Chimie physique générale, Biologie cellulaire oncologique Jean-Bernard REGNOUF de VAINS ........Chimie thérapeutique Bertrand RIHN ..................................Biochimie, Biologie ,
Chimie thérapeutique François BONNEAUXChimie thérapeutique ,
Toxicologie, Microbiologie clinique Béatrice FAIVRE ................................Hématologie Adel FAIZ..........................................Biophysique ,
Biophysique, Informatique Christine PERDICAKIS ........................Chimie ,
Pharmacie galénique PROFESSEUR ASSOCIE, Biochimie et Biologie moléculaire Colette ZINUTTI ,
Anglais ASSISTANT ,
45 3.1. Chromatographie Liquide Haute Performance (HPLC) phase inverse : (Dosage de la teneur en Para-aminophénol), p.48 ,
71 1. arome orange+benzoate de sodium 2. arome orange + saccharine 3. arome orange + saccharose 4. arome orange + paracétamol 5. benzoate de sodium + saccharine 6. benzoate de sodium + saccharose 7. benzoate de sodium + paracétamol 8. saccharine + saccharose 9. saccharine + paracétamol 10. saccharose + paracétamol b. Tests ternaires : 1. arome orange-benzoate de sodium-saccharine 2. arome orange-benzoate de sodium-saccharose 3. arome orange-benzoate de sodium ?paracétamol 4. arome orange-saccharine-saccharose 5. arome orange-saccharine-paracétamol 6. arome orange-saccharose ?paracétamol 7. benzoate de sodium ?saccharine-saccharose 8. benzoate de sodium ?saccharine-paracétamol 9 ,
Suivi de lancement d'un nouvel antalgique de palier 2 : association fixe de Paracétamol-Tramadol. Th : Docteur en pharmacie, Faculté de medecine et de pharmacie Besançon, pp.25-30, 2005. ,
Analytical Profiles of Drug Substances, pp.1-109, 1974. ,
Stability of Aqueous Solutions of N-Acetyl-p-aminophenol, Journal of Pharmaceutical Sciences, vol.50, issue.2, pp.113-118, 1961. ,
DOI : 10.1002/jps.2600500204
Stabilisation by éthylènediamine tétraacetic acid of amid and other groups in drug compound, J. Clin. Pharm. Ther, pp.17-107, 1992. ,
Synthesis, decomposition kinetics, and preliminary toxicological studies of pure N-acetyl-p-benzoquinone imine, a proposed toxic metabolite of acetaminophen, J. Med. Chem, pp.25-885, 1982. ,
The dependence of paracetamol absorption on the rate of gastring emptying, Br. J. Pharmacol, pp.47-415, 1973. ,
The gastrointestinal absorption of paracetamol in the rat, J. Pharm. Pharmacol, pp.31-157, 1979. ,
ENZYME BASED PARACETAMOL ESTIMATION, The Lancet, vol.317, issue.8216, pp.391-392, 1981. ,
DOI : 10.1016/S0140-6736(81)91717-7
PARACETAMOL MEASUREMENT, The Lancet, vol.305, issue.7916, pp.1147-1148, 1975. ,
DOI : 10.1016/S0140-6736(75)92542-8
Estimation of Hepatic First-Pass Effect of Acetaminophen in Humans after Oral Administration, Journal of Pharmaceutical Sciences, vol.64, issue.10, pp.1734-1735, 1975. ,
DOI : 10.1002/jps.2600641044
Inhibition of gastric emptying and drug absorption by narcotic analgesics., British Journal of Clinical Pharmacology, vol.4, issue.6 ,
DOI : 10.1136/bmj.4.5939.265
Paracetamol et phénacétine: pharmacologie Clinique ,
Some factors affecting the absorption of paracetamol, J. Pharm. Pharmacol, pp.615-619, 1972. ,
THE INFLUENCE OF POSTURE ON PARACETAMOL ABSORPTION, British Journal of Clinical Pharmacology, vol.50, issue.4, pp.348-354, 1978. ,
DOI : 10.1136/adc.50.7.500
Effect of food on acetaminophen absorption in young and elderly subjects, J. Clin. Pharmacol, pp.22-571, 1982. ,
LACK OF INHIBITION OF PARACETAMOL ABSORPTION BY CODEINE, British Journal of Clinical Pharmacology, vol.23, issue.4, pp.346-347, 1978. ,
DOI : 10.1111/j.2042-7158.1971.tb08613.x
Bases pharmacologiques de l'emploi du paracetamol : aspects pharmacocinétiques et pharmacodynamiques ,
Paharmacokinetics of acetaminophen after intravenous and oral administration, Eur. J. Clin. Pharmacol, issue.11, pp.283-286, 1977. ,
Correlation entre les taux salivaires et les taux plasmatiques de paracetamol ; interet pour les études de biodisponibilité, S.T.P. Pharm, vol.1, issue.2, pp.114-120, 1985. ,
The binding of paracetamol to plasma proteins of man and pig, Journal of Pharmacy and Pharmacology, vol.2, issue.12, pp.25-964, 1973. ,
DOI : 10.1016/S0140-6736(73)90470-4
Kinetics and matabolismm of paracetamol and phenacetin ,
New insights into the mechanism of action of acetaminophen: Its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases, Clinical Pharmacology & Therapeutics, vol.79, issue.1 ,
DOI : 10.1016/j.clpt.2005.09.009
Acetaminophen elimination kinetics in neonates, children, and adults, Clinical Pharmacology & Therapeutics, vol.19, issue.3, pp.284-294, 1976. ,
DOI : 10.1002/cpt1976193284
Mechanism of Action of Paracetamol, American Journal of Therapeutics, vol.12, issue.1 ,
DOI : 10.1097/00045391-200501000-00008
Toxicité et effets indésirables des antiinflamatoires non stéroidiens Etude des cas rapportés au CNITV, Rec. Med. Vét. Spéciale antiinflamatoires, issue.57, pp.168-615, 1992. ,
Les intoxications medicamenteuses aigues chez les carnivores domestiques : presentation des données épidemiologiques du CNITV d'Alfort et analyse des intoxications les plus frequentes, Th : Vet : ENVA, 1996. ,
Role of Lipid Peroxidation as a Mechanism of Liver Injury after Acetaminophen Overdose in Mice, Toxicological Sciences, vol.76, issue.1, pp.229-236, 2003. ,
DOI : 10.1093/toxsci/kfg220
Paracetamol in the Treatment of Osteoarthritis Pain, Drugs, vol.39, issue.Special Issue 2, pp.23-41, 2003. ,
DOI : 10.2165/00003495-200363992-00005
Oral or intravenous N-acetylcysteine : which is the treatment of choice for acetaminophen (paracetamol) poisoning, J. Toxicol. Clin. Toxicol, issue.6, pp.37-759, 1999. ,
Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen, Drug Metab. Dispos, issue.12, pp.28-1397, 2000. ,
The effect of dose on the pharmacokinetics and absolute biovailability of oral paracetamol, J ,
Plasma concentrations after high-dose (45 mg.kg-1) rectal acetaminophen in children, Can. J. Anaesth, issue.11, pp.42-982, 1995. ,
Nouvelles perspectives avec le paracétamol, Drugs, vol.63, issue.2, pp.51-56, 2003. ,
Renal Clearance and Serum Protein Binding of Acetaminophen and Its Major Conjugates in Humans, Journal of Pharmaceutical Sciences, vol.73, issue.8, pp.73-1038, 1984. ,
DOI : 10.1002/jps.2600730806
Paracetamol: a curriculum resource, 2002. ,
A KINETIC STUDY OF DRUG ELIMINATION: THE EXCRETION OF PARACETAMOL AND ITS METABOLITES IN MANMETABOLITES IN MAN, British Journal of Pharmacology and Chemotherapy, vol.44, issue.2 ,
DOI : 10.1042/bj0440239
Mechanism of the Antinociceptive Effect of Paracetamol*, Drugs, vol.92, issue.Special Issue 2, pp.1-4, 2003. ,
DOI : 10.2165/00003495-200363992-00002
The fate of acetanilide in man, J. Pharmacol ,
The effect on the pain threshold of N -acetyl p aminophenol , a product derived in the body from acetanilide, J ,
Inhibition of Prostaglandin Synthetase in Brain explains the Anti-pyretic Activity of Paracetamol (4-Acetamidophenol), Nature, vol.7, issue.5381 ,
DOI : 10.1111/j.1476-5381.1957.tb00146.x
Analgesic-antipyretic and Antiinflammatory Agents and Drugs Employed in the Treatment of Gout ,
COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression, Proceedings of the National Academy of Sciences, vol.96, issue.6, pp.99-13926, 2002. ,
DOI : 10.1073/pnas.96.6.3275
Acetaminophen and the Cyclooxygenase-3 Puzzle: Sorting out Facts, Fictions, and Uncertainties, Journal of Pharmacology and Experimental Therapeutics, vol.315, issue.1 ,
DOI : 10.1124/jpet.105.085431
Handbook of Photography . Whittlesey House, p.324, 1939. ,
Y a-t-il un rationnel à combiner le paracétamol et un AINS ,
Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic, The FASEB Journal, vol.18, issue.7, pp.780-804, 2004. ,
DOI : 10.1073/pnas.96.13.7563
Évaluation et traitement de la douleur, pp.639-648, 2006. ,
Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase., Proceedings of the National Academy of Sciences, vol.90, issue.24, pp.90-11693, 1993. ,
DOI : 10.1073/pnas.90.24.11693
The Role of 5-HT1A/B Autoreceptors in the Antinociceptive Effect of Systemic Administration of Acetaminophen, Anesthesiology, vol.98, issue.3, pp.98-741, 2003. ,
DOI : 10.1097/00000542-200303000-00025
Orally Administered Paracetamol Does Not Act Locally in the Rat Formalin Test, Anesthesiology, vol.99, issue.4, pp.99-976, 2003. ,
DOI : 10.1097/00000542-200310000-00034
Antinociceptive effect of paracetamol in rats is partly dependent of spinal serotoninergic systems, Eur. J. Pharmacol, pp.193-201, 0193. ,
Mechanism of Action of Paracetamol, American Journal of Therapeutics, vol.12, issue.1 ,
DOI : 10.1097/00045391-200501000-00008
Acetaminophen as a Cosubstrate and Inhibitor of Prostaglandin H Synthase ,
DOI : 10.1007/978-1-4684-5134-4_68
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes, J. Biol. Biol. Chem, vol.254, issue.3, pp.829-836, 1979. ,
Manufacture and uses of the anilines: A vast array of processes and products. Zvi Rappoport. The chemistry of Anilines Wiley, p.764, 2007. ,
Nouvelles perspectives avec le paracétamol, Drugs, vol.63, issue.2, pp.51-56, 2003. ,
Acetaminophen and low-flow myocardial ischemia: efficacy and antioxidant mechanisms, American Journal of Physiology-Heart and Circulatory Physiology, vol.254, issue.4, pp.1341-1349, 2002. ,
DOI : 10.1016/S0008-6363(96)00254-4
URL : http://ajpheart.physiology.org/content/ajpheart/282/4/H1341.full.pdf
Paracetamol, American Journal of Therapeutics, vol.7, issue.2, pp.143-147, 2000. ,
DOI : 10.1097/00045391-200007020-00011
URL : http://onlinelibrary.wiley.com/doi/10.1046/j.1365-2125.2000.00167.x/pdf
Acetylsalicylic acid vs paracetamol: Effects on post-operative course, European Journal of Clinical Pharmacology, vol.I, issue.4, pp.12-257, 1977. ,
DOI : 10.1007/BF00607424
Fièvre de l'enfant et du nourrisson ,
Le paracétamol : produit analgésique, antipyrétique sans action anti-inflammatoire. La revue du praticien-Médecine générale, pp.54-63, 1989. ,
Paracetamol, alcohol and the liver, British Journal of Clinical Pharmacology, vol.62, issue.Suppl. 5A, pp.291-301, 2000. ,
DOI : 10.1016/S0009-9236(97)90148-X
Does Therapeutic Use of Acetaminophen Cause Acute Liver Failure?, Pharmacotherapy, vol.19, issue.9, pp.1219-1230, 2007. ,
DOI : 10.1016/0002-9343(83)90444-8
Paracetamol as a risk factor for allergic disorders. The Lancet, pp.119-121, 2009. ,
Severe hepatotoxicity after therapeutic doses of acetaminophen, Clinical Therapeutics, vol.28, issue.5, pp.28-755, 2006. ,
DOI : 10.1016/j.clinthera.2006.05.002
Guidelines for the management of paracetamol poisoning in Australia and New Zealand-explanation and elaboration. A consensus statement from clinical toxicologists consulting to the Australasian poisons information centres, Med. J. Aust, pp.188-296, 2008. ,
Comparative analgesia, cardiovascular and renal effects of celecoxib. Rofecoxib and acetaminophen (paracetamol), Curr. Pharm. Des, issue.8, pp.1063-1075, 2002. ,
Induction of liver cell tumors in 1 F mice by paracetamol, Carcinogenesis, issue.4, pp.363-368, 1983. ,
Induction by paracetamol of bladder and liver tumors in the rat, Acta. Pathol. Microbio. Immunol. Scand. Section A, pp.93-376, 1985. ,
Studie for tumor initiating effect of acetaminophen in two stage liver carcinogenesis of male F 344 rats ,
Initial sceening for carcinogenicity of commonly used drugs, J. natl. cancer instit, pp.65-723, 1980. ,
Doliprane : tératogénése, fonctions de reproduction mutagénése. Nanterre : Division synthemedica, 1982. ,
Le paracetamol : actualisation des données en 1989, Therapie, vol.44, pp.337-354, 1989. ,
Acute acetaminophen overdose during pregnancy : review of fifty nine cases. annual scientific meeting, 1984. ,
Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Correlation of nuclear Ca2+ accumulation and early DNA fragmentation with cell death, Toxicology and Applied Pharmacology, vol.111, issue.2, pp.242-254, 1992. ,
DOI : 10.1016/0041-008X(91)90028-D
Pharmacological studies on the in vitro cataractogenocity of acetaminophen in mice and rabbits ,
Prupura vasculaire au paracetamol : une observation, La presse médicale, pp.1587-1592, 1988. ,
Toxicité et effets indésirables du paracetamol à doses thérapeutiques et sub-thérapeutiques, Th : Doctorat en pharmacie, U.E.R. des sciences médicales et pharmaceutiques, pp.163-173, 1992. ,
Décrets, arrêtés, circulaires, textes généraux, ministère des solidarités, de la santé et de la famille, Arrêté du 7 mars 2005 portant application de l'article R. 5121-41-2 du code de la santé publique et relatif aux modifications des autorisations de mises sur le marché, 2005. ,