, Sex (n) Female (45), male (29)
, Simpson grade (n) Grade
, Five-year survival Progression free survival: Grade I: 58%
, , p.36
, Grade III: 14% Overall survival: Grade I: 97%
, , p.88
Anaplastic: 18.9% (14/74) Transitional or mixed ,
, HSP27 SQ score (mean ± SEM, range) Total: 3.7 ± 0.3, range 9, pp.0-9
, Grade I: 3.7± 0.5, range 9, pp.0-9
, Grade II: 3.2± 0.5, range 9, pp.0-9
, Grade III: 5.2± 0.8, range 9, pp.0-9
, HSP27 density (AU; mean ± SEM, range) Total: 158.10 6 ± 2.10 6 , range 715, vol.10, pp.0-715
, Grade I: 104.10 6 ± 15.10 6 , range 31, vol.10, pp.0-313
, Grade II:116.10 6 ± 16.10 6 , range 29, vol.10, pp.0-290
, Grade III: 360.10 6 ± 49.10 6 , range 71, vol.10, pp.0-715
, HSP70 SQ score (AU; mean ± SEM, range) Total: 5.2± 0.3, range 9, pp.0-9
, Grade I: 4.9± 0.5, range 9, pp.0-9
, Grade III: 7.7± 0.6, range 9, pp.0-9
, HSP70 density (AU; mean ± SEM, range) Total: 225.10 6 ± 2,6.10 6 ; range 729, vol.10, pp.0-729
, Grade I: 145.10 6 ± 20.10 6 , range 525.10, vol.6, pp.0-525
, Grade II: 147.10 6 ± 21.10 6 , range 440, vol.10, pp.0-440
, Grade III: 546.10 6 ± 37.10 6 , range 729, vol.10, pp.0-729
, SQ score: semi quantitative score; SEM: standard error of mean; SD: standard deviation; WHO: World Health Organization
,
, Hsp27 and its expression pattern in diffusely infiltrating astrocytomas, Histol Histopathol, vol.29, issue.9, pp.1161-1169, 2014.
eat Shock Proteins Promote ancer: t's a Protection Racket, Trends Biochem Sci, vol.41, issue.4, pp.311-334, 2016. ,
WHO Classification of Tumours of the Central Nervous System, Classification-Of-Tumours/Who-Classification-Of-Tumours-Of-The-Central-NervousSystem-2016 4. Search of: Recruiting, Active, not recruiting, Completed, Enrolling by invitation, Unknown status Studies | HSP inhibitor-List Results-ClinicalTrials.gov ,
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review), Int J Oncol, vol.45, issue.1, pp.18-30, 2014. ,
New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells, Oncotarget, vol.7, issue.42, pp.68156-69, 2016. ,
Immunohistochemical detection of pS2 protein and heat shock protein-70 in pancreatic adenocarcinomas. Relationship with disease extent and patient survival, Pathol Res Pract, vol.198, issue.2, pp.77-84, 2002. ,
Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma, J Cell Mol Med, vol.16, issue.8, pp.1776-91, 2012. ,
Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions, Cell Mol Neurobiol, vol.15, issue.2, pp.257-68, 1995. ,
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer, Gut, vol.59, issue.11, pp.1501-1511, 2010. ,
Heat Shock Protein-27,-60 and-90 expression in gastric cancer: association with clinicopathological variables and patient survival, BMC Gastroenterol, vol.9, p.14, 2009. ,
Expression of heat shock proteins in osteosarcoma and its relationship to prognosis, Pathol Res Pract, vol.196, issue.10, pp.665-73, 2000. ,
14-3-3? induces heat shock protein 70 expression in hepatocellular carcinoma, BMC Cancer, vol.14, p.425, 2014. ,
Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma, Gut Liver, vol.8, issue.1, pp.79-87, 2014. ,
Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer, Virchows Arch Int J Pathol, vol.463, issue.4, pp.489-95, 2013. ,
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma, Melanoma Res, vol.13, issue.2, pp.147-52, 2003. ,
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer, Cell Oncol Dordr, vol.35, issue.3, pp.197-205, 2012. ,
Expression of minichromosome maintenance MCM6 protein in meningiomas is strongly correlated with histologic grade and clinical outcome, Am J Surg Pathol, vol.36, issue.2, pp.283-91, 2012. ,
Expression of heat shock proteins in brain tumors, Turk Neurosurg, vol.24, issue.5, pp.745-754, 2014. ,
Opportunities for clinical research in meningioma, J Neurooncol, vol.99, issue.3, pp.417-439, 2010. ,
Targeting heat shock proteins in cancer, Cancer Lett, vol.332, issue.2, pp.275-85, 2013. ,
WHO Classification of Tumours of the Central Nervous System, 2016. ,
, Flint-Richter P, Sadetzki S. Genetic predisposition for the development of radiation-associated meningioma: an epidemiological study, Lancet Oncol, vol.8, issue.5, pp.403-413, 2007.
Pathological classification and molecular genetics of meningiomas, J Neurooncol, vol.99, issue.3, pp.379-91, 2010. ,
Nf2 gene inactivation in arachnoidal cells is rate-limiting for meningioma development in the mouse, Genes Dev, vol.16, issue.9, pp.1060-1065, 2002. ,
, Tumeurs intracrâniennes
Meningiomes:histopronostic. AIP bulletin N°54, 2011. ,
Histological classification and molecular genetics of meningiomas, Lancet Neurol, vol.5, issue.12, pp.1045-54, 2006. ,
Expression of minichromosome maintenance MCM6 protein in meningiomas is strongly correlated with histologic grade and clinical outcome, Am J Surg Pathol, vol.36, issue.2, pp.283-91, 2012. ,
Fractionated stereotactic radiation therapy in the management of primary optic nerve sheath meningiomas, J Neurooncol, vol.94, issue.3, pp.419-443, 2009. ,
Stabilization of disease progression by hydroxyurea in patients with recurrent or unresectable meningioma, J Neurosurg, vol.97, issue.2, pp.341-347, 2002. ,
Intensity-modulated radiation therapy (IMRT) for meningioma, Int J Radiat Oncol Biol Phys, vol.53, issue.5, pp.1265-70, 2002. ,
Gross tumor volume (GTV) and clinical target volume (CTV) in ,
, Cancer Radiother J Soc Francaise Radiother Oncol, vol.5, issue.5, pp.581-96, 2001.
,
, Cancer Radiother J Soc Francaise Radiother Oncol, vol.5, issue.3, pp.217-253, 2001.
The meningioma controversy: postoperative radiation therapy, Int J Radiat Oncol Biol Phys, vol.15, issue.2, pp.299-304, 1988. ,
Radiation therapy in the treatment of partially resected meningiomas, Neurosurgery, vol.20, issue.4, pp.525-533, 1987. ,
Intracranial meningiomas: analysis of recurrence after surgical treatment, Acta Neurochir (Wien), vol.126, issue.2-4, pp.53-61, 1994. ,
The role of radiotherapy in the treatment of subtotally resected benign meningiomas, J Neurooncol, vol.13, issue.2, pp.157-64, 1992. ,
Combined proton and photon conformal radiotherapy for intracranial atypical and malignant meningioma, Int J Radiat Oncol Biol Phys, vol.75, issue.2, pp.399-406, 2009. ,
DOI : 10.1016/j.ijrobp.2008.10.053
Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: long-term experience and prognostic factors, Int J Radiat Oncol Biol Phys, vol.61, issue.3, pp.809-825, 2005. ,
DOI : 10.1016/j.ijrobp.2004.07.669
Heat shock proteins in oncology: diagnostic biomarkers or therapeutic targets?, Biochim Biophys Acta, vol.1816, issue.2, pp.89-104, 2011. ,
Targeting tumour-supportive cellular machineries in anticancer drug development, Nat Rev Drug Discov, vol.13, issue.3, pp.179-96, 2014. ,
DOI : 10.1038/nrd4201
14-3-3? induces heat shock protein 70 expression in hepatocellular carcinoma, BMC Cancer, vol.14, p.425, 2014. ,
DOI : 10.1186/1471-2407-14-425
URL : https://doi.org/10.1186/1471-2407-14-425
Prognostic significance of p53, mTOR, c-Met, IGF-1R, and HSP70 overexpression after the resection of hepatocellular carcinoma, Gut Liver, vol.8, issue.1, pp.79-87, 2014. ,
Heat shock protein 70 (HSP70) expression is associated with poor prognosis in intestinal type gastric cancer, Virchows Arch Int J Pathol, vol.463, issue.4, pp.489-95, 2013. ,
DOI : 10.1007/s00428-013-1461-x
High HSP27 and HSP70 expression levels are independent adverse prognostic factors in primary resected colon cancer, Cell Oncol Dordr, vol.35, issue.3, pp.197-205, 2012. ,
DOI : 10.1007/s13402-012-0079-3
Heat shock protein 70 membrane expression and melanoma-associated marker phenotype in primary and metastatic melanoma, Melanoma Res, vol.13, issue.2, pp.147-52, 2003. ,
DOI : 10.1097/00008390-200304000-00006
Immunohistochemical detection of pS2 protein and heat shock protein-70 in pancreatic adenocarcinomas. Relationship with disease extent and patient survival, Pathol Res Pract, vol.198, issue.2, pp.77-84, 2002. ,
Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas, Cancer Detect Prev, vol.22, issue.6, pp.549-55, 1998. ,
Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients. Cancer Invest, vol.30, pp.317-339, 2012. ,
Stress proteins HSP27 and HSP70i predict survival in non-small cell lung carcinoma, Anticancer Res, vol.28, issue.1B, pp.501-507, 2008. ,
Hsp27 and its expression pattern in diffusely infiltrating astrocytomas, Histol Histopathol, vol.29, issue.9, pp.1161-1169, 2014. ,
Low molecular weight heat shock protein HSP27 is a prognostic indicator in rectal cancer but not colon cancer, Gut, vol.59, issue.11, pp.1501-1511, 2010. ,
DOI : 10.1136/gut.2009.196626
Heat Shock Protein-27,-60 and-90 expression in gastric cancer: association with clinicopathological variables and patient survival, BMC Gastroenterol, vol.9, p.14, 2009. ,
DOI : 10.1186/1471-230x-9-14
URL : https://bmcgastroenterol.biomedcentral.com/track/pdf/10.1186/1471-230X-9-14
Expression of heat shock proteins in osteosarcoma and its relationship to prognosis, Pathol Res Pract, vol.196, issue.10, pp.665-73, 2000. ,
HSP 27 as possible prognostic factor in patients with oral squamous cell carcinoma, Histol Histopathol, vol.19, issue.1, pp.119-147, 2004. ,
Heat shock protein 27 as a prognostic and predictive biomarker in pancreatic ductal adenocarcinoma, Trends Biochem Sci, vol.16, issue.8, pp.311-334, 2012. ,
Hsp27 regulates epithelial mesenchymal transition, metastasis, and circulating tumor cells in prostate cancer, Cancer Res, vol.73, issue.10, pp.3109-3128, 2013. ,
HSP27, 70 and 90, anti-apoptotic proteins, in clinical cancer therapy (Review), Int J Oncol, vol.45, issue.1, pp.18-30, 2014. ,
,
, Med Sci MS, vol.21, issue.6-7, pp.619-644, 2005.
Targeting heat shock proteins in cancer, Cancer Lett ,
Search of: Recruiting, Active, not recruiting, Completed, Enrolling by invitation, Unknown status Studies | HSP inhibitor-List Results-ClinicalTrials.gov, Oncogene, vol.332, issue.2, pp.4153-61, 2015. ,
New HSP27 inhibitors efficiently suppress drug resistance development in cancer cells, Oncotarget, vol.7, issue.42, pp.68156-69, 2016. ,
Expression of the small heat shock protein (hsp) 27 in human astrocytomas correlates with histologic grades and tumor growth fractions, Cell Mol Neurobiol, vol.15, issue.2, pp.257-68, 1995. ,
Expression of heat shock proteins in brain tumors, Turk Neurosurg, vol.24, issue.5, pp.745-754, 2014. ,