Sepsis in European intensive care units: Results of the SOAP study*, Critical Care Medicine, vol.34, issue.2, pp.344-353, 2006. ,
DOI : 10.1097/01.CCM.0000194725.48928.3A
EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units, Intensive Care Med, vol.30, pp.580-588, 2004. ,
Early Goal-Directed Therapy in the Treatment of Severe Sepsis and Septic Shock, New England Journal of Medicine, vol.345, issue.19, pp.1368-1377, 2001. ,
DOI : 10.1056/NEJMoa010307
Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis, Clinical Nutrition, vol.21, issue.5, pp.409-416, 2002. ,
DOI : 10.1054/clnu.2002.0569
Glutamine administration reduces Gram-negative bacteremia in severely burned patients: A prospective, randomized, double-blind trial versus isonitrogenous control, Critical Care Medicine, vol.29, issue.11, pp.2075-2080, 2001. ,
DOI : 10.1097/00003246-200111000-00006
Glutamine-Supplemented Total Parenteral Nutrition Reduces Blood Mononuclear Cell Interleukin-8 Release in Severe Acute Pancreatitis, Nutrition, vol.14, issue.3, pp.261-265, 1998. ,
DOI : 10.1016/S0899-9007(97)00477-2
Infection, multiple organ failure, and survival in the intensive care unit: influence of glutamine-supplemented parenteral nutrition on acquired infection, Nutrition, vol.18, issue.7-8, pp.546-552, 2002. ,
DOI : 10.1016/S0899-9007(02)00817-1
L-alanyl-L-glutamine dipeptide???supplemented total parenteral nutrition reduces infectious complications and glucose intolerance in critically ill patients: The French controlled, randomized, double-blind, multicenter study*, Critical Care Medicine, vol.34, issue.3, pp.598-604, 2006. ,
DOI : 10.1097/01.CCM.0000201004.30750.D1
l-Alanyl-l-glutamine-supplemented parenteral nutrition improves infectious morbidity in secondary peritonitis, Clinical Nutrition, vol.23, issue.1, pp.13-21, 2004. ,
DOI : 10.1016/S0261-5614(03)00055-4
-Glutamine-Supplemented Parenteral Nutrition Decreases Infectious Morbidity Rate in Patients With Severe Acute Pancreatitis, Journal of Parenteral and Enteral Nutrition, vol.32, issue.4, pp.403-411, 2008. ,
DOI : 10.3748/wjg.14.474
Parenteral l-alanyl-l-glutamine improves 6-month outcome in critically ill patients*, Critical Care Medicine, vol.30, issue.9, pp.2032-2037, 2002. ,
DOI : 10.1097/00003246-200209000-00013
Parenterally administered dipeptide alanylglutamine prevents worsening of insulin sensitivity in multiple-trauma patients ,
Six-month outcome of critically ill patients given glutamine-supplemented parenteral nutrition, Nutrition, vol.13, pp.295-302, 1997. ,
Immunonutrition in septic patients: A philosophical view of the current situation, Clinical Nutrition, vol.26, issue.1, pp.25-29, 2007. ,
DOI : 10.1016/j.clnu.2006.08.005
Biologie moléculaire de la cellule. 3 e éd. Flammarion Médecine, 1997. ,
Physiopathologie mitochondriale et syndrome septique, R??animation, vol.17, issue.3, pp.185-191, 2008. ,
DOI : 10.1016/j.reaurg.2008.01.009
PROTEIN STRUCTURE: Molecular Rotary Motors, Science, vol.286, issue.5445, pp.1687-1688, 1999. ,
DOI : 10.1126/science.286.5445.1687
Energy transduction in the F1 motor of ATP synthase, Nature, vol.93, issue.6708, pp.279-282, 1998. ,
DOI : 10.1016/S0092-8674(00)81456-7
Effect of exogenous adenosine and monensin on glycolytic flux in isolated perfused normoxic rat hearts: Role of pyruvate kinase, Molecular and Cellular Biochemistry, vol.98, issue.1-2, pp.55-61, 2005. ,
DOI : 10.1016/0306-3623(95)02053-5
URL : https://hal.archives-ouvertes.fr/inserm-00388743
Lactate??: le substrat ??nerg??tique de demain, R??animation, vol.19, issue.5, pp.384-392, 2010. ,
DOI : 10.1016/j.reaurg.2010.05.016
Cardiac accumulation of citrate during brief myocardial ischaemia and reperfusion in the pig in vivo, Acta Physiologica Scandinavica, vol.27, issue.1, pp.53-59, 1998. ,
DOI : 10.1038/2031171a0
Tricarboxylic acid cycle metabolites during ischemia in isolated perfused rat heart, American Journal of Physiology-Heart and Circulatory Physiology, vol.244, issue.2, pp.281-288, 1983. ,
DOI : 10.1152/ajpheart.1983.244.2.H281
Metabolic responses to cardiac hypoxia. Increased production of succinate by rabbit papillary muscles, Circulation Research, vol.43, issue.5, pp.808-815, 1978. ,
DOI : 10.1161/01.RES.43.5.808
Regulation of the tricarboxylic acid cycle pool size in heart muscle, Journal of Molecular and Cellular Cardiology, vol.16, issue.6, pp.487-495, 1984. ,
DOI : 10.1016/S0022-2828(84)80637-9
Circulating anions usually associated with the Krebs cycle in patients with metabolic acidosis, Critical Care, vol.9, issue.5, pp.591-595, 2005. ,
DOI : 10.1186/cc3806
Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis, The Lancet, vol.354, issue.9177, pp.505-508, 1999. ,
DOI : 10.1016/S0140-6736(98)91132-1
Sepsis alters pyruvate dehydrogenase kinase activity in skeletal muscle, Molecular and Cellular Biochemistry, vol.198, issue.1/2, pp.113-118, 1999. ,
DOI : 10.1023/A:1006993910781
Sepsis does not impair tricarboxylic acid cycle in the heart, American Journal of Physiology-Cell Physiology, vol.38, issue.1, pp.50-57, 1991. ,
DOI : 10.1016/0022-4804(80)90037-2
Endotoxin challenge reduces aconitase activity in myocardial tissue, Archives of Biochemistry and Biophysics, vol.469, issue.2, pp.151-156, 2008. ,
DOI : 10.1016/j.abb.2007.10.018
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction, Critical Care Medicine, vol.27, issue.7, pp.1230-1251, 1999. ,
DOI : 10.1097/00003246-199907000-00002
Cellular processes in sepsis, Swiss Med Wkly, vol.138, pp.629-634, 2008. ,
Metabolic disorders in severe abdominal sepsis: Glutamine deficiency in skeletal muscle, Clinical Nutrition, vol.1, issue.1, pp.25-41, 1982. ,
DOI : 10.1016/0261-5614(82)90004-8
Adaptive Regulation in Skeletal Muscle Glutamine Metabolism in Endotoxin-Treated Rats, The Journal of Trauma: Injury, Infection, and Critical Care, vol.32, issue.5, pp.600-606, 1992. ,
DOI : 10.1097/00005373-199205000-00011
INDUCTION OF MUSCLE GLUTAMINE SYNTHETASE GENE EXPRESSION DURING ENDOTOXEMIA IS ADRENAL GLAND DEPENDENT, Shock, vol.7, issue.5, pp.332-338, 1997. ,
DOI : 10.1097/00024382-199705000-00004
Interorgan glutamine flow in metabolic acidosis, American Journal of Physiology-Renal Physiology, vol.253, issue.6, pp.1069-1076, 1987. ,
DOI : 10.1152/ajprenal.1987.253.6.F1069
Effects of glucocorticoids on lung glutamine and alanine metabolism, Surgery, vol.108, pp.213-218, 1990. ,
The Effects of Sepsis and Endotoxemia on Gut Glutamine Metabolism, Annals of Surgery, vol.211, issue.5, pp.543-549, 1990. ,
DOI : 10.1097/00000658-199005000-00004
The Effects of Endotoxin on the Splanchnic Metabolism of Glutamine and Related Substrates, The Journal of Trauma: Injury, Infection, and Critical Care, vol.31, issue.6, pp.742-751, 1991. ,
DOI : 10.1097/00005373-199106000-00003
Endotoxin Stimulates Lymphocyte Glutaminase Expression, Archives of Surgery, vol.128, issue.8, pp.920-924, 1993. ,
DOI : 10.1001/archsurg.1993.01420200094017
Endotoxin Increases Hepatic Glutamine Transport Activity, Journal of Surgical Research, vol.54, issue.5, pp.393-400, 1993. ,
DOI : 10.1006/jsre.1993.1063
Glucocorticoid-Dependent Induction of Interleukin-6 Receptor Expression in Human Hepatocytes Facilitates Interleukin-6 Stimulation of Amino Acid Transport, Annals of Surgery, vol.223, issue.5, pp.610-618, 1996. ,
DOI : 10.1097/00000658-199605000-00017
Randomised trial of glutamine-enriched enteral nutrition on infectious morbidity in patients with multiple trauma, The Lancet, vol.352, issue.9130, pp.772-776, 1998. ,
DOI : 10.1016/S0140-6736(98)02007-8
ESPEN Guidelines on Parenteral Nutrition: Intensive care, Clinical Nutrition, vol.28, issue.4, pp.387-400, 2009. ,
DOI : 10.1016/j.clnu.2009.04.024
URL : https://hal.archives-ouvertes.fr/inserm-00422460
Anaplerotic molecules: Current and future, Journal of Inherited Metabolic Disease, vol.20, issue.2-3 ,
DOI : 10.1042/bj1010242
Pyruvate carboxylase deficiency: clinical and biochemical response to anaplerotic diet therapy, Molecular Genetics and Metabolism, vol.84, issue.4, pp.305-312, 2005. ,
DOI : 10.1016/j.ymgme.2004.09.007
Evidence of cataplerosis in a patient with neonatal classical galactosemia presenting as citrin deficiency, Journal of Hepatology, vol.48, issue.3, pp.517-522, 2008. ,
DOI : 10.1016/j.jhep.2007.11.016
Propionyl-L-carnitine-mediated improvement in contractile function of rat hearts oxidizing acetoacetate, American Journal of Physiology-Heart and Circulatory Physiology, vol.268, issue.1, pp.441-447, 1995. ,
DOI : 10.1152/ajpheart.1995.268.1.H441
Pyruvate carboxylation prevents the decline in contractile function of rat hearts oxidizing acetoacetate, American Journal of Physiology-Heart and Circulatory Physiology, vol.261, issue.6, pp.1756-1762, 1991. ,
DOI : 10.1152/ajpheart.1991.261.6.H1756
A Review of metabolic staging in severely injured patients, Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, vol.18, issue.1, p.27, 2010. ,
DOI : 10.1186/1757-7241-18-27
Periphere Sauerstoffverf??gbarkeit im Skelettmuskel bei Sepsis und septischem Schock: Vergleich mit begrenzter Infektion und kardiogenem Schock, Infection, vol.24, issue.5, pp.317-323, 1991. ,
DOI : 10.1007/978-1-4684-1188-1_42
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle, Annual Review of Physiology, vol.36, issue.1, pp.413-459, 1974. ,
DOI : 10.1146/annurev.ph.36.030174.002213
Splanchnic lactate production in cardiac surgery patients, Critical Care Medicine, vol.21, issue.Supplement, pp.84-91, 1993. ,
DOI : 10.1097/00003246-199302001-00015
Myocardial fatty acid oxidation during ischemia and reperfusion, Molecular and Cellular Biochemistry, vol.17, issue.suppl III, pp.103-109, 1992. ,
DOI : 10.1161/01.CIR.65.4.731
Effects of excess free fatty acids on mechanical and metabolic function in normal and ischemic myocardium in swine, Circulation Research, vol.43, issue.4, pp.652-661, 1978. ,
DOI : 10.1161/01.RES.43.4.652
RELATION BETWEEN SERUM-FREE-FATTY-ACIDS AND ARRHYTHMIAS AND DEATH AFTER ACUTE MYOCARDIAL INFARCTION, The Lancet, vol.291, issue.7545, pp.710-714, 1968. ,
DOI : 10.1016/S0140-6736(68)92163-6
Control and kinetic analysis of ischemia-damaged heart mitochondria: which parts of the oxidative phosphorylation system are affected by ischemia?, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1272, issue.3, pp.154-158, 1995. ,
DOI : 10.1016/0925-4439(95)00080-1
Early mitochondrial dysfunction in electron transfer activity and reactive oxygen species generation after cardiac arrest, Critical Care Medicine, vol.36, issue.Suppl, pp.447-453, 2008. ,
DOI : 10.1097/CCM.0b013e31818a8a51
Myocardial ischemia selectively depletes cardiolipin in rabbit heart subsarcolemmal mitochondria, American Journal of Physiology-Heart and Circulatory Physiology, vol.269, issue.6 ,
DOI : 10.1021/bi00645a016
The Regulation of Mitochondrial Oxygen Uptake by Redox Reactions Involving Nitric Oxide and Ubiquinol, Journal of Biological Chemistry, vol.314, issue.53, pp.37709-37716, 1999. ,
DOI : 10.1074/jbc.272.44.27812
Nitric oxide inhibits mitochondrial NADH:ubiquinone reductase activity through peroxynitrite formation, Biochemical Journal, vol.359, issue.1, pp.139-145, 2001. ,
DOI : 10.1042/bj3590139
release and cell death in chick cardiomyocytes after simulated ischemia-reperfusion, American Journal of Physiology-Heart and Circulatory Physiology, vol.286, issue.6 ,
DOI : 10.1016/S0024-3205(02)01550-3
Reperfusion, not simulated ischemia, initiates intrinsic apoptosis injury in chick cardiomyocytes, American Journal of Physiology-Heart and Circulatory Physiology, vol.86, issue.1, pp.141-150, 2003. ,
DOI : 10.1016/S0014-5793(01)03228-8
Microvascular Blood Flow Is Altered in Patients with Sepsis, American Journal of Respiratory and Critical Care Medicine, vol.166, issue.1, pp.98-104, 2002. ,
DOI : 10.1152/jappl.1996.81.2.885
Microcirculatory oxygenation and shunting in sepsis and shock, Critical Care Medicine, vol.27, issue.7, pp.1369-1377, 1999. ,
DOI : 10.1097/00003246-199907000-00031
Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F]fluoromisonidazole, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.261, issue.4, pp.965-972, 1991. ,
DOI : 10.1152/ajpregu.1991.261.4.R965
Oxygen consumption and resting metabolic rate in sepsis, sepsis syndrome, and septic shock, Critical Care Medicine, vol.21, issue.7, pp.1012-1019, 1993. ,
DOI : 10.1097/00003246-199307000-00015
Oxygen tension in the bladder epithelium rises in both high and low cardiac output endotoxemic sepsis, Journal of Applied Physiology, vol.79, issue.6, pp.1878-1882, 1995. ,
DOI : 10.1152/jappl.1995.79.6.1878
Skeletal muscle partial pressure of oxygen in patients with sepsis, Critical Care Medicine, vol.22, issue.4, pp.640-650, 1994. ,
DOI : 10.1097/00003246-199404000-00021
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction, Critical Care Medicine, vol.27, issue.7, pp.1230-1251, 1999. ,
DOI : 10.1097/00003246-199907000-00002
Bench-to-bedside review: Cytopathic hypoxia, Critical Care, vol.6, issue.6, pp.491-499, 2002. ,
DOI : 10.1186/cc1824
Cytopathic hypoxia in sepsis, Acta Anaesthesiol Scand Suppl, vol.110, pp.87-95, 1997. ,
Cytopathic hypoxia: Is oxygen use impaired in sepsis as a result of an acquired intrinsic derangement in cellular respiration?, Critical Care Clinics, vol.18, issue.1, pp.165-175, 2002. ,
DOI : 10.1016/S0749-0704(03)00071-X
Cytopathic Hypoxia, Critical Care Clinics, vol.17, issue.1, pp.219-237, 2001. ,
DOI : 10.1016/S0749-0704(05)70161-5
Loss of microvascular negative charges accompanied by interstitial edema in septic rats' heart, Circ. Shock, vol.36, pp.45-56, 1992. ,
ULTRASTRUCTURAL CHANGES IN SKELETAL MUSCLE MITOCHONDRIA IN GRAM-NEGATIVE SEPSIS, Shock, vol.5, issue.5, pp.378-384, 1996. ,
DOI : 10.1097/00024382-199605000-00011
Biology of nitric oxide signaling, Critical Care Medicine, vol.28, issue.Supplement, pp.37-52, 2000. ,
DOI : 10.1097/00003246-200004001-00005
Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols, Biochimica et Biophysica Acta (BBA) - Bioenergetics, vol.1658, issue.1-2, pp.44-49, 2004. ,
DOI : 10.1016/j.bbabio.2004.03.016
Sepsis Induces Diaphragm Electron Transport Chain Dysfunction and Protein Depletion, American Journal of Respiratory and Critical Care Medicine, vol.172, issue.7, pp.861-868, 2005. ,
DOI : 10.1007/BF02254981
URL : http://171.66.122.149/content/172/7/861.full.pdf
A network-based analysis of systemic inflammation in humans, Nature, vol.95, issue.7061, pp.1032-1037, 2005. ,
DOI : 10.1073/pnas.95.25.14863
Mitochondrial dysfunction in a long-term rodent model of sepsis and organ failure, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol.286, issue.3, pp.491-497, 2004. ,
DOI : 10.1016/S0005-2728(99)00031-6
Altered mitochondrial redox responses in gram negative septic shock in primates, Circ. Shock, vol.43, pp.34-43, 1994. ,
Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity, Critical Care Medicine, vol.30, issue.2, pp.276-284, 2002. ,
DOI : 10.1097/00003246-200202000-00002
The effect of nitric oxide on cell respiration: A key to understanding its role in cell survival or death, Proceedings of the National Academy of Sciences, vol.162, issue.3 ,
DOI : 10.1006/abbi.2000.1716
Association between mitochondrial dysfunction and severity and outcome of septic shock, The Lancet, vol.360, issue.9328, pp.219-223, 2002. ,
DOI : 10.1016/S0140-6736(02)09459-X
Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis-induced multiple organ failure, American Journal of Physiology-Endocrinology and Metabolism, vol.291, issue.5, pp.1044-1050, 2006. ,
DOI : 10.2337/diabetes.49.11.1904
Multiorgan failure is an adaptive, endocrine-mediated, metabolic response to overwhelming systemic inflammation, The Lancet, vol.364, issue.9433, pp.545-548, 2004. ,
DOI : 10.1016/S0140-6736(04)16815-3
Mitochondrial function in sepsis: Acute phase versus multiple organ failure, Critical Care Medicine, vol.35, issue.Suppl, pp.441-448, 2007. ,
DOI : 10.1097/01.CCM.0000278049.48333.78
Plasma from septic shock patients induces loss of muscle protein, Critical Care, vol.15, issue.5, p.233, 2011. ,
DOI : 10.1007/s00424-008-0574-6
Altered hepatic mitochondrial fatty acid oxidation and ketogenesis in endotoxic rats, American Journal of Physiology-Endocrinology and Metabolism, vol.68, issue.4, pp.498-505, 1990. ,
DOI : 10.1177/014860718400800114
Insulin sensitivity of glucose and fat metabolism in severe sepsis, Clinical Science, vol.99, issue.4, pp.321-328, 2000. ,
DOI : 10.1042/cs0990321
Stress-hyperglycemia, insulin and immunomodulation in sepsis, Intensive Care Medicine, vol.30, issue.5, pp.748-756, 2004. ,
DOI : 10.1007/s00134-004-2167-y
Insulin Resistance and Substrate Utilization in Human Endotoxemia, The Journal of Clinical Endocrinology & Metabolism, vol.85, issue.10, pp.3770-3778, 2000. ,
DOI : 10.1210/jcem.85.10.6914
Selective impairment of glucose storage in human sepsis, British Journal of Surgery, vol.33, issue.6, pp.813-821, 1999. ,
DOI : 10.1016/0026-0495(81)90074-3
The control of hepatic glycogen metabolism in an in??vitro model of sepsis, Molecular and Cellular Biochemistry, vol.288, issue.1-2, pp.183-192, 2008. ,
DOI : 10.1042/bj2880497
Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis, Journal of Applied Physiology, vol.99, issue.3, pp.1120-1126, 2005. ,
DOI : 10.1152/ajpendo.1986.250.6.E634
SEPSIS-INDUCED ALTERATIONS IN PYRUVATE DEHYDROGENASE COMPLEX ACTIVITY IN RAT SKELETAL MUSCLE, Shock, vol.6, issue.2, pp.89-94, 1996. ,
DOI : 10.1097/00024382-199608000-00002
Lactic Acidosis During Sepsis Is Related to Increased Pyruvate Production, Not Deficits in Tissue Oxygen Availability, Annals of Surgery, vol.224, issue.1 ,
DOI : 10.1097/00000658-199607000-00015
Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study, The Lancet, vol.365, issue.9462, pp.871-875, 2005. ,
DOI : 10.1016/S0140-6736(05)71045-X
Glutamine: an anaplerotic precursor, Nutrition, vol.18, issue.3, pp.222-224, 2002. ,
DOI : 10.1016/S0899-9007(01)00795-X
Cardiogenic shock complicating acute myocardial infarction???etiologies, management and outcome: a report from the SHOCK Trial Registry, Journal of the American College of Cardiology, vol.36, issue.3, pp.1063-1070, 2000. ,
DOI : 10.1016/S0735-1097(00)00879-2
Trends in Management and Outcomes of Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock, JAMA, vol.294, issue.4, pp.448-454, 2005. ,
DOI : 10.1001/jama.294.4.448
ESPEN Guidelines on Parenteral Nutrition: Adult Renal Failure, Clinical Nutrition, vol.28, issue.4, pp.401-414, 2009. ,
DOI : 10.1016/j.clnu.2009.05.016
Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: Consensus statements from an international task force by the American College of Critical Care Medicine, Critical Care Medicine, vol.36, issue.6, pp.1937-1949, 2008. ,
DOI : 10.1097/CCM.0b013e31817603ba