microbiology, vol.47, issue.3, pp.253-256, 1998. ,
DOI : 10.1099/00222615-47-3-253
Communication in bacteria: an ecological and evolutionary perspective, Nature Reviews Microbiology, vol.184, issue.4, pp.249-258, 2006. ,
DOI : 10.4049/jimmunol.169.5.2636
Antifungal activity of miconazole against recent Candida strains, Mycoses, vol.20, issue.5 ,
DOI : 10.1111/j.1439-0507.2009.01728.x
Oral carriage of yeasts, coliforms and staphylococci in patients with advanced malignant disease, Journal of Oral Pathology and Medicine, vol.135, issue.7, 1992. ,
DOI : 10.1016/0003-9969(82)90086-3
Assessment of in vitro activity and stability of antifungal suspensions for mouthrinses: To a reappraisal of empiric practices?, Pathol Biol ,
Muco-adhesive Buccal Tablets of Clotrimazole for Oral Candidiasis, Drug Development and Industrial Pharmacy, vol.57, issue.8, pp.831-837, 1997. ,
DOI : 10.1002/jps.2600530726
Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance, Journal of Hospital Infection, vol.50, issue.4, pp.243-60 ,
DOI : 10.1053/jhin.2001.1151
In vitro susceptibility of oral Candida to seven antifungal agents, Oral Microbiology and Immunology, vol.15, issue.6, pp.349-53, 1992. ,
DOI : 10.1034/j.1399-302x.2000.150406.x
Miconazole mucoadhesive tablet for oropharyngeal candidiasis, Expert Review of Anti-infective Therapy, vol.112, issue.1, pp.13-20 ,
DOI : 10.1002/cncr.23152
A systematic review of oral fungal infections in patients receiving cancer therapy, Supportive Care in Cancer, vol.101, issue.8, pp.985-992, 2010. ,
DOI : 10.1099/jmm.0.45694-0
Optical sectioning of microbial biofilms., Journal of Bacteriology, vol.173, issue.20, pp.6558-6567, 1991. ,
DOI : 10.1128/jb.173.20.6558-6567.1991
A comparative study of the efficacy and safety of fluconazole oral suspension and amphotericin B oral suspension in cancer patients with mucositis, Oral Oncology, vol.38, issue.4, pp.337-342, 2002. ,
DOI : 10.1016/S1368-8375(01)00063-X
A rheological examination of the mucoadhesive/mucus interaction: the effect of mucoadhesive type and concentration, Journal of Controlled Release, vol.50, issue.1-3, pp.1-3167, 1998. ,
DOI : 10.1016/S0168-3659(97)00138-7
Granulocyte macrophagecolony stimulating factor (GM-CSF) and sucralfate in prevention of radiation-induced mucositis: a prospective randomized study, Int J Radiat Oncol Biol Phys. Feb, vol.146, issue.3, pp.525-559, 2000. ,
in Human Immunodeficiency Virus???Infected Patients, Clinical Infectious Diseases, vol.39, issue.4, pp.843-849, 1997. ,
DOI : 10.1097/00002030-199406000-00010
Orofacial complications of chemotherapy for breast cancer. Oral Surg Oral Med Oral Pathol, pp.172-180, 1992. ,
Antifungal drugs: mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biological fluids Antibiotics in laboratory medicine, pp.176-211, 1996. ,
Oral mucosal bioadhesive tablets of pectin and HPMC: in vitro and in vivo evaluation, International Journal of Pharmaceutics, vol.204, issue.1-2, pp.127-159, 2000. ,
DOI : 10.1016/S0378-5173(00)00491-9
Itraconazole oral solution versus clotrimazole troches for the treatment of oropharyngeal candidiasis in immunocompromised patients. Clin Ther, pp.471-80, 1997. ,
Mucoadhesive buccal patches of miconazole nitrate: in vitro/in vivo performance and effect of ageing, International Journal of Pharmaceutics, vol.264, issue.1-2, pp.1-14, 2003. ,
DOI : 10.1016/S0378-5173(03)00371-5
Classifications of oral lesions in HIV infection, Journal of Clinical Periodontology, vol.73, issue.2, 2001. ,
DOI : 10.1016/0030-4220(92)90186-T
Update on terbinafine with a focus on dermatophytoses, Clin Cosmet Investig Dermatol, vol.2, pp.49-63, 2009. ,
Oral pseudomembranous candidiasis, herpes simplex virus-1 infection, and oral mucositis in head and neck cancer patients receiving radiotherapy and granulocyte-macrophage colony-stimulating factor (GM-CSF) mouthwash, Journal of Oral Pathology and Medicine, vol.30, issue.8, pp.471-80, 2001. ,
DOI : 10.1034/j.1600-0714.2001.030008471.x
Uptake of T-2307, a novel arylamidine, in Candida albicans, Journal of Antimicrobial Chemotherapy, vol.109, issue.1, 2010. ,
DOI : 10.1016/S0166-6851(00)00234-6
Candida and Torulopsis: a blinded evaluation of use of pseudohypha formation as basis for identification of medically important yeasts, J Clin Microbiol, vol.35, issue.1, pp.313-319, 1997. ,
Guidelines for the prevention of intravascular catheter-related infections ,
Guidelines for Treatment of Candidiasis, Clinical Infectious Diseases, vol.345, issue.Suppl 1, pp.161-89, 2004. ,
DOI : 10.1056/NEJMoa010494
Clinical Practice Guidelines for the Management of Candidiasis: 2009 Update by the Infectious Diseases Society of America, Clinical Infectious Diseases, vol.48, issue.5, pp.503-535, 2009. ,
DOI : 10.1086/596757
Development and evaluation of a biphasic buccal adhesive tablet for nicotine replacement therapy, International Journal of Pharmaceutics, vol.237, issue.1-2, pp.215-226, 2002. ,
DOI : 10.1016/S0378-5173(02)00041-8
Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.89, issue.3, pp.299-304, 2000. ,
DOI : 10.1016/S1079-2104(00)70092-8
A systematic review of the effectiveness of antifungal drugs for the prevention and treatment of oropharyngeal candidiasis in HIV-positive patients, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.92, issue.2, pp.170-179, 2001. ,
DOI : 10.1067/moe.2001.116600
Oropharyngeal Candidiasis in HIV-infected Patients: a Forgotten Problem?, J Invasive Fungal Infect, vol.2, issue.3, pp.82-90, 2008. ,
Surface, interfacial and molecular aspects of polymer bioadhesion on soft tissues, Journal of Controlled Release, vol.2, issue.2, pp.257-275, 1985. ,
DOI : 10.1016/0168-3659(85)90050-1
International Surveillance of Bloodstream Infections Due to Candida Species: Frequency of Occurrence and In Vitro Susceptibilities to Fluconazole, Ravuconazole, and Voriconazole of Isolates Collected from 1997 through 1999 in the SENTRY Antimicrobial Surveillance Program, Journal of Clinical Microbiology, vol.39, issue.9, pp.3254-3263, 2001. ,
DOI : 10.1128/JCM.39.9.3254-3259.2001
Cross-Resistance between Fluconazole and Ravuconazole and the Use of Fluconazole as a Surrogate Marker To Predict Susceptibility and Resistance to Ravuconazole among 12,796 Clinical Isolates of Candida spp., Journal of Clinical Microbiology, vol.42, issue.7, pp.3137-3178, 2004. ,
DOI : 10.1128/JCM.42.7.3137-3141.2004
ABSTRACT, Antimicrobial Agents and Chemotherapy, vol.55, issue.2, pp.561-567, 2008. ,
DOI : 10.1128/AAC.01079-10
: Figure 1, Biochemical Society Transactions, vol.33, issue.5, pp.1210-1214, 2005. ,
DOI : 10.1042/BST0331210
Development of a bioadhesive tablet, High Performance Biomaterials, pp.231-242, 1991. ,
Oropharyngeal Candidiasis in Patients with AIDS: Randomized Comparison of Fluconazole Versus Nystatin Oral Suspensions, Clinical Infectious Diseases, vol.24, issue.6, 1997. ,
DOI : 10.1086/513664
Clinical Perspective Oropharyngeal Candidiasis in Patients with HIV: Suggested Guidelines for Therapy, AIDS Research and Human Retroviruses, vol.15, issue.18, pp.1619-1642, 1999. ,
DOI : 10.1089/088922299309658
Sensitivity of Candida albicans biofilm cells grown on denture acrylic to antifungal proteins and chlorhexidine, Archives of Oral Biology, vol.54, issue.6, pp.588-94, 2009. ,
DOI : 10.1016/j.archoralbio.2009.01.016
Candida biofilms: an update. Eukaryot Cell, Review, vol.4, issue.4, pp.633-641, 2005. ,
DOI : 10.1128/ec.4.4.633-638.2005
URL : http://ec.asm.org/content/4/4/633.full.pdf
Candidal colonization and oral candidiasis in patients undergoing oral and pharyngeal radiation therapy, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, vol.84, issue.2, pp.149-53, 1997. ,
DOI : 10.1016/S1079-2104(97)90061-5
Evaluating diagnosis and treatment of oral and esophageal candidiasis in Ugandan AIDS patients. Emerg Infect Dis, pp.274-281, 1999. ,
Epidemiology of oropharyngeal Candida colonization and infection in patients receiving radiation for head and neck cancer, J Clin Microbiol, vol.37, issue.12, pp.3896-900, 1999. ,
A Randomized Trial Comparing Fluconazole with Amphotericin B for the Treatment of Candidemia in Patients without Neutropenia, New England Journal of Medicine, vol.331, issue.20, pp.1325-1355, 1994. ,
DOI : 10.1056/NEJM199411173312001
Practice Guidelines for the Treatment of Candidiasis, Clinical Infectious Diseases, vol.183, issue.4, 2000. ,
DOI : 10.1093/jnlids/170.3.644
Epidemiology of Candida albicans Infections and Role of Non-Candidaalbicans Yeasts, Current Drug Targets, vol.7, issue.4, pp.495-504, 2006. ,
DOI : 10.2174/138945006776359421
Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymes, Biochemical Journal, vol.230, issue.3, pp.765-70, 1985. ,
DOI : 10.1042/bj2300765
Candida-associated denture stomatitis, Medicina Oral Patolog??a Oral y Cirugia Bucal, vol.16, issue.2, pp.139-182, 2011. ,
DOI : 10.4317/medoral.16.e139
Oral candidosis: 1. Clinicopathological aspects. Dent Update, 1988. ,
Candida krusei: biology, epidemiology, pathogenicity and clinical manifestations of an emerging pathogen, Journal of Medical Microbiology, vol.41, issue.5, pp.295-310, 1994. ,
DOI : 10.1099/00222615-41-5-295
Candidiasis and other fungal diseases of the mouth, Dermatologic Therapy, vol.10, issue.3, pp.251-69, 2002. ,
DOI : 10.1093/clinids/19.2.357
In Vitro Method To Study Antifungal Perfusion in Candida Biofilms, Journal of Clinical Microbiology, vol.43, issue.2, pp.818-843, 2005. ,
DOI : 10.1128/JCM.43.2.818-825.2005
Epidemiology of oral candidiasis in HIV-infected patients: Colonization, infection, treatment, and emergence of fluconazole resistance, The American Journal of Medicine, vol.97, issue.4, pp.339-385, 1994. ,
DOI : 10.1016/0002-9343(94)90300-X
Miconazole, Drugs, vol.9, issue.6, pp.406-429, 1975. ,
DOI : 10.2165/00003495-197509060-00002
Candida and Oral Candidosis: A Review, Critical Reviews in Oral Biology & Medicine, vol.5, issue.2, pp.125-57, 1994. ,
DOI : 10.1111/j.1600-0714.1991.tb00880.x
Options et Recommandations pour la prévention, le diagnostic et le traitement des candidoses en cancérologie In: Fédération nationale des centres de lutte contre le cancer, Infection et cancer, pp.181-236, 1999. ,
Engineering design and molecular dynamics of mucoadhesive drug delivery systems as targeting agents, European Journal of Pharmaceutics and Biopharmaceutics, vol.71, issue.3, pp.519-547, 2008. ,
DOI : 10.1016/j.ejpb.2008.09.022
Current and emerging azole antifungal agents, Clin Microbiol Rev. Review, vol.12, issue.1, pp.40-79, 1999. ,
Occurrence of oral Candida in irradiated head and neck cancer patients, J Oral Med, vol.39, issue.4, pp.194-200, 1984. ,
Preparation and Evaluation of Buccal Bioadhesive Films Containing Clotrimazole, AAPS PharmSciTech, vol.9, issue.2, pp.660-667, 2008. ,
DOI : 10.1208/s12249-008-9083-3
Cytotoxic drugs, radiotherapy and oral candidiasis, Oral Oncology, vol.40, issue.10, pp.971-979, 2004. ,
DOI : 10.1016/j.oraloncology.2003.12.013
Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals, Microbiology, vol.141, issue.7, pp.1507-1528, 1995. ,
DOI : 10.1099/13500872-141-7-1507
Candidal infections and populations of Candida albicans in mouths of diabetics., Journal of Clinical Pathology, vol.34, issue.7, pp.706-717, 1981. ,
DOI : 10.1136/jcp.34.7.706
Oropharyngeal candidiasis in the era of antiretroviral therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, pp.488-95, 2010. ,
Epidemiology of Candidaemia in Europe: Results of 28-Month European Confederation of Medical Mycology (ECMM) Hospital-Based Surveillance Study, European Journal of Clinical Microbiology & Infectious Diseases, vol.23, issue.4, pp.317-339, 2004. ,
DOI : 10.1007/s10096-004-1103-y
Miconazole, a Broad-Spectrum Antimycotic Agent with Antibacterial Activity, Chemotherapy, vol.17, issue.6, pp.392-404, 1972. ,
DOI : 10.1159/000220875
Fungicidal activity of miconazole against Candida spp. biofilms, Journal of Antimicrobial Chemotherapy, vol.164, issue.4, pp.694-700, 2010. ,
DOI : 10.1083/jcb.200310148
Options for the Management of Mucosal Candidiasis in Patients with AIDS and HIV Infection, Pharmacotherapy, vol.171, issue.1, pp.76-87, 1999. ,
DOI : 10.1097/00002030-199809000-00010
Therapeutic Options for the Management of Oropharyngeal and Esophageal Candidiasis in HIV/AIDS Patients, HIV Clinical Trials, vol.1, issue.1, pp.47-59, 2000. ,
DOI : 10.1310/T7A7-1E63-2KA0-JKWD
Mucosal candidiasis, Infectious Disease Clinics of North America, vol.16, issue.4, pp.793-820, 2002. ,
DOI : 10.1016/S0891-5520(02)00042-9
A Multicenter Randomized Trial Evaluating Posaconazole versus Fluconazole for the Treatment of Oropharyngeal Candidiasis in Subjects with HIV/AIDS, Clinical Infectious Diseases, vol.48, issue.2, pp.1179-86, 2006. ,
DOI : 10.1128/AAC.48.2.568-574.2004
Role of posaconazole in the management of oropharyngeal and esophageal candidiasis. Ther Clin Risk Manag, pp.533-575, 2007. ,
Efficacy and Safety (SMiLES), HIV Clinical Trials, vol.42, issue.4, pp.186-196, 2010. ,
DOI : 10.1111/j.1365-2036.1992.tb00261.x
Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors, Antimicrob Agents Chemother, 2011. ,
Common oral conditions in older persons, Am Fam Physician, vol.78, issue.7, pp.845-52, 2008. ,
Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51) Antimicrob Agents Chemother, pp.4235-4280, 2010. ,