J. Vincent, Y. Sakr, and C. Sprung, Sepsis in European intensive care units: Results of the SOAP study*, Critical Care Medicine, vol.34, issue.2, pp.344-353, 2006.
DOI : 10.1097/01.CCM.0000194725.48928.3A

C. Brun-buisson, P. Meshaka, P. Pinton, and B. Vallet, EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units, Intensive Care Med, vol.30, pp.580-588, 2004.

E. Rivers, B. Nguyen, and S. Havstad, Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock, New England Journal of Medicine, vol.345, issue.19, pp.1368-1377, 2001.
DOI : 10.1056/NEJMoa010307

J. Ockenga, K. Borchert, K. Rifai, M. Manns, and S. Bischoff, Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis, Clinical Nutrition, vol.21, issue.5, pp.409-416, 2002.
DOI : 10.1054/clnu.2002.0569

P. Wischmeyer, J. Lynch, and J. Liedel, Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control, Critical Care Medicine, vol.29, issue.11, pp.2075-2080, 2001.
DOI : 10.1097/00003246-200111000-00006

A. De-beaux, M. O-'riordain, and J. Ross, Glutamine-Supplemented Total Parenteral Nutrition Reduces Blood Mononuclear Cell Interleukin-8 Release in Severe Acute Pancreatitis, Nutrition, vol.14, issue.3, pp.261-265, 1998.
DOI : 10.1016/S0899-9007(97)00477-2

R. Griffiths, K. Allen, F. Andrews, and C. Jones, Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection, Nutrition, vol.18, issue.7-8, pp.546-552, 2002.
DOI : 10.1016/S0899-9007(02)00817-1

P. Déchelotte, M. Hasselmann, and L. Cynober, L-alanyl-L-glutamine dipeptide???supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study*, Critical Care Medicine, vol.34, issue.3, pp.598-604, 2006.
DOI : 10.1097/01.CCM.0000201004.30750.D1

C. Fuentes-orozco, R. Anaya-prado, and A. González-ojeda, l-Alanyl-l-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis, Clinical Nutrition, vol.23, issue.1, pp.13-21, 2004.
DOI : 10.1016/S0261-5614(03)00055-4

C. Fuentes-orozco, G. Cervantes-guevara, and I. Muciño-hernández, -Glutamine-Supplemented Parenteral Nutrition Decreases Infectious Morbidity Rate in Patients With Severe Acute Pancreatitis, Journal of Parenteral and Enteral Nutrition, vol.32, issue.4, pp.403-411, 2008.
DOI : 10.3748/wjg.14.474

C. Goeters, A. Wenn, and N. Mertes, Parenteral l-alanyl-l-glutamine improves 6-month outcome in critically ill patients*, Critical Care Medicine, vol.30, issue.9, pp.2032-2037, 2002.
DOI : 10.1097/00003246-200209000-00013

B. Bakalar, F. Duska, and J. Pachl, Parenterally administered dipeptide alanylglutamine prevents worsening of insulin sensitivity in multiple-trauma patients

R. Griffiths, C. Jones, and T. Palmer, Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition, Nutrition, vol.13, pp.295-302, 1997.

G. Bertolini, D. Luciani, and G. Biolo, Immunonutrition in septic patients: A philosophical view of the current situation, Clinical Nutrition, vol.26, issue.1, pp.25-29, 2007.
DOI : 10.1016/j.clnu.2006.08.005

B. Alberts, Biologie moléculaire de la cellule. 3 e éd. Flammarion Médecine, 1997.

R. Neviere, Physiopathologie mitochondriale et syndrome septique, R??animation, vol.17, issue.3, pp.185-191, 2008.
DOI : 10.1016/j.reaurg.2008.01.009

R. Fillingame, PROTEIN STRUCTURE: Molecular Rotary Motors, Science, vol.286, issue.5445, pp.1687-1688, 1999.
DOI : 10.1126/science.286.5445.1687

H. Wang and G. Oster, Energy transduction in the F1 motor of ATP synthase, Nature, vol.93, issue.6708, pp.279-282, 1998.
DOI : 10.1016/S0092-8674(00)81456-7

S. Peltier, Y. Burelle, and V. Novel-chate, Effect of exogenous adenosine and monensin on glycolytic flux in isolated perfused normoxic rat hearts: Role of pyruvate kinase, Molecular and Cellular Biochemistry, vol.98, issue.1-2, pp.55-61, 2005.
DOI : 10.1016/0306-3623(95)02053-5

URL : https://hal.archives-ouvertes.fr/inserm-00388743

J. Orban, X. Leverve, and C. Ichai, Lactate??: le substrat ??nerg??tique de demain, R??animation, vol.19, issue.5, pp.384-392, 2010.
DOI : 10.1016/j.reaurg.2010.05.016

B. Hassel, A. Ilebekk, and T. Tønnessen, Cardiac accumulation of citrate during brief myocardial ischaemia and reperfusion in the pig in vivo, Acta Physiologica Scandinavica, vol.27, issue.1, pp.53-59, 1998.
DOI : 10.1038/2031171a0

K. Peuhkurinen, T. Takala, E. Nuutinen, and I. Hassinen, Tricarboxylic acid cycle metabolites during ischemia in isolated perfused rat heart, American Journal of Physiology-Heart and Circulatory Physiology, vol.244, issue.2, pp.281-288, 1983.
DOI : 10.1152/ajpheart.1983.244.2.H281

H. Taegtmeyer, Metabolic responses to cardiac hypoxia. Increased production of succinate by rabbit papillary muscles, Circulation Research, vol.43, issue.5, pp.808-815, 1978.
DOI : 10.1161/01.RES.43.5.808

K. Peuhkurinen, Regulation of the tricarboxylic acid cycle pool size in heart muscle, Journal of Molecular and Cellular Cardiology, vol.16, issue.6, pp.487-495, 1984.
DOI : 10.1016/S0022-2828(84)80637-9

L. Forni, W. Mckinnon, and G. Lord, Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis, Critical Care, vol.9, issue.5, pp.591-595, 2005.
DOI : 10.1186/cc3806

J. James, F. Luchette, F. Mccarter, and J. Fischer, Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis, The Lancet, vol.354, issue.9177, pp.505-508, 1999.
DOI : 10.1016/S0140-6736(98)91132-1

T. Vary and S. Hazen, Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle, Molecular and Cellular Biochemistry, vol.198, issue.1/2, pp.113-118, 1999.
DOI : 10.1023/A:1006993910781

R. Hotchkiss, S. Song, and J. Neil, Sepsis does not impair tricarboxylic acid cycle in the heart, American Journal of Physiology-Cell Physiology, vol.38, issue.1, pp.50-57, 1991.
DOI : 10.1016/0022-4804(80)90037-2

K. Mason and D. Stofan, Endotoxin challenge reduces aconitase activity in myocardial tissue, Archives of Biochemistry and Biophysics, vol.469, issue.2, pp.151-156, 2008.
DOI : 10.1016/j.abb.2007.10.018

R. Hotchkiss, P. Swanson, and B. Freeman, Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction, Critical Care Medicine, vol.27, issue.7, pp.1230-1251, 1999.
DOI : 10.1097/00003246-199907000-00002

A. Rudiger, M. Stotz, and M. Singer, Cellular processes in sepsis, Swiss Med Wkly, vol.138, pp.629-634, 2008.

E. Roth, J. Funovics, and F. Mühlbacher, Metabolic disorders in severe abdominal sepsis: Glutamine deficiency in skeletal muscle, Clinical Nutrition, vol.1, issue.1, pp.25-41, 1982.
DOI : 10.1016/0261-5614(82)90004-8

T. Austgen, R. Chakrabarti, M. Chen, and W. Souba, Adaptive Regulation in Skeletal Muscle Glutamine Metabolism in Endotoxin-Treated Rats, The Journal of Trauma: Injury, Infection, and Critical Care, vol.32, issue.5, pp.600-606, 1992.
DOI : 10.1097/00005373-199205000-00011

DOI : 10.1097/00024382-199705000-00004

T. Welbourne, Interorgan glutamine flow in metabolic acidosis, American Journal of Physiology-Renal Physiology, vol.253, issue.6, pp.1069-1076, 1987.
DOI : 10.1152/ajprenal.1987.253.6.F1069

W. Souba, D. Plumley, R. Salloum, and E. Copeland, Effects of glucocorticoids on lung glutamine and alanine metabolism, Surgery, vol.108, pp.213-218, 1990.

W. Souba, K. Herskowitz, and V. Klimberg, The Effects of Sepsis and Endotoxemia on Gut Glutamine Metabolism, Annals of Surgery, vol.211, issue.5, pp.543-549, 1990.
DOI : 10.1097/00000658-199005000-00004

T. Austgen, M. Chen, T. Flynn, and W. Souba, The Effects of Endotoxin on the Splanchnic Metabolism of Glutamine and Related Substrates, The Journal of Trauma: Injury, Infection, and Critical Care, vol.31, issue.6, pp.742-751, 1991.
DOI : 10.1097/00005373-199106000-00003

P. Sarantos, K. Ockert, and W. Souba, Endotoxin Stimulates Lymphocyte Glutaminase Expression, Archives of Surgery, vol.128, issue.8, pp.920-924, 1993.
DOI : 10.1001/archsurg.1993.01420200094017

Y. Inoue, A. Pacitti, and W. Souba, Endotoxin Increases Hepatic Glutamine Transport Activity, Journal of Surgical Research, vol.54, issue.5, pp.393-400, 1993.
DOI : 10.1006/jsre.1993.1063

C. Fischer, B. Bode, K. Takahashi, K. Tanabe, and W. Souba, Glucocorticoid-Dependent Induction of Interleukin-6 Receptor Expression in Human Hepatocytes Facilitates Interleukin-6 Stimulation of Amino Acid Transport, Annals of Surgery, vol.223, issue.5, pp.610-618, 1996.
DOI : 10.1097/00000658-199605000-00017

A. Houdijk, E. Rijnsburger, and J. Jansen, Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma, The Lancet, vol.352, issue.9130, pp.772-776, 1998.
DOI : 10.1016/S0140-6736(98)02007-8

P. Singer, M. Berger, and G. Van-den-berghe, ESPEN Guidelines on Parenteral Nutrition: Intensive care, Clinical Nutrition, vol.28, issue.4, pp.387-400, 2009.
DOI : 10.1016/j.clnu.2009.04.024

URL : https://hal.archives-ouvertes.fr/inserm-00422460

H. Brunengraber and C. Roe, Anaplerotic molecules: Current and future, Journal of Inherited Metabolic Disease, vol.20, issue.2-3
DOI : 10.1042/bj1010242

F. Mochel, P. Delonlay, and G. Touati, Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy, Molecular Genetics and Metabolism, vol.84, issue.4, pp.305-312, 2005.
DOI : 10.1016/j.ymgme.2004.09.007

F. Feillet, M. Merten, and S. Battaglia-hsu, Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency, Journal of Hepatology, vol.48, issue.3, pp.517-522, 2008.
DOI : 10.1016/j.jhep.2007.11.016

R. Russell, J. Mommessin, and H. Taegtmeyer, Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate, American Journal of Physiology-Heart and Circulatory Physiology, vol.268, issue.1, pp.441-447, 1995.
DOI : 10.1152/ajpheart.1995.268.1.H441

R. Russell and H. Taegtmeyer, Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate, American Journal of Physiology-Heart and Circulatory Physiology, vol.261, issue.6, pp.1756-1762, 1991.
DOI : 10.1152/ajpheart.1991.261.6.H1756

M. Aller, J. Arias, A. Alonso-poza, and J. Arias, A Review of metabolic staging in severely injured patients, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol.18, issue.1, p.27, 2010.
DOI : 10.1186/1757-7241-18-27

P. Boekstegers, S. Weidenhöfer, G. Pilz, and K. Werdan, Periphere Sauerstoffverf??gbarkeit im Skelettmuskel bei Sepsis und septischem Schock: Vergleich mit begrenzter Infektion und kardiogenem Schock, Infection, vol.24, issue.5, pp.317-323, 1991.
DOI : 10.1007/978-1-4684-1188-1_42

J. Neely and H. Morgan, Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle, Annual Review of Physiology, vol.36, issue.1, pp.413-459, 1974.
DOI : 10.1146/annurev.ph.36.030174.002213

L. Landow, Splanchnic lactate production in cardiac surgery patients, Critical Care Medicine, vol.21, issue.Supplement, pp.84-91, 1993.
DOI : 10.1097/00003246-199302001-00015

R. Lerch, C. Tamm, I. Papageorgiou, and R. Benzi, Myocardial fatty acid oxidation during ischemia and reperfusion, Molecular and Cellular Biochemistry, vol.17, issue.suppl III, pp.103-109, 1992.
DOI : 10.1161/01.CIR.65.4.731

A. Liedtke, S. Nellis, and J. Neely, Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine, Circulation Research, vol.43, issue.4, pp.652-661, 1978.
DOI : 10.1161/01.RES.43.4.652

M. Oliver, V. Kurien, and T. Greenwood, RELATION BETWEEN SERUM-FREE-FATTY-ACIDS AND ARRHYTHMIAS AND DEATH AFTER ACUTE MYOCARDIAL INFARCTION, The Lancet, vol.291, issue.7545, pp.710-714, 1968.
DOI : 10.1016/S0140-6736(68)92163-6

V. Borutaite, V. Mildaziene, G. Brown, and M. Brand, Control and kinetic analysis of ischemia-damaged heart mitochondria: which parts of the oxidative phosphorylation system are affected by ischemia?, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1272, issue.3, pp.154-158, 1995.
DOI : 10.1016/0925-4439(95)00080-1

F. Han, T. Da, N. Riobo, and L. Becker, Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest, Critical Care Medicine, vol.36, issue.Suppl, pp.447-453, 2008.
DOI : 10.1097/CCM.0b013e31818a8a51

E. Lesnefsky, T. Slabe, M. Stoll, P. Minkler, and C. Hoppel, Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria, American Journal of Physiology-Heart and Circulatory Physiology, vol.269, issue.6
DOI : 10.1021/bi00645a016

J. Poderoso, C. Lisdero, and F. Schöpfer, The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol, Journal of Biological Chemistry, vol.314, issue.53, pp.37709-37716, 1999.
DOI : 10.1074/jbc.272.44.27812

N. Riobó, E. Clementi, and M. Melani, Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation, Biochemical Journal, vol.359, issue.1, pp.139-145, 2001.
DOI : 10.1042/bj3590139

Y. Qin, V. Hoek, T. Wojcik, and K. , release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion, American Journal of Physiology-Heart and Circulatory Physiology, vol.286, issue.6
DOI : 10.1016/S0024-3205(02)01550-3

V. Hoek, T. Qin, Y. Wojcik, and K. , Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes, American Journal of Physiology-Heart and Circulatory Physiology, vol.86, issue.1, pp.141-150, 2003.
DOI : 10.1016/S0014-5793(01)03228-8

D. Backer, D. Creteur, J. Preiser, J. Dubois, M. Vincent et al., Microvascular Blood Flow Is Altered in Patients with Sepsis, American Journal of Respiratory and Critical Care Medicine, vol.166, issue.1, pp.98-104, 2002.
DOI : 10.1152/jappl.1996.81.2.885

C. Ince and M. Sinaasappel, Microcirculatory oxygenation and shunting in sepsis and shock, Critical Care Medicine, vol.27, issue.7, pp.1369-1377, 1999.
DOI : 10.1097/00003246-199907000-00031

R. Hotchkiss, R. Rust, and C. Dence, Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.261, issue.4, pp.965-972, 1991.
DOI : 10.1152/ajpregu.1991.261.4.R965

G. Kreymann, S. Grosser, and P. Buggisch, Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock, Critical Care Medicine, vol.21, issue.7, pp.1012-1019, 1993.
DOI : 10.1097/00003246-199307000-00015

D. Rosser, R. Stidwill, D. Jacobson, and M. Singer, Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis, Journal of Applied Physiology, vol.79, issue.6, pp.1878-1882, 1995.
DOI : 10.1152/jappl.1995.79.6.1878

P. Boekstegers, S. Weidenhöfer, T. Kapsner, and K. Werdan, Skeletal muscle partial pressure of oxygen in patients with sepsis, Critical Care Medicine, vol.22, issue.4, pp.640-650, 1994.
DOI : 10.1097/00003246-199404000-00021

R. Hotchkiss, P. Swanson, and B. Freeman, Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction, Critical Care Medicine, vol.27, issue.7, pp.1230-1251, 1999.
DOI : 10.1097/00003246-199907000-00002

M. Fink, Bench-to-bedside review: Cytopathic hypoxia, Critical Care, vol.6, issue.6, pp.491-499, 2002.
DOI : 10.1186/cc1824

M. Fink, Cytopathic hypoxia in sepsis, Acta Anaesthesiol Scand Suppl, vol.110, pp.87-95, 1997.

M. Fink, Cytopathic hypoxia: Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?, Critical Care Clinics, vol.18, issue.1, pp.165-175, 2002.
DOI : 10.1016/S0749-0704(03)00071-X

M. Fink, Cytopathic Hypoxia, Critical Care Clinics, vol.17, issue.1, pp.219-237, 2001.
DOI : 10.1016/S0749-0704(05)70161-5

L. Gotloib, A. Shostak, P. Galdi, J. Jaichenko, and R. Fudin, Loss of microvascular negative charges accompanied by interstitial edema in septic rats' heart, Circ. Shock, vol.36, pp.45-56, 1992.

K. Welty-wolf, S. Simonson, and Y. Huang, ULTRASTRUCTURAL CHANGES IN SKELETAL MUSCLE MITOCHONDRIA IN GRAM-NEGATIVE SEPSIS, Shock, vol.5, issue.5, pp.378-384, 1996.
DOI : 10.1097/00024382-199605000-00011

L. Liaudet, F. Soriano, and C. Szabó, Biology of nitric oxide signaling, Critical Care Medicine, vol.28, issue.Supplement, pp.37-52, 2000.
DOI : 10.1097/00003246-200004001-00005

G. Brown and V. Borutaite, Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1658, issue.1-2, pp.44-49, 2004.
DOI : 10.1016/j.bbabio.2004.03.016

L. Callahan and G. Supinski, Sepsis Induces Diaphragm Electron Transport Chain Dysfunction and Protein Depletion, American Journal of Respiratory and Critical Care Medicine, vol.172, issue.7, pp.861-868, 2005.
DOI : 10.1007/BF02254981


S. Calvano, X. W. Richards, and D. , A network-based analysis of systemic inflammation in humans, Nature, vol.95, issue.7061, pp.1032-1037, 2005.
DOI : 10.1073/pnas.95.25.14863

D. Brealey, S. Karyampudi, and T. Jacques, Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.286, issue.3, pp.491-497, 2004.
DOI : 10.1016/S0005-2728(99)00031-6

S. Simonson, K. Welty-wolf, and Y. Huang, Altered mitochondrial redox responses in gram negative septic shock in primates, Circ. Shock, vol.43, pp.34-43, 1994.

E. Crouser, M. Julian, D. Blaho, and D. Pfeiffer, Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity, Critical Care Medicine, vol.30, issue.2, pp.276-284, 2002.
DOI : 10.1097/00003246-200202000-00002

B. Beltrán, A. Mathur, M. Duchen, J. Erusalimsky, and S. Moncada, The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death, Proceedings of the National Academy of Sciences, vol.162, issue.3
DOI : 10.1006/abbi.2000.1716

D. Brealey, M. Brand, and I. Hargreaves, Association between mitochondrial dysfunction and severity and outcome of septic shock, The Lancet, vol.360, issue.9328, pp.219-223, 2002.
DOI : 10.1016/S0140-6736(02)09459-X

K. Fredriksson, F. Hammarqvist, and K. Strigård, Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure, American Journal of Physiology-Endocrinology and Metabolism, vol.291, issue.5, pp.1044-1050, 2006.
DOI : 10.2337/diabetes.49.11.1904

M. Singer, D. Santis, V. Vitale, D. Jeffcoate, and W. , Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation, The Lancet, vol.364, issue.9433, pp.545-548, 2004.
DOI : 10.1016/S0140-6736(04)16815-3

M. Singer, Mitochondrial function in sepsis: Acute phase versus multiple organ failure, Critical Care Medicine, vol.35, issue.Suppl, pp.441-448, 2007.
DOI : 10.1097/01.CCM.0000278049.48333.78

H. Van-hees, W. Schellekens, and M. Linkels, Plasma from septic shock patients induces loss of muscle protein, Critical Care, vol.15, issue.5, p.233, 2011.
DOI : 10.1007/s00424-008-0574-6

N. Takeyama, Y. Itoh, Y. Kitazawa, and T. Tanaka, Altered hepatic mitochondrial fatty acid oxidation and ketogenesis in endotoxic rats, American Journal of Physiology-Endocrinology and Metabolism, vol.68, issue.4, pp.498-505, 1990.
DOI : 10.1177/014860718400800114

C. Chambrier, M. Laville, R. Berrada, and K. , Insulin sensitivity of glucose and fat metabolism in severe sepsis, Clinical Science, vol.99, issue.4, pp.321-328, 2000.
DOI : 10.1042/cs0990321

P. Marik and M. Raghavan, Stress-hyperglycemia, insulin and immunomodulation in sepsis, Intensive Care Medicine, vol.30, issue.5, pp.748-756, 2004.
DOI : 10.1007/s00134-004-2167-y

A. Agwunobi, C. Reid, P. Maycock, R. Little, and G. Carlson, Insulin Resistance and Substrate Utilization in Human Endotoxemia, The Journal of Clinical Endocrinology & Metabolism, vol.85, issue.10, pp.3770-3778, 2000.
DOI : 10.1210/jcem.85.10.6914

M. Saeed, G. Carlson, R. Little, and M. Irving, Selective impairment of glucose storage in human sepsis, British Journal of Surgery, vol.33, issue.6, pp.813-821, 1999.
DOI : 10.1016/0026-0495(81)90074-3

J. Wallington, J. Ning, and M. Titheradge, The control of hepatic glycogen metabolism in an in??vitro model of sepsis, Molecular and Cellular Biochemistry, vol.288, issue.1-2, pp.183-192, 2008.
DOI : 10.1042/bj2880497

L. Callahan and G. Supinski, Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis, Journal of Applied Physiology, vol.99, issue.3, pp.1120-1126, 2005.
DOI : 10.1152/ajpendo.1986.250.6.E634

DOI : 10.1097/00024382-199608000-00002

D. Gore, F. Jahoor, J. Hibbert, and E. Demaria, Lactic Acidosis During Sepsis Is Related to Increased Pyruvate Production, Not Deficits in Tissue Oxygen Availability, Annals of Surgery, vol.224, issue.1
DOI : 10.1097/00000658-199607000-00015

B. Levy, S. Gibot, P. Franck, A. Cravoisy, and P. Bollaert, Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study, The Lancet, vol.365, issue.9462, pp.871-875, 2005.
DOI : 10.1016/S0140-6736(05)71045-X

J. Bowtell and M. Bruce, Glutamine: an anaplerotic precursor, Nutrition, vol.18, issue.3, pp.222-224, 2002.
DOI : 10.1016/S0899-9007(01)00795-X

J. Hochman, C. Buller, and L. Sleeper, Cardiogenic shock complicating acute myocardial infarction???etiologies, management and outcome: a report from the SHOCK Trial Registry, Journal of the American College of Cardiology, vol.36, issue.3, pp.1063-1070, 2000.
DOI : 10.1016/S0735-1097(00)00879-2

A. Babaev, P. Frederick, and D. Pasta, Trends in Management and Outcomes of Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock, JAMA, vol.294, issue.4, pp.448-454, 2005.
DOI : 10.1001/jama.294.4.448

N. Cano, M. Aparicio, and G. Brunori, ESPEN Guidelines on Parenteral Nutrition: Adult Renal Failure, Clinical Nutrition, vol.28, issue.4, pp.401-414, 2009.
DOI : 10.1016/j.clnu.2009.05.016

P. Marik, S. Pastores, and D. Annane, Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine, Critical Care Medicine, vol.36, issue.6, pp.1937-1949, 2008.
DOI : 10.1097/CCM.0b013e31817603ba