W. Arlt and B. Allolio, Adrenal insufficiency, The Lancet, vol.361, issue.9372, pp.1881-1893, 2003.
DOI : 10.1016/S0140-6736(03)13492-7

L. Jacobson, Hypothalamic???Pituitary???Adrenocortical Axis Regulation, Endocrinology and Metabolism Clinics of North America, vol.34, issue.2, pp.271-92, 2005.
DOI : 10.1016/j.ecl.2005.01.003

S. Melmed and D. Kleinberg, Anterior Pituitary In: Saunders, editor. Williams Textbook of Endocrinology, pp.177-280, 2003.

P. Stewart, The Adrenal Cortex In: Saunders, editor. Williams Textbook of Endocrinology, pp.491-551, 2003.

P. Cryer, Glucose Homeostasis and Hypoglycemia In: Saunders, editor. Williams Textbook of Endocrinology, pp.1585-1618, 2003.

C. Fanelli, S. Pampanelli, and L. Epifano, Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans, Diabetologia, vol.42, issue.Suppl 1, pp.797-807, 1994.
DOI : 10.1007/BF00404337

H. Himsworth, DIABETES MELLITUS, The Lancet, vol.227, issue.5864, pp.127-130, 1936.
DOI : 10.1016/S0140-6736(01)36134-2

R. Fraser, F. Albrignt, and P. Smith, THE VALUE OF THE GLUCOSE TOLERANCE TEST, THE INSULIN TOLERANCE TEST, AND THE GLUCOSEINSULIN TOLERANCE TEST IN THE DIAGNOSIS OF ENDOCRINOLOGIC DISORDERS OF GLUCOSE METABOLISM1, The Journal of Clinical Endocrinology & Metabolism, vol.1, issue.4, pp.297-306, 1941.
DOI : 10.1210/jcem-1-4-297

T. Addison, On the Constitutional and Local Effects of Disease of the Suprarenal Capsules, p.1855

H. Cushing, THE PITUITARY BODY AND ITS DISORDERS, Annals of Surgery, vol.57, issue.1, 1912.
DOI : 10.1097/00000658-191301000-00015

G. Harris, Neural control of the pituitary gland, Phisyol Rev, vol.28, p.139, 1948.

W. Vale, J. Spiers, C. Rivier, and J. Rivier, Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin, Science, vol.213, issue.4514, pp.585-587, 1981.
DOI : 10.1126/science.6267699

J. Landon, V. Wynn, and V. James, THE ADRENOCORTICAL RESPONSE TO INSULIN-INDUCED HYPOGLYCAEMIA, Journal of Endocrinology, vol.27, issue.2, pp.183-192, 1963.
DOI : 10.1677/joe.0.0270183

F. Greenwood, J. Landon, and T. Stamp, The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin. I. In control subjects., Journal of Clinical Investigation, vol.45, issue.4, pp.429-436, 1966.
DOI : 10.1172/JCI105357

J. Landon, F. Greenwood, T. Stamp, and V. Wynn, The plasma sugar, free fatty acid, cortisol, and growth hormone response to insulin, and the comparison of this procedure with other tests of pituitary and adrenal function. II. In patients with hypothalamic or pituitary dysfunction or anorexia nervosa., Journal of Clinical Investigation, vol.45, issue.4, pp.437-449, 1966.
DOI : 10.1172/JCI105358

F. Finucane, A. Liew, E. Thornton, R. B. Tormey, W. Agha et al., Clinical insights into the safety and utility of the insulin tolerance test (ITT) in the assessment of the hypothalamo-pituitary-adrenal axis, Clinical Endocrinology, vol.60, issue.4, pp.603-607, 2008.
DOI : 10.1515/JPEM.2004.17.8.1105

S. Grinspoon and B. Biller, Clinical review 62: Laboratory assessment of adrenal insufficiency, J Clin Endocrinol Metab, vol.79, issue.4, pp.923-931, 1994.

E. Erturk, C. Jaffe, and A. Barkan, Evaluation of the Integrity of the Hypothalamic-Pituitary-Adrenal Axis by Insulin Hypoglycemia Test, Journal of Clinical Endocrinology & Metabolism, vol.83, issue.7, pp.2350-2354, 1998.
DOI : 10.1210/jc.83.7.2350

M. Pfeifer, K. Kanc, R. Verhovec, and A. Kocijancic, Reproducibility of the insulin tolerance test (ITT) for assessment of growth hormone and cortisol secretion in normal and hypopituitary adult men, Clinical Endocrinology, vol.29, issue.1, pp.17-22, 2001.
DOI : 10.1055/s-2007-979000

E. Nye, J. Grice, and G. Hockings, Comparison of Adrenocorticotropin (ACTH) Stimulation Tests and Insulin Hypoglycemia in Normal Humans: Low Dose, Standard High Dose, and 8-Hour ACTH-(1-24) Infusion Tests, Journal of Clinical Endocrinology & Metabolism, vol.84, issue.10, pp.3648-3655, 1999.
DOI : 10.1210/jc.84.10.3648

C. Courtney, A. Mcallister, and P. Bell, Low- and Standard-Dose Corticotropin and Insulin Hypoglycemia Testing in the Assessment of Hypothalamic-Pituitary-Adrenal Function after Pituitary Surgery, The Journal of Clinical Endocrinology & Metabolism, vol.89, issue.4, pp.1712-1717, 2004.
DOI : 10.1210/jc.2003-031577

E. Endert, A. Ouwehand, E. Fliers, M. Prummel, and W. Wiersinga, Establishment of reference values for endocrine tests. Part IV: Adrenal insufficiency, Neth J Med, vol.63, issue.11, pp.435-443, 2005.

G. Reimondo, S. Bovio, B. Allasino, M. Terzolo, and A. Angeli, Secondary hypoadrenalism, Pituitary, vol.44, issue.2, pp.147-154, 2008.
DOI : 10.7326/0003-4819-80-6-693

K. Borm, M. Slawik, and L. Seiler, Is the plasma ACTH concentration a reliable parameter in the insulin tolerance test?, European Journal of Endocrinology, vol.149, issue.6, pp.535-541, 2003.
DOI : 10.1530/eje.0.1490535

T. Abdu, T. Elhadd, R. Neary, and R. Clayton, Comparison of the low dose short synacthen test (1 microg), the conventional dose short synacthen test (250 microg), and the insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in patients with pituitary disease, J Clin Endocrinol Metab, vol.84, issue.3, pp.838-843, 1999.

B. Ambrosi, L. Barbetta, T. Re, E. Passini, and G. Faglia, The one microgram adrenocorticotropin test in the assessment of hypothalamic-pituitary-adrenal function, European Journal of Endocrinology, vol.139, issue.6, pp.575-579, 1998.
DOI : 10.1530/eje.0.1390575

K. Tordjman, A. Jaffe, N. Grazas, C. Apter, and N. Stern, The role of the low dose (1 microgram) adrenocorticotropin test in the evaluation of patients with pituitary diseases, J Clin Endocrinol Metab, vol.80, issue.4, pp.1301-1305, 1995.

S. Rasmuson, T. Olsson, and E. Hagg, A low dose ACTH test to assess the function of the hypothalamic-pituitary-adrenal axis, Clinical Endocrinology, vol.44, issue.2, pp.151-156, 1996.
DOI : 10.1046/j.1365-2265.1996.600482.x

V. Talwar, S. Lodha, and R. Dash, Assessing the hypothalamo-pituitary-adrenocortical axis using physiological doses of adrenocorticotropic hormone, QJM, vol.91, issue.4, pp.285-290, 1998.
DOI : 10.1093/qjmed/91.4.285

J. Mayenknecht, S. Diederich, V. Bahr, U. Plockinger, and W. Oelkers, Comparison of Low and High Dose Corticotropin Stimulation Tests in Patients with Pituitary Disease, The Journal of Clinical Endocrinology & Metabolism, vol.83, issue.5, pp.1558-1562, 1998.
DOI : 10.1210/jcem.83.5.4831

M. Maghnie, E. Uga, and F. Temporini, Evaluation of adrenal function in patients with growth hormone deficiency and hypothalamic-pituitary disorders: comparison between insulin-induced hypoglycemia, low-dose ACTH, standard ACTH and CRH stimulation tests, European Journal of Endocrinology, vol.154, issue.9, pp.735-741, 2005.
DOI : 10.1007/BF02276714

F. Plumpton and G. Besser, The adrenocortical response to surgery and insulin-induced hypoglycaemia in corticosteroid-treated and normal subjects, British Journal of Surgery, vol.2, issue.3, pp.216-219, 1969.
DOI : 10.1002/bjs.1800560315

P. Vestergaard, H. Hoeck, P. Jakobsen, and P. Laurberg, Reproducibility of Growth Hormone and Cortisol Responses to the Insulin Tolerance Test and the Short ACTH Test in Normal Adults, Hormone and Metabolic Research, vol.29, issue.03, pp.106-110, 1997.
DOI : 10.1055/s-2007-979000

V. Gasco, G. Corneli, and S. Rovere, Diagnosis of adult GH deficiency, Pituitary, vol.153, issue.2, pp.121-128, 2008.
DOI : 10.1007/BF03345251

H. Fish, B. Chernow, O. Brian, and J. , Endocrine and neurophysiologic responses of the pituitary to insulin-induced hypoglycemia: A review, Metabolism, vol.35, issue.8, pp.763-780, 1986.
DOI : 10.1016/0026-0495(86)90245-3

A. Shah, R. Stanhope, and D. Matthew, Hazards of pharmacological tests of growth hormone secretion in childhood., BMJ, vol.304, issue.6820, pp.173-174, 1992.
DOI : 10.1136/bmj.304.6820.173

P. Galloway, E. Mcneill, W. Paterson, and M. Donaldson, Safety of the insulin tolerance test, Archives of Disease in Childhood, vol.87, issue.4, pp.354-356, 2002.
DOI : 10.1136/adc.87.4.354

S. Jones, P. Trainer, L. Perry, J. Wass, G. Bessser et al., An audit of the insulin tolerance test in adult subjects in an acute investigation unit over one year, Clinical Endocrinology, vol.71, issue.1, pp.123-128, 1994.
DOI : 10.1016/S0140-6736(88)92020-X

M. Lange, O. Svendsen, and N. Skakkebaek, An audit of the insulin-tolerance test in 255 patients with pituitary disease, European Journal of Endocrinology, vol.147, issue.1, pp.41-47, 2002.
DOI : 10.1530/eje.0.1470041

M. Thomas, M. Keramidas, E. Monchaux, and J. Feige, Dual Hormonal Regulation of Endocrine Tissue Mass and Vasculature by Adrenocorticotropin in the Adrenal Cortex, Endocrinology, vol.145, issue.9, pp.4320-4329, 2004.
DOI : 10.1210/en.2004-0179

A. Bicknell, K. Lomthaisong, and R. Woods, Characterization of a Serine Protease that Cleaves Pro-??-Melanotropin at the Adrenal to Stimulate Growth, Cell, vol.105, issue.7, pp.903-912, 2001.
DOI : 10.1016/S0092-8674(01)00403-2

G. Thorn and P. Forsham, A TEST FOR ADRENAL CORTICAL INSUFFICIENCY, Journal of the American Medical Association, vol.137, issue.12, pp.1005-1009, 1948.
DOI : 10.1001/jama.1948.02890460001001

J. Nabarro, THE USE OF CORTICOTROPHIN GEL AS A TEST OF ADRENAL CORTICAL FUNCTION, The Lancet, vol.264, issue.6848, pp.1101-1104, 1954.
DOI : 10.1016/S0140-6736(54)90656-X

E. Gold and P. Starr, URINARY EXCRETION OF 17-KETOGENIC STEROIDS IN NORMAL SUBJECTS BEFORE AND AFTER STIMULATION WITH INTRAMUSCULAR ZINC-ACTH*???, The Journal of Clinical Endocrinology & Metabolism, vol.19, issue.8, pp.907-920, 1959.
DOI : 10.1210/jcem-19-8-907

K. Eik-nes, A. Sandberg, D. Nelson, F. Tyler, and L. Samuels, Changes in Plasma Levels of 17-Hydroxycorticosteroids During the Intravenous Administration of ACTH. I. A Test Of Adrenocortical Capacity in the Human1, Journal of Clinical Investigation, vol.33, issue.11, pp.1502-1508, 1954.
DOI : 10.1172/JCI103028

L. Wilson, Protein shock from intravenous ACTH, Lancet, vol.2, issue.6681, pp.478-479, 1951.
DOI : 10.1016/s0140-6736(51)92912-1

G. Baumann, E. Rayfield, L. Rose, G. Williams, and J. Dingman, ???Trace??? Contamination of Corticotropin and Human Growth Hormone with Vasopresssin???Clinical Significance, The Journal of Clinical Endocrinology & Metabolism, vol.34, issue.5, pp.801-804, 1972.
DOI : 10.1210/jcem-34-5-801

H. Kappeler and R. Schwyzer, Die Synthese eines Tetracosapeptides mit der Aminos???uresequenz eines hochaktiven Abbauproduktes des ?-Corticotropins (ACTH) aus Schweinehypophysen. (Vorl???ufige Mitteilung), Helvetica Chimica Acta, vol.41, issue.4, pp.1136-1141, 1961.
DOI : 10.1002/hlca.660410222

J. Landon, V. James, R. Cryer, V. Wynn, and A. Frankland, -Corticotropin???in Man, The Journal of Clinical Endocrinology & Metabolism, vol.24, issue.11, pp.1206-1213, 1964.
DOI : 10.1210/jcem-24-11-1206

J. Wood, A. Frankland, V. James, and J. Landon, A RAPID TEST OF ADRENOCORTICAL FUNCTION, The Lancet, vol.285, issue.7379, pp.243-245, 1965.
DOI : 10.1016/S0140-6736(65)91526-6

H. Kehlet and C. Binder, Value of an ACTH Test in Assessing Hypothalamic-Pituitary-Adrenocortical Function in Glucocorticoid-treated Patients, BMJ, vol.2, issue.5859, pp.147-149, 1973.
DOI : 10.1136/bmj.2.5859.147

H. Kehlet, M. Blichert-toft, J. Lindholm, and P. Rasmussen, Short ACTH test in assessing hypothalamic-pituitary-adrenocortical function., BMJ, vol.1, issue.6004, pp.249-251, 1976.
DOI : 10.1136/bmj.1.6004.249

J. Lindholm, H. Kehlet, M. Blichert-toft, B. Dinesen, and J. Riishede, Reliability of the 30-Minute ACTH Test in Assessing Hypothalamic-Pituitary-Adrenal Function, The Journal of Clinical Endocrinology & Metabolism, vol.47, issue.2, pp.272-274, 1978.
DOI : 10.1210/jcem-47-2-272

G. Borst, H. Michenfelder, O. Brian, and J. , Discordant Cortisol Response to Exogenous ACTH and Insulin-Induced Hypoglycemia in Patients with Pituitary Disease, New England Journal of Medicine, vol.306, issue.24, pp.1462-1464, 1982.
DOI : 10.1056/NEJM198206173062405

S. Cunningham, A. Moore, and T. Mckenna, Normal Cortisol Response to Corticotropin in Patients With Secondary Adrenal Failure, Archives of Internal Medicine, vol.143, issue.12, pp.2276-2279, 1983.
DOI : 10.1001/archinte.1983.00350120066016

M. Graybeal and V. Fang, Physiological dosing of exogenous ACTH, European Journal of Endocrinology, vol.108, issue.3, pp.401-406, 1985.
DOI : 10.1530/acta.0.1080401

R. Dorin, C. Qualls, and L. Crapo, Diagnosis of Adrenal Insufficiency, Annals of Internal Medicine, vol.139, issue.3, pp.194-204, 2003.
DOI : 10.7326/0003-4819-139-3-200308050-00009

G. Dickstein, C. Shechner, and W. Nicholson, Adrenocorticotropin Stimulation Test: Effects of Basal Cortisol Level, Time of Day, and Suggested New Sensitive Low Dose Test*, The Journal of Clinical Endocrinology & Metabolism, vol.72, issue.4, pp.773-778, 1991.
DOI : 10.1210/jcem-72-4-773

G. Dickstein, D. Spigel, E. Arad, and C. Shechner, One microgram is the lowest ACTH dose to cause a maximal cortisol response. There is no diurnal variation of cortisol response to submaximal ACTH stimulation, European Journal of Endocrinology, vol.137, issue.2, pp.172-175, 1997.
DOI : 10.1530/eje.0.1370172

C. Choi, S. Tiu, C. Shek, K. Choi, F. Chan et al., Use of the low-dose corticotropin stimulation test for the diagnosis of secondary adrenocortical insufficiency, Hong Kong Med J, vol.8, issue.6, pp.427-434, 2002.

H. Dokmetas, R. Colak, F. Kelestimur, A. Selcuklu, K. Unluhizarci et al., A comparison between the 1-microg adrenocorticotropin (ACTH) test, the short ACTH (250 microg) test, and the insulin tolerance test in the assessment of hypothalamo-pituitary-adrenal axis immediately after pituitary surgery, J Clin Endocrinol Metab, vol.85, issue.10, pp.3713-3719, 2000.

S. Soule, V. Zyl, S. Parolis, and G. , The low dose ACTH stimulation test is less sensitive than the overnight metyrapone test for the diagnosis of secondary hypoadrenalism, Clinical Endocrinology, vol.84, issue.2, pp.221-227, 2000.
DOI : 10.1210/jcem.83.1.4496

A. Suliman, T. Smith, M. Labib, T. Fiad, and T. Mckenna, The low-dose ACTH test does not provide a useful assessment of the hypothalamic-pituitary-adrenal axis in secondary adrenal insufficiency, Clinical Endocrinology, vol.39, issue.4, pp.533-539, 2002.
DOI : 10.1210/jcem.83.1.4496

K. Tordjman, A. Jaffe, Y. Trostanetsky, Y. Greenman, R. Limor et al., Low-dose (1 mug) adrenocorticotrophin (ACTH) stimulation as a screening test for impaired hypothalamo-pituitary-adrenal axis function: sensitivity, specificity and accuracy in comparison with the high-dose (250 mug) test, Clinical Endocrinology, vol.28, issue.5, pp.633-640, 2000.
DOI : 10.1016/S0140-6736(65)91526-6

R. Kazlauskaite, A. Evans, and C. Villabona, Corticotropin Tests for Hypothalamic-Pituitary- Adrenal Insufficiency: A Metaanalysis, The Journal of Clinical Endocrinology & Metabolism, vol.93, issue.11, pp.4245-4253, 2008.
DOI : 10.1210/jc.2008-0710

D. Wright, M. Shah, and S. Peacey, The insulin stress test performed by an experienced endocrine specialist nurse: a safe and reliable procedure, Clinical Endocrinology, vol.36, issue.5, pp.755-756, 2007.
DOI : 10.1530/eje.0.1470041

L. Nieman, Dynamic evaluation of adrenal hypofunction, J Endocrinol Invest, vol.26, issue.7, pp.74-82, 2003.

K. Borm, M. Slawik, and F. Beuschlein, Low-dose glucose infusion after achieving critical hypoglycemia during insulin tolerance testing: effects on time of hypoglycemia, neuroendocrine stress response and patient's discomfort in a pilot study, European Journal of Endocrinology, vol.29, issue.3, pp.521-526, 2005.
DOI : 10.1055/s-2007-978997

J. Nelson, D. Tindall, and J. , A comparison of the adrenal responses to hypoglycemia, metyrapone and ACTH, The American Journal of the Medical Sciences, vol.275, issue.2, pp.165-172, 1978.
DOI : 10.1097/00000441-197803000-00006

J. Lindholm and H. Kehlet, RE-EVALUATION OF THE CLINICAL VALUE OF THE 30 MIN ACTH TEST IN ASSESSING THE HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL FUNCTION, Clinical Endocrinology, vol.5, issue.1, pp.53-59, 1987.
DOI : 10.1016/S0140-6736(65)91526-6

P. Stewart, C. J. Seckl, J. Edwards, C. Padfield, and P. , A RATIONAL APPROACH FOR ASSESSING THE HYPOTHALAMO-PITUITARY-ADRENAL AXIS, The Lancet, vol.331, issue.8596, pp.1208-1210, 1988.
DOI : 10.1016/S0140-6736(88)92020-X

J. Gonzalbez, C. Villabona, and R. J. , Establishment of reference values for standard dose short synacthen test (250 mug), low dose short synacthen test (1 mug) and insulin tolerance test for assessment of the hypothalamo-pituitary-adrenal axis in normal subjects, Clinical Endocrinology, vol.83, issue.2, pp.199-204, 2000.
DOI : 10.1210/jcem.83.1.4496

R. Giordano, A. Picu, and L. Bonelli, Hypothalamus???pituitary???adrenal axis evaluation in patients with hypothalamo???pituitary disorders: comparison of different provocative tests, Clinical Endocrinology, vol.39, issue.6, pp.935-941, 2008.
DOI : 10.1210/jc.2005-1131

W. Oelkers, The role of high- and low-dose corticotropin tests in the diagnosis of secondary adrenal insufficiency, European Journal of Endocrinology, vol.139, issue.6, pp.567-570, 1998.
DOI : 10.1530/eje.0.1390567

A. Tsatsoulis, S. Shalet, J. Harrison, W. Ratcliffe, C. Beardwell et al., ADRENOCORTICOTROPHIN (ACTH) DEFICIENCY UNDETECTED BY STANDARD DYNAMIC TESTS OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS, Clinical Endocrinology, vol.5, issue.2, pp.225-232, 1988.
DOI : 10.1177/000456328502200501