P. Mildred and T. Stahlman, Centre Universitaire de Formation et de Perfectionnement des, Canada) Professeur Marc LEVENSTON (2005) Institute of Technology, 1982.

D. Stefano, N. Matthews, P. Antel, J. Preul, M. Francis et al., Chemical pathology of acute demyelinating lesions and its correlation with disability, Annals of Neurology, vol.116, issue.6, pp.901-910, 1995.
DOI : 10.1212/WNL.44.11.2120

A. Compston and A. Coles, Multiple sclerosis, The Lancet, vol.372, issue.9648, pp.1502-1519, 2008.
DOI : 10.1016/S0140-6736(08)61620-7

URL : https://hal.archives-ouvertes.fr/hal-00996686

J. Kragt, I. Nielsen, F. Van-der-linden, B. Uitdehaag, and C. Polman, How similar are commonly combined criteria for EDSS progression in multiple sclerosis?, Multiple Sclerosis Journal, vol.12, issue.6, pp.782-788, 2006.
DOI : 10.1212/WNL.46.4.907

D. Stefano, N. Ianucci, G. Sormani, and M. , MR correlates of cerebral atrophy in patients with multiple sclerosis, Journal of Neurology, vol.249, issue.8, pp.1072-1077, 2002.
DOI : 10.1007/s00415-002-0790-5

D. Goodin, Magnetic resonance imaging as a surrogate outcome measure of disability in multiple sclerosis: Have we been overly harsh in our assessment?, Annals of Neurology, vol.62, issue.4, pp.597-605, 2006.
DOI : 10.1093/jnen/62.7.723

V. Parisi, G. Manni, and M. Spadaro, Correlation between morphological and functional retinal impairment in multiple sclerosis patients, Invest Ophthalmol Vis Sci, vol.40, pp.2520-2527, 1999.

P. Albrecht, R. Frohlich, H. Hartung, B. Kieseier, and A. Methner, Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis, Journal of Neurology, vol.58, issue.11, pp.1595-1601, 2007.
DOI : 10.1212/WNL.33.11.1444

C. Lamirel, N. Newman, and V. Biousse, Optical coherence tomography (OCT) in optic neuritis and multiple sclerosis, Revue Neurologique, vol.166, issue.12, pp.978-86
DOI : 10.1016/j.neurol.2010.03.024

M. Debouverie, S. Pittion-vouyovitch, S. Louis, T. Roederer, and F. Guillemin, Increasing incidence of multiple sclerosis among women in Lorraine, Eastern France, Multiple Sclerosis Journal, vol.11, issue.1, pp.962-969, 2007.
DOI : 10.1111/j.1600-0404.2004.00244.x

M. Debouverie, L. Laforest, E. Van-ganse, F. Guillemin, . For et al., Earlier disability of the patients followed in Multiple Sclerosis centers compared to outpatients, Multiple Sclerosis Journal, vol.65, issue.2, pp.251-257, 2009.
DOI : 10.1093/ndt/gfh104

M. Debouverie, S. Pittion-vouyovitch, S. Louis, F. Guillemin, and . Group, Natural history of multiple sclerosis in a population-based cohort, European Journal of Neurology, vol.361, issue.Suppl 2, pp.916-937, 2008.
DOI : 10.1212/WNL.46.4.907

C. Confavreux, D. Compston, O. Hommes, W. Mcdonald, and A. Thompson, EDMUS, a European database for multiple sclerosis., Journal of Neurology, Neurosurgery & Psychiatry, vol.55, issue.8, pp.671-676, 1992.
DOI : 10.1136/jnnp.55.8.671

J. Kurtzke, Rating neurologic impairment in multiple sclerosis: An expanded disability status scale (EDSS), Neurology, vol.33, issue.11, pp.1444-1452, 1983.
DOI : 10.1212/WNL.33.11.1444

C. Poser, D. Paty, L. Scheinberg, W. Mcdonald, F. Davis et al., New diagnostic criteria for multiple sclerosis: Guidelines for research protocols, Annals of Neurology, vol.122, issue.3, pp.227-231, 1983.
DOI : 10.1212/WNL.29.9_Part_2.3

W. Mcdonald, A. Compston, G. Edan, D. Goodkin, H. Hartung et al., Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis, Annals of Neurology, vol.70, issue.1, pp.121-127, 2001.
DOI : 10.1136/jnnp.70.3.390

C. Polman, S. Reingold, G. Edan, M. Filippi, H. Hartung et al., Diagnostic criteria for multiple sclerosis: 2005 revisions to the ???McDonald Criteria???, Annals of Neurology, vol.6, issue.6, pp.840-846, 2005.
DOI : 10.1212/WNL.53.6.1184

F. Lublin and S. Reingold, Defining the clinical course of multiple sclerosis: Results of an international survey, Neurology, vol.46, issue.4, pp.907-911, 1996.
DOI : 10.1212/WNL.46.4.907

J. Sepulcre, M. Murie-fernandez, A. Salinas-alaman, A. Garcia-layana, B. Bejarano et al., Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS, Neurology, vol.68, issue.18, pp.1488-94, 2007.
DOI : 10.1212/01.wnl.0000260612.51849.ed

L. Critères-de-barkhof, Au moins 3 des 4 critères sont requis pour retenir le diagnostic de SEP : ? 1 lésion T1 rehaussée par le gadolinium ou 9 lésions hyper intenses T2, 1997.

. Mcdonald, Les progrès de l'IRM ont permis leur révision par, 2001.