. Un-monitorage-hémodynamique, Ont été posés un cathéter de Swan & Ganz chez 53% des patients de la cohorte (n=35), un cathéter de mesure de la saturation veineuse centrale continue chez En effet, les patients ont-ils été jugés trop graves ou pas assez pour bénéficier d'un traitement par la drotrécogine alfa activée (XIGRIS ® ) ? Ont-ils été en limitation de soins ? Ont-ils tous présenté des contre-indications à la drotrécogine alfa activée (XIGRIS ® ) ? Le délai de prise en charge recommandé était-il dépassé ? Ou même existe-t-il une non adhésion de certains médecins à cette thérapeutique ?

. Dans-notre-Étude, incidence des complications hémorragiques dites graves, telles qu'elles ont été définies dans l'essai PROWESS, est de 3%. Ce taux, qui reste relativement faible, est comparable à ceux observés dans l'étude PROWESS et les autres essais internationaux, 2001.

. Cependant, absence de nouvelles données issues d'essais larges internationaux susceptibles de démontrer le bénéfice réel de cette thérapeutique et en l'absence de thérapeutique alternative le pragmatisme doit inciter à l

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