V. Bibliographie-1, J. Barnholtz-sloan, A. Sloan, F. Davis, F. Vigneau et al., Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System, J Clin Oncol Off J Am Soc Clin Oncol, vol.22, issue.14, pp.2865-72, 2004.

S. Scoccianti and U. Ricardi, Treatment of brain metastases: Review of phase III randomized controlled trials, Radiotherapy and Oncology, vol.102, issue.2, pp.168-79, 2012.
DOI : 10.1016/j.radonc.2011.08.041

L. Gaspar, C. Scott, M. Rotman, S. Asbell, T. Phillips et al., Recursive partitioning analysis (RPA) of prognostic factors in three radiation therapy oncology group (RTOG) brain metastases trials, International Journal of Radiation Oncology*Biology*Physics, vol.37, issue.4, pp.745-51, 1997.
DOI : 10.1016/S0360-3016(96)00619-0

M. Yamamoto, Y. Sato, T. Serizawa, T. Kawabe, Y. Higuchi et al., Subclassification of Recursive Partitioning Analysis Class II Patients With Brain Metastases Treated Radiosurgically, International Journal of Radiation Oncology*Biology*Physics, vol.83, issue.5, pp.1399-405, 2012.
DOI : 10.1016/j.ijrobp.2011.10.018

P. Sperduto, B. Berkey, L. Gaspar, M. Mehta, and W. Curran, A New Prognostic Index and Comparison to Three Other Indices for Patients With Brain Metastases: An Analysis of 1,960 Patients in the RTOG Database, International Journal of Radiation Oncology*Biology*Physics, vol.70, issue.2, pp.510-514, 2008.
DOI : 10.1016/j.ijrobp.2007.06.074

P. Sperduto, N. Kased, D. Roberge, Z. Xu, R. Shanley et al., Summary Report on the Graded Prognostic Assessment: An Accurate and Facile Diagnosis-Specific Tool to Estimate Survival for Patients With Brain Metastases, Journal of Clinical Oncology, vol.30, issue.4, pp.419-444
DOI : 10.1200/JCO.2011.38.0527

P. Sperduto, S. Chao, P. Sneed, X. Luo, J. Suh et al., Diagnosis-Specific Prognostic Factors, Indexes, and Treatment Outcomes for Patients With Newly Diagnosed Brain Metastases: A Multi-Institutional Analysis of 4,259 Patients, International Journal of Radiation Oncology*Biology*Physics, vol.77, issue.3, 2010.
DOI : 10.1016/j.ijrobp.2009.08.025

E. Weltman, J. Salvajoli, R. Brandt, R. De-morais-hanriot, F. Prisco et al., Radiosurgery for brain metastases: a score index for predicting prognosis, International Journal of Radiation Oncology*Biology*Physics, vol.46, issue.5, pp.1155-61, 2000.
DOI : 10.1016/S0360-3016(99)00549-0

J. Lorenzoni, D. Devriendt, N. Massager, P. David, S. Ruíz et al., Radiosurgery for treatment of brain metastases: Estimation of patient eligibility using three stratification systems, International Journal of Radiation Oncology*Biology*Physics, vol.60, issue.1
DOI : 10.1016/j.ijrobp.2004.02.017

R. Patchell, P. Tibbs, J. Walsh, R. Dempsey, Y. Maruyama et al., A Randomized Trial of Surgery in the Treatment of Single Metastases to the Brain, New England Journal of Medicine, vol.322, issue.8, pp.494-500, 1990.
DOI : 10.1056/NEJM199002223220802

C. Vecht, H. Haaxma-reiche, E. Noordijk, G. Padberg, J. Voormolen et al., Treatment of single brain metastasis: Radiotherapy alone or combined with neurosurgery, Annals of Neurology, vol.53, issue.6, pp.583-90, 1993.
DOI : 10.1016/0360-3016(92)90762-7

D. Andrews, C. Scott, P. Sperduto, A. Flanders, L. Gaspar et al., Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial, The Lancet, vol.363, issue.9422, pp.1665-72, 2004.
DOI : 10.1016/S0140-6736(04)16250-8

D. Kondziolka, A. Patel, L. Lunsford, A. Kassam, and J. Flickinger, Stereotactic radiosurgery plus whole brain radiotherapy versus radiotherapy alone for patients with multiple brain metastases, International Journal of Radiation Oncology*Biology*Physics, vol.45, issue.2, pp.427-461, 1999.
DOI : 10.1016/S0360-3016(99)00198-4

E. Chang, J. Wefel, K. Hess, P. Allen, F. Lang et al., Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial, The Lancet Oncology, vol.10, issue.11, pp.1037-1081, 2009.
DOI : 10.1016/S1470-2045(09)70263-3

C. Meyers, J. Smith, A. Bezjak, M. Mehta, J. Liebmann et al., Neurocognitive Function and Progression in Patients With Brain Metastases Treated With Whole-Brain Radiation and Motexafin Gadolinium: Results of a Randomized Phase III Trial, Journal of Clinical Oncology, vol.22, issue.1, pp.157-65, 2004.
DOI : 10.1200/JCO.2004.05.128

H. Aoyama, M. Tago, N. Kato, T. Toyoda, M. Kenjyo et al., Neurocognitive Function of Patients with Brain Metastasis Who Received Either Whole Brain Radiotherapy Plus Stereotactic Radiosurgery or Radiosurgery Alone, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.5, pp.1388-95, 2007.
DOI : 10.1016/j.ijrobp.2007.03.048

E. Eisenhauer, P. Therasse, J. Bogaerts, L. Schwartz, D. Sargent et al., New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1), European Journal of Cancer, vol.45, issue.2, pp.228-275, 1990.
DOI : 10.1016/j.ejca.2008.10.026

G. Minniti, E. Clarke, G. Lanzetta, M. Osti, G. Trasimeni et al., Stereotactic radiosurgery for brain metastases: analysis of outcome and risk of brain radionecrosis, Radiation Oncology, vol.6, issue.1, pp.1-9, 2011.
DOI : 10.1002/cncr.23625

T. Gooley, W. Leisenring, J. Crowley, and B. Storer, Estimation of failure probabilities in the presence of competing risks: new representations of old estimators, Statistics in Medicine, vol.1, issue.6, pp.695-706, 1999.
DOI : 10.1016/0360-3016(94)90416-2

R. A. Gray, A Class of $K$-Sample Tests for Comparing the Cumulative Incidence of a Competing Risk, The Annals of Statistics, vol.16, issue.3, pp.1141-54, 1988.
DOI : 10.1214/aos/1176350951

J. Fine and R. Gray, A Proportional Hazards Model for the Subdistribution of a Competing Risk, Journal of the American Statistical Association, vol.69, issue.446, pp.496-509, 1999.
DOI : 10.1093/biomet/69.1.239

M. Manning, R. Cardinale, S. Benedict, B. Kavanagh, R. Zwicker et al., Hypofractionated stereotactic radiotherapy as an alternative to radiosurgery for the treatment of patients with brain metastases, International Journal of Radiation Oncology*Biology*Physics, vol.47, issue.3, pp.603-611, 2000.
DOI : 10.1016/S0360-3016(00)00475-2

H. Aoyama, H. Shirato, M. Tago, K. Nakagawa, T. Toyoda et al., Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases, JAMA, vol.295, issue.21, pp.2483-91, 2006.
DOI : 10.1001/jama.295.21.2483

P. Lindvall, P. Bergström, P. Löfroth, T. Bergenheim, and A. , A comparison between surgical resection in combination with WBRT or hypofractionated stereotactic irradiation in the treatment of solitary brain metastases, Acta Neurochirurgica, vol.1, issue.9, pp.1053-1062, 2009.
DOI : 10.1016/S0360-3016(01)02645-1

M. Aoki, Y. Abe, Y. Hatayama, H. Kondo, and K. Basaki, Clinical outcome of hypofractionated conventional conformation radiotherapy for patients with single and no more than three metastatic brain tumors, with noninvasive fixation of the skull without whole brain irradiation, International Journal of Radiation Oncology*Biology*Physics, vol.64, issue.2, pp.414-422, 2006.
DOI : 10.1016/j.ijrobp.2005.03.017

A. Ernst-stecken, O. Ganslandt, U. Lambrecht, R. Sauer, and G. Grabenbauer, Phase II trial of hypofractionated stereotactic radiotherapy for brain metastases: Results and toxicity, Radiotherapy and Oncology, vol.81, issue.1, pp.18-24, 2006.
DOI : 10.1016/j.radonc.2006.08.024

A. Narayana, J. Chang, K. Yenice, K. Chan, S. Lymberis et al., Hypofractionated Stereotactic Radiotherapy Using Intensity-Modulated Radiotherapy in Patients with One or Two Brain Metastases, Stereotactic and Functional Neurosurgery, vol.39, issue.2-3, pp.2-382, 2007.
DOI : 10.1159/000097923

C. Giubilei, G. Ingrosso, D. Andrea, M. Benassi, M. Santoni et al., Hypofractionated stereotactic radiotherapy in combination with whole brain radiotherapy for brain metastases, Journal of Neuro-Oncology, vol.16, issue.2, pp.207-219, 2009.
DOI : 10.1016/S0360-3016(98)00447-7

A. Kwon, S. Dibiase, B. Wang, S. Hughes, B. Milcarek et al., Hypofractionated stereotactic radiotherapy for the treatment of brain metastases. Cancer, Feb, vol.15115, issue.4, pp.890-898, 2009.

M. Marchetti, I. Milanesi, C. Falcone, D. Santis, M. Fumagalli et al., Hypofractionated stereotactic radiotherapy for oligometastases in the brain: a single-institution experience, Neurological Sciences, vol.29, issue.10, pp.393-402, 2011.
DOI : 10.1016/S0360-3016(00)00475-2

D. Potter, B. , D. Meerleer, G. , D. Neve et al., Hypofractionated frameless stereotactic intensity-modulated radiotherapy with whole brain radiotherapy for the treatment of 1???3 brain metastases, Neurological Sciences, vol.151, issue.9, pp.647-53, 2013.
DOI : 10.1007/s00701-009-0325-2

G. Minniti, D. Angelillo, R. Scaringi, C. Trodella, L. Clarke et al., Fractionated stereotactic radiosurgery for patients with brain metastases, Journal of Neuro-Oncology, vol.64, issue.2, pp.295-301
DOI : 10.1016/j.ijrobp.2005.07.980

L. Ma, G. Li, H. Zhang, Z. Wang, J. Dang et al., Hypofractionated stereotactic radiotherapy with or without whole-brain radiotherapy for patients with newly diagnosed brain metastases from non-small cell lung cancer, J Neurosurg, vol.117, pp.49-56, 2012.

J. Zindler, G. Rodrigues, C. Haasbeek, D. Haan, P. Meijer et al., The clinical utility of prognostic scoring systems in patients with brain metastases treated with radiosurgery, Radiotherapy and Oncology, vol.106, issue.3, pp.370-374
DOI : 10.1016/j.radonc.2013.01.015

S. Sawrie, B. Guthrie, S. Spencer, R. Nordal, R. Meredith et al., Predictors of Distant Brain Recurrence for Patients With Newly Diagnosed Brain Metastases Treated With Stereotactic Radiosurgery Alone, International Journal of Radiation Oncology*Biology*Physics, vol.70, issue.1, pp.181-187, 2008.
DOI : 10.1016/j.ijrobp.2007.05.084

A. Likhacheva, C. Pinnix, N. Parikh, P. Allen, M. Mcaleer et al., Predictors of Survival in Contemporary Practice After Initial Radiosurgery for Brain Metastases, International Journal of Radiation Oncology*Biology*Physics, vol.85, issue.3, pp.656-61, 2013.
DOI : 10.1016/j.ijrobp.2012.05.047

M. Tsao, W. Xu, and A. Sahgal, A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases, Cancer, vol.29, issue.9, pp.2486-93, 2012.
DOI : 10.1200/JCO.2010.29.6053

L. Duan, R. Zeng, K. Yang, J. Tian, X. Wu et al., Whole Brain Radiotherapy Combined with Stereotactic Radiotherapy Versus Stereotactic Radiotherapy Alone for Brain Metastases: a Meta-analysis, Asian Pacific Journal of Cancer Prevention, vol.15, issue.2, pp.911-916, 2014.
DOI : 10.7314/APJCP.2014.15.2.911

E. Shaw, C. Scott, L. Souhami, R. Dinapoli, R. Kline et al., Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05, International Journal of Radiation Oncology*Biology*Physics, vol.47, issue.2, pp.291-299, 2000.
DOI : 10.1016/S0360-3016(99)00507-6

R. Wiggenraad, A. Kanter, H. Kal, M. Taphoorn, T. Vissers et al., Dose???effect relation in stereotactic radiotherapy for brain metastases. A systematic review, Radiotherapy and Oncology, vol.98, issue.3, pp.292-299, 2011.
DOI : 10.1016/j.radonc.2011.01.011

G. Noël, J. Simon, C. Valery, P. Cornu, G. Boisserie et al., Radiosurgery for brain metastasis: impact of CTV on local control, Radiotherapy and Oncology, vol.68, issue.1, 2003.
DOI : 10.1016/S0167-8140(03)00207-X

D. Kim, T. Schultheiss, E. Radany, B. Badie, and R. Pezner, Clinical outcomes of patients treated with a second course of stereotactic radiosurgery for locally or regionally recurrent brain metastases after prior stereotactic radiosurgery, Journal of Neuro-Oncology, vol.10, issue.11, pp.37-43, 2013.
DOI : 10.1016/S1470-2045(09)70263-3

S. Yomo and M. Hayashi, The efficacy and limitations of stereotactic radiosurgery as a salvage treatment after failed whole brain radiotherapy for brain metastases, Journal of Neuro-Oncology, vol.53, issue.Suppl 1, p.2013
DOI : 10.1002/1097-0142(19801215)46:12<2587::AID-CNCR2820461209>3.0.CO;2-4

G. Noël and J. Mazeron, Reirradiation in primary or secondary brain tumors]. Cancer Radiothérapie J Société Fr Radiothérapie Oncol, pp.6-7421, 2010.

R. Mayer and P. Sminia, Reirradiation Tolerance of the Human Brain, International Journal of Radiation Oncology*Biology*Physics, vol.70, issue.5, pp.1350-60, 2008.
DOI : 10.1016/j.ijrobp.2007.08.015

H. Inoue, K. Seto, A. Nozaki, K. Torikai, Y. Suzuki et al., Three-fraction CyberKnife radiotherapy for brain metastases in critical areas: referring to the risk evaluating radiation necrosis and the surrounding brain volumes circumscribed with a single dose equivalence of 14 Gy (V14), Journal of Radiation Research, vol.90, issue.4, p.14
DOI : 10.3171/jns.2001.94.6.0899

P. Sneed, K. Lamborn, J. Forstner, M. Mcdermott, S. Chang et al., Radiosurgery for brain metastases: is whole brain radiotherapy necessary?, International Journal of Radiation Oncology*Biology*Physics, vol.43, issue.3, pp.549-58, 1999.
DOI : 10.1016/S0360-3016(98)00447-7

A. Stockham, M. Ahluwalia, C. Reddy, J. Suh, A. Kumar et al., Results of a questionnaire regarding practice patterns for the diagnosis and treatment of intracranial radiation necrosis after SRS, Journal of Neuro-Oncology, vol.25, issue.Suppl, pp.469-75, 2013.
DOI : 10.1159/000331194

S. Telera, A. Fabi, A. Pace, A. Vidiri, V. Anelli et al., Radionecrosis induced by stereotactic radiosurgery of brain metastases: results of surgery and outcome of disease, Journal of Neuro-Oncology, vol.68, issue.1, pp.313-338
DOI : 10.1023/B:NEON.0000024744.16031.e9

B. Blonigen, R. Steinmetz, L. Levin, M. Lamba, R. Warnick et al., Irradiated Volume as a Predictor of Brain Radionecrosis After Linear Accelerator Stereotactic Radiosurgery, International Journal of Radiation Oncology*Biology*Physics, vol.77, issue.4, pp.996-1001, 2010.
DOI : 10.1016/j.ijrobp.2009.06.006

P. Kickingereder, F. Dorn, T. Blau, M. Schmidt, M. Kocher et al., Differentiation of local tumor recurrence from radiation-induced changes after stereotactic radiosurgery for treatment of brain metastasis: case report and review of the literature, Radiation Oncology, vol.8, issue.1, p.52, 2013.
DOI : 10.1007/s007010170058

A. Stockham, A. Tievsky, S. Koyfman, C. Reddy, J. Suh et al., Conventional MRI does not reliably distinguish radiation necrosis from tumor recurrence after stereotactic radiosurgery, Journal of Neuro-Oncology, vol.13, issue.Suppl 1, pp.149-58, 2012.
DOI : 10.1093/neuonc/nor075

T. Kang, S. Kim, H. Byun, P. Jeon, K. Kim et al., Morphological and functional MRI, MRS, perfusion and diffusion changes after radiosurgery of brain metastasis, European Journal of Radiology, vol.72, issue.3, pp.370-80, 2009.
DOI : 10.1016/j.ejrad.2008.08.009

L. Horky, E. Hsiao, S. Weiss, J. Drappatz, and V. Gerbaudo, Dual phase FDG-PET imaging of brain metastases provides superior assessment of recurrence versus post-treatment necrosis, Journal of Neuro-Oncology, vol.35, issue.8, pp.137-183, 2011.
DOI : 10.1007/s002590050355

K. Lizarraga, M. Allen-auerbach, J. Czernin, A. Desalles, W. Yong et al., 18)F- FDOPA PET for differentiating recurrent or progressive brain metastatic tumors from late or delayed radiation injury after radiation treatment, J Nucl Med Off Publ Soc Nucl Med, 2014.
DOI : 10.2967/jnumed.113.121418

URL : http://jnm.snmjournals.org/content/55/1/30.full.pdf

J. Gonzalez, A. Kumar, C. Conrad, and V. Levin, Effect of bevacizumab on radiation necrosis of the brain, International Journal of Radiation Oncology*Biology*Physics, vol.67, issue.2, pp.323-329, 2007.
DOI : 10.1016/j.ijrobp.2006.10.010

R. Torcuator, R. Zuniga, Y. Mohan, J. Rock, T. Doyle et al., Initial experience with bevacizumab treatment for biopsy confirmed cerebral radiation necrosis, Journal of Neuro-Oncology, vol.61, issue.6, 2009.
DOI : 10.1148/radiology.217.2.r00nv36377

D. Boothe, R. Young, Y. Yamada, A. Prager, T. Chan et al., Bevacizumab as a treatment for radiation necrosis of brain metastases post stereotactic radiosurgery. Neuro-Oncol, 2013.

V. Levin, L. Bidaut, P. Hou, A. Kumar, J. Wefel et al., Randomized Double-Blind Placebo-Controlled Trial of Bevacizumab Therapy for Radiation Necrosis of the Central Nervous System, International Journal of Radiation Oncology*Biology*Physics, vol.79, issue.5, pp.1487-95, 2011.
DOI : 10.1016/j.ijrobp.2009.12.061

M. Kocher, R. Soffietti, U. Abacioglu, S. Villà, F. Fauchon et al., Adjuvant Whole-Brain Radiotherapy Versus Observation After Radiosurgery or Surgical Resection of One to Three Cerebral Metastases: Results of the EORTC 22952-26001 Study, Journal of Clinical Oncology, vol.29, issue.2, pp.134-175, 2011.
DOI : 10.1200/JCO.2010.30.1655

A. Sun, K. Bae, E. Gore, B. Movsas, S. Wong et al., Phase III Trial of Prophylactic Cranial Irradiation Compared With Observation in Patients With Locally Advanced Non???Small-Cell Lung Cancer: Neurocognitive and Quality-of-Life Analysis, Journal of Clinical Oncology, vol.29, issue.3, pp.279-86, 2011.
DOI : 10.1200/JCO.2010.29.6053

A. Ghia, W. Tomé, S. Thomas, G. Cannon, D. Khuntia et al., Distribution of Brain Metastases in Relation to the Hippocampus: Implications for Neurocognitive Functional Preservation, International Journal of Radiation Oncology*Biology*Physics, vol.68, issue.4, pp.971-978, 2007.
DOI : 10.1016/j.ijrobp.2007.02.016

V. Gondi, R. Tolakanahalli, M. Mehta, D. Tewatia, H. Rowley et al., Hippocampal-Sparing Whole-Brain Radiotherapy: A ???How-To??? Technique Using Helical Tomotherapy and Linear Accelerator???Based Intensity-Modulated Radiotherapy, International Journal of Radiation Oncology*Biology*Physics, vol.78, issue.4, pp.1244-52, 2010.
DOI : 10.1016/j.ijrobp.2010.01.039

URL : http://europepmc.org/articles/pmc2963699?pdf=render

T. Kazda, R. Jancalek, P. Pospisil, O. Sevela, T. Prochazka et al., Why and how to spare the hippocampus during brain radiotherapy: the developing role of hippocampal avoidance in cranial radiotherapy, Radiation Oncology, vol.9, issue.1, p.139, 2014.
DOI : 10.1186/1748-717X-9-139

F. Oskan, U. Ganswindt, S. Schwarz, F. Manapov, C. Belka et al., Hippocampus sparing in whole-brain radiotherapy. A review, Strahlenther Onkol Organ Dtsch Röntgenges Al, 2014.
DOI : 10.1007/s00066-013-0518-8

V. Gondi, B. Hermann, M. Mehta, and W. Tomé, Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors, Int J Radiat Oncol Biol Phys. 2013 Feb, vol.185, issue.2, pp.348-54
DOI : 10.1016/j.ijrobp.2011.10.021

URL : http://europepmc.org/articles/pmc3462659?pdf=render