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Master thesis

CRP, haptoglobine, orosomucoïde: variations biologiques et valeurs de références, relation entre CRP et risque cardiovasculaire

Abstract : Serum CRP concentration was determined with an improved sensitibilityimmunonephelometric assay in 3605 subjects. Subjects were aged from 4 to 75 years and belonging to 1003 nuclear families recruited from the STANISLAS cohort Study between january 1994 and august 1995. In the overall sample, values for CRP ranged from 0.17 mg/L to 100 mg/L, geometrie means (mean - sd; mean + sd) were in men 0.37(0.17-1.07) mg/L for 5-14 age class, 0.47(0.17-1.38) mg/L for 15-28 age class, 0.98(0.34-2.85) mg/L for 29-75 age class and respectively in women 0.38(0.17-1.10) mglL, 0.62(0.20-1.90) and 0.98(0.31-3.13).The interindividual variability varied from 138% to 759% among different age classes. We studied biological factors affecting CRP concentration and calculated that they explain up to 25% of the CRP variability in men and 40% in women. The main biological factors affecting CRP concentration were the following in men: drugs, leukocytes, BMI, tobacco consumption, age and in women : drugs, leukocytes, age, BMI and hemoglobin. These factors served us todefine exclusion and partition criteria for obtaining the reference samples. Medians of reference values ranged from 0.21 to 0.68 mg/L between 4 to 75 years old in men and from 0.20 to 0.78 mg/L in women.
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Master thesis
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https://hal.univ-lorraine.fr/hal-01738859
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Submitted on : Tuesday, March 20, 2018 - 5:30:49 PM
Last modification on : Friday, October 23, 2020 - 5:01:31 PM
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  • HAL Id : hal-01738859, version 1

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Olivier Chenillot. CRP, haptoglobine, orosomucoïde: variations biologiques et valeurs de références, relation entre CRP et risque cardiovasculaire. Sciences pharmaceutiques. 2000. ⟨hal-01738859⟩

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