<?xml version="1.0" encoding="utf-8"?>
<TEI xmlns="http://www.tei-c.org/ns/1.0" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:hal="http://hal.archives-ouvertes.fr/" xmlns:gml="http://www.opengis.net/gml/3.3/" xmlns:gmlce="http://www.opengis.net/gml/3.3/ce" version="1.1" xsi:schemaLocation="http://www.tei-c.org/ns/1.0 http://api.archives-ouvertes.fr/documents/aofr-sword.xsd">
  <teiHeader>
    <fileDesc>
      <titleStmt>
        <title>HAL TEI export of hal-01738655</title>
      </titleStmt>
      <publicationStmt>
        <distributor>CCSD</distributor>
        <availability status="restricted">
          <licence target="https://creativecommons.org/publicdomain/zero/1.0/">CC0 1.0 - Universal</licence>
        </availability>
        <date when="2026-05-11T20:57:01+02:00"/>
      </publicationStmt>
      <sourceDesc>
        <p part="N">HAL API Platform</p>
      </sourceDesc>
    </fileDesc>
  </teiHeader>
  <text>
    <body>
      <listBibl>
        <biblFull>
          <titleStmt>
            <title xml:lang="en">Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial</title>
            <author role="aut">
              <persName>
                <forename type="first">Javaid</forename>
                <surname>Iqbal</surname>
              </persName>
              <idno type="halauthorid">1077634-0</idno>
              <affiliation ref="#struct-153591"/>
              <affiliation ref="#struct-344358"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Renaud</forename>
                <surname>Fay</surname>
              </persName>
              <email type="md5">1905d8152bc9dcb748bbfeadbdae4277</email>
              <email type="domain">chu-nancy.fr</email>
              <idno type="idhal" notation="numeric">942489</idno>
              <idno type="halauthorid" notation="string">676236-942489</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-9793-8884</idno>
              <idno type="IDREF">https://www.idref.fr/09228874X</idno>
              <affiliation ref="#struct-2621"/>
              <affiliation ref="#struct-44949"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">David</forename>
                <surname>Adlam</surname>
              </persName>
              <idno type="idhal" notation="numeric">786576</idno>
              <idno type="halauthorid" notation="string">1330667-786576</idno>
              <idno type="ORCID">https://orcid.org/0000-0002-0080-9884</idno>
              <affiliation ref="#struct-360553"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Iain</forename>
                <surname>Squire</surname>
              </persName>
              <idno type="halauthorid">1330668-0</idno>
              <affiliation ref="#struct-360553"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Yasir</forename>
                <surname>Parviz</surname>
              </persName>
              <idno type="halauthorid">1330669-0</idno>
              <affiliation ref="#struct-153591"/>
              <affiliation ref="#struct-344358"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Julian</forename>
                <surname>Gunn</surname>
              </persName>
              <idno type="halauthorid">1330670-0</idno>
              <affiliation ref="#struct-153591"/>
              <affiliation ref="#struct-344358"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Bertram</forename>
                <surname>Pitt</surname>
              </persName>
              <idno type="idhal" notation="numeric">775891</idno>
              <idno type="halauthorid" notation="string">972081-775891</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-5880-275X</idno>
              <idno type="IDREF">https://www.idref.fr/129368377</idno>
              <affiliation ref="#struct-24332"/>
            </author>
            <author role="aut">
              <persName>
                <forename type="first">Faiez</forename>
                <surname>Zannad</surname>
              </persName>
              <email type="md5">8380c3e701ca330fd9739ebecebe6640</email>
              <email type="domain">chru-nancy.fr</email>
              <idno type="idhal" notation="numeric">756877</idno>
              <idno type="halauthorid" notation="string">159775-756877</idno>
              <idno type="ORCID">https://orcid.org/0000-0001-7456-1570</idno>
              <idno type="IDREF">https://www.idref.fr/028816013</idno>
              <affiliation ref="#struct-254924"/>
              <affiliation ref="#struct-44949"/>
              <affiliation ref="#struct-223006"/>
            </author>
            <editor role="depositor">
              <persName>
                <forename>DCAC</forename>
                <surname>UL</surname>
              </persName>
              <email type="md5">712d3dd189d87ad87af6004c881ef063</email>
              <email type="domain">univ-lorraine.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>
            <edition n="v1" type="current">
              <date type="whenSubmitted">2018-03-20 16:38:39</date>
              <date type="whenModified">2025-11-24 15:10:08</date>
              <date type="whenReleased">2018-03-20 16:38:39</date>
              <date type="whenProduced">2014-06</date>
              <ref type="externalLink" target="https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ejhf.88"/>
            </edition>
            <respStmt>
              <resp>contributor</resp>
              <name key="572733">
                <persName>
                  <forename>DCAC</forename>
                  <surname>UL</surname>
                </persName>
                <email type="md5">712d3dd189d87ad87af6004c881ef063</email>
                <email type="domain">univ-lorraine.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>
            <distributor>CCSD</distributor>
            <idno type="halId">hal-01738655</idno>
            <idno type="halUri">https://hal.univ-lorraine.fr/hal-01738655</idno>
            <idno type="halBibtex">iqbal:hal-01738655</idno>
            <idno type="halRefHtml">&lt;i&gt;European Journal of Heart Failure&lt;/i&gt;, 2014, 16 (6), pp.685 - 691. &lt;a target="_blank" href="https://dx.doi.org/10.1002/ejhf.88"&gt;&amp;#x27E8;10.1002/ejhf.88&amp;#x27E9;&lt;/a&gt;</idno>
            <idno type="halRef">European Journal of Heart Failure, 2014, 16 (6), pp.685 - 691. &amp;#x27E8;10.1002/ejhf.88&amp;#x27E9;</idno>
            <availability status="restricted"/>
          </publicationStmt>
          <seriesStmt>
            <idno type="stamp" n="CARDIO" corresp="INSERM">Cardiovasculaire</idno>
            <idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno>
            <idno type="stamp" n="DCAC-UL">DCAC - Défaillance Cardiovasculaire Aiguë et Chronique</idno>
            <idno type="stamp" n="BMS-UL">Pôle scientifique Biologie, Médecine, Santé de l'Université de Lorraine</idno>
          </seriesStmt>
          <notesStmt>
            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>
            <biblStruct>
              <analytic>
                <title xml:lang="en">Effect of eplerenone in percutaneous coronary intervention-treated post-myocardial infarction patients with left ventricular systolic dysfunction: a subanalysis of the EPHESUS trial</title>
                <author role="aut">
                  <persName>
                    <forename type="first">Javaid</forename>
                    <surname>Iqbal</surname>
                  </persName>
                  <idno type="halauthorid">1077634-0</idno>
                  <affiliation ref="#struct-153591"/>
                  <affiliation ref="#struct-344358"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Renaud</forename>
                    <surname>Fay</surname>
                  </persName>
                  <email type="md5">1905d8152bc9dcb748bbfeadbdae4277</email>
                  <email type="domain">chu-nancy.fr</email>
                  <idno type="idhal" notation="numeric">942489</idno>
                  <idno type="halauthorid" notation="string">676236-942489</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-9793-8884</idno>
                  <idno type="IDREF">https://www.idref.fr/09228874X</idno>
                  <affiliation ref="#struct-2621"/>
                  <affiliation ref="#struct-44949"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">David</forename>
                    <surname>Adlam</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">786576</idno>
                  <idno type="halauthorid" notation="string">1330667-786576</idno>
                  <idno type="ORCID">https://orcid.org/0000-0002-0080-9884</idno>
                  <affiliation ref="#struct-360553"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Iain</forename>
                    <surname>Squire</surname>
                  </persName>
                  <idno type="halauthorid">1330668-0</idno>
                  <affiliation ref="#struct-360553"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Yasir</forename>
                    <surname>Parviz</surname>
                  </persName>
                  <idno type="halauthorid">1330669-0</idno>
                  <affiliation ref="#struct-153591"/>
                  <affiliation ref="#struct-344358"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Julian</forename>
                    <surname>Gunn</surname>
                  </persName>
                  <idno type="halauthorid">1330670-0</idno>
                  <affiliation ref="#struct-153591"/>
                  <affiliation ref="#struct-344358"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Bertram</forename>
                    <surname>Pitt</surname>
                  </persName>
                  <idno type="idhal" notation="numeric">775891</idno>
                  <idno type="halauthorid" notation="string">972081-775891</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-5880-275X</idno>
                  <idno type="IDREF">https://www.idref.fr/129368377</idno>
                  <affiliation ref="#struct-24332"/>
                </author>
                <author role="aut">
                  <persName>
                    <forename type="first">Faiez</forename>
                    <surname>Zannad</surname>
                  </persName>
                  <email type="md5">8380c3e701ca330fd9739ebecebe6640</email>
                  <email type="domain">chru-nancy.fr</email>
                  <idno type="idhal" notation="numeric">756877</idno>
                  <idno type="halauthorid" notation="string">159775-756877</idno>
                  <idno type="ORCID">https://orcid.org/0000-0001-7456-1570</idno>
                  <idno type="IDREF">https://www.idref.fr/028816013</idno>
                  <affiliation ref="#struct-254924"/>
                  <affiliation ref="#struct-44949"/>
                  <affiliation ref="#struct-223006"/>
                </author>
              </analytic>
              <monogr>
                <idno type="halJournalId" status="VALID">13042</idno>
                <idno type="issn">1388-9842</idno>
                <title level="j">European Journal of Heart Failure</title>
                <imprint>
                  <publisher>European Society of Cardiology (Wiley)</publisher>
                  <biblScope unit="volume">16</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">685 - 691</biblScope>
                  <date type="datePub">2014-06</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1002/ejhf.88</idno>
              <idno type="pubmed">24706498</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>
            <langUsage>
              <language ident="en">English</language>
            </langUsage>
            <textClass>
              <keywords scheme="author">
                <term xml:lang="en">Myocardial infarction</term>
                <term xml:lang="en">Heart failure</term>
                <term xml:lang="en">Eplerenone</term>
                <term xml:lang="en">Angioplasty</term>
              </keywords>
              <classCode scheme="mesh">Aged</classCode>
              <classCode scheme="mesh">Aged, 80 and over</classCode>
              <classCode scheme="mesh">Percutaneous Coronary Intervention</classCode>
              <classCode scheme="mesh">Spironolactone</classCode>
              <classCode scheme="mesh">Treatment Outcome</classCode>
              <classCode scheme="mesh">Ventricular Dysfunction, Left</classCode>
              <classCode scheme="mesh">Comorbidity</classCode>
              <classCode scheme="mesh">Double-Blind Method</classCode>
              <classCode scheme="mesh">Female</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Male</classCode>
              <classCode scheme="mesh">Middle Aged</classCode>
              <classCode scheme="mesh">Mineralocorticoid Receptor Antagonists</classCode>
              <classCode scheme="mesh">Myocardial Infarction</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.csc">Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halOldTypology" n="ART">Journal articles</classCode>
              <classCode scheme="halTreeTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">
              <p>AIMS:EPHESUS was a multicentre, double-blind clinical trial in which 6632 patients with acute myocardial infarction (AMI) complicated by LV systolic dysfunction (LVSD) were randomized to receive eplerenone (n = 3319) or placebo (n = 3313). A total of 1580 EPHESUS patients were treated with PCI, which is now the standard treatment for AMI. This EPHESUS substudy examined the effects of eplerenone upon cardiovascular outcomes in PCI-treated patients.METHODS AND RESULTS:EPHESUS patients were divided into PCI-treated and non-PCI-treated cohorts, and the effect of eplerenone upon mortality and other major adverse cardiovascular outcomes was assessed in each cohort. The PCI-treated patients (n = 1580) were younger, and had better renal function and fewer co-morbidities than non-PCI-treated patients (n = 5052). Cardiovascular mortality was significantly lower in PCI-treated patients as compared with non-PCI-treated patients (7% vs. 16%, P &lt; 0.0001). However, the incidence of non-fatal events was similar in PCI-treated and non-PCI-treated cohorts. There was no statistical difference between the PCI-treated and non-PCI-treated cohorts in the primary or secondary outcomes of the trial. Eplerenone administration, compared with placebo, in the PCI-treated cohort did not affect PCI-related clinical outcomes, including recurrence of angina, the occurrence of acute coronary syndromes, or the need for further revascularization.CONCLUSIONS:The beneficial effects of eplerenone in the EPHESUS trial exist for both PCI- and non-PCI-treated AMI patients with LVSD. Eplerenone has minimal, if any, effect upon reducing PCI-related adverse events in the PCI-treated cohort.</p>
            </abstract>
          </profileDesc>
        </biblFull>
      </listBibl>
    </body>
    <back>
      <listOrg type="structures">
        <org type="institution" xml:id="struct-153591" status="VALID">
          <idno type="ROR">https://ror.org/05krs5044</idno>
          <orgName>University of Sheffield [Sheffield]</orgName>
          <desc>
            <address>
              <addrLine>Western Bank Sheffield S10 2TN</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">http://www.sheffield.ac.uk/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-344358" status="INCOMING">
          <orgName>Sheffield Teaching Hospitals</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
        </org>
        <org type="laboratory" xml:id="struct-2621" status="VALID">
          <orgName>Centre d'investigation clinique plurithématique Pierre Drouin [Nancy]</orgName>
          <orgName type="acronym">CIC-P</orgName>
          <date type="start">1995-01-01</date>
          <desc>
            <address>
              <addrLine>Hôpital Brabois – Bâtiment Louis Mathieu, 54500 Vandoeuvre-Les-Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://cic-p-nancy.fr/</ref>
          </desc>
          <listRelation>
            <relation active="#struct-254924" type="direct"/>
            <relation active="#struct-300157" type="indirect"/>
            <relation name="CIC1433" active="#struct-303623" type="indirect"/>
            <relation active="#struct-413289" type="indirect"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-44949" status="VALID">
          <orgName>Service de Cardiologie [CHRU Nancy]</orgName>
          <desc>
            <address>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-360553" status="VALID">
          <orgName>Glenfield Hospital [Leicester, United Kingdom]</orgName>
          <desc>
            <address>
              <addrLine>Groby Road, Leicester, LE3 9QP</addrLine>
              <country key="GB"/>
            </address>
            <ref type="url">https://www.uhleicester.nhs.uk/hospitals/glenfield-hospital/</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-24332" status="VALID">
          <idno type="IdRef">02643198X</idno>
          <idno type="ROR">https://ror.org/00jmfr291</idno>
          <idno type="Wikidata">Q230492</idno>
          <orgName>Université du Michigan = University of Michigan [Ann Arbor]</orgName>
          <orgName type="acronym">UMich</orgName>
          <desc>
            <address>
              <addrLine>500 Church Street Ann Arbor, MI 48109-1090</addrLine>
              <country key="US"/>
            </address>
            <ref type="url">http://www.umich.edu/</ref>
          </desc>
        </org>
        <org type="regrouplaboratory" xml:id="struct-254924" status="VALID">
          <orgName>Centre d'investigation clinique [Nancy]</orgName>
          <orgName type="acronym">CIC</orgName>
          <desc>
            <address>
              <addrLine>4 rue du Morvan - Bâtiment Louis Mathieu - 54500 Vandoeuvre-les-Nancy Cedex</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
            <relation name="CIC1433" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="laboratory" xml:id="struct-223006" status="VALID">
          <idno type="IdRef">181007126</idno>
          <idno type="RNSR">200919207T</idno>
          <idno type="IdUnivLorraine">[UL]RNL--</idno>
          <idno type="ROR">https://ror.org/05ft9wv42</idno>
          <orgName>Défaillance Cardiovasculaire Aiguë et Chronique</orgName>
          <orgName type="acronym">DCAC</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>Faculté de Médecine - 9 avenue de la Forêt de Haye - BP 184 - 54500 Vandoeuvre les Nancy</addrLine>
              <country key="FR"/>
            </address>
          </desc>
          <listRelation>
            <relation active="#struct-300157" type="direct"/>
            <relation name="U1116" active="#struct-303623" type="direct"/>
            <relation active="#struct-413289" type="direct"/>
          </listRelation>
        </org>
        <org type="institution" xml:id="struct-300157" status="VALID">
          <orgName>Centre Hospitalier Régional Universitaire de Nancy</orgName>
          <orgName type="acronym">CHRU Nancy</orgName>
          <desc>
            <address>
              <addrLine>Siège social : 29 avenue du Maréchal de Lattre de Tassigny, CO 60034, 54035 NANCY CEDEXHôpital Central : 29 Avenue du Maréchal de Lattre de Tassigny, 54035 NancyHôpitaux de Brabois / Enfants : Rue du Morvan, 54500 Vandœuvre-lès-NancyMaternité régionale :10 Avenue Dr Heydenreich, 54000 Nancy</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.chu-nancy.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-303623" status="VALID">
          <idno type="IdRef">026388278</idno>
          <idno type="ROR">https://ror.org/02vjkv261</idno>
          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>
            <address>
              <addrLine>101, rue de Tolbiac, 75013 Paris</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
        <org type="institution" xml:id="struct-413289" status="VALID">
          <idno type="IdRef">157040569</idno>
          <idno type="IdUnivLorraine">[UL]100--</idno>
          <idno type="ROR">https://ror.org/04vfs2w97</idno>
          <orgName>Université de Lorraine</orgName>
          <orgName type="acronym">UL</orgName>
          <date type="start">2012-01-01</date>
          <desc>
            <address>
              <addrLine>34 cours Léopold - CS 25233 - 54052 Nancy cedex</addrLine>
              <country key="FR"/>
            </address>
            <ref type="url">http://www.univ-lorraine.fr/</ref>
          </desc>
        </org>
      </listOrg>
    </back>
  </text>
</TEI>