.. Procédés-bottom-up, 110 Technologie d'émulsification Expansion rapide depuis une solution de gaz liquéfié. (Rapid expansion from supercritical to aqueous solution : RESAS), .112 Lyophilisation dans un liquide super critique (SFL : spray freezing into liquid), p.112

B. Abbot, E. Grenade, D. Kennedy, D. Gatfield, K. Thwaites et al., -coupled amino-acid transporter hPAT1, British Journal of Pharmacology, vol.45, issue.3, pp.298-306, 2006.
DOI : 10.1007/BF00232716

R. Andre, Which solutions for polymorphism, stability, phase transition, crystallinity, denaturation of protein, protein ligand interaction, excipient interaction, SETARAM, conference francelab, 2006.

H. Araya, S. Nagao, M. Tomita, and M. Hayashi, The Novel Formulation Design of Self-emulsifying Drug Delivery Systems (SEDDS) Type O/W Microemulsion I: Enhancing Effects on Oral Bioavailability of Poorly Water Soluble Compounds in Rats and Beagle Dogs, Drug Metabolism and Pharmacokinetics, vol.20, issue.4, pp.244-256, 2005.
DOI : 10.2133/dmpk.20.244

H. Araya, S. Nagao, M. Tomita, and M. Hayashi, The novel formulation design of self emulsifing drug delivery system type ow microemulsion ii : stable gastrointestinal absorption of poorly water soluble new compound er-1258, in bile-fistula rats

P. Balakrishnan, B. Lee, D. Oh, J. Kim, Y. Lee et al., Enhanced oral bioavailability of Coenzyme Q10 by self-emulsifying drug delivery systems, International Journal of Pharmaceutics, vol.374, issue.1-2, pp.66-72, 2009.
DOI : 10.1016/j.ijpharm.2009.03.008

P. Baliman and S. Chong, Cell culture-based models for intestinal permeability: A critique, Drug Discovery Today, vol.10, issue.5, pp.335-343, 2005.
DOI : 10.1016/S1359-6446(04)03354-9

D. Behrens, R. Fricker, A. Bodoky, J. Drewe, F. Harder et al., Acceptable analytical practices for dissolution testing of poorly soluble compounds, Pharm. Technol, pp.56-65, 2004.

G. Burckhardt, Polyspecific Organic Cation Transport: Insights into the Substrate Binding Site, Molecular Pharmacology, vol.67, issue.5, pp.1391-1392, 2005.
DOI : 10.1124/mol.105.012161

S. Byrn, W. Xu, and A. Newman, Chemical reactivity in solid-state pharmaceuticals: formulation implications, Advanced Drug Delivery Reviews, vol.48, issue.1, pp.115-136, 2001.
DOI : 10.1016/S0169-409X(01)00102-8

R. Challa, A. Ahuja, J. Ali, and R. Khar, Cyclodextrins in drug delivery: An updated review, AAPS PharmSciTech, vol.6, issue.2, pp.329-57, 2005.
DOI : 10.1208/pt060243

G. Chang, Multidrug resistance ABC transporters, FEBS Letters, vol.276, issue.1, pp.102-105, 2003.
DOI : 10.1074/jbc.C100369200

URL : http://onlinelibrary.wiley.com/doi/10.1016/S0014-5793(03)01085-8/pdf

S. Charman, W. Charman, M. Rogge, T. Wilson, F. Dutko et al., Selfemulsifying drug delivery systems: formulation and biopharmaceutic evaluation of an investigational lipophilic compound, Pharmaceutical Research, vol.09, issue.1, pp.87-93, 1992.
DOI : 10.1023/A:1018987928936

P. Chattopadhyay and R. Gupta, Protein nanoparticles formation by supercritical antisolvent with enhanced mass transfer, AIChE Journal, vol.41, issue.2, pp.235-244, 2002.
DOI : 10.1002/aic.690480207

X. Chen, M. Antman, C. Gesenberg, and O. Gudmundsson, Discovery pharmaceutics???Challenges and opportunities, The AAPS Journal, vol.8, issue.2, pp.402-410, 2006.
DOI : 10.1007/BF02854912

X. Chen, J. Vaughn, M. Yacaman, R. Williams, and K. Johnston, Rapid Dissolution of High???Potency Danazol Particles Produced by Evaporative Precipitation into Aqueous Solution, Journal of Pharmaceutical Sciences, vol.93, issue.7, pp.1867-1878, 2004.
DOI : 10.1002/jps.20001

C. Jerdi, M. Desmeules, J. Dayer, and P. , La glycoprotéine p : un transporteur de médicaments à ne pas négliger, Revue Médicale Suisse, vol.524, 2004.

P. Constantinides, Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects, Pharmaceutical Research, vol.12, issue.11, pp.1561-1572, 1995.
DOI : 10.1023/A:1016268311867

D. Craig, The use of self emulsifying systems as a means of improving drug delivery, bulletin technique Gattefossé, vol.86, 1993.

D. Craig, D. Barker, D. Banning, and S. Booth, An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy, International Journal of Pharmaceutics, vol.114, issue.1, pp.103-110, 1995.
DOI : 10.1016/0378-5173(94)00222-Q

J. Custodio, C. Wu, and L. Benet, Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption, Advanced Drug Delivery Reviews, vol.60, issue.6, pp.717-733, 2008.
DOI : 10.1016/j.addr.2007.08.043

T. Dabros, A. Yeung, J. Masliyah, and J. Czarnecki, Emulsification through Area Contraction, Journal of Colloid and Interface Science, vol.210, issue.1, pp.222-224, 1999.
DOI : 10.1006/jcis.1998.5943

L. Di and E. Kerns, Profiling drug-like properties in discovery research, Current Opinion in Chemical Biology, vol.7, issue.3
DOI : 10.1016/S1367-5931(03)00055-3

C. Dietrich, A. Geier, and R. Elferink, ABC of oral bioavailability: transporters as gatekeepers in the gut, Gut, vol.52, issue.12, pp.1788-1795, 2003.
DOI : 10.1136/gut.52.12.1788

D. Dixon, K. Johnston, and R. Brodemier, Polymeric materials formed by precipitation with a compressed fluid antisolvent, AIChE Journal, vol.39, issue.1, pp.127-139, 1993.
DOI : 10.1002/aic.690390113

W. Dong, Multiparticulate drug delivery system for lipophilic drugs and macromolecule drugs, 2005.

T. Endo, H. Nagase, H. Ueda, S. Kobayashi, and T. Nagai, Isolation, Purification, and Characterization of Cyclomaltodecaose (.EPSILON.-Cyclodextrin), Cyclomaltoundecaose (.ZETA.-Cyclodextrin) and Cyclomaltotridecaose (.THETA.-Cyclodextrin)., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.45, issue.3, pp.532-536, 1997.
DOI : 10.1248/cpb.45.532

F. Falson-rieg, V. Faivre, and F. Pirot, Nouvelles formes médicamenteuses, 2004.

S. Feng, L. Mei, P. Anitha, C. Gan, and W. Zhou, Poly(lactide)???vitamin E derivative/montmorillonite nanoparticle formulations for the oral delivery of Docetaxel, Biomaterials, vol.30, issue.19
DOI : 10.1016/j.biomaterials.2009.02.045

A. Florence, D. Attwood, M. Foltz, A. Meyer, S. Theis et al., Physicochemical principles of pharmacy A rapid in vitro screening for delivery of peptide-derived peptidase inhibitors as potential drug candidates via epithelial peptide transporters, J Pharmacol Exp Ther, vol.310, pp.695-702, 1998.

F. Frey, F. Horber, and B. Frey, Trough levels and concentration time curves of cyclosporine in patients undergoing renal transplantation, Clinical Pharmacology and Therapeutics, vol.43, issue.1, pp.55-62, 1988.
DOI : 10.1038/clpt.1988.11

P. Gao, B. Rush, W. Pfund, T. Huang, and J. Bauer, Development of a supersaturable SEDDS (S???SEDDS) formulation of paclitaxel with improved oral bioavailability, Journal of Pharmaceutical Sciences, vol.92, issue.12, pp.2386-2398, 2003.
DOI : 10.1002/jps.10511

J. Garrigue, Les systèmes autoémulsionnants pour l'administration orale de principes actifs lipophiles : influence de la formulation sur les aspects biopharmaceutiques. Faculté de pharmacie de Chatenay-Malabry, 2001.

T. Gershanik and S. Benita, Positively Charged Self-Emulsifying Oil Formulation for Improving Oral Bioavailability of Progesterone, Pharmaceutical Development and Technology, vol.114, issue.2, pp.147-157, 1996.
DOI : 10.1016/0378-5173(94)00222-Q

T. Gershanik, S. Benzeno, and S. Benita, Interaction of a self-emulsifying lipid drug delivery system with the everted rat intestinal mucosa as a function of droplet size and surface charge, Pharmaceutical Research, vol.15, issue.6, pp.863-869, 1998.
DOI : 10.1023/A:1011968313933

T. Gershanik, E. Haltner, C. Lehr, and S. Benita, Charge-dependent interaction of self-emulsifying oil formulations with Caco-2 cells monolayers: binding, effects on barrier function and cytotoxicity, International Journal of Pharmaceutics, vol.211, issue.1-2, pp.29-36, 2000.
DOI : 10.1016/S0378-5173(00)00591-3

O. Gudmundsson and S. Venkatesh, Strategies for in silico and experimental screening of physicochemical properties, Pharmaceutical profi ling in drug discovery for lead selection

B. Hancock and M. Parks, What is the true solubility advantage for amorphous pharmaceuticals?, Pharmaceutical Research, vol.17, issue.4, pp.397-404, 2000.
DOI : 10.1023/A:1007516718048

M. Hanna and P. York, Method & apparatus for the formation of particles. US Patent, p.5

D. Hauss, S. Fogal, J. Ficorilli, C. Price, T. Roy et al., Lipid-Based Delivery Systems for Improving the Bioavailability and Lymphatic Transport of a Poorly Water-Soluble LTB4 Inhibitor, Journal of Pharmaceutical Sciences, vol.87, issue.2, pp.164-169, 1998.
DOI : 10.1021/js970300n

W. He, S. Horn, and M. Hussain, Improved bioavailability of orally administered mifepristone from PLGA nanoparticles, International Journal of Pharmaceutics, vol.334, issue.1-2, pp.173-178, 2007.
DOI : 10.1016/j.ijpharm.2006.10.025

J. Hecq, M. Deleers, D. Fanara, H. Vranckx, and K. Amighi, Preparation and characterization of nanocrystals for solubility and dissolution rate enhancement of nifedipine, International Journal of Pharmaceutics, vol.299, issue.1-2
DOI : 10.1016/j.ijpharm.2005.05.014

P. Van-hoogevest, X. Liu, and A. Fahr, Drug delivery strategies for poorly water-soluble drugs: the industrial perspective, Expert Opinion on Drug Delivery, vol.6, issue.11, pp.1481-1500, 2011.
DOI : 10.1016/S0928-0987(01)00221-4

S. Hovorka and C. Schöneich, Oxidative degradation of pharmaceuticals: Theory, mechanisms and inhibition, Journal of Pharmaceutical Sciences, vol.90, issue.3, pp.253-269, 2001.
DOI : 10.1002/1520-6017(200103)90:3<253::AID-JPS1>3.0.CO;2-W

J. Hu, K. Johnston, and R. Williams, Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems, European Journal of Pharmaceutical Sciences, vol.20, issue.3, pp.295-303, 2003.
DOI : 10.1016/S0928-0987(03)00203-3

J. Hu, K. Johnston, and R. Williams, Rapid dissolving high potency danazol powders produced by spray freezing into liquid process, International Journal of Pharmaceutics, vol.271, issue.1-2, pp.145-154, 2004.
DOI : 10.1016/j.ijpharm.2003.11.003

J. Hu, K. Johnston, and R. Williams, Stable Amorphous Danazol Nanostructured Powders with Rapid Dissolution Rates Produced by Spray Freezing into Liquid, Drug Development and Industrial Pharmacy, vol.48, issue.7, pp.695-704, 2004.
DOI : 10.1023/A:1011976615750

M. Humphrey, Interface between drug discovery, adme and pharmaceutical development. bulletin technique gattefossé, pp.65-74, 2005.

C. Jacobs, O. Kayser, and R. Müller, Nanosuspensions as a new approach for the formulation for the poorly soluble drug tarazepide, International Journal of Pharmaceutics, vol.196, issue.2, pp.161-164, 2000.
DOI : 10.1016/S0378-5173(99)00412-3

J. Jonker and A. Schinkel, Pharmacological and Physiological Functions of the Polyspecific Organic Cation Transporters: OCT1, 2, and 3 (SLC22A1-3), Journal of Pharmacology and Experimental Therapeutics, vol.308, issue.1, pp.2-9, 2004.
DOI : 10.1124/jpet.103.053298

J. Junghanns and R. Müller, Nanocrystal technology, drug delivery and clinical applications, Int J Nanomedicine, vol.3, pp.295-309, 2008.

A. Karim, R. Gokhale, and J. Cole, 1.hiv protease inhibitor sc-52151: a novel method of optimizing bioavailability profile via a microemulsion drug delivery system, Pharm Res, vol.368, 1994.
URL : https://hal.archives-ouvertes.fr/hal-01691158

T. Katsura and K. Inui, Intestinal Absorption of Drugs Mediated by Drug Transporters: Mechanisms and Regulation, Drug Metabolism and Pharmacokinetics, vol.18, issue.1, pp.1-15, 2003.
DOI : 10.2133/dmpk.18.1

O. Kayser, C. Olbrich, Y. V. Kiderlen, A. Croft, and S. , Formulation of amphotericin B as nanosuspension for oral administration, International Journal of Pharmaceutics, vol.254, issue.1, pp.73-75, 2003.
DOI : 10.1016/S0378-5173(02)00686-5

E. Kerns, High throughput physicochemical profiling for drug discovery, Journal of Pharmaceutical Sciences, vol.90, issue.11
DOI : 10.1002/jps.1134

V. Kharb, M. Bhatia, H. Dureja, and D. Kaushik, Nanoparticle technology for the delivery of poorly water-soluble drugs, Pharmaceutical Technology, vol.30, pp.82-92, 2006.

J. Kiani and S. Imam, Medicinal importance of grapefruit juice and its interaction with various drugs, Nutrition Journal, vol.58, issue.11, p.33, 2007.
DOI : 10.1007/s00228-002-0495-9

J. Kim and Y. Ku, Enhanced absorption of indomethacin after oral or rectal administration of a self-emulsifying system containing indomethacin to rats, International Journal of Pharmaceutics, vol.194, issue.1, pp.81-89, 2000.
DOI : 10.1016/S0378-5173(99)00367-1

U. Kodavanti and H. Mehendale, Cationic amphiphilic drugs and phospholipid storage disorder, Pharmacol Rev, vol.42, pp.327-354, 1990.

K. Krause and R. Müller, Production and characterisation of highly concentrated nanosuspensions by high pressure homogenisation, International Journal of Pharmaceutics, vol.214, issue.1-2, pp.21-24, 2001.
DOI : 10.1016/S0378-5173(00)00626-8

G. Lambert, J. Garrigue, A. Razafindratsita, R. Gursoy, S. Yang et al., Selfemulsifying drug delivery system for poorly soluble drugs (taxoids and oral paclitaxel formulation, p.brevet, 2002.

L. Hir and A. , Abrégés de pharmacie galénique, 2001.

G. Liversidge and P. Conzentino, Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rats, International Journal of Pharmaceutics, vol.125, issue.2, pp.309-313, 1995.
DOI : 10.1016/0378-5173(95)00148-C

G. Liversidge and K. Cundy, Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: I. Absolute oral bioavailability of nanocrystalline danazol in beagle dogs, International Journal of Pharmaceutics, vol.125, issue.1, pp.91-97, 1995.
DOI : 10.1016/0378-5173(95)00122-Y

P. Lockman, R. Mumper, M. Khan, and D. Allen, Nanoparticle Technology for Drug Delivery Across the Blood-Brain Barrier, Drug Development and Industrial Pharmacy, vol.15, issue.3, pp.1-13, 2002.
DOI : 10.1006/phrs.2000.0695

T. Loftsson, M. Brewster, and M. Masson, Role of Cyclodextrins in Improving Oral Drug Delivery, American Journal of Drug Delivery, vol.6, issue.4, pp.261-275, 2004.
DOI : 10.1248/cpb.48.646

T. Loftsson and D. Duchêne, Cyclodextrins and their pharmaceutical applications, International Journal of Pharmaceutics, vol.329, issue.1-2
DOI : 10.1016/j.ijpharm.2006.10.044

S. Martins, B. Sarmento, D. Ferreira, and E. Souto, Lipid-based colloidal carriers for peptide and protein delivery--liposomes versus lipid nanoparticles, Int J Nanomedicine, vol.2, pp.595-607, 2007.

A. Meinzer, E. Mueller, and J. Vonderscher, 1.microemulsion-a suitable galenical approach for the absorption enhancement of low soluble compounds?, bulletin technique Gattefossé, pp.21-26, 1995.
URL : https://hal.archives-ouvertes.fr/hal-01616773

E. Merisko-liversidge, G. Liversidge, and E. Cooper, Nanosizing: a formulation approach for poorly-water-soluble compounds, European Journal of Pharmaceutical Sciences, vol.18, issue.2, pp.113-120, 2003.
DOI : 10.1016/S0928-0987(02)00251-8

M. Morgen, C. Bloom, R. Beyerinck, A. Bello, W. Song et al., Polymeric Nanoparticles for Increased Oral Bioavailability and Rapid Absorption Using Celecoxib as a Model of a Low-Solubility, High-Permeability Drug, Pharmaceutical Research, vol.26, issue.7, pp.427-440, 2012.
DOI : 10.1007/s11095-009-9852-z

R. Muller, R. Becker, B. Kruss, and K. Peters, Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution, p.410, 1999.

R. Muller, B. Bohm, and . Nanosuspensions, In Emulsions & nanosuspensions for the formulation of poorly soluble drugs, pp.149-174, 1998.

R. Muller, B. Bohm, and M. Grau, Nanosuspensions: a formulation approach for poorly soluble and poorly bioavailable drugs. In Handbook of pharmaceutical controlled release technology, pp.345-357, 2000.

R. Muller, B. Bohm, and M. Grau, Nanosuspension for the formulation of poorly soluble drugs, Pharmaceutical emulsion and suspension. Neilloud F

R. Muller and K. Peters, Nanosuspensions for the formulation of poorly soluble drugs, International Journal of Pharmaceutics, vol.160, issue.2, pp.229-237, 1998.
DOI : 10.1016/S0378-5173(97)00311-6

R. Müller, C. Jacobs, and O. Kayser, Nanosuspensions as particulate drug formulations in therapy, Advanced Drug Delivery Reviews, vol.47, issue.1, pp.3-19, 2001.
DOI : 10.1016/S0169-409X(00)00118-6

B. Nanjwade, D. Patel, R. Udhani, and F. Manvi, Functions of Lipids for Enhancement of Oral Bioavailability of Poorly Water-Soluble Drugs, Scientia Pharmaceutica, vol.79, issue.4, pp.705-72, 2011.
DOI : 10.3797/scipharm.1105-09

J. Olivier, Drug transport to brain with targeted nanoparticles, NeuroRX, vol.92, issue.1, pp.108-119, 2005.
DOI : 10.1073/pnas.92.12.5592

G. Pace, M. Vachon, A. Mishra, I. Henrikson, and V. Krukonis, Processes to generate submicron particles of water-insoluble compounds, US Patent, vol.6177103, 2001.

V. Patravale, A. Date, and R. Kulkarni, Nanosuspensions: a promising drug delivery strategy, Journal of Pharmacy and Pharmacology, vol.32, issue.7, pp.827-840, 2004.
DOI : 10.1016/S0169-409X(97)00136-1

URL : http://onlinelibrary.wiley.com/doi/10.1211/0022357023691/pdf

C. Pouton, Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ???self-microemulsifying??? drug delivery systems, European Journal of Pharmaceutical Sciences, vol.11, issue.2, pp.93-101, 2000.
DOI : 10.1016/S0928-0987(00)00167-6

C. Pouton, Formulation of poorly water-soluble drugs for adminidtration, Bulletin technique Gattefossé, vol.98, pp.39-51, 2005.

C. Pouton, Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification, International Journal of Pharmaceutics, vol.27, issue.2-3, pp.335-348, 1985.
DOI : 10.1016/0378-5173(85)90081-X

B. Prajapati, R. Patel, R. Patel, and G. Patel, Beefing up bioavailability. Pharmaceutical formulation and quality, 2007.

R. Ptachcinski, G. Burckart, and R. Venkataramanan, Cyclosporine Concentration Determinations for Monitoring and Pharmacokinetic Studies, The Journal of Clinical Pharmacology, vol.16, issue.5, pp.358-366, 1986.
DOI : 10.1097/00007890-198502000-00005

R. Ptachcinski, R. Venkataramanan, and G. Burckart, Clinical Pharmacokinetics of Cyclosporin, Clinical Pharmacokinetics, vol.11, issue.2, pp.107-132, 1986.
DOI : 10.2165/00003088-198611020-00002

M. Pudipeddi and A. Serajuddin, Trends in Solubility of Polymorphs, Journal of Pharmaceutical Sciences, vol.94, issue.5, pp.929-939, 2005.
DOI : 10.1002/jps.20302

F. Puisieux and M. Seiller, Agents de surface et émulsions, 1983.

A. Puri, K. Loomis, B. Smith, J. Lee, A. Yavlovich et al., Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic, Critical Reviews?? in Therapeutic Drug Carrier Systems, vol.26, issue.6, pp.523-580, 2009.
DOI : 10.1615/CritRevTherDrugCarrierSyst.v26.i6.10

URL : http://europepmc.org/articles/pmc2885142?pdf=render

B. Rabinow, Nanosuspensions in drug delivery, Nature Reviews Drug Discovery, vol.710, issue.Suppl. 2, pp.785-796, 2004.
DOI : 10.1016/0006-8993(95)01375-X

T. Rogers, J. Hu, Z. Yu, K. Johnston, and R. Williams, A novel particle engineering technology: spray-freezing into liquid, International Journal of Pharmaceutics, vol.242, issue.1-2, pp.93-100, 2002.
DOI : 10.1016/S0378-5173(02)00154-0

T. Rogers, A. Nelsen, J. Hu, J. Brown, M. Sarkari et al., A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid, European Journal of Pharmaceutics and Biopharmaceutics, vol.54, issue.3, pp.271-280, 2002.
DOI : 10.1016/S0939-6411(02)00063-2

S. Ruddy, Nanoparticle technology : leveraging rapid dissolution to improve performance of poorly water-soluble drugs, FDA Advisory Committee for Pharmaceutical Science and Clinical Pharmacology, 2008.

. Ruth-h, D. Attwood, D. Ktisis, and C. Taylor, Phase studies and particle size analysis of oil-in-water phospholipid microemulsions, International Journal of Pharmaceutics, vol.116, issue.2, pp.253-261, 1995.
DOI : 10.1016/0378-5173(94)00316-W

M. Sala-rabanal, D. Loo, B. Hirayama, E. Turk, and E. Wright, -oligopeptide cotransporter hPEPT1, The Journal of Physiology, vol.17, issue.1
DOI : 10.1023/A:1007556630189

B. Sarkadi, C. Ozvegy-laczka, K. Német, and A. Váradi, ABCG2 - a transporter for all seasons, FEBS Letters, vol.14, issue.1, pp.116-120, 2004.
DOI : 10.1089/104303403321209005

M. Sarkari, J. Brown, X. Chen, S. Swinnea, R. Williams et al., Enhanced drug dissolution using evaporative precipitation into aqueous solution, International Journal of Pharmaceutics, vol.243, issue.1-2, pp.17-31, 2002.
DOI : 10.1016/S0378-5173(02)00072-8

N. Schöler, K. Krause, O. Kayser, R. Müller, K. Borner et al., Atovaquone Nanosuspensions Show Excellent Therapeutic Effect in a New Murine Model of Reactivated Toxoplasmosis, Antimicrobial Agents and Chemotherapy, vol.45, issue.6, pp.1771-1779, 2001.
DOI : 10.1128/AAC.45.6.1771-1779.2001

A. Serajuddin, P. Sheen, D. Mufson, D. Bernstein, and M. Augustine, Effect of Vehicle Amphiphilicity on the Dissolution and Bioavailability of a Poorly Water-Soluble Drug from Solid Dispersions, Journal of Pharmaceutical Sciences, vol.77, issue.5, pp.414-417, 1988.
DOI : 10.1002/jps.2600770512

N. Shah, W. Carvajal, C. Patel, and M. Infeld, Self-emulsifying drug delivery systems (SEDDS) with polyglycolyzed glycerides for improving in vitro dissolution and oral absorption of lipophilic drugs, International Journal of Pharmaceutics, vol.106, issue.1, pp.15-23, 1994.
DOI : 10.1016/0378-5173(94)90271-2

F. Sharom, Shedding light on drug transport: structure and function of the P-glycoprotein multidrug transporter (ABCB1)This paper is one of a selection of papers published in this Special Issue, entitled CSBMCB ??? Membrane Proteins in Health and Disease., Biochemistry and Cell Biology, vol.8, issue.6, pp.979-992, 2006.
DOI : 10.1016/S0968-0004(99)01514-5

R. Shegokar and R. Müller, Nanocrystals: Industrially feasible multifunctional formulation technology for poorly soluble actives, International Journal of Pharmaceutics, vol.399, issue.1-2, pp.129-139, 2010.
DOI : 10.1016/j.ijpharm.2010.07.044

B. Subramaniam, S. Saim, R. Rajewski, V. Stella, S. Ray et al., Methods for a particle precipitation and coating using near-critical and supercritical antisolvents. US Patent 5 Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of célécoxib, p.891, 1997.

E. Swenson, W. Milisen, and W. Curatolo, Intestinal permeability enhancement: structure-activity and structure-toxicity relationships for nonylphenoxypolyoxyethylene surfactant permeability enhancers, Pharmaceutical Research, vol.11, issue.10, pp.1501-1504, 1994.
DOI : 10.1023/A:1018920728800

B. Tarr and S. Yalkowsky, Enhanced intestinal absorption of ciclosporine in rats through the reduction of emulsion droplet size, Pharmaceutical Research, vol.06, issue.1, pp.40-43, 1989.
DOI : 10.1023/A:1015843517762

D. Thwaites and C. Anderson, -coupled nutrient, micronutrient and drug transporters in the mammalian small intestine, Experimental Physiology, vol.26, issue.Suppl. 3, pp.603-619, 2007.
DOI : 10.1007/s10555-007-9047-1

H. Tønnesen, Formulation and stability testing of photolabile drugs, International Journal of Pharmaceutics, vol.225, issue.1-2, pp.1-14, 2001.
DOI : 10.1016/S0378-5173(01)00746-3

M. Trotta, M. Gallarate, M. Carlotti, and S. Morel, Preparation of griseofulvin nanoparticles from water-dilutable microemulsions, International Journal of Pharmaceutics, vol.254, issue.2, pp.235-242, 2003.
DOI : 10.1016/S0378-5173(03)00029-2

M. Trotta, M. Gallarate, F. Pattarino, and S. Morel, Emulsions containing partially water-miscible solvents for the preparation of drug nanosuspensions, Journal of Controlled Release, vol.76, issue.1-2, pp.119-128, 2001.
DOI : 10.1016/S0168-3659(01)00432-1

M. Turk, B. Helfgen, P. Hils, R. Lietzow, and K. Schaber, Micronization of pharmaceutical substances by the Rapid Expansion of Supercritical Solutions (RESS): a promising method to improve bioavailability of poorly soluble pharmaceutical agents, The Journal of Supercritical Fluids, vol.22, issue.1, pp.75-84, 2002.
DOI : 10.1016/S0896-8446(01)00109-7

A. Ungell, Prediction of human drug absorption using in silico and in vitro techniques. bulletin technique gattefossé, pp.19-30, 2005.

J. Vaughn, X. Gao, M. Yacaman, K. Johnston, and R. Williams, Comparison of powder produced by evaporative precipitation into aqueous solution (EPAS) and spray freezing into liquid (SFL) technologies using novel Z-contrast STEM and complimentary techniques, European Journal of Pharmaceutics and Biopharmaceutics, vol.60, issue.1
DOI : 10.1016/j.ejpb.2005.01.002

S. Vinogradov, Colloidal Microgels in Drug Delivery Applications, Current Pharmaceutical Design, vol.12, issue.36, pp.4703-4712, 2006.
DOI : 10.2174/138161206779026254

URL : http://europepmc.org/articles/pmc1764637?pdf=render

S. Vinogradov, Polymeric nanogel formulations of nucleoside analogs, Expert Opinion on Drug Delivery, vol.45, issue.1, pp.5-17, 2007.
DOI : 10.1080/1061186021000038058

M. Wakerly, C. Pouton, B. Meakin, and F. Morton, Self-emulsification of vegetable oilnon-ionic surfactant mixtures, ACS Symp. Ser, pp.242-255, 1986.

S. Weiss, . De, and . De-châtenay-malabry, Complexes cyclodextrines/ester de vitamine a : stabilisation, solubilisation et promotion de l'absorption cutanée, 2002.

I. Williams, K. Johnston, T. Young, T. Rogers, M. Barron et al., Process for production of nanoparticles and microparticles by spray freezing in to liquid Predicting drug disposition via application of bcs: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system, US Patent Pharm Res, vol.6862890, issue.22, pp.11-23, 2005.

T. Young, K. Johnston, K. Mishima, and H. Tanaka, Encapsulation of lysozyme in a biodegradable polymer by precipitation with a vapor-over-liquid antisolvent, Journal of Pharmaceutical Sciences, vol.88, issue.6, pp.640-650, 1999.
DOI : 10.1021/js980237h

T. Young, S. Mawson, K. Johnston, I. Henriksen, G. Pace et al., Rapid Expansion from Supercritical to Aqueous Solution to Produce Submicron Suspensions of Water-Insoluble Drugs, Biotechnology Progress, vol.16, issue.3, pp.402-407, 2000.
DOI : 10.1021/bp000032q

H. Yuasa, M. Sekiya, S. Ozeki, and J. Watanabe, Evaluation of Milk Fat-Globule Membrane (MFGM) Emulsion for Oral Administration: Absorption of .ALPHA.-Linolenic Acid in Rats and the Effect of Emulsion Droplet Size., Biological & Pharmaceutical Bulletin, vol.17, issue.5, pp.756-758, 1994.
DOI : 10.1248/bpb.17.756