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A. Stojadinovic, D. Leung, A. Hoos, D. P. Jaques, J. J. Lewis et al., Analysis of the prognostic significance of microscopic margins in 2,084 localized primary adult soft tissue sarcomas, Ann Surg, vol.235, issue.3, pp.424-458, 2002.

A. Jemal, T. Murray, E. Ward, A. Samuels, R. C. Tiwari et al., Cancer statistics, vol.55, issue.1, pp.10-30, 2005.

, Adjuvant chemotherapy for localised resectable soft-tissue sarcoma of adults: metaanalysis of individual data. Sarcoma Meta-analysis Collaboration, Lancet, vol.350, issue.9092, pp.1647-54, 1997.

S. Frustaci, F. Gherlinzoni, D. Paoli, A. Bonetti, M. Azzarelli et al., Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: results of the Italian randomized cooperative trial, J Clin Oncol, vol.19, issue.5, pp.1238-1285, 2001.

P. J. Woll, P. Reichardt, L. Cesne, A. Bonvalot, S. Azzarelli et al., Adjuvant chemotherapy with doxorubicin, ifosfamide, and lenograstim for resected soft-tissue sarcoma (EORTC 62931): a multicentre randomised controlled trial, Lancet Oncol, vol.13, issue.10, pp.1045-54, 2012.

A. Italiano, F. Delva, S. Mathoulin-pelissier, L. Cesne, A. Bonvalot et al., Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database, Ann Oncol, vol.21, issue.12, pp.2436-2477, 2010.

L. Cesne, A. Ouali, M. Leahy, M. G. Santoro, A. Hoekstra et al., Doxorubicin-based adjuvant chemotherapy in soft tissue sarcoma: pooled analysis of two STBSG-EORTC phase III clinical trials, Ann Oncol, vol.25, issue.12, pp.2425-2457, 2014.

, Association of Directors of Anatomic and Surgical Pathology, Am J Clin Pathol, vol.111, issue.5, pp.594-602, 1999.

P. Chung, B. M. Deheshi, P. C. Ferguson, J. S. Wunder, A. M. Griffin et al., Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas, Cancer, vol.115, issue.14, pp.3254-61, 2009.

B. A. Guadagnolo, G. K. Zagars, M. T. Ballo, S. R. Patel, V. O. Lewis et al., Excellent local control rates and distinctive patterns of failure in myxoid liposarcoma treated with conservation surgery and radiotherapy, Int J Radiat Oncol Biol Phys, vol.70, issue.3, pp.760-765, 2008.

T. A. Gooley, W. Leisenring, J. Crowley, and B. E. Storer, Estimation of failure probabilities in the presence of competing risks, Statis Med, vol.18, pp.695-706, 1999.

. Fine and R. J. Gray, A Proportional Hazards Model for the Subdistribution of a Competing Risk, J Am Stat Assoc, vol.94, pp.496-509, 1999.

C. A. Bellera, N. Penel, M. Ouali, S. Bonvalot, P. G. Casali et al., Guidelines for time-to-event end point definitions in sarcomas and gastrointestinal stromal tumors (GIST) trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials), Ann Oncol, vol.26, issue.5, pp.865-72, 2015.
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J. C. Yang, A. E. Chang, A. R. Baker, W. F. Sindelar, D. N. Danforth et al., Randomized prospective study of the benefit of adjuvant radiation therapy in the treatment of soft tissue sarcomas of the extremity, J Clin Oncol, vol.16, issue.1, pp.197-203, 1998.

T. Brodowicz, E. Schwameis, J. Widder, G. Amann, C. Wiltschke et al., Intensified Adjuvant IFADIC Chemotherapy for Adult Soft Tissue Sarcoma: A Prospective Randomized Feasibility Trial, Sarcoma, vol.4, issue.4, pp.151-60, 2000.

N. Fakhrai, C. Ebm, W. J. Kostler, M. Jantsch, F. Abdolvahab et al., Intensified adjuvant IFADIC chemotherapy in combination with radiotherapy versus radiotherapy alone for soft tissue sarcoma: long-term follow-up of a prospective randomized feasibility trial, Wien Klin Wochenschr, vol.122, pp.614-623, 2010.

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A. T. Stotter, R. P. Hern, C. Fisher, A. F. Mott, M. E. Fallowfield et al., The influence of local recurrence of extremity soft tissue sarcoma on metastasis and survival, Cancer, vol.65, issue.5, pp.1119-1148, 1990.

F. C. Eilber, G. Rosen, S. D. Nelson, M. Selch, F. Dorey et al., High-grade extremity soft tissue sarcomas: factors predictive of local recurrence and its effect on morbidity and mortality, Ann Surg, vol.237, issue.2, pp.218-244, 2003.

B. K. Potter, P. F. Hwang, J. A. Forsberg, C. B. Hampton, J. C. Graybill et al., Impact of margin status and local recurrence on soft-tissue sarcoma outcomes, J Bone Joint Surg Am, vol.95, issue.20, p.151, 2013.

B. Rööser, P. Gustafson, and A. Rydholm, Is there no influence of local control on the rate of metastases in high-grade soft tissue sarcoma?, Cancer, vol.65, issue.8, pp.1727-1736, 1990.

P. Gustafson, B. Rööser, and A. Rydholm, Is local recurrence of minor importance for metastases in soft tissue sarcoma?, Cancer, vol.67, issue.8, pp.2083-2089, 1991.

R. J. Canter, S. R. Martinez, R. M. Tamurian, M. Wilton, C. Li et al., Radiographic and histologic response to neoadjuvant radiotherapy in patients with soft tissue sarcoma, Ann Surg Oncol, vol.17, issue.10, pp.2578-84, 2010.

F. R. Eilber, D. L. Morton, J. Eckardt, T. Grant, and T. Weisenburger, Limb salvage for skeletal and soft tissue sarcomas. Multidisciplinary preoperative therapy, Cancer, vol.53, issue.12, pp.2579-84, 1984.

F. C. Eilber, G. Rosen, J. Eckardt, C. Forscher, S. D. Nelson et al., Treatmentinduced pathologic necrosis: a predictor of local recurrence and survival in patients receiving neoadjuvant therapy for high-grade extremity soft tissue sarcomas, J Clin Oncol, vol.19, issue.13, pp.3203-3212, 2001.

D. M. Macdermed, L. L. Miller, T. D. Peabody, M. A. Simon, H. H. Luu et al., Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy, Int J Radiat Oncol Biol Phys, vol.76, issue.4, pp.1147-53, 2010.

L. A. Mack, P. J. Crowe, J. L. Yang, N. S. Schachar, D. G. Morris et al., Preoperative chemoradiotherapy (modified Eilber protocol) provides maximum local control and minimal morbidity in patients with soft tissue sarcoma, Ann Surg Oncol, vol.12, issue.8, pp.646-53, 2005.

C. Temple, D. C. Ross, E. Magi, L. M. Difrancesco, E. Kurien et al., Preoperative chemoradiation and flap reconstruction provide high local control and low wound complication rates for patients undergoing limb salvage surgery for upper extremity tumors, J Surg Oncol, vol.95, issue.2, pp.135-176, 2007.

T. F. Delaney, I. J. Spiro, H. D. Suit, M. C. Gebhardt, F. J. Hornicek et al., Neoadjuvant chemotherapy and radiotherapy for large extremity soft-tissue sarcomas, Int J Radiat Oncol Biol Phys, vol.56, issue.4, pp.1117-1144, 2003.

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