Ont été posés un cathéter de Swan & Ganz chez 53% des patients de la cohorte (n=35), un cathéter de mesure de la saturation veineuse centrale continue chez En effet, les patients ont-ils été jugés trop graves ou pas assez pour bénéficier d'un traitement par la drotrécogine alfa activée (XIGRIS ® ) ? Ont-ils été en limitation de soins ? Ont-ils tous présenté des contre-indications à la drotrécogine alfa activée (XIGRIS ® ) ? Le délai de prise en charge recommandé était-il dépassé ? Ou même existe-t-il une non adhésion de certains médecins à cette thérapeutique ? ,
incidence des complications hémorragiques dites graves, telles qu'elles ont été définies dans l'essai PROWESS, est de 3%. Ce taux, qui reste relativement faible, est comparable à ceux observés dans l'étude PROWESS et les autres essais internationaux, 2001. ,
absence de nouvelles données issues d'essais larges internationaux susceptibles de démontrer le bénéfice réel de cette thérapeutique et en l'absence de thérapeutique alternative le pragmatisme doit inciter à l ,
Ordonnance pour la prescription des spécialités médicamenteuses onéreuses de la Tarification à l'Activité (T2A), Annexe, vol.2, p.107 ,
Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock ,
Detecting genetic predisposition for complicated clinical outcomes after burn injury, Burns, vol.32, pp.821-828, 2006. ,
Differential effects of vasopressin and norepinephrine on vascular reactivity in a long-term rodent model of sepsis ,
Safety and dose relationship of recombinant human activated protein C for coagulopathy in severe sepsis ,
Efficacy and safety of recombinant human activated protein C for severe sepsis ,
Influence of drotrecogin alpha (activated) infusion on the variation of Bax/Bcl-2 and Bax/Bclxl ratios in circulating mononuclear cells: a cohort study in septic shock patients ,
Antimicrobial therapy for patients with severe sepsis and septic shock: an evidence-based review ,
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis, The ACCP/SCCM Consensus Conference Committee, pp.1644-55, 1992. ,
Nitric oxide production within cardiac myocytes reduces their contractility in endotoxemia ,
Role of KATP channels in sepsis, Cardiovasc Res, vol.72, pp.220-250, 2006. ,
Effect of hydroxyethylstarch in brain-dead kidney donors on renal function in kidneytransplant recipients, Lancet, vol.348, pp.1620-1622, 1996. ,
Epinephrine plasma metabolic clearance rates and physiologic thresholds for metabolic and hemodynamic actions in man ,
Induction of the ATP-sensitive potassium (uK(ATP)-1) channel by endotoxemia, Muscle Nerve, vol.23, pp.967-976, 2000. ,
Effect of hydroxyethyl starch solution on kidney function in surgical intensive care patients ,
Relationship between infusion rates, plasma concentrations, and cardiovascular and metabolic effects during the infusion of norepinephrine in healthy volunteers ,
Regulation and functions of the protein C anticoagulant pathway, Haematologica, vol.84, pp.363-371, 1999. ,
Dysfunction of endothelial protein C activation in severe meningococcal sepsis ,
Urocortin and adrenomedullin prevent lethal endotoxemia by down-regulating the inflammatory response ,
Hypoglycemic response of blood to live Escherichia coli organisms and endotoxin ,
Activated protein C prevents endotoxin-induced hypotension in rats by inhibiting excessive production of nitric oxide, Circulation, vol.104, pp.1171-1176, 2001. ,
Evaluating the use of Drotrecogin alfa (activated) in adult severe sepsis: a Canadian multicenter observational study, Intensive Care Med, vol.33, pp.517-540, 2007. ,
Vasopressin deficiency contributes to the vasodilation of septic shock, Circulation, vol.95, pp.1122-1127, 1997. ,
SIMPLIFIED ACUTE PHYSIOLOGICAL SCORE FOR INTENSIVE CARE PATIENTS, The Lancet, vol.322, issue.8352, p.741, 1983. ,
DOI : 10.1016/S0140-6736(83)92278-X
Which therapeutic prospects in the septic syndrome? ,
Beneficial effects of L-canavanine, a selective inhibitor of inducible nitric oxide synthase, on lactate metabolism and muscle high energy phosphates during endotoxic shock in rats, Shock, vol.11, pp.98-103, 1999. ,
Inactivation of catecholamines by superoxide gives new insights on the pathogenesis of septic shock ,
Effects of dexamethasone and L-canavanine on the intracellular calcium-contraction relation of the rat tail artery during septic shock ,
Activated protein C treatment: experience about 23 patients in the operative period ,
Activation of cardiac endothelium as a compensatory component in endotoxin-induced cardiomyopathy: role of endothelin, prostaglandins, and nitric oxide, Circulation, vol.104, pp.3137-3181, 2001. ,
Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial ,
Rapid and beneficial hemodynamic effects of activated protein C in septic shock patients, Intensive Care Med, vol.31, pp.1573-1579, 2005. ,
Circulating endothelial cells in patients with septic shock ,
The sirens' songs of confirmatory sepsis trials: selection bias and sampling error ,
Nitric oxide and peroxynitrite in health and disease, Physiol Rev, vol.87, pp.315-424, 2007. ,
Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis ,
Paracrine coronary endothelial control of left ventricular function in humans, Circulation, vol.92, pp.2119-2145, 1995. ,
International integrated database for the evaluation of severe sepsis and drotrecogin alfa (activated) therapy: analysis of efficacy and safety data in a large surgical cohort, Surgery, vol.141, pp.548-61, 2007. ,
Desensitization of rat cardiomyocyte adenylyl cyclase stimulation by plasma of noradrenaline-treated patients with septic shock, Circ Shock, vol.41, pp.48-59, 1993. ,
Early goal-directed therapy in the treatment of severe sepsis and septic shock ,
Depletion of neurohypophyseal content of vasopressin in septic shock ,
Disseminated intravascular coagulation: pathophysiology, diagnosis, and treatment, New Horiz, vol.1, pp.312-335, 1993. ,
Gut and muscle tissue PO2 in endotoxemic dogs during shock and resuscitation ,
Novel functions of thrombomodulin in inflammation ,
Bench-to-bedside review: understanding genetic predisposition to sepsis ,
Effects of nitric oxide in septic shock ,
Efficacy of hypertonic 7.5% saline and 6% dextran-70 in treating trauma: a meta-analysis of controlled clinical studies, Surgery, vol.122, pp.609-625, 1997. ,
Effects of nitric oxide synthase inhibition on regional hemodynamics and oxygen transport in endotoxic dogs, Shock, vol.4, pp.415-435, 1995. ,
Caring for the critically ill patient. High-dose antithrombin III in severe sepsis: a randomized controlled trial ,
double-blind, placebo-controlled crossover pilot study of a potassium channel blocker in patients with septic shock ,
Low levels of protein C are associated with poor outcome in severe sepsis, Chest, vol.120, pp.915-937, 2001. ,
Disseminated intravascular coagulation in sepsis, Chest, vol.128, pp.2864-75, 2005. ,