.. Caractérisation-de-la-masse-moléculaire, 86 3.1. Détermination de la distribution de taille moléculaire de l'AH par chromatographie d'exclusion de taille (SEC) 86 3.2. Caractérisation de la distribution de taille moléculaire de l'AH par technique électrophorétique, ., vol.873, issue.3, p.88

.. Autres-applications-en-ingénierie-tissulaire, 100 3.3.1. Délivrance de cellules : exemple du transfert de kératinocytes pour la cicatrisation de plaies, p.101

H. A. Akdamar, N. Y. Sar?özlü, A. A. Özcan, A. Ersöz, A. Denizli et al., Separation and purification of hyaluronic acid by glucuronic acid imprinted microbeads, Materials Science and Engineering: C, vol.29, issue.4, pp.1404-1408, 2009.
DOI : 10.1016/j.msec.2008.10.038

D. C. Armstrong and M. R. Johns, Culture conditions affect the molecular weight properties of hyaluronic acid produced by Streptococcus zooepidemicus, Applied and Environmental Microbiology, pp.2759-2764, 1997.

A. Asari and S. Miyauchi, Medical Application of Hyaluronan, 2000.
DOI : 10.1016/B978-008044382-9/50052-2

B. Ascher, M. Cerceau, M. Baspeyras, and B. Rossi, Les comblements par l???acide hyaluronique, Annales de Chirurgie Plastique Esth??tique, vol.49, issue.5, pp.465-485, 2004.
DOI : 10.1016/j.anplas.2004.09.001

E. R. Bastow, S. Byers, S. B. Golub, C. E. Clarkin, A. A. Pitsillides et al., Hyaluronan synthesis and degradation in cartilage and bone, Cellular and Molecular Life Sciences, vol.65, issue.3, pp.395-413, 2008.
DOI : 10.1007/s00018-007-7360-z

L. M. Blank, P. Hugenholtz, and L. K. Nielsen, Evolution of the Hyaluronic Acid Synthesis (has) Operon in Streptococcus zooepidemicus and Other Pathogenic Streptococci, Journal of Molecular Evolution, vol.51, issue.1, pp.13-22, 2008.
DOI : 10.4052/tigg.11.187

N. F. Boas, Isolation of hyaluronic acid from the cock's comb, 1949.

S. H. Brown and P. E. Pummill, Recombinant Production of Hyaluronic Acid, Current Pharmaceutical Biotechnology, vol.9, issue.4, pp.239-241, 2008.
DOI : 10.2174/138920108785161488

J. A. Burdick and G. D. Prestwich, Hyaluronic Acid Hydrogels for Biomedical Applications, Advanced Materials, vol.5, issue.12, pp.41-56, 2011.
DOI : 10.1016/j.actbio.2008.09.012

URL : http://europepmc.org/articles/pmc3730855?pdf=render

S. Carlino and F. Magnette, Process for purifying high molecular weight hyaluronic acid, BREVET AMÉRICAIN n° US, vol.6, pp.489-467, 2002.

A. Chaabane, Production d'acide hyaluronique. Rapport bibliographique sur l'acide hyaluronique, 2010.

W. Y. Chen and G. Et-abatangelo, Functions of hyaluronan in wound repair, Wound Repair and Regeneration, vol.12, issue.2, pp.79-89, 1999.
DOI : 10.1016/0142-9612(91)90020-B

L. J. Chien and C. K. Lee, Enhanced Hyaluronic Acid Production in Bacillus subtilis by Coexpressing Bacterial Hemoglobin, Biotechnology Progress, vol.0, issue.0, pp.1017-1022, 2007.
DOI : 10.1021/bp070036w

L. J. Chien and C. K. Lee, Hyaluronic acid production by recombinant Lactococcus lactis, Applied Microbiology and Biotechnology, vol.65, issue.2, pp.339-346, 2007.
DOI : 10.1111/j.1574-6968.1999.tb13374.x

B. F. Chong and L. K. Nielsen, Aerobic cultivation of Streptococcus zooepidemicus and the role of NADH oxidase, Biochemical Engineering Journal, vol.16, issue.2, pp.153-162, 2003.
DOI : 10.1016/S1369-703X(03)00031-7

P. Cornelis, Q. Wei, S. C. Andrews, and T. Vinckx, Iron homeostasis and management of oxidative stress response in bacteria, Metallomics, vol.72, issue.83, pp.540-549, 2011.
DOI : 10.1111/j.1365-2958.2009.06699.x

M. A. Croce, K. Dyne, and F. Boraldi, Hyaluronan affects protein and collagen synthesis by in vitro human skin fibroblasts The six hyaluronidase-like genes in the human and mouse genomes, Tissue Cell Csoka A. Matrix Biol, vol.20, pp.499-508, 2001.

A. Darke, E. G. Finer, R. Moorhouse, and D. A. Rees, Studies of hyaluronate solutions by nuclear magnetic relaxation measurements. Detection of covalently-defmed, stiff segments within the flexible chains, Journal of Molecular Biology, vol.99, issue.3, pp.477-486, 1975.
DOI : 10.1016/S0022-2836(75)80139-2

M. M. Don and N. F. Shoparwe, Kinetics of hyaluronic acid production by Streptococcus zooepidemicus considering the effect of glucose, Biochemical Engineering Journal, vol.49, issue.1, 2009.
DOI : 10.1016/j.bej.2009.12.001

C. Frank, N. Shrive, H. Hiraoka, N. Nakamura, Y. Kaneda et al., Optimisation of the biology of soft tissue repair, Journal of Science and Medicine in Sport, vol.2, issue.3, pp.190-210, 1999.
DOI : 10.1016/S1440-2440(99)80173-X

X. J. Duan, L. Yang, X. Zhang, and W. S. Tan, Effect of oxygen and shear stress on molecular weight of hyaluronic acid produced by streptococcus zooepidemicus, Journal of microbiology biotechnology, vol.18, pp.718-724, 2008.

B. Fong-chong, L. M. Blank, R. Mclaughlin, and L. K. Nielsen, Microbial hyaluronic acid production, Applied Microbiology and Biotechnology, vol.88, issue.4, pp.341-351, 2004.
DOI : 10.1007/s00253-004-1774-4

B. Fong-chong and L. K. Nielsen, Amplifying the cellular reduction potential of, Journal of Biotechnology, vol.100, issue.1, pp.33-41, 2003.
DOI : 10.1016/S0168-1656(02)00239-0

J. George and R. Stern, Serum hyaluronan and hyaluronidase: very early markers of toxic liver injury, Clinica Chimica Acta, vol.348, issue.1-2, pp.189-197, 2004.
DOI : 10.1016/j.cccn.2004.05.018

K. S. Girish and K. Kemparaju, The magic glue hyaluronan and its eraser hyaluronidase: A biological overview, Life Sciences, vol.80, issue.21, pp.1921-1943, 2007.
DOI : 10.1016/j.lfs.2007.02.037

K. L. Goa and P. Benfield, Hyaluronic Acid, Drugs, vol.47, issue.3, pp.536-66, 1994.
DOI : 10.2165/00003495-199447030-00009

G. Gözke and C. Posten, Electrofiltration of Biopolymers, Food Engineering Reviews, vol.8, issue.12, pp.131-146, 2010.
DOI : 10.1111/j.1574-6968.1990.tb13969.x

T. E. Hardingham and A. J. Et-fosang, Proteoglycans: many forms and many functions., The FASEB Journal, vol.6, issue.3, pp.861-870, 1992.
DOI : 10.1096/fasebj.6.3.1740236

S. Hasegawa, M. Nagatsuru, M. Shibutani, S. Yamamoto, and S. Hasebe, Productivity of concentrated hyaluronic acid using a Maxblend?? fermentor, Journal of Bioscience and Bioengineering, vol.88, issue.1, pp.68-71, 1999.
DOI : 10.1016/S1389-1723(99)80178-9

S. S. Hong, J. Chen, J. G. Zhang, Y. C. Tao, and L. Y. Liu, Purification and structure identification of hyaluronic acid, Chinese chemical letters, pp.811-812, 2004.

W. Huang, S. Chen, and T. Chen, Production of hyaluronic acid by repeated batch fermentation, Biochemical Engineering Journal, vol.40, issue.3, pp.460-464, 2008.
DOI : 10.1016/j.bej.2008.01.021

J. Im, J. Song, J. Kang, and D. Kang, Optimization of medium components for high-molecular-weight hyaluronic acid production by Streptococcus sp. ID9102 via a statistical approach, Journal of Industrial Microbiology & Biotechnology, vol.72, issue.11, pp.1337-1344, 2009.
DOI : 10.1007/s10295-009-0618-8

N. Itano, T. Sawai, M. Yoshida, P. Lenas, Y. Yamada et al., Three Isoforms of Mammalian Hyaluronan Synthases Have Distinct Enzymatic Properties, Journal of Biological Chemistry, vol.117, issue.35, pp.25085-25092, 1999.
DOI : 10.1111/j.1432-0436.1993.tb01591.x

S. Jaggannath and K. B. Ramachandran, Influence of competing metabolic processes on the molecular weight of hyaluronic acid synthesized by Streptococcus zooepidemicus, Biochemical Engineering Journal, vol.48, issue.2, pp.148-158, 2009.
DOI : 10.1016/j.bej.2009.09.003

M. J. Jedrzejas, Structural and Functional Comparison of Polysaccharide-Degrading Enzymes, Critical Reviews in Biochemistry and Molecular Biology, vol.8, issue.3, pp.221-251, 2000.
DOI : 10.1006/jmbi.1999.2883

M. J. Jedrzejas and R. Stern, Structures of vertebrate hyaluronidases and their unique enzymatic mechanism of hydrolysis, Proteins: Structure, Function, and Bioinformatics, vol.125, issue.5, pp.227-238, 2005.
DOI : 10.1093/hmg/7.12.1859

D. Y. Kang, W. Kim, I. S. Heo, Y. H. Park, and S. Lee, Extraction of hyaluronic acid (HA) from rooster comb and characterization using flow field-flow fractionation (FlFFF) coupled with multiangle light scattering (MALS), Journal of Separation Science, vol.44, issue.22, pp.3530-3536, 2010.
DOI : 10.1002/jssc.201000478

E. Karousou, M. Kamiryo, S. S. Skandalis, A. Ruusala, T. Asteriou et al., The Activity of Hyaluronan Synthase 2 Is Regulated by Dimerization and Ubiquitination, Journal of Biological Chemistry, vol.1380, issue.31, pp.23647-23654
DOI : 10.1074/jbc.273.4.1923

C. Ke, D. Qiao, D. Gan, Y. Sun, H. Ye et al., Antioxidant acitivity in vitro and in vivo of the capsule polysaccharides from Streptococcus equi subsp. zooepidemicus, Carbohydrate Polymers, vol.75, issue.4, pp.677-682, 2008.
DOI : 10.1016/j.carbpol.2008.09.008

J. H. Kim, S. J. Yoo, D. K. Oh, Y. G. Kneon, D. W. Park et al., Selection of a Streptococcus equi mutant and optimization of culture conditions for the production of high molecular weight hyaluronic acid, Enzyme and Microbial Technology, vol.19, issue.6, pp.440-445, 1996.
DOI : 10.1016/S0141-0229(96)00019-1

S. J. Kim, S. Y. Park, and C. W. Kim, A novel approach to the production of hyaluronic acid by Streptococcus zooepidemicus, Journal of Microbiology Biotechnology, vol.16, pp.1849-1855, 2006.

K. S. Kim, S. J. Park, J. A. Yang, J. H. Jeon, S. H. Bhang et al., Injectable hyaluronic acid???tyramine hydrogels for the treatment of rheumatoid arthritis, Acta Biomaterialia, vol.7, issue.2, pp.666-674, 2011.
DOI : 10.1016/j.actbio.2010.09.030

J. Kirwan, Is there a place for intra-articular hyaluronate in osteoarthritis of the knee?, The Knee, vol.8, issue.2, pp.93-101, 2001.
DOI : 10.1016/S0968-0160(01)00075-8

H. Laroui, Nanosphères polymères à couverture de hyaluronate pour la délivrance ciblée de molécules actives dans le traitement des affections du cartilage, 2007.

L. Liu, G. Du, J. Chen, M. Wang, and J. Sun, Comparative study on the influence of dissolved oxygen control approaches on the microbial hyaluronic acid production of Streptococcus zooepidemicus, Bioprocess and Biosystems Engineering, vol.71, issue.6, 2009.
DOI : 10.1007/s00449-009-0300-6

L. Liu, G. Du, J. Chen, Y. Zhu, M. Wang et al., Microbial production of low molecular weight hyaluronic acid by adding hydrogen peroxide and ascorbate in batch culture of Streptococcus zooepidemicus, Bioresource Technology, vol.100, issue.1, pp.362-367, 2008.
DOI : 10.1016/j.biortech.2008.05.040

L. Liu, J. Sun, D. Zhang, G. Du, J. Chen et al., Culture conditions optimization of hyaluronic acid production by Streptococcus zooepidemicus based on radial basis function neural network and quantum-behaved particle swarm optimization algorithm, Enzyme and Microbial Technology, vol.44, issue.1, pp.24-32, 2008.
DOI : 10.1016/j.enzmictec.2008.09.015

L. Liu, G. Du, J. Chen, M. Wang, and J. Sun, Influence of hyaluronidase addition on the production of hyaluronic acid by batch culture of Streptococcuszooepidemicus, Food Chemistry, vol.110, issue.4, pp.923-926, 2008.
DOI : 10.1016/j.foodchem.2008.02.082

Y. Luo, M. R. Ziebell, and G. D. Prestwich, A Hyaluronic Acid???Taxol Antitumor Bioconjugate Targeted to Cancer Cells, Biomacromolecules, vol.1, issue.2, pp.208-218, 2000.
DOI : 10.1021/bm000283n

J. Magdalou, P. Netter, S. Fournel-gigleux, and M. Ouzzine, L'agr??cane et le cartilage articulaire??: apport des glycosyltransf??rases dans la r??paration du cartilage arthrosique, Journal de la Soci??t?? de Biologie, vol.157, issue.4, pp.281-288, 2008.
DOI : 10.1042/bj2650637

C. Matsubara, M. Kajiwara, H. Akasaka, and S. Haze, Carbon-13 Nuclear Magnetic Resonance Studies on the Biosynthesis of Hyaluronic Acid., CHEMICAL & PHARMACEUTICAL BULLETIN, vol.39, issue.9, pp.2446-2448, 1991.
DOI : 10.1248/cpb.39.2446

E. Menzel and C. Farr, Hyaluronidase and its substrate hyaluronan: biochemistry, biological activities and therapeutic uses, Cancer Letters, vol.131, issue.1, pp.3-11, 1998.
DOI : 10.1016/S0304-3835(98)00195-5

K. Meyer and J. W. Palmer, The polysaccharide of the vitreous humor, J Biol Chem, vol.107, pp.629-663, 1934.

T. Miyazaki, C. Yomota, and S. Okada, Change in molecular weight of hyaluronic acid during measurement with a cone-plate rotational viscometer, Journal of Applied Polymer Science, vol.67, issue.13, pp.2199-2206, 1998.
DOI : 10.1002/(SICI)1097-4628(19980328)67:13<2199::AID-APP10>3.0.CO;2-W

K. Morimoto, H. Yamaguchi, Y. Iwakura, K. Morisaka, Y. Ohashi et al., Effects of viscous hyaluronate-sodium solutions on the nasal absorption of vasopressin and an analogue, Pharmaceutical Research, vol.08, issue.4, pp.471-474, 1991.
DOI : 10.1023/A:1015894910416

M. Morra, Engineering of Biomaterials Surfaces by Hyaluronan, Biomacromolecules, vol.6, issue.3, pp.1205-1223, 2005.
DOI : 10.1021/bm049346i

S. Nair, N. S. Remya, S. Remya, and P. D. Nair, A biodegradable in situ injectable hydrogel based on chitosan and oxidized hyaluronic acid for tissue engineering applications, Carbohydrate Polymers, vol.85, issue.4, pp.838-844, 2011.
DOI : 10.1016/j.carbpol.2011.04.004

P. W. Noble, Hyaluronan and its catabolic products in tissue injury and repair, Matrix Biology, vol.21, issue.1, pp.25-29, 2002.
DOI : 10.1016/S0945-053X(01)00184-6

T. K. Nykopp, K. Rilla, M. I. Tammi, R. H. Tammi, R. Sironen et al., Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma, BMC Cancer, vol.149, issue.1, p.512, 2010.
DOI : 10.1210/en.2008-0175

C. S. Ogrodowski, C. O. Hokka, and M. H. Santana, The Effects of the Addition of Lysozyme and Aeration on the Formation and the Rheological Properties of the Product, Applied Biochemistry and Biotechnology, pp.121-124, 2005.

O. O. Olutoye, E. J. Barone, D. R. Yager, T. Uchida, I. K. Cohen et al., Hyaluronic acid inhibits fetal platelet function: Implications in scarless healing, Journal of Pediatric Surgery, vol.32, issue.7, pp.1037-1040, 1997.
DOI : 10.1016/S0022-3468(97)90394-8

G. D. Prestwich, D. M. Marecak, J. F. Marecek, K. P. Vercruysse, and M. R. Ziebell, Controlled chemical modification of hyaluronic acid: synthesis, applications, and biodegradation of hydrazide derivatives, Journal of Controlled Release, vol.53, issue.1-3, pp.93-103, 1997.
DOI : 10.1016/S0168-3659(97)00242-3

R. D. Price, M. G. Berry, and H. A. Navsaria, Hyaluronic acid: the scientific and clinical evidence, Journal of Plastic, Reconstructive & Aesthetic Surgery, vol.60, issue.10, pp.1110-1119, 2007.
DOI : 10.1016/j.bjps.2007.03.005

M. J. Rah, A review of hyaluronan and its ophthalmic applications, Optometry - Journal of the American Optometric Association, vol.82, issue.1, pp.38-43, 2011.
DOI : 10.1016/j.optm.2010.08.003

V. Rangaswamy and D. Jain, An efficient process for production and purification of hyaluronic acid from Streptococcus equi subsp. zooepidemicus, Biotechnology Letters, vol.156, issue.3, pp.493-496, 2008.
DOI : 10.1007/s10529-007-9562-8

V. Rangaswamy, V. Santosh, J. Dharmendra, V. Nataraj, H. Velankar et al., Efficient process for purification of high molecular weight hyaluronic acid, p.35372, 2008.

L. Requena, C. Requena, L. Christensen, U. S. Zimmermann, H. Kutzner et al., Adverse reactions to injectable soft tissue fillers, Journal of the American Academy of Dermatology, vol.64, issue.1, pp.1-34, 2011.
DOI : 10.1016/j.jaad.2010.02.064

M. Romagnoli and M. Belmontesi, Hyaluronic acid???based fillers: theory and practice, Clinics in Dermatology, vol.26, issue.2, pp.123-159, 2008.
DOI : 10.1016/j.clindermatol.2007.09.001

C. E. Schanté, G. Zuber, C. Herlin, and T. F. Vandamme, Chemical modifications of hyaluronic acid for the synthesis of derivatives for a broad range of biomedical applications, Carbohydrate Polymers, vol.85, issue.3, pp.469-489, 2011.
DOI : 10.1016/j.carbpol.2011.03.019

J. Schiller, B. Fuchs, J. Arnhold, and K. Arnold, Contribution of Reactive Oxygen Species to Cartilage Degradation in Rheumatic Diseases: Molecular Pathways, Diagnosis and Potential Therapeutic Strategies, Current Medicinal Chemistry, vol.10, issue.20, pp.2123-2145, 2003.
DOI : 10.2174/0929867033456828

S. K. Seidlits, C. T. Drinnan, R. R. Petersen, J. B. Shear, L. J. Suggs et al., Fibronectin???hyaluronic acid composite hydrogels for three-dimensional endothelial cell culture, Acta Biomaterialia, vol.7, issue.6, pp.2401-2409, 2011.
DOI : 10.1016/j.actbio.2011.03.024

A. Shiedline, R. Bigelow, W. Christopher, S. Arbari, L. Yang et al., , Rooster Comb, Bovine Vitreous, and Human Umbilical Cord, Biomacromolecules, vol.5, issue.6, pp.2122-2127, 2004.
DOI : 10.1021/bm0498427

S. Stahl, Method and means for the production of hyaluronic acid, Brevet américain, issue.6, 2003.

R. Stern and H. I. Maibach, Hyaluronan in skin: aspects of aging and its pharmacologic modulation, Clinics in Dermatology, vol.26, issue.2, pp.106-122, 2008.
DOI : 10.1016/j.clindermatol.2007.09.013

S. Surini, H. Akiyama, M. Morishita, T. Nagai, and K. Takayama, Release phenomena of insulin from an implantable device composed of a polyion complex of chitosan and sodium hyaluronate, Journal of Controlled Release, vol.90, issue.3, pp.291-301, 2003.
DOI : 10.1016/S0168-3659(03)00196-2

A. Szarpak, Layer-by-Layer capsules of hyaluronic acid as potential drug carriers: synthesis, characterization and manipulating the properties, 2009.

Y. Tokita and A. Okamoto, Hydrolytic degradation of hyaluronic acid, Polymer Degradation and Stability, vol.48, issue.2, pp.269-273, 1995.
DOI : 10.1016/0141-3910(95)00041-J

J. Tritz-schiavi, N. Charif, C. Henrionnet, N. De-isla, D. Bensoussan et al., Original approach for cartilage tissue engineering with mesenchymal stem cells, 2010.

S. R. Van-tomme, G. Storm, and W. E. Hennink, In situ gelling hydrogels for pharmaceutical and biomedical applications, International Journal of Pharmaceutics, vol.355, issue.1-2, pp.1-18, 2008.
DOI : 10.1016/j.ijpharm.2008.01.057

J. A. Weigel and P. H. Weigel, Characterization of the Recombinant Rat 175-kDa Hyaluronan Receptor for Endocytosis (HARE), Journal of Biological Chemistry, vol.28, issue.44, pp.42802-42811, 2003.
DOI : 10.1152/physrev.1999.79.3.703

P. Weigel and P. De-angelis, Organisms for large scale hyaluronan production, Industrial Bioprocessing, vol.27, 2005.

M. R. Wessels, A. E. Moses, J. B. Goldberg, and T. J. Dicesare, Hyaluronic acid capsule is a virulence factor for mucoid group A streptococci., Proc. Natl. Sci, pp.8317-8321, 1991.
DOI : 10.1073/pnas.88.19.8317

D. C. West, I. N. Hampson, and F. Arnold, Angiogenesis induced by degradation products of hyaluronic acid, Science, vol.228, issue.4705, pp.1324-1330, 1991.
DOI : 10.1126/science.2408340

W. T. Winter, P. J. Smith, and S. Arrott, Hyaluronic acid: Structure of a fully extended 3-fold helical sodium salt and comparison with the less extended 4-fold helical forms, Journal of Molecular Biology, vol.99, issue.2, pp.219-235, 1975.
DOI : 10.1016/S0022-2836(75)80142-2

H. Yu, Q. Li, X. Zhou, V. P. Kolosov, and J. M. Perelman, Role of hyaluronan and CD44 in reactive oxygen species-induced mucus hypersecretion, Molecular and Cellular Biochemistry, vol.14, issue.1-2, pp.65-75, 2011.
DOI : 10.1038/nsmb1201

H. Yu and G. Stephanopoulos, Metabolic engineering of Escherichia coli for biosynthesis of hyaluronic acid, Metabolic Engineering, vol.10, issue.1, pp.24-32, 2008.
DOI : 10.1016/j.ymben.2007.09.001

X. Zhang, X. J. Duan, and W. S. Tan, Mechanism for the effect of agitation on the molecular weight of hyaluronic acid produced by Streptococcus zooepidemicus, Food Chemistry, vol.119, issue.4, pp.1643-1646, 2010.
DOI : 10.1016/j.foodchem.2009.09.014