. Genentech, . Mitsubishi, . Ferring, . Norgine, . Tillots et al.,

J. Kirchgesner, M. Lemaitre, and A. Rudnichi, Therapeutic management of inflammatory bowel disease in real-life practice in the current era of anti-TNF agents: analysis of the French administrative health databases, Aliment Pharmacol Ther, vol.45, pp.37-49, 2009.

G. G. Kaplan, The global burden of IBD: from 2015 to 2025, Nat Rev Gastroenterol Hepatol, vol.12, pp.720-727, 2015.

J. Ferlay, E. Steliarova-foucher, and J. Lortet-tieulent, Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012, Eur J Cancer Oxf Engl, vol.49, pp.1374-403, 1990.

D. Hui, Definition of supportive care: does the semantic matter?, Curr Opin Oncol, vol.26, pp.372-381, 2014.

M. H. Kyaw, C. E. Rose, A. M. Fry, and J. A. Singleton, The influence of chronic illnesses on the incidence of invasive pneumococcal disease in adults, J Infect Dis, vol.192, pp.377-86, 2005.

A. Sangil, M. Xercavins, and M. Rodríguez-carballeira, Impact of vaccination on invasive pneumococcal disease in adults with focus on the immunosuppressed, J Infect, vol.71, pp.422-429, 2015.

S. S. Huang, K. M. Johnson, and G. T. Ray, Healthcare utilization and cost of pneumococcal disease in the United States. Vaccine, vol.29, pp.3398-412, 2011.

N. Eliakim-raz and I. Vinograd, Zalmanovici Trestioreanu A. Influenza vaccines in immunosuppressed adults with cancer. Cochrane Database Syst Rev, vol.008983, 2013.

A. Fowlkes, A. Steffens, and J. Temte, Incidence of medically attended influenza during pandemic and post-pandemic seasons through the Influenza Incidence Surveillance Project, 2009-13, Lancet Respir Med, vol.3, pp.709-727, 2015.

A. Lopez, X. Mariette, and H. Bachelez, Vaccination recommendations for the adult immunosuppressed patient: A systematic review and comprehensive field synopsis, J Autoimmun, vol.80, pp.10-27, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01909042

C. R. Beck, B. C. Mckenzie, and A. B. Hashim, Influenza vaccination for immunocompromised patients: summary of a systematic review and meta-analysis. Influenza Other Respir Viruses, vol.7, pp.72-77, 2013.

T. Nordøy, I. S. Aaberge, and A. Husebekk, Cancer patients undergoing chemotherapy show adequate serological response to vaccinations against influenza virus and Streptococcus pneumoniae, Med Oncol Northwood Lond Engl, vol.19, pp.71-79, 2002.

W. Poeppl, H. Lagler, and M. Raderer, Influenza vaccination perception and coverage among patients with malignant disease, Vaccine, vol.33, pp.1682-1689, 2015.

S. Parker, C. White, L. Spangler, and C. , A quality improvement project significantly increased the vaccination rate for immunosuppressed patients with IBD, Inflamm Bowel Dis, vol.19, pp.1809-1823, 2013.

S. K. Wasan, A. H. Calderwood, and M. D. Long, Immunization rates and vaccine beliefs among patients with inflammatory bowel disease: an opportunity for improvement, Inflamm Bowel Dis, vol.20, pp.246-50, 2014.

I. Vinograd, R. Baslo, and N. Eliakim-raz, Factors associated with influenza vaccination among adult cancer patients: a case-control study, Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis, vol.20, pp.899-905, 2014.

M. L. Wumkes, A. Van-der-velden, and A. Van-der-velden, Influenza vaccination coverage in patients treated with chemotherapy: current clinical practice, Neth J Med, vol.71, pp.472-479, 2013.

G. Malhi, A. Rumman, and R. Thanabalan, Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge, and Uptake, J Crohns Colitis, vol.9, pp.439-483, 2015.

S. L. Goff, K. M. Mazor, and S. J. Gagne, Vaccine counseling: a content analysis of patient-physician discussions regarding human papilloma virus vaccine, Vaccine, vol.29, pp.7343-7352, 2011.

J. Halfvarson, L. Bodin, and C. Tysk, Inflammatory bowel disease in a Swedish twin cohort: a long-term follow-up of concordance and clinical characteristics, Gastroenterology, vol.124, pp.1767-73, 2003.

M. Orholm, V. Binder, and T. I. Sørensen, Concordance of inflammatory bowel disease among Danish twins. Results of a nationwide study, Scand J Gastroenterol, vol.35, pp.1075-81, 2000.

N. P. Thompson, R. Driscoll, and R. E. Pounder, Genetics versus environment in inflammatory bowel disease: results of a British twin study, BMJ, vol.312, pp.95-101, 1996.

U. Monsén, O. Bernell, and C. Johansson, Prevalence of inflammatory bowel disease among relatives of patients with Crohn's disease, Scand J Gastroenterol, vol.26, pp.302-308, 1991.

G. C. Parkes, K. Whelan, and J. O. Lindsay, Smoking in inflammatory bowel disease: impact on disease course and insights into the aetiology of its effect, J Crohns Colitis, vol.8, pp.717-742, 2014.

R. E. Andersson, G. Olaison, and C. Tysk, Appendectomy and protection against ulcerative colitis, N Engl J Med, vol.344, pp.808-822, 2001.

E. V. Loftus, P. Schoenfeld, and W. J. Sandborn, The epidemiology and natural history of Crohn's disease in population-based patient cohorts from North America: a systematic review, Aliment Pharmacol Ther, vol.16, pp.51-60, 2002.

J. Cosnes, C. Gower-rousseau, and P. Seksik, Epidemiology and natural history of inflammatory bowel diseases, Gastroenterology, vol.140, pp.1785-94, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00631553

J. Cosnes, S. Cattan, and A. Blain, Long-term evolution of disease behavior of Crohn's disease, Inflamm Bowel Dis, vol.8, pp.244-50, 2002.

J. Torres, S. Mehandru, J. Colombel, P. , and L. , Crohn's disease. The Lancet, vol.389, pp.1741-55, 2017.

S. Ghosh and R. Mitchell, Impact of inflammatory bowel disease on quality of life: Results of the European Federation of Crohn's and Ulcerative Colitis Associations (EFCCA) patient survey, J Crohns Colitis, vol.1, pp.10-20, 2007.

S. Massironi, R. E. Rossi, and F. A. Cavalcoli, Nutritional deficiencies in inflammatory bowel disease: therapeutic approaches, Clin Nutr Edinb Scotl, vol.32, pp.904-914, 2013.

T. Jess, C. Rungoe, and L. Peyrin-biroulet, Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, vol.10, pp.639-684, 2012.

J. Ferlay, E. Steliarova-foucher, and J. Lortet-tieulent, Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012, Eur J Cancer Oxf Engl, vol.49, pp.1374-403, 19902013-04.

P. Grosclaude, L. Remontet, and A. Belot, Survie des personnes atteintes de cancer en France, 2013.
URL : https://hal.archives-ouvertes.fr/hal-02087526

A. Bouvier, Z. Uhry, and V. Jooste, Focus on an unusual rise in pancreatic cancer incidence in France, Int J Epidemiol, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01541663

G. A. Decker, M. J. Batheja, and J. M. Collins, Risk Factors for Pancreatic Adenocarcinoma and Prospects for Screening, Gastroenterol Hepatol, vol.6, pp.246-54, 2010.

A. Verdecchia, I. Corazziari, and G. Gatta, Explaining gastric cancer survival differences among European countries, Int J Cancer, vol.109, pp.737-778, 2004.

Y. Zhang, Epidemiology of esophageal cancer, World J Gastroenterol WJG, vol.19, pp.5598-606, 2013.

M. Harbord, R. Eliakim, and D. Bettenworth, Third European Evidence-based Consensus on Diagnosis and Management of Ulcerative Colitis. Part 2: Current Management, J Crohns Colitis, vol.11, pp.769-84, 2017.

F. Gomollón, A. Dignass, and V. Annese, 3rd European Evidence-based Consensus on the Diagnosis and Management of Crohn's Disease 2016: Part 1: Diagnosis and Medical Management, J Crohns Colitis, vol.11, pp.3-25, 2017.

B. Feagan, Update on Tofacitinib for Inflammatory Bowel Disease, Gastroenterol Hepatol, vol.12, pp.572-576, 2016.

W. J. Sandborn, S. Ghosh, and J. Panes, Tofacitinib, an oral Janus kinase inhibitor, in active ulcerative colitis, N Engl J Med, vol.367, pp.616-640, 2012.

G. Bouguen, B. G. Levesque, and B. G. Feagan, Treat to target: a proposed new paradigm for the management of Crohn's disease, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, vol.13, pp.1042-1050, 2015.

L. Peyrin-biroulet, W. Sandborn, and B. E. Sands, Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE): Determining Therapeutic Goals for Treat-to-Target, Am J Gastroenterol, vol.110, pp.1324-1362, 2015.
URL : https://hal.archives-ouvertes.fr/hal-01191653

J. Colombel, R. Panaccione, and P. Bossuyt, Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial, Lancet Lond Engl, 2017.

L. Peyrin-biroulet, Y. Bouhnik, and X. Roblin, Algorithmes de prise en charge de la rectocolite hémorragique en 2015 : Consensus National Français. Hépato-Gastro Oncol Dig, vol.23, pp.32-42, 2016.

A. D. Levin, M. E. Wildenberg, and G. R. Van-den-brink, Mechanism of Action of Anti-TNF Therapy in Inflammatory Bowel Disease, J Crohns Colitis, vol.10, pp.989-97, 2016.

W. J. Sandborn, B. G. Feagan, and C. Marano, Subcutaneous golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis, Gastroenterology, vol.146, pp.85-95, 2014.

W. J. Sandborn, B. G. Feagan, and C. Marano, Subcutaneous golimumab maintains clinical response in patients with moderate-to-severe ulcerative colitis, Gastroenterology, vol.146, pp.96-109, 2014.

L. Peyrin-biroulet, Anti-TNF therapy in inflammatory bowel diseases: a huge review, Minerva Gastroenterol Dietol, vol.56, pp.233-276, 2010.

W. J. Sandborn, C. Gasink, and L. Gao, Ustekinumab induction and maintenance therapy in refractory Crohn's disease, N Engl J Med, vol.367, pp.1519-1547, 2012.

J. F. Colombel, W. J. Sandborn, and W. Reinisch, Infliximab, azathioprine, or combination therapy for Crohn's disease, N Engl J Med, vol.362, pp.1383-95, 2010.

R. Panaccione, S. Ghosh, and S. Middleton, Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis, Gastroenterology, vol.146, pp.392-400, 2014.

S. Schneeweiss, J. Korzenik, and D. H. Solomon, Infliximab and other immunomodulating drugs in patients with inflammatory bowel disease and the risk of serious bacterial infections, Aliment Pharmacol Ther, vol.30, pp.253-64, 2009.

N. Andersen, N. Pasternak, B. Friis-møller, and N. , Association between tumour necrosis factor-? inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide Danish cohort study, BMJ, vol.350, p.2809, 2015.

M. T. Osterman, W. J. Sandborn, and J. Colombel, Crohn's Disease Activity and Concomitant Immunosuppressants Affect the Risk of Serious and Opportunistic Infections in Patients Treated With Adalimumab, Am J Gastroenterol, vol.111, pp.1806-1821, 2016.

A. N. Ananthakrishnan, A. Cagan, and T. Cai, Diabetes and risk of infections with immunomodulator therapy in inflammatory bowel diseases, Aliment Pharmacol Ther, vol.41, pp.1141-1149, 2015.

L. Beaugerie and S. H. Itzkowitz, Cancers complicating inflammatory bowel disease, N Engl J Med, vol.372, pp.1441-52, 2009.
URL : https://hal.archives-ouvertes.fr/hal-01301711

L. Peyrin-biroulet, K. Khosrotehrani, and F. Carrat, Increased risk for nonmelanoma skin cancers in patients who receive thiopurines for inflammatory bowel disease, Gastroenterology, vol.141, pp.1621-1628, 2011.
URL : https://hal.archives-ouvertes.fr/hal-00631539

M. Löbermann, D. Bor?o, and I. Hilgendorf, Immunization in the adult immunocompromised host, Autoimmun Rev, vol.11, pp.212-220, 2012.

C. C. Goodnow, Pathways for self-tolerance and the treatment of autoimmune diseases, Lancet Lond Engl, vol.357, pp.2115-2136, 2001.

M. H. Kyaw, C. E. Rose, and A. M. Fry, The influence of chronic illnesses on the incidence of invasive pneumococcal disease in adults, J Infect Dis, vol.192, pp.377-86, 2005.

J. Mauskopf, M. Klesse, and S. Lee, The burden of influenza complications in different high-risk groups: a targeted literature review, J Med Econ, vol.16, pp.264-77, 2013.

A. Gutierrez, Coordinating preventive medicine in patients with inflammatory bowel disease: whose responsibility is it anyway?, Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc, vol.7, pp.500-501, 2009.

A. Gupta, F. A. Macrae, and P. R. Gibson, Vaccination and screening for infections in patients with inflammatory bowel disease: a survey of Australian gastroenterologists, Intern Med J, vol.41, pp.462-469, 2011.

S. K. Wasan, J. A. Coukos, and F. A. Farraye, Vaccinating the inflammatory bowel disease patient: deficiencies in gastroenterologists knowledge, Inflamm Bowel Dis, vol.17, pp.2536-2576, 2011.

Y. S. Jung, J. H. Park, and H. J. Kim, Insufficient knowledge of korean gastroenterologists regarding the vaccination of patients with inflammatory bowel disease, Gut Liver, vol.8, pp.242-249, 2014.

A. Vollaard, I. Schreuder, and L. Slok-raijmakers, Influenza vaccination in adult patients with solid tumours treated with chemotherapy, Eur J Cancer Oxf Engl, vol.76, pp.134-177, 19902017-05.

G. Y. Melmed, A. F. Ippoliti, and K. A. Papadakis, Patients with inflammatory bowel disease are at risk for vaccine-preventable illnesses, Am J Gastroenterol, vol.101, pp.1834-1874, 2006.

L. Peyrin-biroulet, A. Oussalah, and N. Williet, Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease, Gut, vol.60, pp.930-936, 2011.

Y. Urun, H. Akbulut, and A. Demirkazik, Perception about influenza and pneumococcal vaccines and vaccination coverage among patients with malignancies and their family members, J BUON Off J Balk Union Oncol, vol.18, pp.511-516, 2013.

G. Malhi, A. Rumman, and R. Thanabalan, Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge, and Uptake, J Crohns Colitis, vol.9, pp.439-483, 2015.

G. Malhi, A. Rumman, and R. Thanabalan, Vaccination in Inflammatory Bowel Disease Patients: Attitudes, Knowledge, and Uptake, J Crohns Colitis, vol.9, pp.439-483, 2015.

J. A. Sinclair, S. K. Wasan, and F. A. Farraye, Health maintenance in the inflammatory bowel disease patient, Gastroenterol Clin North Am, vol.41, pp.325-362, 2012.

S. K. Wasan, J. A. Coukos, and F. A. Farraye, Vaccinating the inflammatory bowel disease patient: deficiencies in gastroenterologists knowledge, Inflamm Bowel Dis, vol.17, pp.2536-2576, 2011.

L. Selby, A. Hoellein, and J. F. Wilson, Are primary care providers uncomfortable providing routine preventive care for inflammatory bowel disease patients?, Dig Dis Sci, vol.56, pp.819-843, 2011.

. Levine, Pediatric modification of the Montreal classification for inflammatory bowel disease: the Paris classification, Inflamm. Bowel Dis, 2011.