P. Karia, J. Han, and C. Schmults, Cutaneous squamous cell carcinoma: Estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012, Journal of the American Academy of Dermatology, vol.68, issue.6, pp.957-66, 2013.
DOI : 10.1016/j.jaad.2012.11.037

F. Grange and B. Guillot, Epidémiologie des cancers cutanés en France. Dépistage et cancer cutanés, Paris: Spinger, pp.9-20
DOI : 10.1007/978-2-287-71050-6_1

J. Bonerandi, C. Beauvillain, L. Caquant, J. Chassagne, V. Chaussade et al., Guidelines for the diagnosis and treatment of cutaneous squamous cell carcinoma and precursor lesions, Journal of the European Academy of Dermatology and Venereology, vol.29, issue.2 Pt 1, pp.1-51, 2011.
DOI : 10.1016/0190-9622(93)70174-R

J. Halna, M. Grandadam, and A. Buemi, Etude épidémiologique des cancers cutanés basée sur la population d'un département français de 1998 à 1996: résultats du registre des cancers du Haut?Rhin, Nouv Dermatol, vol.19, pp.48-55, 2000.

P. Bernard, C. Derancourt, E. Arnoult?coudoux, R. Picot, and C. Delvincourt, Les cancers cutanés diagnostiqués par les dermatologues dans la région Champagne?Ardenne: une étude prospective, Ann Dermatol Venereol, vol.128, pp.883-890, 2001.

H. Rogers, M. Weinstock, A. Harris, M. Hinckley, S. Feldman et al., Incidence estimate of nonmelanoma skin cancer in the United States, Arch Dermatol, vol.146, pp.283-290, 2006.

D. Rowe, R. Carroll, C. Day, and . Jr, Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip, Journal of the American Academy of Dermatology, vol.26, issue.6, pp.976-90, 1992.
DOI : 10.1016/0190-9622(92)70144-5

K. Brantsch, C. Meisner, B. Schönfisch, B. Trilling, J. Wehner?caroli et al., Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study, The Lancet Oncology, vol.9, issue.8, pp.713-733, 2008.
DOI : 10.1016/S1470-2045(08)70178-5

R. Motley, P. Kersey, and C. Lawrence, Multiprofessional guidelines for the management of the patient with primary cutaneous squamous cell carcinoma, British Journal of Dermatology, vol.141, issue.1, pp.18-25, 2002.
DOI : 10.1046/j.1365-2133.1999.3029a.x

C. Mourouzis, A. Boynton, J. Grant, T. Umar, A. Wilson et al., Cutaneous head and neck SCCs and risk of nodal metastasis ??? UK experience, Journal of Cranio-Maxillofacial Surgery, vol.37, issue.8, pp.443-450, 2009.
DOI : 10.1016/j.jcms.2009.07.007

M. Alam and D. Ratner, Cutaneous Squamous-Cell Carcinoma, New England Journal of Medicine, vol.344, issue.13, pp.975-83, 2001.
DOI : 10.1056/NEJM200103293441306

D. Shin, B. Glisson, F. Khuri, J. Clifford, G. Clayman et al., Phase II and Biologic Study of Interferon Alfa, Retinoic Acid, and Cisplatin in Advanced Squamous Skin Cancer, Journal of Clinical Oncology, vol.20, issue.2, pp.364-70, 2002.
DOI : 10.1200/JCO.2002.20.2.364

S. Euvrard, J. Kanitakis, and A. Claudy, Skin Cancers after Organ Transplantation, New England Journal of Medicine, vol.348, issue.17, pp.1681-91, 2003.
DOI : 10.1056/NEJMra022137

P. Combemale, M. Bousquet, J. Kanitakis, and P. Bernard, Malignant transformation of leg ulcers: a retrospective study of 85 cases, Journal of the European Academy of Dermatology and Venereology, vol.146, issue.7, pp.935-976, 2007.
DOI : 10.1111/j.1524-4725.1993.tb03445.x

R. Freeman, Carcinogenic effects of solar radiation and prevention measures, Cancer, vol.17, issue.6, pp.1114-1134, 1968.
DOI : 10.1001/archderm.1963.01590150031006

C. Bajdik, R. Gallagher, G. Astrakianakis, G. Hill, S. Fincham et al., Non-solar ultraviolet radiation and the risk of basal and squamous cell skin cancer, British Journal of Cancer, vol.73, issue.12, pp.1612-1616, 1996.
DOI : 10.1038/bjc.1996.303

B. Barr, E. Benton, K. Mclaren, M. Bunney, I. Smith et al., HUMAN PAPILLOMA VIRUS INFECTION AND SKIN CANCER IN RENAL ALLOGRAFT RECIPIENTS, The Lancet, vol.333, issue.8630, pp.124-133, 1989.
DOI : 10.1016/S0140-6736(89)91143-4

M. Dubina and G. Goldenberg, Viral-Associated Nonmelanoma Skin Cancers: A Review, The American Journal of Dermatopathology, vol.31, issue.6, pp.561-73, 2009.
DOI : 10.1097/DAD.0b013e3181a58234

C. Baudouin, M. Charveron, R. Tarroux, and Y. Gall, Environmental pollutants and skin cancer, Cell Biology and Toxicology, vol.18, issue.5, pp.341-349, 2002.
DOI : 10.1023/A:1019540316060

G. Clayman, J. Lee, F. Holsinger, X. Zhou, M. Duvic et al., Mortality Risk From Squamous Cell Skin Cancer, Journal of Clinical Oncology, vol.23, issue.4, pp.759-65, 2005.
DOI : 10.1200/JCO.2005.02.155

C. Schmults, P. Karia, J. Carter, J. Han, and A. Qureshi, Factors Predictive of Recurrence and Death From Cutaneous Squamous Cell Carcinoma, JAMA Dermatology, vol.149, issue.5, pp.541-548, 2013.
DOI : 10.1001/jamadermatol.2013.2139

A. Jambusaria?pahlajani, P. Kanetsky, P. Karia, W. Hwang, J. Gelfand et al., Evaluation of AJCC Tumor Staging for Cutaneous Squamous Cell Carcinoma and a Proposed Alternative Tumor Staging System, JAMA Dermatology, vol.149, issue.4, pp.1-9, 2013.
DOI : 10.1001/jamadermatol.2013.2456

N. Dean, L. Sweeny, J. Magnuson, W. Carroll, D. Robinson et al., Outcomes of Recurrent Head and Neck Cutaneous Squamous Cell Carcinoma, Journal of Skin Cancer, vol.26, issue.6, pp.10-1155, 2011.
DOI : 10.1016/0190-9622(92)70144-5

J. Martinez and J. Cook, High-Risk Cutaneous Squamous Cell Carcinoma without Palpable Lymphadenopathy, Dermatologic Surgery, vol.33, issue.4, pp.410-430, 2007.
DOI : 10.1097/00042728-200704000-00003

S. Stoeckli, H. Steinert, M. Pfaltz, and S. Schmid, Sentinel Lymph Node Evaluation in Squamous Cell Carcinoma of the Head and Neck, Otolaryngology-Head and Neck Surgery, vol.125, issue.3, pp.221-227, 2001.
DOI : 10.1001/archotol.124.7.790

B. Moore, R. Weber, V. Prieto, A. El?naggar, F. Holsinger et al., Lymph Node Metastases from Cutaneous Squamous Cell Carcinoma of the Head and Neck, The Laryngoscope, vol.24, issue.9, pp.1561-1568, 2005.
DOI : 10.1001/archotol.128.5.521

A. Ross and C. Schmults, Sentinel Lymph Node Biopsy in Cutaneous Squamous Cell Carcinoma, Dermatologic Surgery, vol.32, issue.11, pp.1309-1330, 2006.
DOI : 10.1097/00042728-200611000-00001

J. Chavaudra and A. Bridier, D??finition des volumes en radioth??rapie externe??: rapports ICRU 50 et 62, Cancer/Radioth??rapie, vol.5, issue.5, pp.472-480, 2001.
DOI : 10.1016/S1278-3218(01)00117-2

A. Han and D. Ratner, What is the role of adjuvant radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion? Cancer, pp.1053-1062, 2007.

W. Waxweiler, J. Sigmon, and D. Sheehan, Adjunctive radiotherapy in the treatment of cutaneous squamous cell carcinoma with perineural invasion, Journal of Surgical Oncology, vol.43, issue.1, 2011.
DOI : 10.1016/S0360-3016(98)00474-X

A. Jambusaria?pahlajani, C. Miller, H. Quon, N. Smith, R. Klein et al., Surgical Monotherapy Versus Surgery Plus Adjuvant Radiotherapy in High-Risk Cutaneous Squamous Cell Carcinoma, Dermatologic Surgery, vol.35, issue.4, pp.574-85, 2009.
DOI : 10.1111/j.1524-4725.2009.01095.x

M. Veness, C. Palme, and G. Morgan, High-risk cutaneous squamous cell carcinoma of the head and neck, Cancer, vol.60, issue.11, pp.2389-96, 2006.
DOI : 10.1016/j.ijrobp.2004.03.006

M. Veness, S. Porceddu, C. Palme, and G. Morgan, Cutaneous head and neck squamous cell carcinoma metastatic to parotid and cervical lymph nodes, Head & Neck, vol.106, issue.7, pp.621-652, 2007.
DOI : 10.1001/archotol.1978.00790060038010

W. Mendenhall, R. Amdur, R. Hinerman, A. Cognetta, and N. Mendenhall, Radiotherapy for cutaneous squamous and basal cell carcinomas of the head and neck, The Laryngoscope, vol.19, issue.10, pp.1994-2003, 2009.
DOI : 10.1016/0360-3016(90)90529-S

M. Maroñas, J. Guinot, L. Arribas, M. Carrascosa, M. Tortajada et al., Treatment of facial cutaneous carcinoma with high???dose rate contact brachytherapy with customized molds, Brachytherapy, vol.10, issue.3, pp.221-228, 2011.
DOI : 10.1016/j.brachy.2010.08.005

B. Guix, F. Finestres, J. Tello, C. Palma, A. Martinez et al., Treatment of skin carcinomas of the face by high-dose-rate brachytherapy and custom-made surface molds, International Journal of Radiation Oncology*Biology*Physics, vol.47, issue.1, pp.95-102, 2000.
DOI : 10.1016/S0360-3016(99)00547-7

S. Beauvois, S. Hoffstetter, D. Peiffert, E. Luporsi, J. Carolus et al., Brachytherapy for lower lip epidermoid cancer: tumoral and treatment factors influencing recurrences and complications, Radiotherapy and Oncology, vol.33, issue.3, pp.195-203, 1994.
DOI : 10.1016/0167-8140(94)90354-9

A. Ducassou, I. David, T. Filleron, M. Rives, J. Bonnet et al., Retrospective Analysis of Local Control and Cosmetic Outcome of 147 Periorificial Carcinomas of the Face Treated With Low???Dose Rate Interstitial Brachytherapy, International Journal of Radiation Oncology*Biology*Physics, vol.81, issue.3, pp.726-757, 2011.
DOI : 10.1016/j.ijrobp.2010.05.061

D. Visscher, J. Botke, G. Schakenraad, and J. , A comparison of results after radiotherapy and surgery for stage I squamous cell carcinoma of the lower lip, Head & Neck, vol.110, issue.6, pp.526-556, 1999.
DOI : 10.1002/(SICI)1097-0347(199909)21:6<526::AID-HED5>3.0.CO;2-B

M. Delannes, E. Rio, X. Mirabel, T. Brun, A. Ducassou et al., Curieth??rapie des carcinomes cutan??s et de la l??vre, Cancer/Radioth??rapie, vol.17, issue.2, pp.136-145, 2013.
DOI : 10.1016/j.canrad.2013.02.003

D. Decker, A. Drelichman, J. Jacobs, J. Hoschner, J. Kinzie et al., Adjuvant chemotherapy with Cis-diamminodichloroplatinum II and 120-hour infusion 5-fluorouracil in stage III and IV squamous cell carcinoma of the head and neck, Cancer, vol.66, issue.8, pp.1353-1358, 1983.
DOI : 10.1148/73.6.845

T. Khansur and A. Kennedy, Cisplatin and 5-fluorouracil for advanced locoregional and metastatic squamous cell carcinoma of the skin, Cancer, vol.4, issue.8, pp.2030-2032, 1991.
DOI : 10.1002/1097-0142(19910415)67:8<2030::AID-CNCR2820670803>3.0.CO;2-K

Y. Fujisawa, Y. Umebayashi, E. Ichikawa, Y. Kawachi, and F. Otsuka, Chemoradiation using low-dose cisplatin and 5-fluorouracil in locally advanced squamous cell carcinoma of the skin: A report of two cases, Journal of the American Academy of Dermatology, vol.55, issue.5, pp.81-85, 2006.
DOI : 10.1016/j.jaad.2005.12.035

H. Sadek, N. Azli, J. Wendling, E. Cvitkovic, M. Rahal et al., Treatment of advanced squamous cell carcinoma of the skin with cisplatin, 5-fluorouracil, and bleomycin, Cancer, vol.8, issue.8, pp.1692-1698, 1990.
DOI : 10.1002/1097-0142(19901015)66:8<1692::AID-CNCR2820660807>3.0.CO;2-Y

A. Eggermont, J. De-wilt, and T. Hagen, Current uses of isolated limb perfusion in the clinic and a model system for new strategies, The Lancet Oncology, vol.4, issue.7, pp.429-466, 2003.
DOI : 10.1016/S1470-2045(03)01141-0

T. Guthrie, . Jr, L. Mcelveen, E. Porubsky, and J. Harmon, Cisplatin and doxorubicin. An effective chemotherapy combination in the treatment of advanced basal cell and squamous carcinoma of the skin, Cancer, vol.92, issue.8, pp.1629-1661, 1985.
DOI : 10.1097/00007611-197807000-00019

T. Guthrie, . Jr, E. Porubsky, M. Luxenberg, K. Shah et al., Cisplatin-based chemotherapy in advanced basal and squamous cell carcinomas of the skin: results in 28 patients including 13 patients receiving multimodality therapy., Journal of Clinical Oncology, vol.8, issue.2, pp.342-348, 1990.
DOI : 10.1200/JCO.1990.8.2.342

G. Cartei, F. Cartei, G. Interlandi, G. Meneghini, A. Jop et al., Oral 5-Fluorouracil in Squamous Cell Carcinoma of the Skin in the Aged, American Journal of Clinical Oncology: Cancer Clinical Trials, vol.23, issue.2, pp.181-185, 2000.
DOI : 10.1097/00000421-200004000-00015

U. Wollina, G. Hansel, A. Koch, and E. Köstler, Oral capecitabine plus subcutaneous interferon alpha in advanced squamous cell carcinoma of the skin, Journal of Cancer Research and Clinical Oncology, vol.45, issue.5, pp.300-304, 2005.
DOI : 10.1007/s00432-004-0656-6

E. Jones, A. Korzenko, and D. Kriegel, Oral isotretinoin in the treatment and prevention of cutaneous squamous cell carcinoma, J Drugs Dermatol, vol.3, pp.498-502, 2004.

S. Lippman, D. Parkinson, L. Itri, R. Weber, S. Schantz et al., 13-cis-Retinoic Acid and Interferon ?? -2a: Effective Combination. Therapy for Advanced Squamous Cell Carcinoma of the Skin, JNCI Journal of the National Cancer Institute, vol.84, issue.4, pp.235-276, 1992.
DOI : 10.1093/jnci/84.4.235

A. Brewster, J. Lee, G. Clayman, J. Clifford, M. Reyes et al., -Retinoic Acid and Interferon Alfa for Patients With Aggressive Skin Squamous Cell Carcinoma, Journal of Clinical Oncology, vol.25, issue.15, pp.1974-1982, 2007.
DOI : 10.1200/JCO.2006.05.9873

L. Cranmer, C. Engelhardt, and S. Morgan, Treatment of Unresectable and Metastatic Cutaneous Squamous Cell Carcinoma, The Oncologist, vol.15, issue.12, pp.1320-1328, 2010.
DOI : 10.1634/theoncologist.2009-0210

F. Ciardiello and G. Tortora, EGFR Antagonists in Cancer Treatment, New England Journal of Medicine, vol.358, issue.11, pp.1160-74, 2008.
DOI : 10.1056/NEJMra0707704

K. Ang, B. Berkey, X. Tu, H. Zhang, R. Katz et al., Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma, Cancer Res, vol.62, pp.7350-7356, 2002.

R. Grandis, J. Melhem, M. Gooding, W. Day, R. Holst et al., Levels of TGF-?? and EGFR Protein in Head and Neck Squamous Cell Carcinoma and Patient Survival, JNCI: Journal of the National Cancer Institute, vol.120, issue.3, pp.824-856, 1998.
DOI : 10.1007/BF01221026

N. Magné, X. Pivot, R. Bensadoun, E. Guardiola, G. Poissonnet et al., The relationship of epidermal growth factor receptor levels to the prognosis of unresectable pharyngeal cancer patients treated by chemo-radiotherapy, European Journal of Cancer, vol.37, issue.17, pp.2169-77, 2001.
DOI : 10.1016/S0959-8049(01)00280-5

E. Maubec, P. Duvillard, V. Velasco, B. Crickx, and M. Avril, Immunohistochemical analysis of EGFR and HER?2 in patients with metastatic squamous cell carcinoma of the skin, Anticancer Res, vol.25, pp.1205-1215, 2005.

U. Wollina, A. Frenkl, B. Knöll, U. Hipler, and R. Wetzker, Inhibition of signal transduction in EGF-dependent epithelial cell lines, International Journal of Molecular Medicine, vol.12, pp.673-680, 2003.
DOI : 10.3892/ijmm.12.4.673

J. Mendelsohn and J. Baselga, Status of Epidermal Growth Factor Receptor Antagonists in the Biology and Treatment of Cancer, Journal of Clinical Oncology, vol.21, issue.14, pp.2787-99, 2003.
DOI : 10.1200/JCO.2003.01.504

D. Cunningham, Y. Humblet, S. Siena, D. Khayat, H. Bleiberg et al., Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer, New England Journal of Medicine, vol.351, issue.4, pp.337-382, 2004.
DOI : 10.1056/NEJMoa033025

URL : http://www.nejm.org/doi/pdf/10.1056/NEJMoa033025

J. Vermorken, R. Mesia, F. Rivera, E. Remenar, A. Kawecki et al., Platinum-Based Chemotherapy plus Cetuximab in Head and Neck Cancer, New England Journal of Medicine, vol.359, issue.11, pp.1116-1143, 2008.
DOI : 10.1056/NEJMoa0802656

L. Licitra, R. Mesia, F. Rivera, E. Remenár, R. Hitt et al., Evaluation of EGFR gene copy number as a predictive biomarker for the efficacy of cetuximab in combination with chemotherapy in the first-line treatment of recurrent and/or metastatic squamous cell carcinoma of the head and neck: EXTREME study, Annals of Oncology, vol.63, issue.5, pp.1078-87, 2011.
DOI : 10.1200/JCO.2006.07.6554

U. Wollina, Cetuximab in non-melanoma skin cancer, Expert Opinion on Biological Therapy, vol.38, issue.7, pp.949-56, 2012.
DOI : 10.1159/000092836

E. Maubec, P. Petrow, I. Scheer?senyarich, P. Duvillard, L. Lacroix et al., Phase II Study of Cetuximab As First-Line Single-Drug Therapy in Patients With Unresectable Squamous Cell Carcinoma of the Skin, Journal of Clinical Oncology, vol.29, issue.25, pp.3419-3445, 2011.
DOI : 10.1200/JCO.2010.34.1735

S. Preneau, E. Rio, A. Brocard, L. Peuvrel, J. Nguyen et al., Efficacy of cetuximab in the treatment of squamous cell carcinoma, Journal of Dermatological Treatment, vol.23, issue.5
DOI : 10.1016/j.clon.2011.07.007

D. Giacchero, J. Barrière, K. Benezery, B. Guillot, C. Dutriaux et al., Efficacy of Cetuximab for Unresectable or Advanced Cutaneous Squamous Cell Carcinoma ??? A Report of Eight Cases, Clinical Oncology, vol.23, issue.10, pp.716-724, 2011.
DOI : 10.1016/j.clon.2011.07.007

S. Kalapurakal, J. Malone, K. Robbins, L. Buescher, J. Godwin et al., Cetuximab in Refractory Skin Cancer Treatment, Journal of Cancer, vol.3, pp.257-61, 2012.
DOI : 10.7150/jca.3491

URL : http://www.jcancer.org/v03p0257.pdf

J. Bauman, K. Eaton, and R. Martins, Treatment of Recurrent Squamous Cell Carcinoma of the Skin With Cetuximab, Archives of Dermatology, vol.143, issue.7, pp.889-92, 2007.
DOI : 10.1001/archderm.143.7.889

J. Suen, L. Bressler, S. Shord, M. Warso, and J. Villano, Cutaneous squamous cell carcinoma responding serially to single-agent cetuximab, Anti-Cancer Drugs, vol.18, issue.7, pp.827-836, 2007.
DOI : 10.1097/CAD.0b013e32809ef9e0

A. Arnold, L. Bruckner?tuderman, C. Zuger, and P. Itin, Cetuximab Therapy of Metastasizing Cutaneous Squamous Cell Carcinoma in a Patient with Severe Recessive Dystrophic Epidermolysis Bullosa, Dermatology, vol.219, issue.1, pp.80-83, 2009.
DOI : 10.1159/000218714

R. Casadevall, J. Graña?suárez, B. Hernandez?yagüe, X. , V. Ribera et al., Xeroderma pigmentosum: neck lymph node metastasis of a squamous cell carcinoma of the skin treated with cetuximab, Eur J Dermatol, vol.19, pp.163-168, 2009.

K. Miller, W. Sherman, and D. Ratner, Complete Clinical Response to Cetuximab in a Patient with Metastatic Cutaneous Squamous Cell Carcinoma, Dermatologic Surgery, vol.36, issue.12, pp.2069-74, 2010.
DOI : 10.1111/j.1524-4725.2010.01786.x

A. Chen, A. Setser, M. Anadkat, J. Cotliar, E. Olsen et al., Grading dermatologic adverse events of cancer treatments: The Common Terminology Criteria for Adverse Events Version 4.0, Journal of the American Academy of Dermatology, vol.67, issue.5, pp.1025-1064, 2012.
DOI : 10.1016/j.jaad.2012.02.010

F. Peyrade, E. Saâda, K. Benezery, C. Hebert, and O. Dassonville, Chimioth??rapie d???induction des carcinomes ??pidermo??des de la t??te et du cou, Cancer/Radioth??rapie, vol.15, issue.6-7, pp.460-465, 2011.
DOI : 10.1016/j.canrad.2011.07.233

C. Lewis, B. Glisson, L. Feng, F. Wan, X. Tang et al., A Phase II Study of Gefitinib for Aggressive Cutaneous Squamous Cell Carcinoma of the Head and Neck, Clinical Cancer Research, vol.18, issue.5, pp.1435-1481, 2012.
DOI : 10.1158/1078-0432.CCR-11-1951